IIIM Srinagar (Br.)

Overview

Indian Institute of Integrative Medicine (IIIM) Branch, Srinagar is a state of the art laboratory located in the suburbs of the picturesque Srinagar city. From the very inception this branch of IIIM has contributed immensely towards the social betterment/upliftment by fostering HRD as well as setting up small scale industries. Currently the main focus of the institute is to exploit the unique bio-diversity of Kashmir valley with special emphasis on medicinal and aromatic plants and microbes for drug development.

The process involves multidisciplinary scientific teams which include plant and microbial biologists, natural and synthetic chemists, biotechnologists, pharmacologists. In addition the Institute has huge experimental Farms at Bonera (Pulwama), Yarikha (Tangmarg) and Verinag (Anantnag) aiming at the development of national aroma centre with primary interests for value addition of indigenous aromas.

Flowcytometer

Vision & Mission

 

  • Vision: To become a Centre of Excellence in Natural Products chemistry and biotechnology driven  drug discovery, integrating modern biology with chemistry
  • Mission: The vision of the Institute is to position IIIM as a International center of excellence for natural products chemistry, chemical biology, pharmacology and biotechnology to discover new chemical entities (NCEs) as drugs for unmet medical needs and provide scientific rationale and validity to various Indian systems of medicine. The institute aspires to achieve leadership position as a research Institute for creating a broad knowledge base, a work force of dedicated and trained scientists and a  technology  development center through scientific exploration of secondary metabolites from plants and microbial biodiversity, at the same time generating awareness for their conservation and protection.

Competencies

 

  • Microbial Biotechnology
  • Plant Molecular Biology & Biotechnology
  • Natural Product/ Synthetic, Bio-Organic and Medicinal Chemistry
  • Clinical Microbiology and PK & PD
  • Neuropharmacology
  • Agrotechnology and extension
  • with reduced steps & solvents.

Research Facilities

List of research facilities/ infrastructure available

  • 400MHz NMR
  • LC-MS
  • GC-MS
  • HPLC
  • LN2 generation plant
  • Distillations Units
  • Flow Cytometer

NMR

People/Research Group

Name Designation
Er. Abdul Rahim Head & Chief Scientist 
Dr. Fayaz A Malik Sr. Principal Scientist
Dr. Zahoor Ahmad Parry Sr. Principal Scientist
Dr. Qazi Parvaiz Hassan Sr. Principal Scientist
Dr. Syed Riyaz-UI-Hassan Sr. Principal Scientist
Dr. Khursheed Ahmad Bhat  Sr. Principal Scientist
Dr. Muzamil Ahmad Principal Scientist
Dr. Syed Sajad Hussain Principal Scientist
Dr. Bilal Ahmad Bhat
 Principal Scientist
Dr. Nasheeman Ashraf Principal Scientist
Dr. Shahid Rasool Senior Scientist
Dr. Nazia Abbas Senior Scientist
Dr. Firdoous Ahmad Mir Scientist
Dr. Syed Khalid Yousuf Scientist
Dr. Padma Lay Scientist
Dr. Phalisteen Sultan Technical Officer(II)
Mr. Habibullah Technical Assistant
Mr. Zabir Ahmad Technical Assistant

Ongoing Projects

• Endosymbiotic bacteria in plant associated fungi; elucidating their role in fungal biology, endophytism and pathogenesis

• Chemical characterization and bio-evaluation of two medicinal plants, Rheum emodi and Arnebia benthamii against triple negative breast cancer.

• Floriculture Mission

• Cloning and characterisation of key enzymes involved in biosynthesis of some of the novel steroidal saponins and their biological efficacy from Dioscorea deltoidea endemic to Kashmir Himalayas.

