Fermentation Technology Division

Overview

Fermentation Technology Division is involved in microbial biodiversity research leading to the production of industrially important biopharmaceuticals including bioactives, biocatalysts, biotransformation of drug/intermediates, nutraceuticals and enhanced agriculture crop yields through microbial fertilizers, biopesticides and mineral. Research and development activities include production, process optimization, scale up, downstream processing, purification & characterization of biomolecules for industrial applications.

Vision and Mission

  • Vision: To become recognised Centre of Excellence for Industrial microbiology research
  • Mission: Helping Indian industries for scale up of processes and building confidence in Indian industry through transferring technology and training on microbial fermentation processes

Competencies

  • Isolation, characterization & identification of microbes, screening for specific microbial enzymes and secondary metabolites, enantio/ regio-specific biotransformations
  • Chemo-profiling of biocatalysts, biotransformations
  • Multi-functional fermentation scale up facility from lab scale to 500L capacity with compatible downstream processing
  • Technology development for agricultural crop yield increase by biofertilizers, biocontrol agents and micronutrients.

Research Facilities

  • State of Art Micro-processor controlled fermentation facility upto 500L scale with supporting down-stream processing facilities for bacterial, fungal and yeast based products.
  • State-of–art equipments required for Microbiology, Enzymology and Bio-process development
  • Micro/ultrafiltration
  • Incubator shakers
  • Microscope
  • Biosafety cabinets
  • Refrigerated centrifuge, basket centrifuge, sharpels centrifuge
  • Spectrophotometer
  • Electrophoresis units
  • -86oC deep freezer
  • Autoclave
  • PCR machine
  • Ultrasonicator
  • Rotary evaporators from lab to pilot scale

People/Research Group

Dr. Asha Chaubey
Principal Scientist

Dr. Saurabh Saran

Dr. Saurabh Saran
Senior Scientist

Dr. Vikas Babu
Senior Scientist

Dr. Vinod Kumar
Scientist

Mrs. Urmila Jamwal
Principal Technical Officer

On Going Projects

MLP-110004- Development of Zinc gluconate-Vitamin C formulation for immunity improvement and management of coronavirus disease(COVID-19)

MLP-1008- Bioprospecting microbial species from unexplored ecological niches for novel molecules and enzymes

GAP-2179- Characterization, recombinant expression, process scale-up and validation of selected hydrolases from native actinobacteria for commercial exploitation

GAP-2187- Fermentation based process development for production of Tacrolimus drug

Publication and Patents

Authors Title Journal
Rahul V Singh, Hitesh Sharma, Ananta Ganjoo, Amit Kumar and Vikash Babu Novel amidase catalysed process for the synthesis of vorinostat drug J Applied Microbiology
Diksha Koul, Devtulya Chander,  Ravi  S. Manhas and Asha Chaubey Isolation and characterization of Serratiopeptidase producing bacteria from Mulberry phyllosphere Current Microbiology
Manoj Kumar, Nipunta Tanoj and Saurabh Saran A Modified, Efficient and Sensitive pH Indicator Dye Method for the Screening of Acid-Producing Acetobacter Strains Having Potential Application in Bio-Cellulose Production Applied Biochemistry and Biotechnology
 Hitesh Sharma, Rahul.V.Singh, Chand Raina and Vikash Babu Amide hydrolysing potential of amidase from halophilicbacterium Brevibacterium sp. IIIMB2706 Biocatalysis & Biotransformation
Shifali Chib, Ashish Dogra, Utpal Nandi & Saurabh Saran Consistent production of kojic acid from Aspergillus sojae SSC-3 isolated from rice husk Molecular Biology Reports
Richa Sharma, Ankita Magotra, Ravi S.Manhas, Asha Chaubey Antagonistic potential of a psychrotrophic fungus: Trichoderma velutinum ACR-P1 Biological Control
·         Ibidapo S. Williams, ShifaliChib, , Vijay K. Nuthakki, Linda Gatchie, Prashant Joshi, Niteen A. Narkhede, Ram A.

·         Vishwakarma, Sandip B. Bharate, Saurabh Saran and

·         Bhabatosh Chaudhuri

 Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme Journal of Agricultural and Food Chemistry
Richa Sharma, Vijay Lakshmi Jamwal,  Varun P. Singh, Praveen Awasthi, Deepika Singh, Ram A. Vishwakarma, Sumit G. Gandhi and Asha Chaubey Revelation and cloning of valinomycin synthetase genes in Streptomyces lavendulae ACR-DA1 and their expression analysis under different fermentation and elicitation conditions Journal of Biotechnology
Richa Sharma, Varun P. Singh, Deepika Singh, Farnaz Yusuf, Anil Kumar, Ram A. Vishwakarma, Asha Chaubey Optimization of nonribosomal peptides production by a psychrotrophic fungus: Trichoderma velutinum ACR-P1 Applied Microbiology and Biotechnology
Ankita Magotra, Manjeet Kumar, Manoj Kushwaha, Praveen Awasthi, Chand Raina, Ajai Prakash Gupta, Bhahwal A. Shah, Sumit G. Gandhi and Asha Chaubey Epigenetic modifier induced enhancement of fumiquinazoline C production in Aspergillus fumigatus (GA-L7): an endophytic fungus from Grewia asiatica L. AMB Express