Screen Reader Access
Dr. Yedukondalu Nalli
Scientist
Natural Products Chemistry
CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: dr[dot]yknalli[dot]iiim[dot]res[dot]in
Bio Sketch
Dr. Yedukondalu Nalli is a Scientist in Natural Products Chemistry at CSIR-Indian Institute of Integrative Medicine, India. After completing his M.Sc.(Organic Chemistry), in 2009 (School of Chemistry, Andhra University), he began working as a researcher in various natural product drug discovery programs for over ten years. This period of his career provided opportunities for him to develop world-leading expertise in the application of a diversity of modern analytical chemistry and spectroscopic analysis techniques (particularly chromatography, 2D NMR, and mass spectrometry) used to identify complex organic molecules and this culminated in the design and implementation of methods for high throughput extraction, purification, and structure determination of new drug leads from plant and micro-organisms.
Dr. Yedukondalu Nalli is currently an author and co-author of over 30 peer-reviewed publications in international Chemistry/Biology journals and an inventor or co-inventor on two patent applications. Dr. Nalli’s research has resulted in the isolation and structure determination of >100 natural products from plant and microbial sources. He received an award for his outstanding contribution of natural products to Col Sir R.N Chopra Repository, CSIR-IIIM, Jammu.
Dr. Nalli’s research group focuses on the
- Preparation of crude extracts, enriched fractions from natural sources, including those from plants, microbial cultures, and marine invertebrates
- Isolation/purification of novel/bio-active natural products at a milligram to gram scale
- Characterization of structures of purified metabolites
- Expansion of new/bio-active chemical diversity of natural products
- Utilization of natural products for drug discovery of various human diseases, in particular cancer and infectious diseases, by collaborating with Scientists in diverse disciplines, including pharmacology, virology, and microbiology
- Overall, they focus on revealing the biological potential of compounds from nature
Researchers working in Dr. Nalli’s group develop skills in various modern chromatographic, and spectroscopic techniques.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph.D. | Chemical Sciences (Natural Products Chemistry) | AcSIR, CSIR-Indian Institute of Integrative Medicine | 2016 |
| M.Sc. | Organic Chemistry | Andhra University | 2009 |
| B.Sc. | Maths, Physics, Chemistry | Andhra University | 2007 |
Position Held
| Position Held | Period | Organization |
| Scientist | 2022 – Present | CSIR – IIIM, Jammu |
| Senior Project Associate | 2021 – 2022 | CSIR – IIIM, Jammu |
| Postdoctoral Fellow | 2019 – 2021 | CSIR – CSMCRI, Bhavnagar |
| Senior Project Fellow | 2016 – 2019 | CSIR – IIIM, Jammu |
| Senior Research Fellow | 2012 – 2016 | CSIR – IIIM, Jammu |
| Junior Research Fellow | 2010 – 2012 | CSIR – IIIM, Jammu |
Area of Expertise
Natural Products Chemistry – Organic Chemistry – Drug Discovery
- Exploring/expanding the novel/bio-active natural products of plants, microorganisms, and marine invertebrates
- Utilizing the natural products for drug discovery of various human diseases, in particular, cancer and infectious diseases
Ph.D. Work, under Dr. Asif Ali (Principal Scientist), CSIR– IIIM, Jammu
N-PDF Work, under Dr. Pramod B Shinde (Sr. Scientist), CSIR– CSMCRI, Bhavnagar
Work on Cannabis sativa, under Dr. D. Srinivasa Reddy (Director), CSIR– IIIM, Jammu
Projects
- Extract engineering of Cannabis sativa: a versatile tailoring tool towards expansion of Cannabinoids chemical diversity (CSPS24/RDSF/IIIM/IHP24/08) – PI
- Centre for marine therapeutics (CMT) (GAP3138) – Co-PI
- Translational neuroscience: pharmacological validation of key biological pathways involved in the neurodegenerative diseases (HCP532401) – Co-PI
