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सीएसआईआर-भारतीय समवेत औषध संस्थान

सीएसआईआर-भारतीय समवेत औषध संस्थान

(Council of Scientific & Industrial Research)

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Dr. Sumit G. Gandhi

Dr. Sumit G. Gandhi

Senior Principal Scientist & Head

Infectious Diseases Division

CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: sumit[at]iiim[dot]res[dot]in

  • Profile
  • Position Held
  • Area of Expertise
  • Project Involved / Ongoing Projects
  • Publications and Patents
  • Awards / Honours
  • Group

Profile

Bio Sketch

I am a gold medalist in Bachelors, and Doctorate from Centre for Cellular and Molecular Biology, Hyderabad. My earlier training in Bachelor’s and Master’s was in microbiology while in PhD I got hands-on-experience on cutting edge molecular biology techniques and traditional genetics. My doctoral research focused on understanding the interrelationships between various gene silencing phenomena using the Drosophila model.  I have been awarded Research Fellowships and have won various state level science awards. Since 2008, I have been working on various aspects of secondary metabolism in microorganisms and plants at CSIR-IIIM. During these years, we have used genomics, transcriptomics and metabolomics coupled with functional characterization of genes to understand secondary metabolite pathways. Long term goals of my lab are to understand secondary metabolite pathways, their regulation, their roles in host physiology and ecological interactions as well as their pharmacological activities. I have successfully completed several externally funded projects and coordinated CSIR Network Project as PI. Three PhD students have completed their degrees under my supervision and more than 50 Bachelor’s and Master’s internships / dissertations have been supervised by me. We have published in reputed peer-reviewed SCI journals such as Science, FEBS Journal, Chemosphere, Journal of Hazardous Materials, etc.

Education

Degree Subjects University Qualifying Year
Ph.D. Life Sciences (Molecular Biology) Centre for Cellular and Molecular Biology, Hyderabad (PhD registration : Jawaharlal Nehru University, New Delhi) 2009
M.Sc. Microbiology M.S. University of Baroda, Vadodara, Gujarat 2002
B.Sc. Microbiology S.P. University, VV Nagar, Anand, Gujarat 2000

Position Held

Position Held

Position Held Period Organization
Senior Principal Scientist 08-Aug-2021 to Present CSIR-IIIM, Jammu
Principal Scientist 08-Aug-2016 to 07-Aug-2021 CSIR-IIIM, Jammu
Senior Scientist (Scientist E1) 08-Aug-2012 to 07-Aug-2016 CSIR-IIIM, Jammu
Scientist (Scientist C) 08-Aug-2008 to 07-Aug-2012 CSIR-IIIM, Jammu

 

 

Area of Expertise

Area of Expertise

  • Expertise and experience in the area of plant and microbial secondary metabolism, genomics and synthetic biology
  • Development of diagnositcs for plant and animal diseases

 

 

 

 

Project Involved / Ongoing Projects

Projects

  • Understanding the role of forskolin in physiology of Coleus forskohlii (PI; CSIR)
  • Using endophytes from Coleus forskohlii as elicitors and modulators of secondary metabolism (PI; CSIR)
  • Demonstration of Cultivation, Processing and Value Addition of Selected Aromatic Crops in Bundelkhand region (Co-PI; DBT)
  • Nutraceutical product development from Algae (PI; RIL)
  • Development of nutraceutical product targetting protein and iron deficiency (PI; RIL)
  • Setting up of platform for screening of inhibitors of SARS-CoV2 RdRp and TMPRSS2 (PI; CSIR)
  • Optimization and preparation of RT-LAMP Kit for molecular diagnosis of COVID-19 (PI; RIL)

 

 

Publications and Patents

Publications

Authors Title Journal
Archana Katoch, Vijay Lakshmi Jamwal, Mir Mohd. Faheem, Sriram Kumar, Shantibhusan Senapati, Govind Yadav, Sumit G. Gandhi* and Anindya Goswami* Overlapping targets exist between the Par-4 and miR-200c axis which regulate EMT and proliferation of pancreatic cancer cells (2021) Translational Oncology 14:100879 Translational Oncology

 

IF: 3.558

Shagun Bali, Vijay Lakshmi Jamwal, Sukhmeen Kaur Kohli, Parminder Kaur, Ruchi Tejpal, Vandana Bhalla, Puja Ohri, Sumit G. Gandhi*, Renu Bhardwaj*, Asma A.Al-Huqail, Manzer H.Siddiqui, Hayssam M.Ali, Parvaiz Ahmad* Jasmonic acid application triggers detoxification of lead (Pb) toxicity in tomato through the modifications of secondary metabolites and gene expression (2019) Chemosphere 235:734-748 Chemosphere

 

IF: 5.778

Khanna K, Jamwal VL, Sharma A, Gandhi SG*, Ohri P, Bhardwaj R*, Al-Huqail AA, Siddiqui MH, Ali HM, Ahmad P* Supplementation with plant growth promoting rhizobacteria (PGPR) alleviates cadmium toxicity in Solanum lycopersicum by modulating the expression of secondary metabolites (2019) Chemosphere 230:628-639 Chemosphere

