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सीएसआईआर-भारतीय समवेत औषध संस्थान

सीएसआईआर-भारतीय समवेत औषध संस्थान

(Council of Scientific & Industrial Research)

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Dr. Muzamil Ahmad

Dr. Muzamil Ahmad

Scientist-F

Neuropharmacology Laboratory

CSIR – Indian Institute of Integrative Medicine, Branch Laboratory, Srinagar
Email: mahmad[dot]iiim[at]csir[dot]res[dot]in

  • Profile
  • Position Held
  • Area of Expertise
  • Project Involved / Ongoing Projects
  • Publications and Patents
  • Awards / Honours
  • Group

Profile

Bio Sketch

Dr. Muzamil Ahmad received his master's and Ph.D. in Toxicology from Hamdard University in 2003. Following his doctoral studies, he completed seven years of postdoctoral research at institutions including Johns Hopkins University and the University of Pittsburgh in the United States. In 2010, Dr. Ahmad joined the CSIR-Indian Institute of Integrative Medicine, where he currently holds the position of Scientist F. His research is centered on elucidating the molecular mechanisms underlying neurodegeneration and regeneration, with a particular emphasis on stroke, Parkinson’s disease, and Alzheimer’s disease, utilizing both in vivo and in vitro models. The primary objective of his laboratory is to identify strategies to slow the progression of neurodegenerative diseases and to develop novel therapeutic approaches. His team also generates molecular evidence supporting the therapeutic potential of AYUSH-complementary and alternative medicines in neurodegenerative disorders and pain management. Dr. Ahmad has published 52 research articles in peer-reviewed journals, accumulating 4,900 citations and an h-index of 35. He serves on several international reviewer panels and editorial boards of leading journals in his field. In recognition of his scientific contributions, Dr. Ahmad has received the Ramalingaswamy Fellowship from the Department of Biotechnology (DBT), Government of India, and has been conferred the Distinguished Alumnus Award by Hamdard University, New Delhi.

Education

Degree Subjects University Qualifying Year
Ph.D.

Toxicology

(Neurotoxicology)

Hamadard University,

New Delhi

August, 2003
M.Sc. Toxicology

Hamadard University,

New Delhi

May, 1999
B.Sc. Biological Sciences

University of Kashmir,

Srinagar

April , 1997

Position Held

Position Held

Position Held Period Organization
Scientist-F 04/09/2019 – Present CSIR- Indian Institute of Integrative Medicine
Scientist-E 09/2010 – 09/2019 CSIR- Indian Institute of Integrative Medicine
Research Associate 11/2006 – 8/2010 University of Pittsburgh/ SOM (USA)
Post-doctoral research scholar 10/2003 – 10/2006 The Johns Hopkins University/ SOM (USA)

Area of Expertise

Area of Expertise

  • Modelling of stroke, Parkinson’s and Alzheimer’s disease
  • Plant-based drugs in neurodegeneration and excitotoxicity
  • Neuroinflammatory cascade in neurodegeneration
  • Pharmacological intervention in models of neurodegeneration
  • Molecular biomarkers in neurodegeneration
  • Signaling cascades in neurodegeneration

 

 

 

Project Involved / Ongoing Projects

Projects

  • Treating Neuropathic Pain using Peptide Libraries Based on Conotoxins.
  • Pre-clinical validation of Anti-Alzheimer activity of a classical Unani Formulation.
  • Role of PGE2-mediated inflammatory alterations in the deregulation of metastatic
    suppressors in glioblastoma.
  • Neuro- and mito-protective effects of small molecules in Parkinson’s disease.
  • Role of inositol analogues in Alzheimer’s disease.
  • Role of plant based drugs in neurodegeneration.

 

 

 

Publications and Patents

Publications

Authors Title Journal

Dar NJ, Gull B, Hamid A, Ahmed Z, Ahmad M.

Withaferin-A kills neuronal cells: An off-putting facet of Withania somnifera as a neuroprotectant. Steroids. 2025 Oct; 222:109662.

Mushtaq U, Ganai RA, Ahmad M, Khanday FA.

