Dr. Bhahwal Ali Shah

Senior Principal Scientist

Natural Products & Medicinal Chemistry Division

CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: bashah[at]iiim[dot]res[dot]in

Profile

Bio Sketch

Bhahwal Ali Shah is a Senior Principal Scientist at CSIR-Indian Institute of Integrative Medicine, Jammu. His research interests include Natural Product Chemistry, Medicinal Chemistry and the Development of New Synthetic Methods using Photoredox Catalysis. He has been instrumental in establishing and the Microbial Natural Product Chemistry facility at CSIR-IIIM, Jammu. He has more than 15 years of research experience with over 100 publications in international journals of repute. Dr Bhahwal also received the prestigious CSIR Young Scientist Award in Chemical Sciences 2015 and NASI-Platinum Jubilee Young Scientist Award in Chemical Sciences 2016.

Education

Degree	Subjects	University	Qualifying Year
Ph. D.	Chemical Science	Guru Nanak Dev University, Amritsar	2009
M. Sc.	Chemistry	Ch. Charan Singh University, Meerut, UP	2004
B. Sc.	Chemistry, Zoology, Botany, English	Govt. Gandhi Memorial Science College, University of Jammu, Jammu	2002

Position Held

Position Held	Period	Organization
Senior Principal Scientist	02-04-2024 to Present	CSIR-Indian institute of Integrative Medicine, Canal Road, Jammu
Principal Scientist	04-2019 to 04-2024	CSIR-Indian institute of Integrative Medicine, Canal Road, Jammu
Sr. Scientist	04-2015 to 04-2019	CSIR-Indian institute of Integrative Medicine, Canal Road, Jammu
Scientist	04-2011 to 04-2015	CSIR-Indian institute of Integrative Medicine, Canal Road, Jammu
Jr. scientist	04-2008 to 04-2011	CSIR-Indian institute of Integrative Medicine, Canal Road, Jammu

Area of Expertise

Research Area

Project Involved / Ongoing Projects

Projects

Design and Synthesis of Mupirocin Analogues as New Antibacterial Agents [2018-21].[completed]
Isolation Synthesis of Bioactive Molecules from Microbial Sources [2016-21]. [completed]
Process Development for COVID-19 API’s: [2020-21] [completed]
Discovery and Pre-clinical development of Anti-virals for COVID-19 and other diseases (HCP-041) ( 2022-23) [completed}
Exploration of Photoredox Generated Vinyl Radicals as Precursors to Bio-relevant Scaffolds (GAP-3112) [ongoing].

