Dr. Qazi Naveed Ahmed

Dr. Qazi Naveed Ahmed

Head & Senior Principal Scientist

Head Natural Products & Medicinal Chemistry Division

CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001,J&K,India
Email: naqazi[at]iiim[dot]res[dot]in

Profile

Bio Sketch

Dr. Qazi Naveed Ahmed is from the Jammu and Kashmir region (a northern state of India) and was born in Kishtwar in 1978. He obtained his Ph.D. from Kashmir University under the combined supervision of Dr. H. M. Sampath Kumar and Prof. M. A. Qureshi at the CSIR-Indian Institute of Integrative Medicine.He completed hisPost-Doctorial fellowship from University of Paris Sud-XI (France) under CNRS program (Aug 2008-2009) in the group of Prof. David Bonnaffe (Head, Glycochemistry Division). In 2012, he obtained a scientific position in IIIM Jammu and currently he is serving as Principal Scientist in Medicinal Chemistry Division. Dr. Qazi also served as Assistant Professor in Higher education department (March 2010 to Dec 2012). His current researchinterests are medicinal chemistry and applications of functional group driven synthetic methodologies across glycochemistry, bio-conjugation/bioorthogonal chemistry and late stage modification of bioactives.

Education

Degree Subjects University Qualifying Year
Ph. D. Chemical Science University of Kashmir 2007
M. Sc. Chemistry University of Jammu 2004
B. Sc. Chemistry, Zoology, Botany, English University of Jammu 1999

Position Held

Position Held

Position Held Period Organization
Head &Senior Principal Scientist 2022-till date CSIR-Indian institute of Integrative Medicine, Canal Road, Jammu
Principal Scientist &Head 2017- 2022 CSIR-Indian institute of Integrative Medicine, Canal Road, Jammu
Senior Scientist 2012-2017 CSIR-Indian institute of Integrative Medicine, Canal Road, Jammu
Assistant Professor 2010-2012 Higher Education Department

Area of Expertise

Area of Expertise

  • Organic synthesis, medicinal chemistry
  • In particular applications of functional group driven synthetic methodologies across glycochemistry, bio-conjugation/bioorthogonal chemistry and late stage modification of bioactives.

Project Involved / Ongoing Projects

Projects

 

Title Of Project Project Category Participating Agencies Role as defined
(HCP-39)- CSIR Molecules for filing investigational new drug (IND) applications. CSIR-Mission project CSIR PI
(HCP-40) – Pan CSIR Cancer Research Program making cancer care affordable empowering Women’s health focusing on breast and gynaecological cancer of India Relevance. CSIR-Mission project CSIR PI
(HCP-41) – Antiviral Mission CSIR: Discovery and Pre-Clinical Development of antivirals for COVID-19 and other diseases. CSIR-Mission project CSIR PI
Repurposing of antiviral drugs for covid-19 drug (HCP 29)
(2020-2021).Completed		 R&D CSIR PI
Medicinal chemistry of natural products for cancer and malaria. Completed
 (MLP 5006) CSIR-IIIM, Jammu member
Chemistry of glycoconjugates; new opportunities for basic biology and therapeutics. (MLP 4016) CSIR-IIIM Jammu PI
Development of novel synthetic methodologies. RC-Approved CSIR-IIIM Jammu PI
(GAP-3102) – Synthesis of reference standards and in-vitro and in-vivo studies (PK studies) on the metabolites and long-term metabolites. R&D NDTL PI
(GAP-3113)- Strategic S-P Bond Forming Bio-orthogonal Functionalization Technique: A systematic Analysis, Standardization and Site-Specific Coupling Strategy for Carrier Drugs Conjugates R&D SERB (DST) PI
Phytopharma Mission, III CSIR-Mission Mode project CSIR Nodal PI

 

