Dr. Prasoon Kumar Gupta

Dr. Prasoon Kumar Gupta

Senior Principal Scientist

Natural Products & Medicinal Chemistry Division

CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: guptap[at]iiim[dot]re[dot]in

Profile

Bio Sketch

Dr. Prasoon Gupta has over 20 years of research experience in the field of Traditional Indian Medicine which  includes terrestrial, microbial and marine natural product chemistry.  Dr. Gupta has obtained his BS and MS degree in Pharmaceutical Chemistry from Devi Ahilya Vishva Vidhyalaya, Indore, India. He has started his carrier as a Project Assistant (JRF) in the field of Natural Product Chemistry, at NIPER, Mohali, India and  he was associated with many projects of national importance, one to discuss is “Development of Herbal Pharmacopeia for ISM Drugs” for quality standards of Indian traditional medicines. He has obtained his Ph.D. degree in Natural Product Chemistry from Central Drug Research Institute, India in the year 2007.

Dr. Gupta moved to USA for advanced training in the area of NPs first at University of Georgia (2007-2008) then to Florida Atlantic University, Boca Raton (2008-2012) where he was actively engaged in the development of high throughput methods for identification of bioactive metabolites from marine natural products that impact the growth of human embryonic stem cells. Further, he moved to University of North Carolina (2012-2013), Wilmington, USA to work at MARBION center for marine natural product as a Research Assistant Professor, and he was actively engaged in drug discovery from marine algae and microbes.

In 2013, he joined CSIR-IIIM as a Senior Scientist. At present, he is working as a Principal Scientist at CSIR-IIIM and focusing on “high-throughput identification of natural products from traditional medicinal plants”. So far Dr. Gupta has published over 35 research articles in high -tier scientific journals and also has eight published book chapter in credit. He has been awarded many travel grants and research funding to carry out his research. He is a life member of Chemical Research Soc of India, Soc of Pharmacognosy; Assoc Member of American Soc of Pharmacognosy, and American Cancer Soc. He has delivered several invited talks in India and abroad. He is also associated with National and International journals in different capacities.

Education

Degree Subjects University Qualifying Year
Ph. D. Chemistry Central Drug Research Institute, Lucknow, India 2007
M.Sc. Pharmaceutical Chemistry Institute of Chemical Sciences, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India.

 

 2000
B. Sc Pharmaceutical Chemistry and Microbiology Maharaja Ranjeet Singh College of Professional Sciences, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India 1998

Position Held

Position Held

Position Held Period Organization
Senior Principal Scientist 2022-till date CSIR-IIIM
Principal Scientist 2017-Conti CSIR-IIIM
Senior Scientist 2013-2017 CSIR-IIIM
Research Assistant Professor 2012-2013 University of North Carollina, Wilmington, NC, USA
Assistant Scientist 2008-2012 Florida Atlantic University, Boca Raton, FL, USA
Research Associate 2007-2008 University of Georgia, Athens, GA, USA
Research Chemist 2002-2002 Dr. Reddy’s Laboratories Limited, Hyderabad, India
Project Assistant (JRF) 2000-2002 National Institute of Pharmaceutical Education and Research, Mohali (Punjab) India
Chemist 1999-1999 IPCA Laboratories Limited, Ratlam, M.P. India

Area of Expertise

Area of Expertise

  • Terrestrial, Microbial and Marine Natural Products
  • Metabolic Fingerprinting (LC-MS, HPTLC)
  • Development of High-throughput Methods to Identify Biological Active Molecules
  • NMR and Structural Elucidation
  • Medicinal Chemistry

 

 

 

 

Project Involved / Ongoing Projects

Projects

  • Dengue Herbal Project (Advanced Phase, Sun Pharma Limited)
  • Novel Strategy to Generate Drug Like Marine Natural Product Library to Discover Bioactive Compounds (SERB)
  • Fermentation Based Process Development for Production of Tacrolimus Drug (ICMR)
  • Effect of Epigenetic Modifiers on Secondary Metabolite Production in Drug Producing Fungi (SERB)
  • CSIR-Phytopharmaceutical Mission (CSIR)
  • CSIR-Sickle Cell Anaemia Mission (CSIR)
  • CSIR-Aroma Mission (CSIR)

 

Publications and Patents

Publications

Authors Title Journal
Singh, G.; Singh, J.;  Singamaneni, V.; Singh, S.; Gupta, Prasoon, Katoch, M. Serine-glycine-betaine, a novel dipeptide from an endophyte Macrophomina phaseolina: isolation, bioactivity and biosynthesis Journal of Applied Microbiology 2021, 1-12. https://doi.org/10.1111/jam.14995
Singamaneni, V, Lone, B., Siingh, S., Kumar, P., Gairola, S., Singh, S., Gupta, Prasoon. Coronarin K and L: Two Novel Labdane Diterpenes From Roscoea purpurea: An Ayurvedic Crude Drug Frontiers in Chemistry 2021,9,1-9

