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Dr. Rajkishor Rai
Senior Scientist
Natural Products & Medicinal Chemistry Division
CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: raj[at]iiim[dot]res[dot]in
Bio Sketch
Dr. Rajkishor Rai received his Ph.D. degree at the Department of Chemistry, Banaras Hindu University, Varanasi, and did postdoctoral research at the Molecular Biophysics Unit, Indian Institute of Science (IISc), Bangalore. Before joining the CSIR-Indian Institute of Integrative Medicine in August 2009, he was an assistant professor at the Indian Institute of Advanced Research, Gandhinagar, followed by Senior Research Scientist at Gennova Biopharmaceuticals Ltd., Pune. His research interests are in the area of structural chemistry of peptides incorporating non-protein amino acids, peptidomimetics, bioactive peptides and self-assembled peptides as therapeutic agents.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph .D | Chemistry | Banaras Hindu University, Varanasi (U.P.) | 2002 |
| M.Sc. | Chemistry | Gorakhpur University, Gorakhpur (U.P) | 1996 |
| B.Sc. | Chemistry & Botany | Gorakhpur University, Gorakhpur (U.P) | 1994 |
Position Held
| Position Held | Period | Organization |
| Senior Scientist | 06/2010-Present | CSIR-Indian Institute of Integrative Medicine, Jammu |
| Scientist Fellow | 08/2009 -06/2010 | CSIR-Indian Institute of Integrative Medicine, Jammu |
| Senior Research Scientist | 01/2008-08/2009 | Gennova Biopharmaceuticals Ltd., Pune. |
| Assistant Professor | 06/2006 -12/2007 | Indian Institute of Advanced Research, Gandhinagar |
| Post-doctoral Fellow | 12/2002 – 07/2006 | Molecular Biophysics Unit, Indian Institute of Science, Bangalore.
(Advisor: Prof. P. Balaram) |
Area of Expertise
- Peptide Chemistry
Projects
- Development of b-Hairpin Peptidomimetics and Self Assembled Ultra short Hybrid Peptide Nanostructures as Anti-infective Agents.
- Design and Synthesis of Novel Antimicrobial Peptides under 12th Five Year Plan Network Project “Centre for Biotheurapautic Molecule Discovery Program” funded by CSIR. (Completed).
- Designer peptides based on b-amino acids funded by IIIM under Major Lab projects. (Completed)
- Investigation of the Role of Melanin Co-polymers and Antioxidant Peptides in Skin Biology: A Semi-synthetic Approach Funded by CSIR under EMPOWER Scheme. (Completed)
Publications
- S. Shankar, J. Ur Rahim, R. Rai. Self-Assembly in Peptides containing b-and g-amino acids. Current Protein & Peptide Science 2020, 21, 584-597.
- Shankar, G. Singh, J. Ur Rahim, A. Qayum, P. R. Sharma, M. Katoch, R. Rai. Investigation of α/γ hybrid peptide self-assembled structures with antimicrobial and antibiofilm properties. J. Pept. Sci. 2020, (DOI: 10.1002/psc.3243).
- Malhotra, S. Shankar, R. Rai, Y. Singh. Broad-spectrum antibacterial activity of proteolytically stable self-assembled αγ-hybrid peptide gels. Biomacromolecules. 2018, 19,782-792.
- Shankar, M. M. Faheem, D. Nayak, N. A. Wani, S. Farooq, S. Koul, A. Goswami, R. Rai. Cyclodipeptide c(Orn-Pro) Conjugate with 4-Ethylpiperic Acid Abrogates Cancer Cell Metastasis through Modulating MDM2. Bioconjugate Chemistry 2018, 29,164-175.
- A. Wani, G. Singh, S. Shankar, A. Sharma, M. Katoch, R. Rai. Short Hybrid Peptides Incorporating b- and g-Amino Acids as Antimicrobial Agents. Peptides 2017, 97, 46-53.
- A. Wani, S. Raghothama, U.P. Singh, R. Rai. C11 /C9 -Helical Folding in αβ Hybrid Peptides Containing 1-Amino-cyclohexane acetic acid (β3, 3 -Ac6 c). Chem. Eur. J. 2017, 23, 8364-8370.
- Amin, N. A. Wani, S. Farooq, D. Nayak, S. Chakraborty, S. Shankar, R. ur Rasool, S. Koul, A. Goswami, R. Rai. Inhibition of Invasion in Pancreatic Cancer Cells by Conjugate of EPA with β3,3-Pip-OH via PI3K/Akt/NF-kB Pathway. ACS Med. Chem. Lett., 2015, 6(10), 1071-1074.
- Chhabra, A. S. Haque, R. K. Pal, A. Goyal, R. Rai, S. Joshi, S. Panjikar, S. Pasha, R. Sankaranarayanan and R. S. Gokhale. Nonprocessive [2+2]e- Offloading Reductase Domains from Mycobacterial Non-ribosomal Peptide Synthetases. Proc. Natl. Acad. Sci. USA 2012, 109, 5681-5686.
- S. Raghavender, S. Aravinda, N. Shamala, Kantharaju, R. Rai, P. Balaram. Characterization of Water Wires inside Hydrophobic Tubular Peptide Structures. J. Am. Chem. Soc. 2009, 131, 15130-15132.
- Rai, S. Raghothama, P. Balaram. Design of a Peptide Hairpin Containing a Central Three Residue Loop. J. Am. Chem. Soc. 2006, 128, 2675-2681.
- Aravinda, N. Shamala, R. Rai, H.N. Gopi, P. Balaram. A Crystalline b-Hairpin Peptide Nucleated by a Type I’ Aib-DAla b-Turn: Evidence for Cross –Strand Aromatic Interactions. Angew. Chem. Int. Ed., 2002, 41, 3863-65.
Patents
Manika Vij, Ritika Grover, Vishwabandhu Gotherwal, Naiem Ahmad Wani, Prashant Joshi, Munia Ganguli, Rajkishor Rai, Vivek Tirunelveli Natrajan, Rajesh Sudhir Gokhale. Synthetic melanin nanoparticles for skin pigmentation. (NFNO 0218NF2015/IN).
Awards and Honours
NIL
Students
| Photo | Name | Area of Interest | Education |
 |
Junaid Ur Rahim | UGC-SRF | |
 |
Rubina Chowdhary | CSIR-JRF |