Notable Contributions

      • In the CSIR mission project for Molecules for filing investigational new drug (IND) applications, IIIM-152 in combination with paclitaxel is considered as a Pre-IND lead against drug resistant triple negative breast cancer and has successfully moved from Category-2 to Category-1.
      •  In first phase of project (GAP-3102), we successfully carried out the synthesis and delivered four different secondary metabolites to NDTL (National Dope Testing Laboratory) and also performed in-vivo studies (PK studies) around Etamivan sulfate. This collaboration has resulted in patent as well.
      • Developed a novel S-P Bond Forming Bio-orthogonal Functionalization Technique and currently established different one step coupling protocols for the systematic analysis, standardization and application towards developing of alternative site-specific coupling strategies for carrier drugs conjugates.
      • Acquired external grants of Rs 110 Lakh for “Synthesis of Reference Standards and in-vitro and in-vivo studies (PK studies) on the metabolites and long-term metabolites” from NDTL (Ministry of Youth Affairs & Sports, Government of India).
      • Principal Investigator of a CSIR mission program “Progressing CSIR molecules for filing investigational new drug (IND) application where in 1888.20 lakh have been sanctioned under National Laboratories Scheme of CSIR.
      • Got projects approved from SERB (DST) and CSIR-FIRST.
      •  Filling Patent for 
        • The Development of Non-Infringing Process for The Synthesis Of N4-Hydroxycytidine And Its Derivatives for Covid-19. Patent Application: 0207NF2020  
    • Amino acid containing Imidazoles (IIIM-152) as Potential stem cell modulator useful against paclitexal resistant triple negative breast cancer. Patent Application: 202211066609
    •  Supervisor to 6 Ph.D., 2 SPA and 2 project assistants ad 6 trainee students where in five Ph.D. students have already defended their thesis.
    • Contributed through publications in peer reviewed journals of high impact and as reviewer of prestigious scientific journals.
    • Administrative Experience as Member of CSIR-IIIM Committees
    • Ph.D. Course Work committee
    • AcSIR syllabus framing committee   
    • Administrative Experience as Member of screening committee for Post Code S-1, 2, 4 & 6 of Advt. No.30/2021.
    • Active participation in other Institutional organizational committees (Chairman of Annual Physical Verification Committee for stores).
    • Coordinated Symposium on Drug Discovery in one Week One lab program.
    • Contributed through publications in peer reviewed journals of high impact such as Organic Letters, Jouranl of Organic Chemistry, Chemical Communication, Chemistry a European Journal etc.
    • Currently Heading department of NPMC and nodal PI of phytopharmaceutical CSIR-mission III. 

