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Dr. Asha Chaubey
Sr. Principal Scientist / HOD Fermentation and Microbial Biotechnology Division
FMB Division
CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: achaubey[at]iiim[dot]res[dot]in
Bio Sketch
| Dr. Asha Chaubey is presently working as Senior Principal Scientist and Head of Fermentation and Microbial Biotechnology Division. She is working in the area of fermentation technology for exploration and exploitation of microorganisms for production of bioactives and novel enzymes for more than 21 years. These include isolation and characterization of microorganisms from unexplored niches of North-Western Himalayas, Shivalik foothills and endophytes. The significant contributions include biotransformation of industrially important molecules, immobilization of enzymes for enantioselectivity improvement, production of industrially important biopharmaceuticals and published her work in best journals of the field. During the doctoral research; she has significantly contributed towards the development of biosensors for health care and generated good quality publications and patents. Presently, she has been actively involved in developing fermentation processes for production of biopharmaceuticals, nutraceuticals, therapeutic enzymes and enzymes/products for agriculture applications. |
Education
| Degree | Subjects | University | Qualifying Year |
| Ph.D. | Biochemistry | LLRM Medical College, CCS University, Meerut | 2003 |
| M.Sc. | Org/Biochemsitry | CCS University, Meerut | 1995 |
| B.Sc. | Botany, Chemistry Zoology | CCS University, Meerut | 1993 |
Position Held
| Position Held | Period | Organization |
| Senior Principal Scientist | Nov2020 – Present | CSIR-Indian Institute of Integrative Medicine |
| Principal Scientist | Nov. 2015-Nov2020 | CSIR-Indian Institute of Integrative Medicine |
| Senior Scientist | Nov.2010-Nov.2015 | CSIR-Indian Institute of Integrative Medicine |
| Scientist | Nov.2006-Nov.2010 | CSIR-Indian Institute of Integrative Medicine |
| Scientist ‘B’ | Nov.2003-Nov.2006 | CSIR-Indian Institute of Integrative Medicine
(Formerly Regional Research Laboratory) |
Area of Expertise
- Bioprospection of microorganisms for industrial enzymes & bioactives production
- Endophytes and their role in Plant-microbe interaction
- Biotransformation of industrially important molecules
- Production of therapeutic enzymes , biocatalysis and immobilization of enzymes
- Development of fermentation processes and nutraceutical products
- Development of biosensors for healthcare
Projects
MLP-21002: Bioprospecting microbial species from unexplored ecological niches and biotransformation for novel molecules and enzymes
GAP-3138: Centre for Marine Therapeutics (CMT)
MMP 025201: Fermentation scale up and technology development of lead industrial enzymes for Biofuel, Food, Feed, Agriculture and Vaccine applications
FTT020510: A new chemo-enzymatic process for the synthesis of pregabalin
FTT 050511: Optimization and scale-up of marine-derived peptide antibiotic molecule using bacterial fermentation route
HCP-0007- CSIR Aroma Mission
HCP-0101: CSIR-Jigyasa 2.0 Virtual Laboratory Integration project
Publications
| Authors | Title | Journal | ||
| Koul, D, Chander D., Manhas RS., Hossain, M. M. Dar, M. J., & Chaubey A. |
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Journal of Biotechnology (2024) 387:58-68 | ||
| Koul D, Manhas RS, Chaubey A | Production of geraniol and geranic acid: High value compounds of citral biosynthetic pathway from lemongrass oil using Aspergillus niger AUD-C2 as catalyst |
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Identification and taxonomy of Streptomyces justiciae strain RA-WS2: a novel setomimycin producing actinobacterium | 3 Biotech. 2023 Feb;13(2):47 | ||
| Ntemafack A, Ali S, Dzelamonyuy A, Manhas RS, Atsafack SS, Kuiate JR, Waffo AB, Chaubey A | Chemical profile, biological potential, bioprospection and biotechnological application of endophytes of Rumex: A systematic review | Industrial Crops and Products. 2023 May 1;195:116474 | ||
| Manhas RS, Tiwari H, Noor M, Ahmed A, Vishwakarma J, Tripathi R, Ramachandran R, Madishetti S, Mukherjee D, Nargotra A, Chaubey A. |
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Molecular Diversity(2022) 27, 619–633
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| Ntemafack A, Chouhan R, Kapoor N, Kumar A, Dhiman SK, Manhas RS, Chaubey A, Hassan QP, Gandhi SG | Protective effect of Bacillus species associated with Rumex dentatus against postharvest soil borne disease in potato tubers and GC–MS metabolite profile | Archives of Microbiology. 2022 Sep;204(9):1-4
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| Manhas RS, Kumar A, Chaubey A | A biostatistical approach for augmenting rare bianthraquinone antibiotic production by Streptomyces sp. RA-WS2 using Taguchi design |
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| Manhas RS, Ahmad SM, Mir KB, Ahmed A, Sharma S, Manhas D, Tiwari H, Kumar A, Nargotra A, Nandi U, Mukherjee D, Chaubey A | Isolation and anticancer activity evaluation of rare Bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region | Chemico-Biological Interactions(2022) 365
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| Manhas RS, Koul D, Kumar P, Kumar A, Bhagat A, Madishetti S, Sangwan PL, Ahmed Z, Chaubey A. | Talaromyces purpurogenus MRS-F13 catalyzed biotransformation of (-)-verbenone to (-)-10-hydroxyverbenone and their anti-inflammatory activity profile
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Biocatalysis and Biotransformation (2022) 42, 118-128.
