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CSIR-Indian Institute of Integrative Medicine

CSIR-Indian Institute of Integrative Medicine

(Council of Scientific & Industrial Research)

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Dr. Muzamil Ahmad

Dr. Muzamil Ahmad

IIIM (Br) Srinagar Division

CSIR – Indian Institute of Integrative Medicine, Branch Laboratory, Srinagar
Email: mahmad@iiim.res.in

  • Profile
  • Position Held
  • Area of Expertise
  • Project Involved / Ongoing Projects
  • Publications and Patents
  • Awards / Honours
  • Group

Profile

Bio Sketch

Dr. Ahmad’s current research focuses on the pharmacologic regulation of inflammatory mechanisms in acute and chronic models of neurodegenerative diseases. His research is particularly focused on understanding the molecular basis of the protective role of some bioactive molecules that have demonstrated potential benefits in folkloric and traditional medicine in India. Dr. Ahmad is fascinated with the molecular mechanisms pertaining to neurodegeneration and regeneration. His researches pertain to stroke, Parkinson’s, and Alzheimer’s employing both in vivo and in vitro models. The overall goal of the laboratory remains to slow down the disease progression of the neurodegenerative disease and eventually develop a modality against these dreaded diseases.

Dr. Ahmad is a career neuroscientist having worked immensely on stroke and Parkinson. He has published 45 research papers in his chosen field in the journals of repute. His researches have been cited 3280 times in literature and have an h-index of 30. Dr. Ahmad sits on editorial boards of some prestigious journals and some international reviewer panels in his field.

Education

Degree Subjects University Qualifying Year
Ph.D. Toxicology

(Neurotoxicology)

Hamadard University,

New Delhi

August, 2003
M.Sc. Toxicology Hamadard University,

New Delhi

May, 1999
B.Sc. Biological Sciences University of Kashmir,

Srinagar

April , 1997

Position Held

Position Held

Position Held Period Organization
Principal Scientist 09/2010-present CSIR- Indian Institute of Integrative Medicine
Research Associate 11/ 2006 – 8/ 2010 University of Pittsburgh/ SOM (USA)
Post-doctoral research scholar 10/ 2003- 10/2006 The Johns Hopkins University/ SOM (USA)

 

Area of Expertise

Area of Expertise

  • Modelling of stroke, parkinson and Alzheimer disease
  • Plant based drugs in neurodegeneration and excitotoxicity
  • Neuroinflammatory cascade in neurodegeneration
  • Pharmacological intervention in models of neurodegeneration
  • Molecular biomarkers in neurodegeneration
  • Signaling cascades in neurodegeneration

 

 

Project Involved / Ongoing Projects

Projects

  • Role of inositol in Alzheimer’s disease
  • Role of plant based drugs in neurodegeneration

 

 

 

 

 

 

 

 

Publications and Patents

Publications

Authors Title Journal
 

Dar NJ, Satti NK, Dutt P, Hamid A, Ahmad M.

 

Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway. Mol Neurobiol.  2018 Apr;55(4):2725-2739.
Dar NJ, Bhat JA, Satti NK, Sharma PR, Hamid A, Ahmad M. Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells. Mol Neurobiol. 2017 Sep; 54(7):5061-5073.
Singh P, Dar MS, Singh G, Jamwal G, Sharma PR, Ahmad M, Dar MJ Dynamics of GFP-Fusion p110α and p110β Isoforms of PI3K Signaling Pathway in Normal and Cancer Cells J Cell Biochem. 2016 Dec; 117(12):2864-2874.
Lone AM, Dar NJ, Hamid A, Shah WA, Ahmad M, Bhat BA Promise of Retinoic Acid-Triazolyl Derivatives in Promoting Differentiation of Neuroblastoma Cells ACS Chem Neurosci. 2016 Jan 20; 7(1):82-9.
Shaik JS, Ahmad M, Li W, Rose ME, Foley LM, Hitchens TK, Graham SH, Hwang SH, Hammock BD, Poloyac SM. Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1605-13.
Liu H, Li W, Rose ME, Pascoe JL, Miller TM, Ahmad M, Poloyac SM, Hickey RW, Graham SH. Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. Neurotoxicology. 2013 Dec;39:35-44.

 

Liu H, Li W, Ahmad M, Miller TM, Rose ME, Poloyac SM, Uechi G, Balasubramani  M, Hickey RW, Graham SH. Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury. Neurobiol Dis. 2011 Feb;41(2):318-28.

 

Ahmad M, Zhang Y, Liu H, Rose ME, Graham SH. Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. Brain Res. 2009 Jul 7; 1279:168-73.
Ahmad M, Rose ME, Vagni V, Griffith RP, Dixon CE, Kochanek PM, Hickey RW, Graham SH. Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice. J Neurosci Res. 2008 Dec;86(16):3605-12.

 

Ahmad M, Ahmad AS, Zhuang H, Maruyama T, Narumiya S, Doré S. Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury.

 

J Neuroimmunol. 2007 Mar;184(1-2):172-9.
Ahmad M, Saleem S, Zhuang H, Ahmad AS, Echeverria V, Sapirstein A, Doré S. 1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia. Eur J Neurosci. 2006 Jan;23(1):35-42.

 

Awards / Honours

Awards and Honours

  • Ramalingaswamy Fellowship
  • Academic Editor PLOSone
  • Academic editor Scientific Reports
  • Review editor ‘Frontiers of Neurophamacology’

 

 

 

 

 

Group

Students

S NO. Name Area of Interest  Education
1. Nayeem Sultan Pharmacology of AD and PD

 

 

 

 

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