Dr. Rashmi Sharma
Scientist
Infectious Diseases Division
CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: Rashmi.sharma.09@iiim.res.in
Bio Sketch
The evolution of drug resistance continues to afflict TB control where MDR/XDR-TB have become a global health concern. There is an urgent need to combat the current TB menace through multidisciplinary approaches and strategies making use of the recent advances in understanding the molecular biology and pathogenesis of Mtb.
We need to focus on novel pathways, targets and structures for combating the menace. Construction of sensitive reporter strain and establishing new drug discovery platforms for high throughput screen are important for finding new and potent drugs against the resistant bacterial strains. I would like to focus my work on understanding host-pathogen interactions; and identifying host-chemical-modulators that could be exploited for the development of anti-TB drugs by targeting host-pathogenic interactions along with the conventional one targeting the pathogen alone.
Education
Degree | Subjects | University | Qualifying Year |
PhD | Biological Sciences | Academy of Scientific and Innovative Research | 2017 |
B.tech | Industrial Biotechnology | Shri Mata Vaishno Devi University | 2010 |
Position Held
Position Held | Period | Organization |
Scientist | June, 2020- present | CSIR-Indian Institute of Integrative Medicine |
DBT-Research Associate | Jan,2020-June, 2020 | National Centre for Biological Sciences, Bengaluru |
Postdoctoral Fellow | Feb, 2019- Dec,2019 | National Centre for Biological Sciences, Bengaluru |
Indo-US SERB Postdoctoral Fellow | Dec 2017 – Jan, 2019 | Infectious Disease Research Institute, Seattle, USA |
Area of Expertise
- Microbiology
- Drug Discovery
- Molecular Biology
Projects
- Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance.
Discovery of NCEs and new combination drugs for tuberculosis using High through put and High content screen - Targeting host-pathogen homeostasis between Mycobacterium tuberculosis and the human macrophage using chemical modulators.
- Chemical modulation of bacterial ATP synthase to identify novel chemical scaffolds targeting active and latent Mycobacterium tuberculosis.
- Modulating the Glyoxylate shunt pathway targeting latent Mycobacterium tuberculosis for shortening the tuberculosis chemotherapy.
- Testing of 2019 novel coronavirus (2019-nCoV) in human clinical samples
Publications
Authors | Title | Journal |
Saini, Sapna, Anjali Gangwar, and Rashmi Sharma*. | “Harnessing Host-Pathogen Interactions for Innovative Drug Discovery and Host-Directed Therapeutics to tackle tuberculosis.” | Microbiological Research (2023): 127466.
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Mukherjee, Srestha, Summaya Perveen, Anjali Negi, and Rashmi Sharma*. | “Evolution of tuberculosis diagnostics: From molecular strategies to nanodiagnostics.”
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Tuberculosis 140 (2023): 102340.
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Perveen Summaya, Anjali Negi, Varun Gopalakrishnan, Satyajit Panda, Vinay Sharma, and Rashmi Sharma*. | COVID-19 diagnostics: Molecular biology to nanomaterials. | Clinica Chimica Acta (2022) |
Summaya Perveen, Diksha Kumari, Kuljit Singh, Rashmi Sharma*
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Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance.
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European Journal of Medicinal Chemistry (2021): 114066.
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Summaya Perveen, Rashmi Sharma* | Screening approaches and therapeutic targets: the two driving wheels of tuberculosis drug discovery
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Biochemical Pharmacology (2022): 114906.
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Kumari Diksha, Perveen Summaya, Rashmi Sharma, Kuljit Singh.
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Advancement in leishmaniasis diagnosis and therapeutics: An update |
European Journal of Pharmacology (2021): 174436. .
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Prateek Kour, Anul Kumar, Rashmi Sharma, Reena Chib, Inshad Ali Khan, Vijai K Rai | Synthesis of 20amino-4H-chromen-4-ylphosphonates and βphosphonomalonates via tandem Knoevenagel-Phospha-Michael reaction and antimicrobial evaluation of newly synthesized β-phosphonomalonates |
Research on Chemical Intermediates 43.12 (2017): 7319-7329. 10.1007/s11164-017-3077-2 (2017) .
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Rashmi Sharma, Rani Chitra, Mehra Rukmankesh, Nargotra Amit, Chib Reena, Rajput S. Vikrant, Kumar Sunil, Singh Samsher, Sharma R. Parduman, and Khan A. Inshad. | Identification and characterization of novel small molecule inhibitors of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU) | Applied microbiology and biotechnology 100.7 (2016): 3071-3085. 10.1007/s00253-015-7123-y
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Rashmi Sharma, Lambu Rao Mallikharjuna, Jamwal Urmila, Rani Chitra, Chib Reena, Wazir Priya, Mukherjee Debaraj, Chaubey Asha, Khan Ali Inshad. | Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU) inhibitory activity of terreic acid isolated from Aspergillus terreus. | Journal of biomolecular screening 21.4 (2016): 342-353.
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Rashmi Sharma, Khan Ali Inshad. | Mechanism and Potential Inhibitors of GlmU: A Novel Target for Antimicrobial Drug Discovery. | Current Drug Targets (2016) |
Mehra Rukmankesh, Rashmi Sharma, Khan A. Inshad, and Nargotra Amit.
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Identification and optimization of Escherichia coli GlmU inhibitors: an in silico approach with validation thereof. | European journal of medicinal chemistry 92 (2015): 78-90. |
Rani Chitra, Mehra Rukmankesh, Rashmi Sharma, Chib Reena, Wazir Priya, Nargotra Amit, and Khan A. Inshad. | High-throughput screen identifies small molecule inhibitors targeting acetyltransferase activity of Mycobacterium tuberculosis GlmU. | Tuberculosis 95.6 (2015): 664-677.
