Skip to content
ENG हिंदी اردو
  Last updated: May 23rd, 2022
facebook
twitter

Screen Reader Access

CSIR-Indian Institute of Integrative Medicine

CSIR-Indian Institute of Integrative Medicine

(Council of Scientific & Industrial Research)

  • Home
    • About Us
    • IIIM Current Focus Areas
    • Organogram
  • Research
    • Research Achievements
      • Publications
      • All Patents
      • Projects
      • Technologies Developed
      • Honours & Awards
    • Research Groups
    • Research Facilitation
    • Research Collaborations
    • Research Council
    • Budget for 2015-2021
    • Facilities
  • Services
    • Business Overview
    • Trainings
  • Tenders
  • Notifications
  • Jobs
    • Permanent Position
    • Temporary Position
  • People
  • Contact

Dr. Fayaz A Malik

Dr. Fayaz A Malik

Sr. Principal Scientist

Cancer Pharmacology Division

CSIR-Indian Institute of Integrative Medicine Sanat Nagar Srinagar

Email: fmalik@iiim.res.in

  • Profile
  • Position Held
  • Area of Expertise
  • Project Involved / Ongoing Projects
  • Publications and Patents
  • Awards / Honours
  • Group

Profile

Bio Sketch

Dr. Malik is a Pr. Scientist in the Division of Cancer Pharmacology at CSIR-Indian Institute of Integrative Medicine. Dr. Malik earned a Ph.D. from Punjab University, Punjab India and did his postdoctoral work with Prof. Dr. Max A. Wicha at the University of Michigan Ann Arbor, USA. Dr. Malik joined the CSIR-IIIM, as a scientist in 2008 and has been promoted to the positions of Sen. Scientist in 2011 and Pr. Scientist in 2015

Research Statement

Major research interest of his group is to understand the fundamental regulatory mechanisms associated with Tumor metastasis and therapeutic resistance. Metastasis remains the major cause of cancer associated deaths and a huge clinical challenge with no therapeutic intervention. His current research goals are to understand the underlying mechanisms of cancer stem cells and metastasis in triple-negative breast cancer (TNBC) to identify the new targets, and identify small molecules against highly aggressive and drug resistant breast cancers.

Education

Degree Subjects University Qualifying Year
Phd Life Science Punjab University 2009
M.Sc Biotechnology Punjab University 2001

Position Held

Position Held

Position Held Period Organization
Sr. Principal Scientist 02.04.2020 TO Present CSIR-IIIM
Principal Scientist 02.04.2015 TO 02.04.2020 CSIR-IIIM

Area of Expertise

Area of Expertise

  • Cancer metastasis, drug discovery, Stem Cell Biology, Autophagy, Neurobiology (depression)

Project Involved / Ongoing Projects

Projects

  •  Uncovering the role of stem cells in tumor invasion and metastasis.
  •  Targeting drug resistant cancer stem cells by using small molecules

 

 

Publications and Patents

Publications

Sno. Author Title Journal
 

1

Wadhwa B, Paddar M, Khan S, Mir S, Clarke P, Grabowska A, Vijay D,  Vishwakarma R,  Malik F*

 

AKT isoforms have discrete expression in Triple Negative breast cancers and roles in cisplatin sensitivity  

Oncotarget

2020

 

 

2

Korkaya H, Kim G, Davis A, Malik F, Henry N, Ithimakin S, Quraishi A, Tawakkol…., Hassan K, Zen Q, Clouthier SG, Wicha M. Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population. Mol. Cell

(2012)
47: (4) 570–584

 

 

 

3

 

Pathania AS, Guru SK, Kumar S, Kumar A, Ahmad M, Korkaya H and Malik F*

Interplay between cell cycle and autophagy induced by boswellic acid analog  

Scientific Reports  (2016) 6: 33146

 

 

 

4

Ithimakin S#, Day K#, Malik F#, Zen Q, Dawsey J, Bersano-Begey F, Quraishi…… Korkaya H, Wicha MS HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: Implications for efficacy of adjuvant trastuzumab  

Cancer Research (2013)

73:1635-46

 

 

 

5

Guru SK, Pathania AS, Kumar S, Ramesh D, Kumar M, Rana S, Kumar A, Malik F,  Shah BA, Saxena AK, Vishwakarma RA, Bhushan S. Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade. Cancer Research (2015) 75(14):2886-96
 

 

6

Pathania A, Wani Z, Guru S, Kumar S, Bhushan S, Korkaya H, Seals D, Kumar A, Mondhe D, Ahmed Z, Chandan B, Malik F* The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors. Molecular Cancer

(2015)14:6

 

 

 

 

7

Kim G, Ouzounova M, Quraishi A, Davis A, Tawakkol N, Clouthier S, Malik F, ….  Wicha MS, Korkaya H. SOCS-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model Oncogene

(2014): 1–10

 

 

8

Singh U, Chashoo G, Khan S, Mahajan P, Nargotra A, Mahajan G, Singh A, Sharma A, Mintoo M, Guru SK, Kumar V, Mir S, Bharate S,  Bhushan S, Malik F*, Mignani S, Vishwakarma R, Singh P* Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model.  

J Medicinal Chem.

