Dr. Parvinder Pal Singh
Natural Products & Medicinal Chemistry Division
CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Dr. Singh is working as Pr. Scientist in the Medicinal Chemistry of CSIR-IIIM, Jammu and pursuing research in the area of Organic Synthesis and Medicinal Chemistry. He has been awarded with JK-DST-Young Scientist Award-2012 in Chemical Sciences. He has been awarded with CSIR-Young Scientist Award- 2014 in Chemical Sciences.
|Ph. D.||Chemical Science (Organic Chemistry)
|Institute: CSIR-Indian Institute of Integrative Medicine-Jammu
University: Guru Nanak Dev University-Amritsar (Punjab)
|M. Phil.||Chemical Science (Organic Chemistry)||University of Jammu, Jammu||2004|
|M.Sc.||Chemical Science (Specialization: Organic Chemistry)||Institute: D.A.V. (PG) College-Muzafar Nagar, UP
University: Ch. Charan Singh University, Meerut (UP)
|B.Sc.||Science (Chemistry, Zoology, Botany, English)||Institute: Govt. Degree College, Poonch (J&K)
University: University of Jammu, Jammu (J&K)
|Pr. Scientist||4/2018 – present||CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu|
|Sr. Scientist||4/2014 – 4/2018||CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu|
|Scientist||4/2011 – 4/2014||CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu|
|Jr. Scientist||4/2008 – 4/2011||CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu|
Area of Expertise
Research Area: “Organic Synthesis and Medicinal Chemistry”
- New Method Development (C-H Functionalization Reactions): Application in the Synthesis of Bio-actives and Natural products
C-H functionalization reactions via free-radical reactions provide a unique opportunity for the synthesis of C-C, C-N, C-O, C-S bond formation. Our group is exploiting this approach for the development of new methodology as well as late-stage functionalization and synthesis of bio-actives and natural products.
(Selected Publications: J. Org. Chem. 2020, 85, 716; Eur. J. Org. Chem. 2019, 3591; J. Org. Chem., 2018, 83 12420; J. Org. Chem., 2017, 82, 1000; Org. Lett. 2016, 18, 3638; J. Org. Chem. 2016, 14, 5886; Org. Biomol. Chem. 2016, 14, 4312; Org. Lett. 2015, 17, 5547; Org.Biomol.Chem. 2015, 13, 11341; Eur. J. Org. Chem. 2015, 6526-6533; J. Org. Chem. 2015, 80, 1929; RSC Adv. 2014, 4, 50208; J. Org. Chem. 2013, 78, 2639)
- Medicinal Chemistry in the area of Infection and Oncology
Drug discovery has high attrition rate and majority of the failure is because of poor drug-like properties and labilities issues of genotoxicity, mutagenicity etc. Our group is working on the identification of new lead-like candidates in the area of infection, oncology and inflammation. Our efforts have led to the identification of anti-infective and anti-cancer leads and few are now being investigated in pre-clinical studies.
(Selected Publications: J. Med. Chem., 2018, 60, 9470; Nature Communications 2018, 9, 4217; Drug Discovery Today, 2018, 23, 605; Tuberculosis, 2018, 108, 56–63; Pulm. Pharmacol Ther. 2018, 48, 151; ACS Med. Chem. Lett. 2015, 6, 1041; ACS Med. Chem. Lett. 2015, 6, 1059; Org. Biomol. Chem. 2015, 13, 3610; PLoS ONE, 2014, 9, e110411; Med. Chem. Commun. 2014, 5, 521-527; Chem. Rev. 2013, 113, 6761–6815)
- Carbohydrate Chemistry (GPI anchor and Phospholipids based Probes)
Glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins along with cholesterol and sphingolipids create functional micro-domains (lipid rafts) as signaling platforms at the cell surface. The molecular understanding of the mechanism of the localized clustering of GPI-anchored proteins and cholesterol in lipid rafts requires synthetic probes based on GPI structures and Phospholipids. A collaborative Programme with NCBS, Bangalore (Prof. Satyajit Mayor’s group) is going on to elucidate the structural role of GPIs and Phospholipids in clustering of cholesterol-rich ordered domains, where the challenging synthesis of fluorescently labelled and metabolically stable probes is of focus of interest of our group.