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| Koul D, Chander D, Manhas RS, Chaubey A | Isolation and characterization of serratiopeptidase producing bacteria from mulberry phyllosphere. | Current Microbiology. 2021 Jan;78(1):351-7 | ||
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A Review on Arthrobacter sp. Lipase: A Versatile Biocatalyst for the Kinetic Resolution to Access Enantiomerically Pure/Enriched Compounds |
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Patents
| Inventors/ Contributors | Title | Description | Year |
| Chaubey Asha, Sharma Neha, Manhas Ravi S., Nalli Yedukondalu, Verma Mahendra Kumar, Kumar Amit, Reddy Srinavasa Dumballa | A process for the production of Actinomycin D
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Indian Patent Application Number
202411012579PP |
2024 |
| Chaubey Asha, Manhas Ravi S., Khosla, Ahmad Ajaz, Ahmad Syed Mudabir, Tiwari Harshita, Nargotra Amit, Mukherjee Debaraj and Goswami Anindya | A process for the preparation of Tetrahydroanthracenes from Streptomyces (MTCC-25420) and anticancer activity thereof
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Indian Patent Application number 202111047805 | 2021 |
| Pandey Manoj Kumar, Chaubey Asha, Pande Krishan Kant, Sharma Rajendra Kumar Saini Krishan Kumar, Malhotra Bansi Dhar and Rajesh
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Lactate biosensing strip | CA 2512281 | 2010 |
| Pandey Manoj Kumar, Chaubey Asha, Pande Krishan Kant, Sharma Rajendra Kumar, Saini Krishan Kumar, Malhotra Bansi Dhar and Rajesh | Method for preparing lactate biosensing strip | CA 2512279 | 2010 |
| Pandey Manoj Kumar , Chaubey Asha, Pande Krishan Kant, Sharma Rajendra Kumar ,Saini Krishan Kumar ,Malhotra Bansi Dhar and Rajesh
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Method for manufacture of lactate biosensing strip | United States Patent No 7364873 | 2008 |
| Pandey Manoj Kumar, Chaubey Asha, Pande Krishan Kant, Sharma Rajendra Kumar, Saini Krishan Kumar ,Malhotra BD and Rajesh
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Lactate biosensing strip with two electrodes | United States Patent No. 7,319,018 | 2008 |
| Kumar A., Chaubey Asha Rajesh and Malhotra BD
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A novel conducting polymer based electrode for the estimation of cholesterol in aqueous solution | United States Patent No. Us 7,175,746 B2 | 2007 |
| Pandey Manoj Kumar, Chaubey Asha, Pande Krishan Kant, Rajesh, Sharma Rajendra Kumar, Saini Krishan Kumar, Malhotra BD and Rajesh
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Process for the preparation of lactate biosensing strip useful for the preparation of lactate in aqueous solution | Indian Patent No. 197458 | 2006 |
Awards and Honours
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- BOYSCAST Fellowship by the Department of Science and Technology, Government of India
- Research Associateship by the Department of Biotechnology, Government of India
- Dr K.S. Krishnan Research Associateship by Bhabha Atomic Research Center, Trombay, Mumbai, India
- Research Fellowship from Council of Scientific and Industrial Research (CSIR), Government of India
- Best Poster Award during Sixth Asian Conference on Solid State Ionics, 29 Nov.-4 Dec, 1998, Surajkund, Haryana, India
- Best Poster Award during 4th National Conference on Solid State Ionics, 3-5 March, 2000 at Indian Institute of Technology, Mumbai, India
- Bharat Ratna Rajiv Gandhi Gold Medal Award by GEPRA (2022)
Students
| Photo | Name | Area of Interest | Position |
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Diksha Koul | Applied Microbiology, Endophytes & Biotransformation | Research Scholar |
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Devtulya Chander | Biotechnology, Enzymology | Research Scholar |
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Neha Sharma | Actinobacteria | Senior Research Fellow |
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Parna Saha | Endophytes | Senior Research Fellow |
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Inderjeet Singh | Virtual Lab, Animation & Simulation | Project Associate |
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Nawaz Hussian | Endophytes | Junior Research Fellow |
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Tanishka Pathania | Biotransformation of Aromatic Compounds | Project Associate |
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Mansi Vij | Microbiology, Molecular Biology, Downstream Processing, Cell Culture | Project Associate |
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Niharika Khajuria | Enzymatic synthesis | Project Associate |
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Srishti | Enzymology, Applied microbiology | Project Associate |
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Mohd Owais Khan | Biotransformation of aromatic compounds | Project Associate |