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Dr. Asha Chaubey
Sr. Principal Scientist / HOD Fermentation and Microbial Biotechnology Division
Fermentation Technology Division
CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: achaubey@iiim.res.in
Bio Sketch
Dr. Asha Chaubey is presently working as Principal Scientist and Head of Fermentation Technology Division. She is working in the area of fermentation technology for exploration and exploitation of microorganisms for production of bioactives and novel enzymes for more than 15 years. These include isolation and characterization of microorganisms from unexplored niches of North-Western Himalayas, Shivalik foothills and endophytes. The significant contributions include biotransformation of industrially important molecules, immobilization of enzymes for enantioselectivity improvement, production of industrially important biopharpaceuticals and published her work in best journals of the field During the doctoral research; she has significantly contributed towards the development of biosensors for health care and generated good quality publications and patents. Presently, she has been actively involved in developing fermentation processes for production of biopharmaceuticals, nutraceuticals, therapeutic enzymes and enzymes/products for agriculture applications.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph.D. | Biochemistry | LLRM Medical College, CCS University, Meerut | 2003 |
| M.Sc. | Org/Biochemsitry | CCS University, Meerut | 1995 |
| B.Sc. | Botany, Chemistry Zoology | CCS University, Meerut | 1993 |
Position Held
| Position Held | Period | Organization |
| Sr. Principal Scientist | Nov2020 – Present | CSIR-Indian Institute of Integrative Medicine |
| Principal Scientist | Nov. 2015-Nov2020 | CSIR-Indian Institute of Integrative Medicine |
| Senior Scientist | Nov.2010-Nov.2015 | CSIR-Indian Institute of Integrative Medicine |
| Scientist | Nov.2006-Nov.2010 | CSIR-Indian Institute of Integrative Medicine |
| Scientist ‘B’ | Nov.2003-Nov.2006 | CSIR-Indian Institute of Integrative Medicine
(Formerly Regional Research Laboratory) |
Area of Expertise
- Bioprospection of microorganisms for industrial enzymes & bioactives production
- Endophytes and their role in Plant-microbe interaction
- Biotransformation of industrially important molecules
- Production of therapeutic enzymes , biocatalysis and immobilization of enzymes
- Development of fermentation processes and nutraceutical products
- Development of biosensors for healthcare
Projects
MLP-110004- Development of Zinc gluconate-Vitamin C formulation for immunity improvement and management of coronavirus disease(COVID-19)
MLP-0048- Deciphering the mechanism(s) for host-endophytes, coevolution, enhanced secondary metabolite production and crop productivity
GAP-2179- Characterization, recombinant expression, process scale-up and validation of selected hydrolases from native actinobacteria for commercial exploitation
MLP-1008- Bioprospecting microbial species from unexplored ecological niches for novel molecules and enzymes
MLP-1003– Value addition and product development based on bioresources of Jammu and Kashmir
MLP-4012- Unravelling mysteries of fermentation based drugs (Asavas and Arishtas) in Ayurveda
HCP-0007- CSIR Aroma Mission
STS-0006: Bioprospecting microbial species for novel molecules and enzymes
Publications
| Authors | Title | Journal |
| Ravi S. Manhas, Harshita Tiwari, Mateen Noor, Ajaz Ahmed, Jyoti Vishwakarma, Raja B. M. Tripathi, Ravishankar Ramachandran, Sreedhar Madishetti, Debaraj Mukherjee, Amit Nargotra, Asha Chaubey | Setomimycin as a Potential molecule for COVID-19 Target: In silico approach and in vitro validation | Molecular Diversity
DOI: 10.1007/s11030-022-10441-5 |
| Devtulya Chander, Jasmine Kour Khosla, Diksha Koul, Md. Mehedi Hossain, Mohd Jamal Dar, Asha Chaubey | Purification and characterization of thermoactive serratiopeptidase from Serratia marcescens AD-W2. | AMB Express 11 (2021) 53 |
| Pankaj Gupta, Asha Chaubey, Neha Mahajan, Naveen Anand | A Review on Arthrobacter sp. Lipase: A Versatile Biocatalyst for the Kinetic Resolution to Access Enantiomerically Pure/Enriched Compounds | Chirality 33 (2021) 209–225. |
| Sadaqat Farooq, Arem Qayum, Yedukondalu Nalli, Gianluigi Lauro, Maria Giovanna Chini, Giuseppe Bifulco, Asha Chaubey, Shashank K. Singh, Syed Riyaz-Ul-Hassan and Asif Ali | Discovery of a Secalonic Acid Derivative from Aspergillus aculeatus, an Endophyte of Rosa damascena Mill., Triggers Apoptosis in MDAMB-231 Triple Negative Breast Cancer Cells. | ACS Omega 5 (38) (2020) 24296-24310
|
| Diksha Koul, Devtulya Chander, Ravi S. Manhas and Asha Chaubey | Isolation and characterization of Serratiopeptidase producing bacteria from Mulberry phyllosphere | Current Microbiology (DOI: 10.1007/s00284-020-02280-0)
|
| Sadaqat Farooq, Arem Qayum, Yedukondalu Nalli, Gianluigi Lauro, Maria Giovanna Chini, Giuseppe Bifulco, Asha Chaubey, Shashank K. Singh, Syed Riyaz-Ul-Hassan and Asif Ali | Discovery of a Secalonic Acid Derivative from Aspergillus aculeatus, an Endophyte of Rosa damascena Mill., Triggers Apoptosis in MDAMB-231 Triple Negative Breast Cancer Cells. | ACS Omega 5 (38) (2020) 24296-24310
|
| Varun P. Singh, Richa Sharma, Vandana Sharma, Chand Raina, Anil Kumar, Deepika Singh, Asha Chaubey, and Ram A. Vishwakarma | Enhanced production of Valinomycin from psychrotrophic isolate Streptomyces lavendulae from cold deserts of North-Western Himalayas | Journal of Antibiotics 72 (2019)617–624.