(Selected Publications: J. Org. Chem. 2020, 85, 7757; J. Org. Chem. 2015, 80, 11916; Cell, 2015, 161, 581; Org. Biomol. Chem. 2014, 12, 1163-1172)
- Natural Product Chemistry (Isolation, Synthesis and Phytopharmaceutical drugs development)
Natural products are always being an inevitable source of new therapeutic drugs, however, has been least focussed in last two decades because of many reasons starting from their availability, booms of synthetic chemistry, high-throughput and combinatorial chemistry etc. The issue of liabilities and high attrition rate has again attracted interest and is being exploited to those areas which are ignored in the past. One such example is phytocannabinoids, a unique class of compound found in cannabis crop, which is being less pursued in the past because of their poor drug-like properties and restriction because of its psychoactivity and NDPS Act. The seldom work in this area in last few decades has brought the clear understanding regarding its psychoactivity and therapeutic potential and presenting a reason for bringing this into main stream drug discovery. In India, cannabis grows all over India as weed, there is an emergent great opportunity to explore this valuable plant for the production of non-psychotic phytocannabinoids and explore their potential for biomedical applications. Recently, CSIR-IIIM has sought approval from regulatory authority regarding the R&D of cannabis for therapeutic potential. As our group is working in the drug discovery and have initiated extensive research programme on cannabis crop to utilize its full potential i) development of phytopharmaceutical based drugs; ii) development of synthetic route for the phytocannabinoids; iii) Creation of database for Cannabis accessions from different geographical region; iv) Creation of repository of chemical constituents of Cannabis as most phytocannabinoids still await an evaluation of their biological profile and pharmaceutical potential.
- Lead optimization of identified anti-TB chemotypes to develop novel pre-clinical candidate: Synthesis, In vitro, Structure-activity relationship, Pharmacokinetics and In vivo evaluation (3 Years, 2018-2021, GAP2181, DST/SERB Funded)
- Genotype-Phenotype relationship in rare genetic disorder: Physiochemical analysis of mutations in GNE myopathy nad phenotypic modulation by small molecule effector (3 Years, 2017-2020, GAP2171, DBT Funded)
- COVID-19 API Mission (9 Months, HCP-29, June 2020-Mar 2021, CSIR Funded).
- R&D on cannabis (Isolation, testing, Synthesis and Medicinal Chemistry) (CSIR-IIIM RC Approved, MLP1001)
- Medicinal chemistry of natural products for cancer, malaria and M. tuberculosis drug discovery (CSIR-IIIM RC Approved, MLP 5005)
- Chemistry of glycoconjugates; new opportunities for basic biology (CSIR-IIIM RC Approved, MLP 4016)
|Mukesh Kumar, Riyaz Ahmed, Maninder Singh, Shweta Sharma, Thanusha Thatikonda and Parvinder Pal Singh*||Functionalization of Alkynes and Alkenes Using a Cascade Reaction Approach: Synthesis of β-Keto Sulfones under Metal-free Conditions.||J. Org. Chem., 2020, 85, 716-725.|
|Shweta Sharma, Mukesh Kumar, Ram A. Vishwakarma, Mahendra K. Verma, and Parvinder Pal Singh*
|Room Temperature Metal-Catalyzed Oxidative Acylation of Electron-Deficient Heteroarenes with Alkynes, Its Mechanism, and Application Studies||J. Org. Chem., 2018, 83, 12420–12431|
|Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P. Singh, Marta C. Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A. del Pozo, Robert G. Parton, Madan Rao, Pramod Pullarkat,
Pere Roca-Cusachs & Satyajit Mayor
|Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells
|Nature Communications 2018, 9, 4217|
|Umed Singh, Gousia Chashoo, Sameer U. Khan, Priya Mahajan, Amit Nargotra, Girish Mahajan, Amarinder Singh, Anjna Sharma, Mubashir J. Mintoo, Santosh Kumar Guru, Hariprasad Aruri, Thanusha Thatikonda,Promod Sahu, Pankaj Chibber, Vikas Kumar, Sameer A. Mir, Sonali S. Bharate, Sreedhar Madishetti, Utpal Nandi, Gurdarshan Singh, Dilip Manikrao Mondhe, Shashi Bhushan, Fayaz Malik,* Serge Mignani, Ram A. Vishwakarma, and Parvinder Pal Singh*
|Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model,
|J. Med. Chem., 2018, 60, 9470–9489.