(2017)

60:9470-89

 

 

 

9

Kumar S, Pathania A, Guru S, Kumar A, Bhushan S and Malik F*. Autophagy triggered by Magnolol derivative negatively regulates angiogenesis. Cell Death and Disease

(2013) 4, e889

 

 

10

 

Ke J, Zhao Z, Hong S, Bai S, He Z, Malik F, Xu J, Zhou L, Chen W,  Wu X, Lan P, Yi Y, Ginestier C, McDermott S, Clouthier SG, Wicha MS, Liu S Role of MicroRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells Oncotargets

(2015)

6(6):3709-21

 

Patents

Inventors/ Contributors Title Description Year
ThatikondaThansha, Kumar Suresh, Singh Umed, MahajanPriya, MahajanGirish, NagrotaAmit, Malik, Fayaz, MondheDilip, Vishwakarma Ram, Singh parvinder pal Novel 1,3,5- Triazine based PI3K inhibitors as anticancer agents and a process for the preparation thereof US20170342049, WO/2016/079760A4, EP3221307A1 2016
A. Khajuria, A. Gupta, S.Singh, F. Malik, Jaswant Singh, KL Bedi, KA Suri, NK Satti, OP Suri, GN Qazi, VK Srinivas, Gopinathan, K Ella  

Iridoid glycoside composition

EP1837027A1, US20070275006

 

2007
Qazi, GhulamNabi, TanejaSubash Chandra.; Singh, Jaswant; SaxenaAjit Kumar; Sethi Vijay Kumar; Shah Bhahwal Ali, Kumar Ajay, Andotra Samar Singh, Malik, Fayaz; MuthiahShanmugavel, Agarwal, Satyam Kuma Use of semi synthetic analogues of boswellic acids for anticancer activity US20090298938 2009
   
 

Awards / Honours

Awards and Honours

  • 2015 National Bioscience Award (NBA) in Biological Sciences. by. Department of Biotechnology (DBT) Government of India.
  • 2014 Golden Jubilee (SWARANAJA YANTI) Fellowship Award in Biological , by Department of Science and Technology (DST) Govt. of India
  • 2010 Young Scientist Award for Biological Sciences, of Jammu and Kashmir,
  • 2009 CSIR Young Scientist Award (CSIR YSA_2009) for Biological Sciences, India.

Group

Students

Photo Name Area of Interest  Education
Nadiem Bhat

Focus is to study contrasting transcriptomic conditions using RNA-Seq technologies in highly aggressive cancers to identify new therapeutic targets by using CSCs, CTCs and clinical samples. I am also involved in virtual screening of small molecule against various biological targets.

Postdoc fellow/RA
Baseerat Hamza Research interests  is to study  proteome and metabolome changes of highly aggressive and therapeutically changing breast cancer subtypes, by using high throughput mass spectrometry technology. Aim is to try to understand the dynamics of functional protein networks to delineate biological mechanisms of disease. DST-SRF/Research Associate
Masroor Ahmed

Research interest is to explore the new therapeutic targets and target specific agents in drug resistance HER2 Breast Cancer.

PhD, CSIR-SRF
Sameer Mir Research focus is on identify small molecule stem cell modulators. Currently working on pre-clinical development of identified small molecule targeting drug resistant Cancer Stem Cells in Tripe Negative Breast Cancers (TNBCs). PhD, UGC-SRF
Sameer Ullah khan

Research interest is towards understanding the role of authophagy in anikious resistance Breast cancer cells and identifying their survival mechanism.

PhD, CSIR-SRF
Loveleena kaur Anand Research interest is to identify potent anti-depressant agents from natural products by using cellular and animal models and exploring the biological mechanism of the disease PHD, DST-INSPIRE SRF
Mir Shahid

Research interest is to explore the metastatic potential of tumor suppressors and their role in clinical manifestation of Breast cancer subtypes TNBCs.

PhD, CSIR-SRF
Kaneez Fatima Research interest is to understand the role of critical interaction between immune system and breast cancer metastasis. PhD,UGC-JRF

 

ALUMNI

Dr. Anup Singh Pathania ( Currently Postdoctoral fellow at University of California USA)

Dr. Suresh Kumar Thakur
(Currently Postdoctoral Fellow at University of New Mexico USA)

Mr. Ubaid Makhdoomi (Currently Ass. Prof at Govt. Degree College J&K)

Mr. Abid Akbar ( Current at Govt. of  J&K)

Dr. Bhumika Wadhwa (Submitted PhD thesis)

Ms. Sonia Sharma (Submitted  PhD Thesis)

IIIM Links

About IIIM

IIIM in Media

IIIM Srinagar Branch

IIIM Intranet

IIIM Webmail

IIIM Circulars

Past Directors

NASI (India) Chapter at J&K

Facilities

Guest House

e-Payment

Purchase

Experimental Farm

IIIM Directory

Important Links

Right To Information (RTI)

Annual Reports

E-Journals

Indian Plants Overseas

J&K Aroma Project

QCQA & CMC

CSIR CUReD

Phytopharmaceutical Mission

Janaki Ammal Herbarium

Major Equipments & Facilities

National Government Services Portal

Management Council

Research Council

IAEC (Animal Ethics)

Tweets by csiriiim
Website Policies | Disclaimer | Feedback | Sitemap

© 2021, CSIR - Indian Institute of Integrative Medicine (IIIM), Jammu | Developed by CSIR-IIIM

Scroll Up Skip to content
Open toolbar

Accessibility Tools

  • Increase Text
  • Decrease Text
  • Grayscale
  • High Contrast
  • Negative Contrast
  • Light Background
  • Links Underline
  • Readable Font
  • Reset
  • Sitemap
  • Feedback