Amyloid beta-activated alpha-1-syntrophin has ramifications on Rac1 activation, ROS production and neuronal cell death. Eur J Neurosci. 2024 Dec;60(11): 6935-6952.

Dar NJ, Satti NK, Dutt P, Hamid A, Ahmad M.

Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway. Mol Neurobiol.  2018 Apr;55(4):2725-2739.
Dar NJ, Bhat JA, Satti NK, Sharma PR, Hamid A, Ahmad M. Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells. Mol Neurobiol. 2017 Sep; 54(7):5061-5073.
Singh P, Dar MS, Singh G, Jamwal G, Sharma PR, Ahmad M, Dar MJ Dynamics of GFP-Fusion p110α and p110β Isoforms of PI3K Signaling Pathway in Normal and Cancer Cells J Cell Biochem. 2016 Dec; 117(12):2864-2874.
Lone AM, Dar NJ, Hamid A, Shah WA, Ahmad M, Bhat BA Promise of Retinoic Acid-Triazolyl Derivatives in Promoting Differentiation of Neuroblastoma Cells ACS Chem Neurosci. 2016 Jan 20; 7(1):82-9.
Shaik JS, Ahmad M, Li W, Rose ME, Foley LM, Hitchens TK, Graham SH, Hwang SH, Hammock BD, Poloyac SM. Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1605-13.
Liu H, Li W, Rose ME, Pascoe JL, Miller TM, Ahmad M, Poloyac SM, Hickey RW, Graham SH. Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites.

Neurotoxicology. 2013 Dec;39:35-44.

 

Liu H, Li W, Ahmad M, Miller TM, Rose ME, Poloyac SM, Uechi G, Balasubramani  M, Hickey RW, Graham SH. Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury. Neurobiol Dis. 2011 Feb;41(2):318-28.
Ahmad M, Zhang Y, Liu H, Rose ME, Graham SH. Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. Brain Res. 2009 Jul 7; 1279:168-73.
Ahmad M, Rose ME, Vagni V, Griffith RP, Dixon CE, Kochanek PM, Hickey RW, Graham SH. Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice.

J Neurosci Res. 2008 Dec;86(16):3605-12.

 

Ahmad M, Ahmad AS, Zhuang H, Maruyama T, Narumiya S, Doré S. Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury. J Neuroimmunol. 2007 Mar;184(1-2):172-9.
Ahmad M, Saleem S, Zhuang H, Ahmad AS, Echeverria V, Sapirstein A, Doré S. 1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia. Eur J Neurosci. 2006 Jan;23(1):35-42.

Awards / Honours

Awards and Honours

  • Ramalingaswamy Fellowship (2011), Department of Biotechnology, GOI
  • Cover Page of Brain Research- July 2009
  • Distinguished Alumnus Award from Hamdard University, New Delhi
  • Academic Editor PLOSone
  • Academic editor Scientific Reports
  • Review editor ‘Frontiers of Neurophamacology’

 

 

 

 

Group

Students

S.NO. Name Designation Area of Interest Education
1. Dr. Mir Mohd Faheem DBT-Research Associate Metastatic Suppressors in Glioblastoma Ph. D. Biochemistry
2. Dr. Ishrat Rasool Reshi DHR Woman Scientist Plant-based drugs & mitochondrial dysfunction in Parkinson’s Disease Ph .D. Immunology
3. Mr. Mohd Abbass Malik PhD Scholar (AcSIR) Small-molecule interventions against AD. Integrated B.Sc./M.Sc. Biotechnology
4. Miss. Bisma Gull PhD Scholar (AcSIR) Excitotoxicity as a primary driver of neurodegeneration. M. Sc. in
Biotechnology
5. Mr. Faizan Magray Project Associate Therapeutic potential of conotoxin-based synthetic peptides against neuropathic pain. M. Sc. Clinical Biochemistry
6. Miss. Anjuman Chowdhary Project Assistant Evidence-based evaluation Small-molecule interventions against Parkinson’s Disease. M. Sc. Human Genetics
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