|Hariprasad Aruri, Umed Singh, Sanjay Kumar, Manoj Kushwaha, Ajai Prakash Gupta, Ram A Vishwakarma, and Parvinder Pal Singh*
|I2/Aqueous TBHP-Catalyzed Coupling of Amides with Methylarenes/ Aldehydes/ Alcohols: Metal free Synthesis of Imides||Org. Lett. 2016, 18, 3638.|
|Sravan Kumar Aithagani, Mukesh Kumar, Mahipal Yadav, Ram A. Vishwakarma and Parvinder Pal Singh*
|Metal-free, Phosphonium Salt Mediated Sulfoximination of Azine N-oxides; Approach for the Synthesis of N-azine Sulfoximines||J. Org. Chem. 2016, 14, 5886
|Sravan Kumar Aithagani, Saidulu Dara, Gurunadham Munagala, Hariprasad Aruri, Mahipal Yadav, Shweta Sharma, Ram A. Vishwakarma and Parvinder Pal Singh*
|Metal-free Approach for the Synthesis of N-aryl Sulfoximines via Aryne Intermediate.
|Org. Lett. 2015, 17, 5547.|
|Kushalava Reddy Yempalla, M. Gurunadham, S. Singh, A. Magotra, S. Kumar,V. S. Rajput, Sonali S. Bharate, Manoj Tikoo, G. D. Singh , I. A. Khan,* Ram. A. Vishwakarma* and Parvinder Pal Singh.*
|Nitrofuranyl Methyl Piperazines as New Anti-TB agents: Identification, Validation, Medicinal Chemistry and PK Studies.
|ACS Med. Chem. Lett. 2015, 6, 1041-1046.
|Riya Raghupathy, Anupama Ambika Anilkumar, Anirban Polley, Parvinder Pal Singh, Mahipal Yadav, Charles Johnson, Sharad Suryawanshi, Varma Saikam, Sanghpal D. Sawant, Aniruddha panda, Zhongwu Guo, Ram A. Vishwakarma, Madan Rao, Satyajit Mayor
| Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid Anchored Protiens.
|Cell, 2015, 161, 581-594.|
|Mungala Gurunadham, Kushalava Reddy Yempalla, Samsher Singh, Sumit Sharma, Nitin Pal Kalia, Vikrant Singh Rajput, Sunil Kumar, Sanghapal D. Sawant, Inshad Ali Khan,* Ram A. Vishwakarma* and Parvinder Pal Singh.*
|Synthesis of new generation triazolyl and isoxazolyl containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: In vitro, Structure-activity relationship, pharmacokinetics and in vivo evaluation.||Org. Biomol. Chem. 2015, 13, 3610- 3624|
|Parvinder Pal Singh, Gurunadham Mungala,
Reddy Yempalla Kushalava,
Inshad Ali Khan,
Nitin Pal Kalia,
Sanghapal Damodhar Sawant, Ram Asray Vishwakarma
|6-Nitro-2,3-dihydroimidazo[2,1-b]oxazoles and a process for the preparation thereof||Status (Active)
|Filling Date 2013-10-04
|Inshad Ali Khan, Gurunadham Munagala, Sumit Sharma, ,Samsher Singh, Ram Asrey Vishwakarma, Reddy Yempalla Kushalava, Parvinder Pal Singh||Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation there of||CN107108650A;
|Filling Date 2014-10-21
|Sumit Sharma, Riyaz Ahmed, Sushil Raina, Ram Ashrey vishwakarma , Parvinder Pal Singh||Process for the preparation of derivatives of 1,1-dialkylethane-1,2-diols as useful intermediates||WO2020202205A1||Filling Date 2019-04-01|
|Hari Prasad Aruri, Vishwakarma RamAsrey Vishwakarma, Satish Sonbarao Gudup, Inshad Ali Khan, Sanjay Kumar, Gurunadham Munagala, Parvinder Pal Singh, Samsher Singh,Umed Singh,Reddy Yempalla Kushalava||Substituted aurone alkaloids as anti-mycobacterial agents||CN108699047A;
|Filling Date 2016-03-03|
|Suresh Kumar, Girish Mahajan, Priya Mahajan, Fayaz Malik, Dilip Manikrao Mondhe, Amit Nargotra, Parvinder Pal Singh, Umed Singh, Thanusha Thatikonda, Ram Asrey Vishwakarma||Novel 1,3,5 -triazine based pi3k inhibitors as anticancer agents and a process for the preparation thereof||CN107428730A;||Filling Date 2014-11-20|
|Umed Singh, Hari Prasad Aruri, Gousia Chashoo, Satish Sonbarao Gudup, Girish Mahajan, Priya Mahajan, Dilip Manikrao Mondhe, Amit Nargotra, , , Thanusha Thatikonda, Ram Asrey Vishwakarma, Parvinder Pal Singh||3-Pyrimidinyl pyrrolo [2,3-b] pyridine as anticancer agents and the process for the preparation thereof||EP3383875A1;
|Filling Date 2015-11-30|
|Satyajit Mayor, Akankshi Munjal, Taslimarif Saiyed, Anandi Karumbati, Ram Asrey Vishwakarma, Parvinder Pal Singh, Shweta Sharma, Gurunadham Munagala, Reddy Kushalava Yempalla, Srinivas Ambala, Shahid Jameel, , , Satyajit Rath||Inhibitors to target hiv-1 nef-cd80/cd86 interactions for therapeutic intervention||WO2020035880A1||Filling Date 2018-08-13|
Awards and Honours
- CSIR-Young Scientist Award-2014 in Chemical Sciences
- JK-DST-Young Scientist Award-2012 in Chemical Sciences
- Referee for various journals published by ACS, RSC, Elsevier, Nature, Bentham, etc
|Photo||Name||Thesis / Area of Interest||Education|
|Riyaz Ahmed(UGC-SRF)||Thesis Title: Medicinal chemistry around s-triazine and development of new synthetic methodologies
Area of Interest: Medicinal chemistry, synthetic methodology for C-C, C-N, C-H functionalization.
