Dr. Boobalan. G
Scientist
Pharmacology Division
CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: boobalan[dot]g[at]iiim[dot]res[dot]in
Bio Sketch
My group screens and validates new drug targets for anti-cancer activity using in-vitro and in-vivo non-clinical studies. We aim to develop and standardize specific breast and ovarian cancer biomarkers to study the anti-cancer activity of the in-housed synthesized compounds. We are going to establish both cell-line (CDX) and patient-derived (PDX) xenograft models for in-vivo evaluation of phytopharmaceuticals using syngeneic and immunocompromised mice (Athymic/SCID/NSG) for validating the in-vitro selected drug. And also, we are currently trying to establish cancer tissue organoid/spheroid cultures and humanized mice to mimic the pathophysiology of the human disease.
My focus will also be on establishing an OECD-GLP-certified test facility with supporting departments as an adjunct of the new animal house. As part of the GLP facility establishment in our institute, my responsibility is to ensure compliance with OECD principles of Good Laboratory Practices, and regulatory (IAEC/CPCSEA, IBSC, state agencies) recommendations, and conduct of GLP study (acute, repeated, and safety pharmacology) using rodents/non-rodents in animal facilities.
As a veterinarian, I ensure the proper health, care, and management of laboratory animals maintained in our laboratory animal facility.
Education
Degree | Subjects | University | Qualifying Year |
Ph.D. | Veterinary Pharmacology and Toxicology | Sri PV Narsimha Rao Telangana Veterinary University, Hyderabad, India | 2016 |
Certificate course | Lab Animal Sciences | FELASA-Europe, LASA-India and TANUVAS, Chennai, India | 2016 |
PG Diploma | Management | Madurai Kamaraj University, Madurai, India | 2015 |
Certificate course | Regulation for Biologics & Pharmaceutical Products | Indian Biological Sciences and Research Institute, Noida, India | 2014 |
M.V.Sc | Veterinary Pharmacology and Toxicology | Sri Venkateswara Veterinary University, Tirupati, India | 2013 |
B.V.Sc. & A.H. | Veterinary Science | Tamil Nadu Veterinary and Animal Sciences University, Chennai, India | 2010 |
Position Held
Position Held | Period | Organization |
Scientist | July 2020 – Present | CSIR – Indian Institute of Integrative Medicine |
Senior Research Associate | September 2018 – July 2020 | Vimta Labs Ltd |
Research Biologist | October 2016 – September 2018 | Sphaera Pharma Pvt Ltd |
Area of Expertise
- Ensuring principles of animal welfare (Health, care, and management) activities as per CPCSEA and AAALAC guidelines for laboratory animals viz., Rats, Mice, Guinea Pigs, Hamsters, Rabbits, and Beagle Dogs.
- Conduct GLP Toxicity study – Acute, repeated dose, and safety pharmacology studies in rodents/non-rodents as per OECD guidelines.
- Experience in facing successful audits evaluation by US-FDA, AAALAC International, and NGCMA, India.
- Pharmacokinetic evaluation of NCE’s compounds in laboratory animals through different analysis systems viz., bioavailability, bioequivalence, PK-PD interaction, tissue distribution, stability, solubility studies, HPLC analysis.
- Development and validation of animal models for screening NCEs in drug discovery and development viz., pain, inflammation, arthritic, hepatotoxic, inflammatory bowel disease, and obesity.
- Establishment of xenograft tumor models using various cell lines in immunocompromised mice.
Projects
- HCP-040: PAN CSIR Cancer Program – Making cancer care affordable Empowering Women’s health: Focussing on Breast and Gynaecological cancer of Indian relevance.
- MLP-6007: Screening of novel anti-cancer compounds through non-invasive detection and quantification of experimental human tumours.