• In-Silico-Steered Synthesis of Architecturally Challenging Inosito- Inositols: A New Approach to Prevent Amyloid-β Aggregation in Alzheimer’s Disease : (GAP-2196)

• Target Identification, Pharmacokinetics of a Novel Antituberculosis Lead that is Effective against MDR-TB : (GAP-3103)

• A Unified Approach to Spiro lactones: Applications towards the Synthesis of Related Natural Products :(GAP-2193)

• Comprehensive identification and characterization of apocarotenoid biosynthetic pathways and their regulation in Crocus sativus

• In-Silico-Steered Synthesis of Architecturally Challenging Inosito- Inositols: A New Approach to Prevent Amyloid-β Aggregation in Alzheimer’s Disease : (GAP-2196)

• Catalysing rural empowerment through cultivation, processing, value addition and marketing of aromatic Plants: (HCP-0007)

• Endosymbiotic bacteria in plant associated fungi; elucidating their role in fungal biology, endophytism and pathogenesis.
• Biostimulants: Plant-Microbe interactions in Glycyrrhiza glabra (FBR)
• Target Identification and ADME Pharmacokinetic properties of a novel antituberculosis Lead that is effective against MDR-TB.

• Development of b-Hairpin Peptidomimetics and Self-Assembled Ultrashort Hybrid Peptide Nanostructures as Anti-Infective Agents.

• Deciphering role of astrocytes in pathogenesis of central nervous system tuberculosis (CNS-TB) and exploiting its related pathways as potential therapeutic targets for CNS-TB.

• Elucidation of molecular basis of drug and multidrug tuberculosis of Mycobacterium tuberculosis in Kashmir Valley.

• Bio-prospection of Actinomycestes from high altitude Salt lakes of Leh – Ladakh for drug discovery against Tuberculosis.

• CSIR – Sickle cell Anemia Mission project

• Glycoengineering of Nicotiana tabacum using CRISPR Cas based genome editing: Glyco-optimization for humanized therapeutic protein production in plants
• Exploring Small molecules to unravel vulnerabilities of tumor cells
• Investigating the regulation of stem cell plasticity during tumor invasion and metastasis.

• Identification of new phyto-pharmaceuticals in the treatment of depression

Publications

Authors Title Journal

 

Dar NJ, Satti NK, Dutt P, Hamid A, Ahmad M.

 

Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway.

Mol Neurobiol.  2018 Apr;55(4):2725-2739.

Wadhwa B, Paddar M, Khan S, Mir S, Clarke P, Grabowska A, Vijay D,  Vishwakarma R,  Malik F

AKT isoforms have discrete expression in Triple Negative breast cancers and roles in cisplatin sensitivity

Oncotarget

2020; 11:4178-4194)

 

 

Bhat ZS, Rather MA, Ullah H, Hussain A, Maqbool M, Syed KY, Jabeen Z, Wani MA,   and Ahmad Z

In vitro bactericidal activity of 3-Cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against susceptible, drug tolerant and drug resistant isolates of Mycobacterium tuberculosis

Journal of Global Antimicrobial Resistance

HussainA, Dar MS, Bano N, Hossain MM, B Rafia, Bhat AQ, Aga MA, Ali S, Qazi Parvaiz Hassan*, Dar MS.

Identification of dinactin, a macrolide antibiotic, as a natural product based small molecule targeting Wnt/β-catenin signalling pathway in cancer cells

Cancer Chemotherapy and Pharmacology, 2019 Sep;84(3):551-559

 

Ahmad T, Arora P, Nalli Y, Ali A., Riyaz-Ul-Hassan S

Antibacterial potential of Juglomycin A isolated from Streptomyces achromogenes, an endophyte of Crocus sativus Linn.

Journal of Applied Microbiology. 2020. 128(5): 1366-1377

Shabir H. Lone, Salman Jameel, Muzzaffar A. Bhat, Rayees A. Lone, Ray J. Butcher and Khursheed A. Bhat

Synthesis of an unusual quinazoline alkaloid: theoretical and experimental investigations of its structural, electronic, molecular and biological properties

RSC Adv. 2018, 8, 8259-

8268.

