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Dr. Sreedhar Madishetti
Sr. Scientist
Pharmacology division
CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: sreedhar[at]iiim[dot]res[dot]in
Bio Sketch
Current research work involves anti-diabetic activity investigations using rodent models and in vitro, in vivo anti -inflammatory activity assays. Past indicates experience in deducing the signalling events via PI3K gamma following stimulation of mu-opioid receptor and industrial experience of Pharmacokinetics as part of drug discovery.
Emerging trends indicate life style disorders like diabetes mellitus, obesity and rheumatoid arthritis are chronic inflammatory conditions. Cytokines, nitric oxide play an important role in mediating inflammatory processes leading to disease states. Herbal extracts/preparations/derivatives and novel dosage forms of natural compounds form a promising group of agents, from the times of Ayurveda and other ancient Indian medical systems, for the treatment of chronic diseases/inflammatory conditions. The main research focus is towards discovery and development of natural products as promising therapies for alleviation of inflammation with an aim to develop anti-diabetic/ anti-obesity/ pain relieving medications.
Education
| Degree | Subjects | University | Qualifying Year |
| Dr.rer.nat | Molecular Pharmacology & Cell Biology | Friedrich Schiller University-Jena, Germany | 2012 |
| M. Pharm | Pharmacology | Kakatiya University, Warangal, Telangana State | 2005 |
| B. Pharm | Pharmaceutical Sciences | Kakatiya University, Warangal, Telangana State | 2002 |
Position Held
| Position Held | Period | Organization |
| Senior Scientist | 02/2021 to Present | CSIR-IIIM, Jammu |
| Scientist | 02/2016 to 02/2021 | CSIR-IIIM, Jammu |
| Associate Professor | 10/2012 – 02/2016 | VIPS, affiliated to Kakatiya University, Warangal |
| Assistant Research Scientist-2 | 08/2007 – 06/2009 | Infection Pharmacology department
AstraZeneca India, Pvt. Ltd., Bengaluru, India |
| Assistant Research Scientist-1 | 07/2005 – 07/2007 | Drug Metabolism and Pharmacokinetics department
AstraZeneca India, Pvt. Ltd., Bengaluru, India |
Area of Expertise
- Pharmacology of Inflammation and Diabetes
Projects
- Investigation of one of the premier products (ZPIM-001/15) of Emami healthcare Ltd., a) establishing the chemical fingerprints of decoction of 35 ingredients prior to fermentation and that of finished marketable product b) effect on bioavailability of micronutrients – CNP1309
- Isolation, pharmacopeial standardization and Immunomodulatory activity of Unani drug Habb-e-suranjan and Habbe-e-Asgand – GAP2143
- Phytopharmaceutical Development of Ficus semicordata Buch.-Ham. ex Sm. as per regulatory guidelines of DCGI – GAP2180
- Investigation on the anti-obesity activity of Argyreia nervosa, Garcinia – GAP2190
- CSIR-Aroma Mission
- Discovery of cannabinoids and their derivatives from Cannabis sativa for the management of chronic disease conditions like rheumatoid arthritis/neuropathic pain – MLP110012
- Anti-inflammatory and anti-neuropathic pain activity investigations in normal and diabetic animals – MLP21007
Publications
| Authors | Title | Journal |
| 1. Jitendar Reddy, Sreedhar Madishetti, Prakash R Vachaspati | Fast mouse PK (fast PK ): A rapid screening method to increase pharmacokinetics throughput in preclinical drug discovery
Phosphoinositide 3-kinase γ integrates cAMP and AKT signaling of the μ-opioid receptor
|
European Journal of Pharmaceutical Sciences 2012, 47, 444-450 |
| 2. Sreedhar Madishetti, Nadine Schneble, Chrisitian König, Emilio Hirsch, Stefan Schulz, Jörg P. Müller and Reinhard Wetzker | Phosphoinositide 3-kinase γ integrates cAMP and AKT signaling of the μ-opioid receptor | British Journal of Pharmacology 2014, 171, 3328–3337 |