Publications
Authors | Title | Journal |
Balakrishnan, R.,
Satish Kumar, C.S., Rani, M.U., Srikanth, M.K., Boobalan, G. and Reddy, A.G. |
An evaluation of the protective role of α-tocopherol on free radical induced hepatotoxicity and nephrotoxicity due to chromium in rats. | Indian Journal of Pharmacology, 2013; 45(5): 490-495.
|
Balakrishnan, R.,
Kumar, C.S., Rani, M.U., Kavita, K., Boobalan, G. and Gopala Reddy, G. |
Evaluation of protective action of α-tocopherol in chromium-induced oxidative stress in female reproductive system of rats. | Journal of Natural Sciences, Biology and Medicine, 2013; 4(1): 87-93. |
Balakrishnan, R.,
Kumar, C.S.V.S., Reddy, K.K., Rani, M.U., Srikanth, M.K, Kavitha, K., Boobalan, G. and Reddy, A.G. |
Antioxidant activity of coated probiotic Lactobacillus casei on chromium (VI) induced oxidative stress in rats. | Proceedings of National Academy of Sciences India B: Biological Section, 2014; 84(2):305-310. |
Gopu, B.,
Dileep, D., Rani, M.U., Kumar, C.S., Kumar, M.V. and Reddy, A.G. |
Protective role of curcumin and flunixin against acetic-acid induced IBD via modulating inflammatory mediators and cytokine profile in rats. | Journal of Environmental Pathology, Toxicology and Oncology, 2015; 34(4): 309-20. |
Satish Kumar, C.S.,
Kondal Reddy, K., Reddy, A.G., Vinoth, A., Ch, S.R., Boobalan, G. and Rao, G.S. |
Protective effect of Lactobacillus plantarum 21, a probiotic on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats. | International Immunopharmacology, 2015; 25(2): 504-10.
|
Devi, P.R.S,
Reddy, A.G., Rao, G.S., Kumar, C.S.V.S. and Boobalan, G. |
Pharmacokinetic interaction of curcumin and glibenclamide in diabetic rats, | Veterinary World, 2015; 8(4): 508-511. |
Anudeep Reddy, M.,
Kala Kumar, B., Boobalan, G., Vijay Kumar, M., Kasi Reddy, M., Satish Kumar, C.S.V. and Gopala Reddy, A. |
Pharmacokinetic analysis of atorvastatin against experimental hepatotoxicity with special reference to CYP3A4 functioning in rats. | Current Trends in Biotechnology and Pharmacy 2016; 10(3): 230-237. |
Dileep, R.,
Rani, M.U., Boobalan, G., Kumar, M.V. and Reddy, A.G. |
Pharmacological evaluation of ginger extract and dexamethasone in experimental ulcerative colitis in rats. | Indian Veterinary Journal 2016; 93(9): 73-75.
|
Reddy, M. A., Kalakumar, B., Gopu, B., Reddy, M.K., Satish Kumar, C.S.V., Reddy, A.G. and Lakshman, M. | Hepatoprotective Potential of Green Tea Extract against Experimental Hepatotoxicity in Rats
|
Indian Journal of Pharmaceutical Sciences, 2017; 79(1): 58-64. |
Satish Kumar, C.S.V., Kondal Reddy, K., Boobalan, G.,
Gopala Reddy, A., Sudha Rani Chowdary, CH., Vinoth, A., Jayakanth, K. and Srinivasa Rao, G. |
Immunomodulatory effects of Bifidobacterium bifidum 231 on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats. | Research in Veterinary Science, 2017; 110: 40-46. |
Awards and Honours
- 2014 : JRF fellowship under Rajiv Gandhi National Fellowship
- 2016 : SRF fellowship under Rajiv Gandhi National Fellowship
Students
Photo | Name | Focus of Interest | Position |
Ajay Singh | Evaluation of anti-cancer potential of natural and semi-synthetic natural products. | Junior Research Fellow
CSIR-UGC NET JRF, GATE Pharmacology division M.Sc. Zoology, HNB Garhwal University (Uttarakhand) Email: jaralajay1995@gmail.com |
|
Bikram Singh | Evaluation of anti-cancer potential of natural and semi-synthetic natural products. | Junior Research Fellow
CSIR-UGC NET JRF, GATE Pharmacology division M.Sc. Zoology, Lovely Professional University, Jalandhar (Punjab) Email: bikkshaan@gmail.com |
|
Ruhi Singh | Focusing on breast and gynaecological cancers of Indian relevance -HCP 040 | Project Associate-I
Pharmacology division M.Sc. Biotechnology, SMVDU, Katra (J&K) Email: ruhis1813@gmail.com |