Dar MI,  Jan S, Reddy GL, Wani R, Mudassir S, Dar MJ, Sawant SD, Ram A Vishwakarma RA, Syed SH

Differentiation of human neuroblastoma cell line IMR-32 by sildenafil and its newly discovered analogue IS00384

Cellular Signalling 2020 Jan;65:109425

 

B Teli, MA Waseem, S Rashid, BA Ganaie, BA Bhat

Catalyst Free Synthesis of 2‐Aryl‐2H‐benzo[b][1,4]oxazines and 3‐Aryl‐2H‐benzo[b][1,4]thiazin‐2‐ones: An Ultrasonication‐assisted Strategy

Journal of Heterocyclic Chemistry, 2021

https://doi.org/10.1002/jhet.4267

Baba SA and Ashraf N

Functional characterization of flavonoid 3′-hydroxylase, CsF3′H, from Crocus sativus L: Insights into substrate specificity and role in abiotic stress.

Archives of Biochemistry and Biophysics (2019), 667: 70–78

Farooqi, F.S., Rasool, S.  and Simnani, S.A. 2018.  

Problems & prospects of fisherwomen of Kashmir Valley.

International Journal of Fisheries and Aquatic Studies 2018; 6(3): 358-360.

Abbas N., Maurya J.P., Senapati D., Gangappa S.N and Chattopadhyay S

 

Arabidopsis CAM7 and HY5 physically interact and directly bind to the HY5 promoter to regulate its expression and thereby promote photomorphogenesis.  

The Plant Cell

Meenakshi Singh, Yogesh P. Bharitkar, Abhijit Hazra

Natural products containing olefinic bond: important substrate for semisynthetic modification toward the value addition. Current organic chemistry

Current Organic Chemistry, 2020, 24, 709-745

 

Patents

Inventors/ Contributors Title Description Year

ThatikondaThansha, Kumar Suresh, Singh Umed, MahajanPriya, MahajanGirish, NagrotaAmit, Malik, Fayaz, MondheDilip, Vishwakarma Ram, Singh parvinder pal

Novel 1,3,5- Triazine based PI3K inhibitors as anticancer agents and a process for the preparation thereof

US20170342049, WO/2016/079760A4, EP3221307A1

2016

A. Khajuria, A. Gupta, S.Singh, F. Malik, Jaswant Singh, KL Bedi, KA Suri, NK Satti, OP Suri, GN Qazi, VK Srinivas, Gopinathan, K Ella

 

Iridoid glycoside composition

EP1837027A1, US20070275006

 

2007

Qazi, Ghulam Nabi, TanejaSubash Chandra.; Singh, Jaswant; SaxenaAjit Kumar; Sethi Vijay Kumar; Shah Bhahwal Ali, Kumar Ajay, Andotra Samar Singh, Malik, Fayaz; MuthiahShanmugavel, Agarwal, Satyam Kuma

Use of semi synthetic analogues of boswellic acids for anticancer activity

US20090298938

2009

Qazi GN, Verma V and Riyaz-Ul-Hassan S.

Oligonucleotide primers of sequence ID. Nos. 1-21 and a process for detection of Salmonella using oligonucleotide primers.

IN 225146, dt. Dt. 30/09/2004,

2008

Qazi GN, Puri SC, Braroo A, Verma V, Riyaz-Ul-Hassan S, Anand R, Bhardwaj LM, Bhondakar AP, Kumar A and Bajpai RP.

Microbial decontaminator

Application 3930/DELNP/2004

2007

Qazi, GN, Verma, V and Riyaz-Ul-Hassan S.

Oligonucleotide primers of sequenceID. Nos. 1-21 and a process for detection of Salmonella using oligonucleotide primers.

US10/440, 211. No. 7,041,482, May 9, 2006.

2006

SD Sawant, GL Reddy, M Srinavas, SH Syed, MI Dar, A Nargotra, M Priya, RA Vishwakarma.

Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof

WO2015/114647 (43)

2015