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Dr. Yedukondalu Nalli
Scientist
Natural Products Chemistry
CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: dr.yknalli@iiim.res.in
Bio Sketch
Dr. Yedukondalu Nalli is a Scientist in Natural Products Chemistry at CSIR-Indian Institute of Integrative Medicine, India. After completing his M.Sc.(Organic Chemistry), in 2009 (School of Chemistry, Andhra University), he began working as a researcher in various natural product drug discovery programs for over ten years. This period of his career provided opportunities for him to develop world-leading expertise in the application of a diversity of modern analytical chemistry and spectroscopic analysis techniques (particularly chromatography, 2D NMR, and mass spectrometry) used to identify complex organic molecules and this culminated in the design and implementation of methods for high throughput extraction, purification, and structure determination of new drug leads from plant and micro-organisms.
Dr. Yedukondalu Nalli is currently an author and co-author of over 30 peer-reviewed publications in international Chemistry/Biology journals and an inventor or co-inventor on two patent applications. Dr. Nalli’s research has resulted in the isolation and structure determination of >100 natural products from plant and microbial sources. He received an award for his outstanding contribution of natural products to Col Sir R.N Chopra Repository, CSIR-IIIM, Jammu.
Dr. Nalli’s research group focuses on the
- Preparation of crude extracts, enriched fractions from natural sources, including those from plants, microbial cultures, and marine invertebrates
- Isolation/purification of novel/bio-active natural products at a milligram to gram scale
- Characterization of structures of purified metabolites
- Expansion of new/bio-active chemical diversity of natural products
- Utilization of natural products for drug discovery of various human diseases, in particular cancer and infectious diseases, by collaborating with Scientists in diverse disciplines, including pharmacology, virology, and microbiology
- Overall, they focus on revealing the biological potential of compounds from nature
Researchers working in Dr. Nalli’s group develop skills in various modern chromatographic, and spectroscopic techniques.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph.D. | Chemical Sciences (Natural Products Chemistry) | AcSIR, CSIR-Indian Institute of Integrative Medicine | 2016 |
| M.Sc. | Organic Chemistry | Andhra University | 2009 |
| B.Sc. | Maths, Physics, Chemistry | Andhra University | 2007 |
Position Held
| Position Held | Period | Organization |
| Scientist | 2022 – Present | CSIR – IIIM, Jammu |
| Senior Project Associate | 2021 – 2022 | CSIR – IIIM, Jammu |
| Postdoctoral Fellow | 2019 – 2021 | CSIR – CSMCRI, Bhavnagar |
| Senior Project Fellow | 2016 – 2019 | CSIR – IIIM, Jammu |
| Senior Research Fellow | 2012 – 2016 | CSIR – IIIM, Jammu |
| Junior Research Fellow | 2010 – 2012 | CSIR – IIIM, Jammu |
Area of Expertise
Natural Products Chemistry – Organic Chemistry – Drug Discovery
- Exploring/expanding the novel/bio-active natural products of plants, microorganisms, and marine invertebrates
- Utilizing the natural products for drug discovery of various human diseases, in particular, cancer and infectious diseases
Ph.D. Work, under Dr. Asif Ali (Principal Scientist), CSIR– IIIM, Jammu
N-PDF Work, under Dr. Pramod B Shinde (Sr. Scientist), CSIR– CSMCRI, Bhavnagar
Work on Cannabis sativa, under Dr. D. Srinivasa Reddy (Director), CSIR– IIIM, Jammu
Projects
Discovery of bio-active therapeutics from microorganisms associated with untapped Marine bio-resources (DST No: PDF/2018/000758) – PI
Publications
Complete list of publications: View here
| Authors | Title | Journal |
| Abid Bashir, Tanveer Ahmad, Sadaqat Farooq, Waseem I Lone, Malik M Manzoor, Yedukondalu Nalli, Phalisteen Sultan, Asha Chaubey, Asif Ali, Syed Riyaz-Ul-Hassan | A Secondary metabolite of Cercospora sp., associated with Rosa damascena Mill.,inhibits proliferation, biofilm production, ergosterolsynthesis and other virulence factors in Candida albicans