 

IF: 5.778

Bali S, Jamwal VL, Kaur P, Kohli SK, Ohri P, Gandhi SG*, Bhardwaj R*, Al-Huqail AA, Siddiqui MH, Ahmad P* Role of P-type ATPase metal transporters and plant immunity induced by jasmonic acid against Lead (Pb) toxicity in tomato (2019) Ecotoxicology and Environmental Safety 174: 283-294 Ecotoxicology and Environmental Safety

 

IF: 4.527

Awasthi P, Gupta AP, Bedi YS, Vishwakarma RA, Gandhi SG* Mannitol Stress Directs Flavonoid Metabolism toward Synthesis of Flavones via Differential Regulation of Two Cytochrome P450 Monooxygenases in Coleus forskohlii (2016) Frontiers in Plant Sciences 7: 985

 

Frontiers in Plant Sciences

 

 

IF 4.407

Farnaz Yusuf, Irshad Ahmad Rather,
Urmila Jamwal, Sumit G. Gandhi* & Asha
Chaubey*
Cloning and functional characterization
of nitrilase from Fusarium proliferatum
AUF-2 for detoxification of nitriles (2015) Functional and Integrative Genomics 15: 413
Functional and Integrative Genomics

 

IF: 3.058

 

Awasthi P, Mahajan V, Rather IA, Gupta AP, Rasool S, Bedi YS, Vishwakarma RA,

Gandhi SG*

Plant Omics: Isolation, Identification, and Expression Analysis of Cytochrome P450 Gene Sequences from Coleus forskohlii (2015) OMICS: A Journal of Integrative Biology 19: 782 OMICS: A Journal of Integrative Biology

 

 

IF: 2.720

Gandhi SG, Bag I, Sengupta S, Pal-Bhadra M, Bhadra U* Drosophila oncogene Gas41 is an RNA interference modulator that intersects heterochromatin and the small interfering RNA pathway (2015) FEBS Journal 282: 153 FEBS Journal

 

IF: 4.739

 

Mahajan V, Rather IA, Awasthi P, Gairola S, Meena SR, Anand R, Bedi YS, Gandhi SG* Development of chemical and EST-SSR markers for Ocimum genus (2015) Industrial Crops and Products 63: 65

 

Industrial Crops and Products

 

IF: 4.450

Pal-Bhadra M, Leibovitch BA, Gandhi SG, Chikka MR, Bhadra U*, Birchler JA*, Elgin SC* Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery (2004) Science 303(5658): 669-72

 

Science

 

IF: 41.845

Patents

Inventors/ Contributors Title Description Year
Bharate SS, Kumar V, Gupta M, Gandhi SG, Kumar A, Bharate SB, Vishwakarma RA Sustained release formulations of Dysoxylum binectariferum Indian Application no. IN201811014818; CSIR Ref No. 0179NF2017 Dated: 15-Sept-2017 15-Sept-2017 (filed)

Awards / Honours

Awards and Honours

  • Minaxi Lalit Science Academy Award of Gujarat Science Academy (state level exam in B.Sc.)(First position – Bioscience)
  • Minaxi Lalit Science Academy Award of Gujarat Science Academy (state level exam in B.Sc.) (First position – Botany)
  • Minaxi Lalit Science Academy Award of Gujarat Science Academy (state level exam in M.Sc.) (Third position – Microbiology)
  • ‘Gaurav Ratna’ by CVM trust, Vallabh Vidyanagar, Anand, Gujarat
  • Gold Medal in B.Sc. by NV Patel College of Pure & Applied Science, VVNagar, Gujarat
  • Qualified Gujarat State Level Eligibility Test (GSLET) for lecturership
  • Qualified CSIR-National Eligibility Test (CSIR-NET) with Fellowship and eligbility for lecturership
  • Qualified CSIR-NET JRF in top 20% slot and invited for SPM examination
  • Best Paper Presentation at Indo-French Confernece on RNAi and Genome Control at CCMB, Hyderabad from 12-14 Dec, 2007

Group

Students

Photo Name Area of Interest
Nitika Kapoor Study on regulatory aspects of rohitukine biosynthesis in Dysoxylum binectariferum
Vijay Lakshmi Jamwal Towards understanding the physiological and ecological role of forskolin in Coleus forskohlii
Rekha Chouhan Study of metabolite transport in Cannabis sativa
Sajad Ahmed Studies towards understanding the physiological role of rohitukine in Dysoxylum binectariferum
Ntemafack Augustin Evaluation of bioactivities of secondary metabolites of Rumex species and their endophytes
Piyush Singh Jamwal Molecular elucidation of secondary metabolite pathways

 

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वैज्ञानिक तथा औद्योगिक अनुसंधान परिषद्
Council of Scientific & Industrial Research

विज्ञान एवं प्रौद्योगिकी मंत्रालय
Ministry of Science & Technology

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