Dr. Prasoon Kumar Gupta
Principal Scientist
Natural Products & Medicinal Chemistry Division
CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: guptap@iiim.res.in
Bio Sketch
Dr. Prasoon Gupta has over 20 years of research experience in the field of Traditional Indian Medicine which includes terrestrial, microbial and marine natural product chemistry. Dr. Gupta has obtained his BS and MS degree in Pharmaceutical Chemistry from Devi Ahilya Vishva Vidhyalaya, Indore, India. He has started his carrier as a Project Assistant (JRF) in the field of Natural Product Chemistry, at NIPER, Mohali, India and he was associated with many projects of national importance, one to discuss is “Development of Herbal Pharmacopeia for ISM Drugs” for quality standards of Indian traditional medicines. He has obtained his Ph.D. degree in Natural Product Chemistry from Central Drug Research Institute, India in the year 2007.
Dr. Gupta moved to USA for advanced training in the area of NPs first at University of Georgia (2007-2008) then to Florida Atlantic University, Boca Raton (2008-2012) where he was actively engaged in the development of high throughput methods for identification of bioactive metabolites from marine natural products that impact the growth of human embryonic stem cells. Further, he moved to University of North Carolina (2012-2013), Wilmington, USA to work at MARBION center for marine natural product as a Research Assistant Professor, and he was actively engaged in drug discovery from marine algae and microbes.
In 2013, he joined CSIR-IIIM as a Senior Scientist. At present, he is working as a Principal Scientist at CSIR-IIIM and focusing on “high-throughput identification of natural products from traditional medicinal plants”. So far Dr. Gupta has published over 35 research articles in high -tier scientific journals and also has eight published book chapter in credit. He has been awarded many travel grants and research funding to carry out his research. He is a life member of Chemical Research Soc of India, Soc of Pharmacognosy; Assoc Member of American Soc of Pharmacognosy, and American Cancer Soc. He has delivered several invited talks in India and abroad. He is also associated with National and International journals in different capacities.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph. D. | Chemistry | Central Drug Research Institute, Lucknow, India | 2007 |
| M.Sc. | Pharmaceutical Chemistry | Institute of Chemical Sciences, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India.
|
2000 |
| B. Sc | Pharmaceutical Chemistry and Microbiology | Maharaja Ranjeet Singh College of Professional Sciences, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India | 1998 |
Position Held
| Position Held | Period | Organization |
| Principal Scientist | 2017-Conti | CSIR-IIIM |
| Senior Scientist | 2013-2017 | CSIR-IIIM |
| Research Assistant Professor | 2012-2013 | University of North Carollina, Wilmington, NC, USA |
| Assistant Scientist | 2008-2012 | Florida Atlantic University, Boca Raton, FL, USA |
| Research Associate | 2007-2008 | University of Georgia, Athens, GA, USA |
| Research Chemist | 2002-2002 | Dr. Reddy’s Laboratories Limited, Hyderabad, India |
| Project Assistant (JRF) | 2000-2002 | National Institute of Pharmaceutical Education and Research, Mohali (Punjab) India |
| Chemist | 1999-1999 | IPCA Laboratories Limited, Ratlam, M.P. India |
Area of Expertise
- Terrestrial, Microbial and Marine Natural Products
- Metabolic Fingerprinting (LC-MS, HPTLC)
- Development of High-throughput Methods to Identify Biological Active Molecules
- NMR and Structural Elucidation
- Medicinal Chemistry
Projects
- Dengue Herbal Project (Advanced Phase, Sun Pharma Limited)
- Novel Strategy to Generate Drug Like Marine Natural Product Library to Discover Bioactive Compounds (SERB)
- Fermentation Based Process Development for Production of Tacrolimus Drug (ICMR)
- Effect of Epigenetic Modifiers on Secondary Metabolite Production in Drug Producing Fungi (SERB)
- CSIR-Phytopharmaceutical Mission (CSIR)