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097143/
Arora, D.; Gupta, Prasoon; Roullier, C.; Grovel, O.; Jaglan, S.; Bertrand, S Expanding the Chemical Diversity through Microorganisms Co-culture: Current Status and Outlook Biotechnology Advances 2020, 40:107521
Khan, I. A.; Singh, A.; Mindala, D. P.; Meena. S.; Gupta Prasoon et.al. Preclinical development of gastroprotective botanical candidate from Woodfordia fruticosa (Linn.) Kurz: Chemical standardization, efficacy, pharmacokinetics and safety pharmacology. Journal of Ethanopharmacology 2019, 241, 112023-112056

 
Sharma, V.; Singamaneni, V.; Sharma, N. ; Sharma, A.; Arora, D.; Kushwaha, M.; Bhushan, S.; Jaglan, S.; Gupta, Prasoon Valproic acid induces three novel cytotoxic Secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill. Bioorganic and Medicinal Chemistry Letters 2018, 28(12), 2217-2221
Arora, N.; Kumar, S.; Satti, N. K.; Ali, A.; Gupta, Prasoon. Katoch, M. A strain of Streptomyces sp. isolated from rhizospheric soil of Crataegus oxycantha producing nalidixic acid, a synthetic antibiotic. Journal of Applied Microbiology 2018, 124(6), 1393-1400.
Arora, Divya; Chashoo, Gousia; Singamaneni, Venugopal ; Sharma, Nisha; Gupta, Prasoon; Jaglan, Sundeep. Bacillus amyloliquefaciens induces production of a novel blennolide k in co-culture of Setophoma terrestris. Journal of Applied Microbiology 2018, 124 (3), 730-739
Sharma, N.; Kushwaha, M.; Arora, D.; Jain, S.; Singamaneni, V.; Sharma, S.; Shankar, R.; Bhushan, S.; Gupta, Prasoon; ; Jaglan, S. New cytochalasin from Rosellinia sanctae-cruciana, an endophytic fungus of Albizia lebbeck. Journal of Applied Microbilogy 2018, 125(1), 111-120.
Arora, D.; Sharma, N.; Singamaneni, V.; Sharma, V.; Manoj, K.; Abrol, V.; Guru, S.; Sharma, S.; Gupta, A. P.; Bhushan, S.; Jaglan, S.; Gupta, Prasoon. Isolation and characterisation of bioactive metabolites from Xylaria psidii, an endophyte fungus of the medicinal plant Aegle marmelos and their role in mitochondrial dependent apoptosis against pancreatic cancer cells. Phytomedicine 2016, 23, 1312-1320.

 
Dubey, R. D.; Saneja, A.; Gupta, Prasoon, Gupta, P. N. Recent advances in drug delivery strategies for improved therapeutic efficacy of gemcitabine. European Journal of Pharmaceutical Sciences 2016, 93, 147-162.
Gupta, Prasoon; Sharma, U.; Gupta, P. K.; Maurya, R. Evolvosides C-E, Flavonol-4′-O-triglycosides from Evolvulus alsinoides and their anti-stress activity. Bioorganic and Medicinal Chemistry 2013, 21, 1116-1122.

 
Gupta, Prasoon; Sharma, U.; Schulz, T.; Sherrer, E.; McLean, A.; Robins, A.;

West, L.

 Bicyclic C21 terpenoids from the marine sponge Clathria compressa. Journal of Natural Products 2012, 75(6), 1223-1227.
Gupta, Prasoon; Sharma, U.; Schulz, T.; Sherrer, E.; McLean, A.; Robins, A.;

West, L.

 Bioactive diterpenoid containing a reversible “Spring-Loaded” (E,Z)-dieneone Michael acceptor. Organic Letters 2011, 13, 3920-3923.
Gupta, Prasoon; Yadav, D. K.;Siripurapu, K. B.; Palit, G.; Maurya, R. Constituents of Ocimum sanctum with anti-stress activity. Journal of Natural Products 2007, 70(9), 1410-1416.
Gupta, Prasoon; Akanksha; Siripurapu, K. B.; Ahmad, A.; Palit, G.; Arora, A.; Maurya, R. Anti-stress constituents of Evolvulus alsinoides: an Ayurvedic crude drug. Chemical and Pharmaceutical Bulletin 2007, 55 (5), 771-775.

Awards / Honours

Awards and Honours

  • Awarded EMR Project Grant from SERB
  • Awarded EMR Project Grant from ICMR
  • Member of Managing Committee of IASTAM, India
  • Become Member of Asian Council of Science Editors
  • Selected as Young Scientist in Brainstorming Session for Drugs from Sea Program of MOES
  • Ultra International Team Award by EOAI

 

 

 

Group

Students

Photo Name Area of Interest  Position
Venugopal Singamaneni
  • Bioactivity guided identification, isolation and structure elucidation of natural products from terrestrial, microbial and marine source.
  • Development of high throughput methods for biological screening and identification of natural products to accelerate drug discovery research.
  • Optimization of extraction and purification techniques.
  • Development of NMR and LC-MS methods for identification of novel natural products.
  • Synthesis and chemical modification of biologically active secondary metabolites to study structure activity relationship (SAR) for lead optimization.
  • Biomedical interest includes stem cell research, anti-cancer, anti-viral, anti-microbial, PTPase 1B inhibitors and neurodegenerative disease.
 CSIR-SRF
Anil Bhushan CSIR-SRF
Bashir Ahmad Lone Project Assistant-II
Amardeep Singh Project Assistant-III