|
MicrobEcol, (2022). https://doi.org/10.1007/s00248-022-02003-x |
| YedukondaluNalli, Santosh K Guru, Priti Jain, Vishal Mishra, Shreyans K Jain | Bioassay-guided fractionation and dereplicationstudies of sesame oil: Isolation of 8-acetoxypinoresinol as an anti-proliferative metabolite and prediction of target | Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. (2022). https://doi.org/10.1007/s40011-021-01308-0 |
| JaveedUr Rasool, Khalid Bashir,Majeed Shaikh, AabidH.Bhat, Yedukondalu Nalli, Anam Khalid, Syed Mudabir Ahmad, AnindyaGoswami, AsifAli | Palladium catalyzedmigratory Heck coupling of arteannuin B and boronicacids: An approach towards the synthesis of antiproliferative agents in breast and lung cancer cells | Bioorganic Chemistry, 22, 2022, 105694 |
| Rabia Hamid Rohina Bashir, Ovais Ahmad Zargar, Abid Hamid Dar, Yedukondalu Nalli, QaziParvaiz | The modulation of PI3K/Akt pathway by 3β hydroxylup-12-en-28-oic acid isolated from Thymus linearis induces cell death in HCT-116 cells | Chemical Biology & Drug Design,99,2022, 162
|
| Javeed Ur asool, GiftySawhney, MajeedShaikh, Yedukondalu Nalli, SreedharMadishetti, Zabeer Ahmed, AsifAli | Site selective synthesis and anti-inflammatory evaluation of spiro-isoxazolinestitched adducts of arteannuin B | Bioorganic Chemistry, 117, 2021, 105408 |
| Sanju Singh, Vishal A Ghadge, Pankaj Kumar, DoniyaElze Mathew, AsmitaDhimmar, HarshalSahastrabudhe, Yedukondalu Nalli, Mina R Rathod, Pramod B Shinde | Biodiversity and antimicrobial potential of bacterial endophytes from halophyte Salicorniabrachiata | Antonie van Leeuwenhoek, 114, 2021, 591 |
| Yedukondalu Nalli, Suraya Jan, GianluigiLauro, Javeed Ur Rasool, Waseem I Lone, Aminur R Sarkar, JunaidBanday, Giuseppe Bifulco, HartmutLaatsch, Sajad H Syed, Asif Ali | Isolation, synthesis and structure determination of cannabidiolderivatives and their cytotoxic activities | Natural Product Research, 35, 2021, 471
|
| Sadaqat Farooq, AremQayum, Yedukondalu Nalli, GianluigiLauro, Maria Giovanna Chini, Giuseppe Bifulco, Asha Chaubey, Shashank K. Singh, Syed Riyaz-Ul-Hassan, and Asif Ali | Discovery of a secalonic Acid derivative from Aspergillusaculeatus, an endophyte of Rosa damascena Mill., triggers apoptosis in MDA-MB-231 triple negative breast cancer cells | ACS Omega, 5, 2020, 24296 |
| T Ahmad, P Arora, Yedukondalu Nalli, A Ali, S Riyaz‐Ul‐Hassan | Antibacterial potential of Juglomycin A isolated from Streptomyces achromogenes, an endophyte of Crocus sativus Linn | J ApplMicrobiol, 128, 2020, 1366 |
| Chetan Kumar, Anil Kumar, Yedukondalu Nalli, Waseem I Lone, Naresh K Satti, MK Verma, Zabeer Ahmed, Asif Ali | Design, synthesis and biological evaluation of alantolactone derivatives as potential anti-inflammatory agents | Med Chem Res, 28, 2019, 849 |
| Inventors/ Contributors | Title | Description | Year |
| Asif Ali,Goswami, A, Souneek, C, Khalid, M. B, Veeranjaneyulu, G, Waseem, I. L, YedukondaluNalli
|
Cannabinoids C-and O-glycosides possessing anti-proliferative and anti-metastatic roperties and process for preparation thereof | IN patent application No. IN202111044828 | 2022 |
| Padmanabhan, B, Asif Ali, Deshmukh, P, Unni, S, YedukondaluNalli, Bharath, M. M. S, Syed, R. H, Ahmed, W. Z | Phialomustin B, a natural product isolated from an endophytic fungus PhialophoraMustea with novel therapeutic potential for Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS) | IN patent application number IN202211019288 | 2022 |
Awards and Honours
- SERB – National Postdoctoral Fellowship, 2019 – 2021
- CSIR – Research Associateship, 2019 – 2020
- UGC – Research Fellowship, 2012 – 2016
- UGC – Research Fellowship, 2010 – 2012
- Award for Outstanding Contribution of Natural Products to Repository on CSIR Foundation day Sep 26, 2014
- Qualified Joint CSIR – UGC Test for Junior Research Fellowship, Dec – 2008
Students
NIL