Dr. Mohd Jamal Dar

Dr. Mohd Jamal Dar

Senior Principal Scientist

Pharmacology Division

CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: jamal[at]iiim[dot]res[dot]in

Profile

Bio Sketch

Mohd Jamal Dar received PhD from the department of Molecular Biology and Genetics Unit ( MBGU) at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) under the supervision of Prof. Namita Surolia. He then joined as a postdoctoral fellow at Harvard Medical School / Dana-Farber Cancer Institue with the group of Prof. Alan Engelman and worked on. HIV–1 integrase,  the enzyme responsible for the insertion of the viral DNA into host DNA, as the critical target of anti-AIDS therapy. Following this he worked as a Research Associate (Staff Scientist) with Prof. Paul Monga at University of Pittsburgh Medical Centre (UPMC) and investigated the role of wnt/beta-catenin signaling in cancer and stem cell biology.

Present Research Interest

Stem Cell Biology and Regenerative Medicine:

  • The role of wnt /beta-catenin signalling in cancer and stem cell biology
  • The role of PI3K pathway in cancer and stem cell biology
  • Understanding mechanism of hair regeneration

Education

Degree Subjects University Qualifying Year
Ph. D Molecular Biology Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR),  Bangaluru- India 2005
M.Sc Biochemistry University of Kashmir Srinagar, J&K 1999
B. Sc Medical University of Kashmir Srinagar, J&K 1996

Position Held

Position Held

Position Held Period                                                       To Organization
Senior Principal Scientist 2022 till now CSIR-IIIM, Jammu, India
Principal Scientist 2017 2022 CSIR-IIIM, Jammu, India
Senior Scientist 25/10/2012 25/10/2017 CSIR-IIIM, Jammu, India
Senior Scientist (Fast-track-CSIR Quick-Hire) 11/05/2011 24/10/2012 CSIR-IIIM, Jammu, India
Assisstant Professor

(Honorary)

 19-12-2013 Continuing Academy of Scientific and Innovative Research (AcSIR), New Delhi
Research Associate 01/05/2009 21/04//2011 UPMC/University of Pittsburgh, Pittsburgh, USA
Postdoctoral Fellow 17/05/2006 30/04/2009 Harvard Medical School/DFCI,  Boston, USA
DBT-Postdoctoral Fellow 01/01/2005 01/04/2006 Centre for DNA Diagnostics and Fingerprinting (CDFD), Hyderababad,  India

Area of Expertise

Area of Expertise

  • Cancer Biology and Regenerative Medicine

Project Involved / Ongoing Projects

Projects

  • Discovery and in-vivo validation of small molecules promoting hair regeneration. Principal Investigator on this intra-institute CSIR-IIIM Project ((MLP-6003-WP3) at CSIR-IIIM Jammu
  • Identification and in vivo validation of c-Jun-N-Terminal Kinase 3 (JNK-3) inhibitors as novel therapeutics for neurodegenerative diseases. Co- Investigator on this DST-SERB Project with Prof. Partha Sarthy Das at  Indian Institute of Technology (IIT) Dhanabad- 00 Lakh for 3 Years,  2018 -2021)
  • Preclinical development of small molecule(s) promoting hair regeneration and studying mechanism of hair regeneration. (Principal Investigator – CSIR approved this project for 3 years on April 11, 2020. Cost of Project: 00 Lakhs)

 

 

Publications and Patents

Publications

Authors Title Journal
  1. Ayaz MO, Bhat AQ, Akhter Z, Badsera N, Hossain MM, Showket F, Parveen S, Dar MS, Tiwari H, Kumari N, Bhardwaj M, Hussain R, Sharma A, Kumar M, Singh U, Nargorta A, Kshatri AS, Nandi U, Monga SP, Ramajayan P, Singh PP, Dar MJ. 
  Identification of a novel GSK3β inhibitor involved in abrogating KRas dependent pancreatic tumors in Wnt/beta-catenin and NF-kB dependent manner.

 

 Life Sci. 2024 Aug 15;351:122840. Impact Factor-6.7
Md Mehedi Hossain  , Arfan Khalid , Zaheen Akhter , Sabra Parveen , Mir Owais Ayaz , Aadil Qadir Bhat , Neetu Badesra , Farheen Showket , Mohmmad Saleem Dar , Farhan Ahmed , Sumit Dhiman , Mukesh Kumar , Umed Singh , Razak Hussain , Pankaj Keshari , Ghulam Mustafa , Amit Nargorta , Neha Taneja , Somesh Gupta , Riyaz A Mir , Aravind Singh Kshatri , Utpal Nandi , Nooruddin Khan , P Ramajayan , Govind Yadav , Zabeer Ahmed , Parvinder Pal Singh , Mohd Jamal Dar.  Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter.