|
| Swati Sharma, Abhay B. Fulke, Asha Chaubey | Bioprospection of marine actinomycetes: recent advances,challenges and future perspectives
|
Acta Oceanol. Sin., 38 (2019) 1–17
|
| Richa Sharma, Ankita Magotra, Ravi S.Manhas, Asha Chaubey | Antagonistic potential of a psychrotrophic fungus: Trichoderma velutinum ACR-P1 | Biological Control 115 (2017) 15-17. |
| Richa Sharma, Vijay Lakshmi Jamwal, Varun P. Singh, Praveen Awasthi, Deepika Singh, Ram A. Vishwakarma, Sumit G. Gandhi and Asha Chaubey | Revelation and cloning of valinomycin synthetase genes in Streptomyces lavendulae ACR-DA1 and their expression analysis under different fermentation and elicitation conditions | J Biotechnol. 253 (2017) 40-47
|
| Ankita Magotra, Manjeet Kumar, Manoj Kushwaha, Praveen Awasthi, Chand Raina, Ajai Prakash Gupta, Bhahwal A. Shah, Sumit G. Gandhi and Asha Chaubey | Epigenetic modifier induced enhancement of fumiquinazoline C production in Aspergillus fumigatus (GA-L7): an endophytic fungus from Grewia asiatica L. | AMB Expr (2017) 7:43
|
| Richa Sharma, Varun P. Singh, Deepika Singh, Farnaz Yusuf, Anil Kumar, Ram A. Vishwakarma, Asha Chaubey | Optimization of nonribosomal peptides production by a psychrotrophic fungus: Trichoderma velutinum ACR-P1 | Appl Microbiol Biotechnol 100(21) (2016) 9091-9102 |
| Ryan J. Marcheschi, Kechun Zhang, E.L. Noey, S. Kim, Han Li, Asha Chaubey, K.N. Houk, James C. Liao | A Synthetic Recursive “+1” Pathway for Carbon Chain Elongation | ACS Chem Biol. 7 (2012) 689–697
|
Patents
| Inventors/ Contributors | Title | Description | Year |
| Chaubey Asha, Manhas Ravi S., Khosla, Ahmad Ajaz, Ahmad Syed Mudabir, Tiwari Harshita, Nargotra Amit, Mukherjee Debaraj and Goswami Anindya | A process for the preparation of Tetrahydroanthracenes from Streptomyces (MTCC-25420) and anticancer activity thereof
|
Indian Patent Application number 202111047805 | 2021 |
| Pandey Manoj Kumar, Chaubey Asha, Pande Krishan Kant, Sharma Rajendra Kumar Saini Krishan Kumar, Malhotra Bansi Dhar and Rajesh
|
Lactate biosensing strip | CA 2512281 | 2010 |
| Pandey Manoj Kumar, Chaubey Asha, Pande Krishan Kant, Sharma Rajendra Kumar, Saini Krishan Kumar, Malhotra Bansi Dhar and Rajesh | Method for preparing lactate biosensing strip | CA 2512279 | 2010 |
| Pandey Manoj Kumar , Chaubey Asha, Pande Krishan Kant, Sharma Rajendra Kumar ,Saini Krishan Kumar ,Malhotra Bansi Dhar and Rajesh
|
Method for manufacture of lactate biosensing strip | United States Patent No 7364873 | 2008 |
| Pandey Manoj Kumar, Chaubey Asha, Pande Krishan Kant, Sharma Rajendra Kumar, Saini Krishan Kumar ,Malhotra BD and Rajesh
|
Lactate biosensing strip with two electrodes | United States Patent No. 7,319,018 | 2008 |
| Kumar A., Chaubey Asha Rajesh and Malhotra BD
|
A novel conducting polymer based electrode for the estimation of cholesterol in aqueous solution | United States Patent No. Us 7,175,746 B2 | 2007 |
| Pandey Manoj Kumar, Chaubey Asha, Pande Krishan Kant, Rajesh, Sharma Rajendra Kumar, Saini Krishan Kumar, Malhotra BD and Rajesh
|
Process for the preparation of lactate biosensing strip useful for the preparation of lactate in aqueous solution | Indian Patent No. 197458 | 2006 |
Awards and Honours
- BOYSCAST Fellowship by the Department of Science and Technology, Government of India
- Research Associateship by the Department of Biotechnology, Government of India
- Dr K.S. Krishnan Research Associateship by Bhabha Atomic Research Center, Trombay, Mumbai, India
- Senior Research Fellowship from Council of Scientific and Industrial Research (CSIR), Government of India
- Best Poster Award during Sixth Asian Conference on Solid State Ionics, 29 Nov.-4 Dec, 1998, Surajkund, Haryana, India
- Best Poster Award during 4th National Conference on Solid State Ionics, 3-5 March, 2000 at Indian Institute of Technology, Mumbai, India
Students
| Photo | Name | Area of Interest | Position |
 |
Ravi Singh Manhas | Bioactives producing actinobacteria | Senior Research Fellow |
 |
Devtulya Chander | Biotechnology, Enzymology | JRF |
 |
Diksha Koul | Applied Microbiology, Endophytes | Project Assistant |
 |
Parna Saha | Endophytes | Junior Research Fellow |
 |
Neha Sharma | Actinobacteria | Junior Research Fellow |
 |
Snigdha Sharma | Applied Microbiology | Project Associate |
 |
Dhanishta Sagotra | Endophytes | Project Associate |
 |
Inderjeet Singh | Virtual Lab, Animation & Simulation | Project Associate |