Publications and Patents

Publications

1. Bhat, S. A; Ahmed, Q. N., Bhat, K. A.; DMSO–KOH mediated stereoselective synthesis of Z-enamides: an expeditious route to Z-enamide bearing natural products: Chem. Commun., 2024, 60, 114-117.
2. Hussain, F.; Ahmed, S.: Padder, A. H.; Ahmed, Q. N.; Synthesis of mixed phosphorotrithioates via thiol coupling with bis(diisopropylamino)chlorophosphine and sulphenyl chloride: Org. Biomol. Chem., 2024, 22, 284–288.
3. Hussain, F.; Mahajan, S.; Ahmed, S.: and Ahmed, Q. N.; Synthesis of unsymmetric phosphorotrithioates by sequential coupling of 1,1-dichloro-N, N-diethylphosphanamine with thiols and sulfenyl chloride, Org. Biomol. Chem., 2024, 22, 2007-2011.
4. Bhat, S. A; Bhat, M. Y.; Rather, S. A.; Jameel, S.: Bhat, K. A.; Ahmed, Q. N., I2-DMSO Promoted Deaminative Coupling Reactions of Glycine Esters: Access to 5-(Methylthio) pyridazin-3(2H)-ones, Organic Letters 2023, 25, 14, 2382-2387.
5. Ahmed, S.: Bhat, M. Y.; Hussain, F.; and Ahmed, Q. N.; BF3–Et2O Promoted Heteronucleophilic Addition Reactions for the Synthesis of Unsymmetrical gem-Diarylmethyl Thioethers, Organic Letters 2023, 25, 27, 5017-5021.
6. Bhat, M. Y.; Padder, A. H.; Gupta, R; Ahmed, Q. N., Tf2O-Promoted Regioselective Heteronucleophilic Ring-Opening Approaches of Tetrahydrofuran: The Journal of Organic Chemistry 2023, 88, 20, 14323-14338.
7. Ahmed, S.: Shafeeq, Z.: Hussain, F.; and Ahmed, Q. N.; BF3–Et2O promoted bifunctionalization of aldehydes for the synthesis of arylmethyl substituted organophosphorus compounds: Chem. Commun., 2023, 59, 12334-12337.
8. Ganjoo, A.; Singh, A.P.; Kansal, R.; Ayoub, N.; Shafeeq, H.; Shankar, R.; Q Ahmed, Q. N.; Gautam, H.K.; Babu, V.; Ahmed, Z.; Biocatalytic synthesis, in silico analysis and in vitro validation of hydroxamic acids against Histone Deacetylases: 133, 2023, 241-250.
9. Padder, A. H.; Bhat, M. Y.; H. Rao S. P; Gupta, R; Ahmed, Q. N., Microwave-Assisted PEG-400 Medaited Synthesis of 4,5-dihydro-1H-benzo[g]indazole Derivatives: An Enaminone Approach, Volume 8, Issue 12 March 28, 2023 e202204951.
10. Bhat, M. Y.; Ahmed, S.; Ahmed, Q. N., Tf2O- and Cu(OTf)2-Assisted Acylamination Reaction of Unactivated Alcohols with Nitriles: A One-Pot P(IV) Activation, Stereoretention in Cycloalkanols and Deprotection Approach. The Journal of Organic Chemistry 2022, 87 (17), 11608-11624.
11. Rather, S. A.; Athimoolam, S.; Ahmed, Q. N., Q., Cesium-Fluoride-Promoted Synthesis of Stable Organocesium Reagents and Their Ambident Reactivities with Arynes. Chemistry–A European Journal 2022, 28 (40), e202200822.
12. Hussain, F.; Dar, T. A.; Ahmed, Q. N., Coupling of 1-Chloro-N, N-diisopropylphosphanamine-Based Reagents with Alcohols and Thiosulfonates: A Precise Construction of O–P(O)–S Bonds. Organic Letters 2022, 24 (29), 5324-5328.
13. Bhat, S. A.; Bhat, M. Y.; Rather, S. A.; Gani, I.; Bhat, K. A.; Ahmed, Q. N., Iodine, and ammonium persulfate mediated activation of DMSO: an approach to N-formylation of amides and synthesis of isatins. Organic & Biomolecular Chemistry 2022, 20 (42), 8197-8202.
14. Khan, A.; Naaz, F.; Basit, R.; Das, D.; Bisht, P.; Shaikh, M.; Lone, B. A.; Pokharel, Y. R.; Ahmed, Q. N.; Parveen, S.; Ali, I.; Singh, S. K.; Chashoo, G.; Shafi, S., 1,2,3-Triazole Tethered Hybrid Capsaicinoids as Antiproliferative Agents Active against Lung Cancer Cells (A549). ACS Omega 2022, 7 (36), 32078-32100.
15. Ahmed, A.; Ahmed, Q. N.; Mukherjee, D., Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose. RSC Advances 2021, 11 (57), 36143-36147.
16. Rather, S. A.; Bhat, M. Y.; Hussain, F.; Ahmed, Q. N., Sulfonyl-Promoted Michaelis–Arbuzov-Type Reaction: An Approach to S/Se–P Bonds. The Journal of Organic Chemistry 2021, 86 (19), 13644-13663.
17. Raina, G.; Kannaboina, P.; Ahmed, Q. N.; Mondal, K.; Das, P., Palladium-Catalyzed Barluenga-Valdes Type Cross-Coupling Reaction: Alkenylation of 7-Azaindoles. Asian Journal of Organic Chemistry 2021, 10 (1), 251-256.
18. Yaqoob Bhat, M.; Kumar, A.; Ahmed, Q. N., Selenium dioxide promoted dinitrogen extrusion/direct selenation of arylhydrazines and anilines. Tetrahedron 2020, 76 (16), 131105.
19. Kumar, A.; Gannedi, V.; Rather, S. A.; Vishwakarma, R. A.; Ahmed, Q. N., Introducing Oxo-Phenylacetyl (OPAc) as a Protecting Group for Carbohydrates. The Journal of Organic Chemistry 2019, 84 (7), 4131-4148.
20. Singh, D.; Kumar, G.; Dheer, D.; Jyoti; Kushwaha, M.; Ahmed, Q. N.; Shankar, R., BCl3-Mediated C–N, C–S, and C–O Bond Formation of Imidazo[1,2-a]pyridine Benzylic Ethers. ACS Omega 2019, 4 (3), 4530-4539.
21. Rather, S. A.; Kumar, A.; Ahmed, Q. N., Iodine–DMSO-promoted divergent reactivities of arylacetylenes. Chemical Communications 2019, 55 (31), 4511-4514.
22. Raina, G.; Kannaboina, P.; Mupparapu, N.; Raina, S.; Ahmed, Q. N.; Das, P., Programmed synthesis of triarylnitroimidazoles via sequential cross-coupling reactions. Organic & Biomolecular Chemistry 2019, 17 (8), 2134-2147.
23. Chalotra, N.; Ahmed, A.; Rizvi, M. A.; Hussain, Z.; Ahmed, Q. N.; Shah, B. A., Photoredox Generated Vinyl Radicals: Synthesis of Bisindoles and β-Carbolines. The Journal of Organic Chemistry 2018, 83 (23), 14443-14456.
24. Mupparapu, N.; Khan, S.; Bandhoria, P.; Athimoolam, S.; Ahmed, Q. N., One-Pot Tandem Approach to Functionalized 3-Hydroxy-2-furanyl-acrylamides. ACS Omega 2018, 3 (5), 5445-5452.