- Discovery of bio-active therapeutics from microorganisms associated with untapped Marine bio-resources (DST No: PDF/2018/000758) – PI
Publications
| Authors | Title | Journal | |||
| Ruhi Singha, Bikram Singh, Ajay Singh, Shivani Rana, Kirti Sharma, Pooja Viswakarma, Boobalan Gopu, Yedukondalu Nalli | Cannaprene B, a new prenylated dihydrostilbene with cytotoxic activities from the leaves of Cannabis sativa |
|
|||
|
Neuroprotective Effects of Cannabispirenone A against NMDA-Induced Excitotoxicity in Differentiated N2a Cells |
|
|||
| Khalid B. Mir, Souneek Chakraborty, Tanzeeba Amin, Aviral Kumar, Abdul Rouf War, Yedukondalu Nalli, Rakesh Kumar, Lekha Dinesh Kumar, Asif Ali, Anindya Goswami | Canonical DDR activation by EMT inducing agent 5-Fluorouracil is modulated by a cannabinoid based combinatorial approach via inducing autophagy and suppression of vimentin expression |
|
|||
| Yedukondalu Nalli, Sahil Bharti, Tanzeeba Amin, Rohit Singh, Jayaprakash Behera, Sagar S. Bhayye, Yogesh P. Bharitkar, Anindya Goswami & Mahendra Kumar Verma | Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their in-silico analysis. |
|
|||
| Sruthi Unni, Padmini Kommu, Snehal Aouti, Yedukondalu Nalli, M. M. Srinivas Bharath, Asif Ali, Balasundaram Padmanabhan | Structural insights into the modulation Of SOD1 aggregation By a fungal metabolite Phialomustin-B: Therapeutic potential in ALS |
|
|||
| Yedukondalu Nalli, Khalid Bashir, Tanzeeba Amin, Veeranjaneyulu G, Ehtesham Jameel,
Anindya Goswami, Asif Ali |
Divergent synthesis of fractionated Cannabis sativa extract led to multiple cannabinoids C-&O-glycosides with anti-proliferative/anti-metastatic properties. |
|
PATENTS
| Inventors/ Contributors | Title | Description | Year |
| Asif Ali,Goswami, A, Souneek, C, Khalid, M. B, Veeranjaneyulu, G, Waseem, I. L, YedukondaluNalli
|
Cannabinoids C-and O-glycosides possessing anti-proliferative and anti-metastatic roperties and process for preparation thereof | IN patent application No. IN202111044828 | 2022 |
| Padmanabhan, B, Asif Ali, Deshmukh, P, Unni, S, YedukondaluNalli, Bharath, M. M. S, Syed, R. H, Ahmed, W. Z | Phialomustin B, a natural product isolated from an endophytic fungus PhialophoraMustea with novel therapeutic potential for Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS) | IN patent application number IN202211019288 | 2022 |
Awards and Honours
- SERB – National Postdoctoral Fellowship, 2019 – 2021
- CSIR – Research Associateship, 2019 – 2020
- UGC – Research Fellowship, 2012 – 2016
- UGC – Research Fellowship, 2010 – 2012
- Award for Outstanding Contribution of Natural Products to Repository on CSIR Foundation day Sep 26, 2014
- Qualified Joint CSIR – UGC Test for Junior Research Fellowship, Dec – 2008
Students
Current Group Members
| Photo | Name | Area of Interest | Position | |
 |
Dr. Chandan Thappa |
|
Senior Project Associate: GAP3138
Email: chandanthappa2@gmail.com |
|
 |
Safeya Begum | Discovery of neuro-protective secondary metabolites from non-edible mushrooms under the Translational neuroscience | Project Associate-I: HCP53240
Email: akhtarsafeya@gmail.com |
|
 |
Komal |
Expansion of new/bio-active cannabinoids-diversity employing an extract engineering approach | Project Associate-I: CSPS24/RDSF/IIIM/IHP24/08
Email: komalgupta141299@gmail.com |
Past Group Members
| Photo | Name | Area of Interest | Position |
 |
Pooja Vishwakarma
|
Phytochemical investigation of Cannabis sativa: isolation and structure determination of spiro-indans | Post-Graduate Trainee
12th June 2023 – 11th Dec 2023 |
 |
Komal
|
Phytochemical Investigation of Cannabis Sativa: Isolation and Characterization of Phenethylcinnamides | Post-Graduate Trainee
10th July 2023 – 9th Jan 2023 |
 |
Safeya Begum
|
North Western Himalayas: A Hidden Treasure of Microorganisms for
Bioactive Natural Products |
Post-Graduate Trainee
10th July 2023 – 9th Jan 2023 |
 |
Kirti Sharma
|
Phytochemical Investigation of Cannabis Sativa:
Dihydrophenanthrenes, Panacea for cancer?
|
Post-Graduate Trainee
10th July 2023 – 9th Jan 2023 |