- CSIR-Sickle Cell Anaemia Mission (CSIR)
- CSIR-Aroma Mission (CSIR)
Publications
| Authors | Title | Journal |
| Arora, D.; Gupta, Prasoon; Roullier, C.; Grovel, O.; Jaglan, S.; Bertrand, S | Expanding the Chemical Diversity through Microorganisms Co-culture: Current Status and Outlook | Biotechnology Advances 2020, 40:107521 |
| Khan, I. A.; Singh, A.; Mindala, D. P.; Meena. S.; Gupta Prasoon et.al. | Preclinical development of gastroprotective botanical candidate from Woodfordia fruticosa (Linn.) Kurz: Chemical standardization, efficacy, pharmacokinetics and safety pharmacology. | Journal of Ethanopharmacology 2019, 241, 112023-112056
|
| Sharma, V.; Singamaneni, V.; Sharma, N. ; Sharma, A.; Arora, D.; Kushwaha, M.; Bhushan, S.; Jaglan, S.; Gupta, Prasoon | Valproic acid induces three novel cytotoxic Secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill. | Bioorganic and Medicinal Chemistry Letters 2018, 28(12), 2217-2221 |
| Arora, N.; Kumar, S.; Satti, N. K.; Ali, A.; Gupta, Prasoon. Katoch, M. | A strain of Streptomyces sp. isolated from rhizospheric soil of Crataegus oxycantha producing nalidixic acid, a synthetic antibiotic. | Journal of Applied Microbiology 2018, 124(6), 1393-1400. |
| Arora, Divya; Chashoo, Gousia; Singamaneni, Venugopal ; Sharma, Nisha; Gupta, Prasoon; Jaglan, Sundeep. | Bacillus amyloliquefaciens induces production of a novel blennolide k in co-culture of Setophoma terrestris. | Journal of Applied Microbiology 2018, 124 (3), 730-739 |
| Sharma, N.; Kushwaha, M.; Arora, D.; Jain, S.; Singamaneni, V.; Sharma, S.; Shankar, R.; Bhushan, S.; Gupta, Prasoon; ; Jaglan, S. | New cytochalasin from Rosellinia sanctae-cruciana, an endophytic fungus of Albizia lebbeck. | Journal of Applied Microbilogy 2018, 125(1), 111-120. |
| Arora, D.; Sharma, N.; Singamaneni, V.; Sharma, V.; Manoj, K.; Abrol, V.; Guru, S.; Sharma, S.; Gupta, A. P.; Bhushan, S.; Jaglan, S.; Gupta, Prasoon. | Isolation and characterisation of bioactive metabolites from Xylaria psidii, an endophyte fungus of the medicinal plant Aegle marmelos and their role in mitochondrial dependent apoptosis against pancreatic cancer cells. | Phytomedicine 2016, 23, 1312-1320.
|
| Dubey, R. D.; Saneja, A.; Gupta, Prasoon, Gupta, P. N. | Recent advances in drug delivery strategies for improved therapeutic efficacy of gemcitabine. | European Journal of Pharmaceutical Sciences 2016, 93, 147-162. |
| Gupta, Prasoon; Sharma, U.; Gupta, P. K.; Maurya, R. | Evolvosides C-E, Flavonol-4′-O-triglycosides from Evolvulus alsinoides and their anti-stress activity. | Bioorganic and Medicinal Chemistry 2013, 21, 1116-1122.
|
| Gupta, Prasoon; Sharma, U.; Schulz, T.; Sherrer, E.; McLean, A.; Robins, A.;
West, L. |
Bicyclic C21 terpenoids from the marine sponge Clathria compressa. | Journal of Natural Products 2012, 75(6), 1223-1227. |
| Gupta, Prasoon; Sharma, U.; Schulz, T.; Sherrer, E.; McLean, A.; Robins, A.;
West, L. |
Bioactive diterpenoid containing a reversible “Spring-Loaded” (E,Z)-dieneone Michael acceptor. | Organic Letters 2011, 13, 3920-3923. |
| Gupta, Prasoon; Yadav, D. K.;Siripurapu, K. B.; Palit, G.; Maurya, R. | Constituents of Ocimum sanctum with anti-stress activity. | Journal of Natural Products 2007, 70(9), 1410-1416. |
| Gupta, Prasoon; Akanksha; Siripurapu, K. B.; Ahmad, A.; Palit, G.; Arora, A.; Maurya, R. | Anti-stress constituents of Evolvulus alsinoides: an Ayurvedic crude drug. | Chemical and Pharmaceutical Bulletin 2007, 55 (5), 771-775. |
Awards and Honours
- Awarded EMR Project Grant from SERB
- Awarded EMR Project Grant from ICMR
- Member of Managing Committee of IASTAM, India
- Become Member of Asian Council of Science Editors
- Selected as Young Scientist in Brainstorming Session for Drugs from Sea Program of MOES
- Ultra International Team Award by EOAI
Students
| Photo | Name | Area of Interest | Position |
 |
Venugopal Singamaneni |
|
CSIR-SRF |
 |
Anil Bhushan | CSIR-SRF | |
 |
Bashir Ahmad Lone | Project Assistant-II | |
 |
Amardeep Singh | Project Assistant-III |