|B.Sc. (Jammu University, 2012)
M.Sc. (Jammu University, 2014)
Ph.D (CSIR-IIIM, pursuing)
|Ria Gupta (INSPIRE-JRF)||Thesis Title: Synthesis of best in class nitro-imidazole analogs against infectious diseases.
Area of Interest: Medicinal Chemistry to develop new anti-infective agents, Development of new methods for the synthesis of C-C/C-N/C-S bond via C-H activation/functionalization.
|B.Sc. (University of Jammu, 2015)
M.Sc. (University of Jammu, 2017)
Ph.D (CSIR-IIIM, Ongoing)
|Zaheen Akhter (CSIR-JRF)||Thesis Title: Development of methods for C-H functionalization and its application in the synthesis of bio-active molecule.
Area of Interest: Medicinal Chemistry, Development of synthetic methodologies.
|BSc. (University of Jammu, 2014)
MSc. (University of Jammu, 2018)
Ph. D (CSIR-IIIM, pursuing)
|Pankaj Singh Cham (Project Asst.)||Thesis Title: Isolation and modification of Phytocannabinoids
Area of Interest: Medicinal chemistry, naturally product and analytical chemistry
|BSc (University of Jammu, 2011)
MSc (Ch. Charan Singh University, 2013)
Ph. D. CSIR-IIIM (ongoing)
|Maninder Singh (Project Asst.)||Thesis Title:
Area of Interest: Synthesis of Probe to investigate membrane qualities of the phospholipid bilayers of cell membranes
|B.Sc. (G.N.D.U, 2014)
M.Sc. (P.T.U, 2017)
Ph.D (CSIR-IIIM, pursuing)
|Radhika Anand (Project Asst.)||Thesis Title: Synthesis of phytocannabinoids and related analogs
Area of Interest: Medicinal chemistry, Total synthesis and Synthetic Methodology.
|B.Sc (University of Jammu, 2014)
M.Sc (University of Jammu, 2016)
Ph.D (CSIR-IIIM, persuing)
|Dr. Rohit Singh (Project Associate)||Thesis Title: Modification of Natural products for the Potential Anti-Inflammatory Effects and Development of Synthetic Methodology
Area of Interest: Medicinal chemistry, naturally product and analytical chemistry, synthetic methodology for C-H functionalization.
Currently, he is involved in synthesis of API (Favipiravir, Nafamostat) for use against COVID-19
|B.Pharmacy (RGPV, 2011)
M.Pharmacy (RGPV, 2013)
Ph.D (CSIR-IIIM, 2020)
|Sumit Sharma (ICMR-DHR)||Thesis Title: Medicinal Chemistry on Nitro-imidazole Scaffold to Discover New Generation anti-TB Lead.
Area of Interest: Medicinal chemistry, Analytical chemistry
|B.Pharmacy (Himachal Pradesh University, 2010)
M.Pharmacy (Shoolini University, 2012)
Ph. D. (CSIR-IIIM, Submitted)
|Dr. Mukesh Kumar (Project Associate)||Thesis Title: Development of new C-H functionalization methods and their applications
Area of Interest: Development of new synthetic methodologies for C-H functionalization, Medicinal chemistry
|Pharmacy (PTU, 2010)
Pharmacy (Shoolini University, 2012)
Ph. D. (CSIR-IIIM, 2020)