Book published:
Published complete book with Science direct on” Chemistry of 2-Oxoaldehydes and 2-Oxoacids” eBook ISBN: 9780128242865 (1st Edition – September 28, 2021)
Encyclopedia of Reagents for Organic Synthesis: Ahmed, Q. N., Khan S., Methyl Glycine. Encyclopedia of Reagents for Organic Synthesis
Patents:
Kumar, H.M.S.; Sawant, S.D.; Qazi, N.A.; Singh, S.K.; Verma, M.; Saxena, A.K.; Sethi, V.K.; Taneja, S.C.; Qazi, G.N. Spiro-derivatives of parthenin as novel anticancer agents (WO/2009/110007A8).
Kumar, H.M.S.; Saxena, A.K.; Taneja, S.C.; Singh, S.K.; Sethi, V.K.; Qazi, N.A.; Sawant, S.D. Reddy, D.M.;, Banday, A.H.; Verma, M.; Qazi, G.N.; Spiro derivatives of parthenin as novel anticancer agents. (US 2011/0201661 A1)
Combination of AMINO ACID-CONTAINING IMIDAZOLES AND PACLITAXEL FOR TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER (Patent Application: 202211066609)
NON-INFRINGING PROCESS FOR THE SYNTHESIS OF N4-HYDROXYCYTIDINE AND ITS DERIVATIVES (Patent Application: 0207NF2020).
SYNTHESIS OF 17- KETOPROSTANOZOL (Patent Application: IN202311059079 Filed on 01-09-2023).
Invited talks:
Invitation to deliver a CRSI Bronze Medal Lecture at the CRSI-NSC-32 (BITS Pilani, 2-4 Feb 2024).
Invitation to deliver a lecture_Indo-French Joint Lab Seminar_CSIR-IICT (1st to 3rd November 2023).
Invitation to deliver invited lecture at 60th ACC 2023 IIT-Delhi (20-21st December 2023).
Invitation to Participate in FIC-24, Central University Rajasthan 2023.
“Strategic S-P Bond Forming Bio-orthogonal Functionalization Technique: A Systematic Analysis, Standardization and Site-Specific Coupling Strategy for Conjugates” Department of Chemistry Laboratory of Catalysis & Organic Synthesis Indian Institute of Technology Roorkee, Uttarakhand-247667 (INDIARSC-CFOS-2022 conference at IIT Roorkee), “01-04th December 2022”.
“Strategic S-P Bond Forming Bio-orthogonal Functionalization Technique: A Systematic Analysis, Standardization and Site-Specific Coupling Strategy for Conjugates” Department of Chemistry and Chemical Sciences, Central University of Jammu International Conference on Recent Advances in Chemical Sciences (RACS-2022), “11th November 2022”.
Invited to attend prestigious NOST conference in Chennai, November 2021.
“The transformative power of functional group driven chemistry” (International Conference on Chemical & Biological Sciences in Drug Discovery-2019 (IC-CBSDD-2019) Berhampur University, Odisha “08-03-2019”.
“Applications of α-Oxo Driven Reactions in α-Oxoaldehydes and α-Oxoesters for the Generation of Different Exigent Structures” (International Conference on EMERGING TRENDS IN DRUGS DEVELOPMENT AND NATURAL-PRODUCTS, ETDDNP-2018) Department of Chemistry, University of Delhi” 12-01-2018”.
“2-oxo-driven unconventional reactions” (11th National Conference, University of Jammu)) Indian Chemical society “03-12-2016”.
“2-oxo-driven unconventional reactions” (52nd International Conference on Annual Convention of Chemists 2015 and International Conference on Recent Advances in Chemical Sciences, Jaipur) Indian Chemical society “28-12-2015”.