| 3. Umed Singh, Gousia Chashoo, Sameer U. Khan, Priya Mahajan, Amit Nargotra, Girish Mahajan, Amarinder Singh, Anjna Sharma, Mubashir J. Mintoo, Santosh Kumar Guru, Hariprasad Aruri, Thanusha Thatikonda, Promod Sahu, Pankaj Chibber, Vikas Kumar, Sameer A. Mir, Sonali S. Bharate, Sreedhar Madishetti, Utpal Nandi, Gurdarshan Singh, Dilip Manikrao Mondhe, Shashi Bhushan, Fayaz Malik, Serge Mignani, Ram A. Vishwakarma and Parvinder Pal Singh.,., |
Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model |
J. Med. Chem. 2017, 60, 9470−9489 |
| 4. Bimala Tripathy, S. Satyanarayana, K. Abedulla Khan, Zabeer Ahmed, M. Sreedhar, Gifty Sawhney, K. Raja, | Biological evaluation of Crude plant extracts for ant-adipogenic activity in 3T3L-1 cells | IJIPSR / 7 (01), 2019, 14-29, DOI: 10.21276/IJIPSR.2019.07.01.764 |
| 5. Reyaz Hassan Mir & Gifty Sawhney & Faheem Hyder Pottoo & Roohi Mohi-ud-din & Sreedhar Madishetti &
Sanjay M. Jachak & Zabeer Ahmed & Mubashir Hussain Masoodi |
Role of environmental pollutants in Alzheimer’s disease: a review | Environmental Science and Pollution Research doi:10.1007/s11356-020-09964-x Published online: 27 July 2020 |
| 6. Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi, Mubashir Hussain Masoodi | Oreganum Vulgare: In-vitro assessment of cytotoxicity, Molecular docking studies, Antioxidant, and evaluation of anti-inflammatory activity in LPS stimulated RAW 264.7 cells
|
Medicinal Chemistry
DOI : 10.2174/1573406416666200904110828 |
| 7.Rasool, J.U., Sawhney, G., Shaikh, M., Nalli, Y., Madishetti, S., Ahmed, Z. and Ali, A., 2021. | Site selective synthesis and anti-inflammatory evaluation of Spiro-isoxazoline stitched adducts of arteannuin B. Bioorganic Chemistry, 117, p.105408. | |
| 8. Manhas, R.S., Tiwari, H., Noor, M., Ahmed, A., Vishwakarma, J., Tripathi, R., Ramachandran, R., Madishetti, S., Mukherjee, D., Chaubey, A. and Nargotra, A., 2022. |
Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation. Molecular Diversity, pp.1-15 | |
| Manhas, R.S., Koul, D., Kumar, P., Kumar, A., Bhagat, A., Madishetti, S., Sangwan, P.L., Ahmed, Z. and Chaubey, | Talaromyces purpurogenus MRS-F13 catalyzed biotransformation of (-)-verbenone to (-)-10-hydroxyverbenone and their anti-inflammatory activity profile | Biocatalysis and Biotransformation, pp.1-11 |
Awards and Honours
- Best team award as part of PK – PD team at AstraZeneca India Pvt Ltd., Bangalore, 2008
- Appreciation award at AstraZeneca India Pvt. Ltd., Bangalore, 2008
- Jitendar Reddy, Sreedhar Madishetti, Sheshagiri Gaonkar, Prakash Vachaspati., A fast PK method to Screen compounds in Drug Discovery’, at the international conference on Laboratory Animal Science held in Mumbai, 2009. Won best poster award. (as a co-author)
- Sreedhar Madishetti, Suvarna T, Harikrishna D, Vidya Sagar J, Rama Krishna D., “Anticancer activity of some novel copper complexes” at UGC sponsored National Seminar on Recent Development in Co–ordination & Bioinorganic Chemistry held at Department of Chemistry, Kakatiya University, Warangal 2005 – Won 2nd best poster award
- Qualified GATE- 2003 with 94.05 percentile to receive AICTE fellowship during M. Pharm
Students
| Photo | Name | Area of Interest | Position |
 |
Parveen Kumar | Investigation on antidiabetic and anti-inflammatory potential of phytochemicals in combination |
Senior Research Fellow CSIR-JRF 2017 GATE- 2018 M.Sc. Zoology H N B Garhwal University Uttarakhand
|
 |
Abdul Mateen Noor | Investigations on anti-inflammatory activity of Setomimycin and its utility in chronic inflammatory disorders
|
Senior Research Fellow UGC-JRF M.Sc. Zoology H N B Garhwal University Uttarakhand |
 |
Omesh Manhas | Investigation of anti-inflammatory activities of Cannabinoids and their utility in diabetic complications |
Junior Research Fellow UGC-JRF GATE -2019 JKSET-2018 M.Sc. Zoology H N B Garhwal University Uttarakhand
|
Project Associate:
Diksha Saroch