 

 Journal of Translational Medicine.  2024 Apr 18;22(1):370. Impact Factor-8.44

 
Aadil Qadir Bhat , Mir Owais Ayaz , Razak Hussain , Mohmmad Saleem Dar , Md Mehedi Hossain , Farheen Showket , Mohd Saleem Dar , Yusuf Akhter , Mohd Jamal Dar Identification of a stretch of four discontinuous amino acids involved in regulating kinase activity of IGF1R

 

 Journal of Cell Science, 10 JUNE 2022
Gurjinder Singh , Md Mehedi Hossain , Aadil Qadir Bhat , Mir Owais Ayaz , Nasima Bano , Rafiqa Eachkoti , Mohd Jamal Dar   

Identification of a cross-talk between EGFR and Wnt/beta-catenin signaling pathways in HepG2 liver cancer cells

 

 Cell Signalling 2020 Dec 17;79:109885
MS Dar, A Hussain, P Singh, QP Hassan, SP Monga, Dar MJ Cancer Research-

2017. 77 (13 Supplement), 333-333 Impact Factor-9.1

 Identification of a natural product small molecule inhibitor against Wnt/β- catenin signalling pathway
Jamwal G, Singh G, Dar MS, Singh P, Bano N, Syed SH, Sandhu P, Akhter Y, Monga SP, Dar MJ. Biochim Biophys Acta Mol

Cell Research (BBA-MCR). 2018 Jun;1865(6 ):920-93. Impact Factor-4.57

 Identification of a unique loss-of-function mutation in IGF1R and a crosstalk between IGF1R and Wnt/β- catenin signaling pathways.
Dar MS, Singh P, Singh G, Jamwal G, Hussain SS, Rana A, Akhter Y, Monga SP, Dar MJ Biochim Biophys Acta Mol

Cell Research (BBA-MCR). 2016 Sep;1863(9):2345-57 Impact Factor-4.57

 Terminal regions of β-catenin are critical for regulating its adhesion and transcription functions.
Singh P, Dar MS, Dar MJ. FEBS Lett. 2016 Sep;590(18):3071-82. Impact Factor- 3.0

 

 p110α and p110β isoforms of PI3K signaling: are they two sides of the same coin?
Singh, Paramjeet ; Dar, Mohd; Singh, Gurjinder ; Jamwal, Gayatri ; P. R. Sharma, P. ; Ahmed, Muzamil ; Dar, MJ. Journal of Cellular Biochemistry (JCB). 2016 Dec;117(12):2864-2874. Impact Factor- 3.54

 

 Dynamics of GFP-fusion p110α and p110β isoforms of PI3K signaling pathway in normal and cancer cells.
Thompson MD, Dar MJ, Monga SP. Journal of Hepatology – 2011 Mar;54(3): 506-12. Impact Factor-20.58 Pegylated interferon alpha targets Wnt signaling by inducing nuclear export of β-

catenin.
Kari  N.  Nejak-Bowen,v  Michael  D.  Thompson,vSucha  Singh,vWilliam  C.  Bowen,  Jr., Mohd Jamal Dar, Jaspal Khillan, Chunsun Dai,            and  Satdarshan P.S. Hepatology.

2010 May;51(5): 1603-13.

Impact Factor-14.07

 Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine- 45 mutant beta-catenin.
Dar MJ,  Monel  B,  Krishnan  L,  Shun  MC,  Di  Nunzio  F,  Helland  DE,  Engelman  A Retrovirology. 2009, 19;6:94. Impact factor- 6.47 Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase
Hughes S, Jenkins V, Dar MJ, Engelman A, Cherepanov P.  

Journal of Biological  Chemistry (JBC). 2010 Jan 1;285(1):541-54.   Impact factor- 4.52

 

 Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity.

Awards / Honours

Awards and Honours

  • National Eligibility Test (NET) for Lectureship/JRF-1999 conducted by University Grants Commission (UGC) and Council for Scientific and Industrial Research (CSIR), New Delhi, India
  • National Level DBT-PDF Fellowship Department of Biotechnology (DBT), India (2005-2006)
  • Postdoctoral Fellowship at Harvard Medical School/ DFCI Boston, USA ( 2006-2009)
  • Postdoctoral Fellowship at University of Pittsburgh, USA ( 2009-2011)

Group

Students

Photo Name Ph. D thesis  Title Position Education
Farheen showket Structural characterization of IGF1R allosteric inhibitor binding pocket CSIR-JRF M.Sc. Zoology
Sabra Parveen Identification of small molecules involved in hair regeneration DST-Inspire

( JRF)

 M.Sc. Biotechnology
Md Mehedi Hossain Identification of small molecule inhibitors targeting JAK-STAT signalling pathway for promoting hair regeneration CSIR-SRF M.Sc. Molecular Biology and Biotechnology
Mir Owais Ayaz Identification of GSK-3 beta specific small moleule inhibitors as novel anti-cancer agents

Exploring the role of betacatenin in pancreatic cancer

 UGC SRF MSC in zoology/ Animal Biotechnology
Neetu GSK-3 beta specific small moleules as novel anti-cancer agents CSIR-JRF M.Sc. Zoology
Mohammad Saleem Pan Cancer Project Project Assistant M.Sc. Biochemistry

 

Alumni ( PhD students):

      S.No Name of the student Ph. D thesis  Title
1. Nasima Bano

 

 Analyzing structural differences in the allosteric binding pocket region  between insulin receptor (IR) and IGF1R for  designing anti-cancer agents
2. Aadil Qadir Bhat

 

 Characterization of newly identified  allosteric inhibitor pocket of IGF1R
3. Paramjeet Singh

 

 Analyzing the distinct and overlapping roles of p110-alpha and p110-beta isoforms of PI3K signalling in normal and cancer cells
4. Gurjinder Singh

 

 Analyzing kinase dependent and independent functions of EGFR and IGF-1R receptor tyrosine kinases in normal and cancer cells
5. Gayatri jamwal

 

 

 Identification of an allosteric inhibitor binding pocket in IGF-1R and a cross-talk between IGF-1R and Wnt/ β-catenin signalling pathways
6. Mohd Saleem Dar

 

 Elucidating role of beta-catenin terminal regions in its nuclear translocation and regulation of transcription