Awards / Honours

Awards and Honours

  • CRSI Bronze Medal (2024).
  • CNRS-post doc. Fellowship (University of Paris Sud-XI, France) 2008-2009.
  • CSIR-RA Fellowship 2008.
  • CSIR-IIIM best paper award 2005

 

Invited talks:

  • “Strategic S-P Bond Forming Bio-orthogonal Functionalization Technique: A Systematic Analysis, Standardization and Site-Specific Coupling Strategy for Conjugates” Department of Chemistry Laboratory of Catalysis & Organic Synthesis Indian Institute of Technology Roorkee, Uttarakhand-247667 (INDIARSC-CFOS-2022 conference at IIT Roorkee), “01-04th December 2022”.
  • “Strategic S-P Bond Forming Bio-orthogonal Functionalization Technique: A Systematic Analysis, Standardization and Site-Specific Coupling Strategy for Conjugates” Department of Chemistry and Chemical Sciences, Central University of Jammu International Conference on Recent Advances in Chemical Sciences (RACS-2022), “11th November 2022”.
  • Invited to attend prestigious NOST conference in Chennai, November 2021.
  • “The transformative power of functional group driven chemistry” (International Conference on Chemical & Biological Sciences in Drug Discovery-2019 (IC-CBSDD-2019) Berhampur University, Odisha “08-03-2019”.
  • “Applications of α-Oxo Driven Reactions in α-Oxoaldehydes and α-Oxoesters for the Generation of Different Exigent Structures” (International Conference on EMERGING TRENDS IN DRUGS DEVELOPMENT AND NATURAL-PRODUCTS, ETDDNP-2018) Department of Chemistry, University of Delhi” 12-01-2018”.
  • “2-oxo-driven unconventional reactions” (11th National Conference, University of Jammu)) Indian Chemical society “03-12-2016”.
  • “2-oxo-driven unconventional reactions” (52nd International Conference on Annual Convention of Chemists 2015 and International Conference on Recent Advances in Chemical Sciences, Jaipur) Indian Chemical society “28-12-2015”.

Group

Students

Current group:
Ph.D. Students:

 

Kabir Hussain(JRF) Miss Bisma Rasool (SRF)
Mr. Sajjad Hussain (SRF) Miss Norein Sakander (SRF)
Mr. Feroze Hussain (SRF) Miss Zoya Sarwal (PA)
Mr. Tariq Ahmad Dar (JRF) Mr. Junaid Shafi Banday (PA)
Mr. Irshad Ahmad Zargar (SRF) Shweta Gadeecha(PA)
Murtaza Ali(JRF)

Guided Ph.D. Students:
CSIR/ UGC Fellow

Mr. Anil K. Padala (awarded) Mr. Shahnawaz Khan (awarded)
Mr. Satyam Battula (awarded) Mr. Javaid Rasool (awarded)
Mr. Nagaraju Mupparapu (awarded) Mr. Suhail Ahmad Rather (awarded)
Mr. Narsaiah Battini (awarded) Mr. Javaid Rasool (awarded)
Mr. Atul Kumar (awarded) Mr. Arif Khan (awarded)
Mr. Gorav Raina (awarded) Mr.Mohammad Yaqoob Bhat(awarded)

Postdoc students:

 Dr. Sheena Mahajan Dr. Ashiq Hussain Padder(SPA) Dr. Annah Gupta(WISE)