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Sharma Deepak K., Tripathi K. Anil, Rashmi Sharma, Chib Reena, Rasool ur Reyaz, Hussain Altaf, Singh Baldev, Goswami Anindya, Khan A. Inshad, and Mukherjee Debaraj. | A new class of bactericidal agents against S. aureus, MRSA and VRE derived from bisindolylmethane. | Medicinal Chemistry Research 23.4 (2014): 1643-1653.
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Suresh Narva, Nagesh Nagendra Hunsur, Janupally Renuka, Rajput Vikrant, Rashmi Sharma, Khan A. Inshad, and Gowri Venkata Kondapalli Sekhar Chandra. | Synthesis and evaluation of 1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(4-(2-(4-substitutedpiperazin-1-yl) acetyl) piperazin-1-yl) quinoline-3-carboxylic acid derivatives as anti-tubercular and antibacterial agents. | European journal of medicinal chemistry 71 (2014): 324-332.
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Kamal Ahmed, Hussaini Ali Mohammed Syed, Faazil Shaikh, Poornachandra Y., Reddy Narender G., Kumar Ganesh C., Rajput Singh Vikrant, Rani Chitra Rashmi Sharma, Khan Ali Inshad , Babu Jagadeesh. N. | “Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1, 2, 3-triazoles.” | Bioorganic & medicinal chemistry letters 23.24 (2013): 6842-6846.
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Singh Baljinder, Rajinder Parshad, R. K. Khajuria, Santosh K. Guru, Anup S. Pathania, Rashmi Sharma, Reena Chib Chib Reena, Aravinda Subrayashastry, Gupta,K. Vivek , Khan A. Inshad , Bhushan Shashi, Bharate B Sandip and Vishwakarma A. Ram.
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Saccharonol B, a new cytotoxic methylated isocoumarin from Saccharomonospora azurea.” | Tetrahedron Letters 54.49 (2013): 6695-6699.
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Singh Baljinder, Guru K. Santosh, Rashmi Sharma, Bharate S. Sonali, Khan A. Inshad, Bhushan Shashi, Bharate B. Sandip, and Vishwakarma A. Ram. | Synthesis and anti-proliferative activities of new derivatives of embelin. | Bioorganic & medicinal chemistry letters 24.20 (2014): 4865-4870.
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Book Chapters
- Perveen, Summaya, and Rashmi Sharma. “Lung Microbiome: Friend or Foe of Mycobacterium tuberculosis.” Microbiome in Inflammatory Lung Diseases. Springer, Singapore, 2022. 207-226.
- Advances in the synthesis and antimicrobial applications of metal oxide nanostructures Navpreet Kaur, Rashmi Sharma, V Sharma; Advanced ceramics for versatile interdisciplinary applications: A volume in Elsevier series in advanced ceramic material (ISBN: 978-0-323-89952-9)
- Mehul Mahajan, Summaya perveen, Rashmi Sharma*. Nanozymes for Bioimaging and Disease Diagnostics. Nanozymes in Medicine. Springer, 2023 (Volume 72)
Awards and Honours
- Awarded SERB Start up Research Grant (SRG), 2022
- Awarded DBT-Research Associate, 2020
- Awarded SERB Indo-U.S. Postdoctoral Fellowship, 2017 to undertake research at Infectious Disease Research Institute, Seattle, U.S.
- Awarded Nehru Fullbright Postdoctoral Fellowship, 2018.
- Qualified Graduate aptitude test in Engineering (GATE) in Life sciences, 2011 with 98.9 percentile
- Qualified Graduate aptitude test in Engineering (GATE) in Life sciences, 2010 with 92 percentile
Students
Photo | Name | Area of intrest | Position | Education |
Summaya Perveen | Pre-clinical drug development against Mycobacterium tuberculosis by targeting the bacterial energy metabolism pathway. | PhD Scholar- UGC JRF | M.Sc Life Sciences- Jamia Millia Islamia- Delhi, qualified CSIR UGC-NET JRF 2019 and GATE Life Sciences 2020. | |
Anjali Negi | Targeting glyoxylate shunt pathway of Mycobacterium tuberculosis for development of potential anti-TB drugs. | PhD Scholar- UGC JRF) | M.Sc Biotechnology – Chandigarh University- Punjab, qualified CSIR UGC-NET JRF 2020 and GATE Life Sciences 2021. | |
Sapna Saini
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Identification of novel inhibitors against Mycobacterium tuberculosis.
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PhD Scholar- UGC JRF
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M.Sc Zoology- Punjabi University Patiala- Punjab, qualified CSIR UGC-NET JRF 2021 and GATE Life Sciences 2022.
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Anjali Gangwar | Targeting peptidoglycan biosynthesis pathway of Mycobacterium tuberculosis | PhD Scholar- DST INSPIRE | M.Sc. Zoology- Ch. Charan Singh University – Meerut, qualified GATE- Life Sciences 2022. | |
Rabia Mushtaq | Area of Interest: Pre-clinical development of Guduchi (Tinospora cordifolia (Thunb) Miers) stem through AYUSH route for adjunct therapy in tuberculosis to reduce anti-tubercular treatment (ATT) induced hepatotoxicity. | (Project Associate-I) | M.Sc. Zoology- Central University of Punjab, qualifies CSIR NET-LS 2022 and GATE-Life Sciences 2023. |