Publications and Patents

Publications

Selected publications:
1. Bhat, M.S.; Ganie, M.A.; Kumar, S.; Rizvi, M.A.; Raheem,S.; Shah, B.A.* Visible light mediated synthesis of thioesters using thiocarboxyllic acid as a dual reagent. J. Org. Chem., 2024, https://doi.org/10.1021/acs.joc.3c02877.
2. Ganie, M.A.; Fayaz, F.; Bhat, M.S.; Rizvi, M.A.; Raheem,S.; Shah, B.A.* Visible-Light-Mediated Synthesis of N-Acyl-N,O-hemiacetals from Terminal Alkynes: Access to N,N-N,S-, and N,O-Acetals. Org. Lett., 2023, 8234−8239.
3. Bhat, M. S.; Ganie, M. A.; Shah, B. A.* Metal-Free Tunable 1,2-Difunctionalization of Terminal Alkynes: Synthesis of β-Substituted α,β-Unsaturated Ketones. Chem.Eur.J., 2023, e202302294.
4. Ganie, M.A.; Bhat, M.S.; Rizvi, M.A.; Raheem, S.; Shah, B. A.* Synthesis of 1,2-oxazetidines with a free –NH group via photoredox catalysis. Chem Commun., 2022, 58, 8508-8511.
5. Bhat, M.S.; Ganie, M.A.; Rizvi, M.A.; Raheem, S.; Shah, B. A.*. Photoredox Catalyzed Thioformylation of Terminal Alkynes Using Nitromethane as a Formyl Source. Org. Lett., 2022, 24, 6658-6663
6. Ganie, M.A.; Bhat, M.S.; Rizvi, M.A.; Raheem, S.; Shah, B. A.*. Photoredox-Promoted Selective Synthesis of C-5 Thiolated 2-Aminothiazoles from Terminal Alkynes. Org. Lett.,, 2022, 24, 7757-7762
7. Kumar, S.; Kumar, J.; Naqvi, T.; Raheem, S.; Rizvi,M.A.; Shah, B. A.*.Synthesis of (E)-β-Iodovinyl Sulfones via Photoredox Catalyzed Difunctionalization of Terminal Alkynes. ChemPhotoChem, 2022, 6, e202200110
8. Chalotra,N.; Kumar, J.; Naqvi, T.; Shah, B. A.*.Photocatalytic functionalizations of alkynes. Chem. Commun, 2021, 57, 11285-11300
9. Kumar, J.; Ahmad, A.; Rizvi, M. A.; Ganie, M. A.; Khajuria, C.; Shah, B. A.*. Photoredox-Mediated Synthesis of Functionalized Sulfoxides from Terminal Alkynes. Org. Lett., 2020, 22, 5661-5665
10. Chalotra, N.; Rizvi, M. A.; Shah, B. A.* Photoredox-Mediated Generation of gem-Difunctionalized Ketones: Synthesis of α,α-Aminothioketones. Org. Lett., 2019, 21, 4793-4797
11. Sultan, S.; Bhat, M.-u.-S.; Rizvi, M. A.; Shah, B. A.* Visible Light-Mediated [2 + 2] Cycloaddition Reactions of 1,4-Quinones and Terminal Alkynes. J. Org. Chem., 2019, 84, 8948-8958.
12. Chalotra, N.; Ahmed, A.; Rizvi, M. A.; Hussain, Z.; Ahmed, Q. N.; Shah, B. A.* Photoredox Generated Vinyl Radicals: Synthesis of Bisindoles and β-Carbolines. J. Org. Chem., 2018, 83, 14443-14456.
13. Sultan, S.; Rizvi, M. A.; Kumar, J.; Shah, B. A.* Acyl Radicals from Terminal Alkynes: Photoredox-Catalyzed Acylation of Heteroarenes. Chem.Eur. J., 2018, 24, 10617-10620.
14. Devari, S.; Shah, B. A.* Visible light-promoted C–H functionalization of ethers and electron-deficient arenes. Chem. Commun. 2016, 52, 1490-1493.
15. Kumar, A.; Shah, B. A. Synthesis of Biaryls via Benzylic C–C Bond Cleavage of Styrenes and Benzyl Alcohols. Org. Lett., 2015, 17, 5232-5235.
16. Devari, S.; Kumar, A.; Deshidi, R.; Shah, B. A. C–H functionalization of terminal alkynes towards stereospecific synthesis of (E) or (Z) 2-methylthio-1,4-ene-diones. Chem. Commun., 2015, 51, 5013-5016.

Full List of Publication

Awards / Honours

Awards and Honours

NASI Platinum Jubilee Young Scientist Award in Chemical Sciences 2016
CSIR Young Scientist Award in Chemical Sciences 2015.
INDO-US Research Science and Technology Forum Fellowship for the year 2011.
BOYSCAST Fellowship for the year 2011
Fast Track Research Grant by DST (2010)

Group

Students

Photo	Name	Area of Interest	Position
	Dr. Ghazala Khanum (NPDF)
	Faheem Fayaz
	Majid Ahmad Ganie	Photoredox Functionalization of Heterocyclic Compounds	Research Fellow Natural Product Chemistry Division CSIR-JRF, GATE, SET M.Sc Chemistry, University of Kashmir. e-mail: ganiemajid7@gmail.com
	Muneer-ul-Shafi Bhat	Photoredox Functionalization of Natural Products	Project Fellow Natural Product Chemistry Division. GATE M.Sc Chemistry, Jamia Hamdard University, Delhi e-mail: munnerbhat442@gmail.com
	Iftkhar Hussain Shah	Developments of new cross- coupling methods using Metallaphotoredox catalysis	Research Fellow Natural Product Chemistry Division. CSIR-JRF M.Sc Chemistry, Aligarh Muslim University. e-mail: naqviiftkhar647@gmail.com
	Sourav Kumar	Development of Novel Photoredox C-H activation strategies	Research Fellow Natural Product Chemistry Division. CSIR-JRF M.sc(Hons.) Chemistry, Guru Nanak Dev University, Amritsar. e-mail: coolsourav418@gmail.com