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Dr Gousia Chashoo
Pharmacology Division
CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Bio Sketch
Dr. Gousia Chashoo is currently working as a Women Scientist under the DST-WISE Postdoctoral Fellowship programme in the Pharmacology Division of CSIR-IIIM Jammu. She earned her Ph.D. from the Cancer Pharmacology Division of CSIR-IIIM (registered under BVP Pune), where she investigated the anticancer efficacy of novel semisynthetic boswellic acid analogs. Her doctoral work yielded significant mechanistic insights and resulted in publications in esteemed, peer-reviewed scientific journals.
Following her Ph.D., Dr. Chashoo advanced her research career through highly competitive fellowships, serving as a CSIR Research Associate, a CSIR Senior Research Associate (Pool Scientist), and later as an ICMR-DHR Young Scientist. During this period, she concentrated on targeting cyclin-dependent kinases (CDKs) in cancer, contributing substantially to the field through impactful publications and patent filings.
Presently, her research focuses on the development and preclinical evaluation of PARP inhibitors as promising therapeutic agents for breast and ovarian cancers. In addition to her primary project, she actively contributes to several ongoing research initiatives within the cancer pharmacology programme at the institute. Throughout her scientific journey, Dr. Chashoo has been honoured with prestigious national fellowships and awards, reflecting her commitment to advancing translational cancer research in India.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph.D | Cancer Pharmacology | CSIR-IIIM /BVP-Pune | 2012 |
| M.Sc | Biotechnology | University of Kashmir | 2006 |
| B.Sc | Zoology, Botany, Chemistry | University of Kashmir | 2004 |
Position Held
| Position Held | Period | Organization |
| Women Scientist | July 2025 till date | DST |
| Consultant | September 2024 – June 2025 | CSIR-IIIM, Jammu |
| Young Scientist | August 2020 – August 2023 | ICMR-DHR |
| POOL Scientist | November 2016-November 2019 | CSIR |
| Research Associate | April 2013- March 2016 | CSIR |
Area of Expertise
- Design and evaluation of anticancer molecules.
- Targeting key oncogenic pathways in cancer.
- Use of advanced cell-based assays, analytical techniques, and molecular tools.
- Focus on translational cancer research and preclinical development.
- Scientific writing, patents, and collaborative research.
Projects
- Strategic Development of Rucaparib-Based for Breast and Ovarian Cancer: A Rationale Approach from Discovery to Preclinical Advancements.
- Development of IIIM-368 (A Novel 3-Pyrimidinylazaindole) as a potent CDK inhibitor for the treatment of Cancer: Studies towards preclinical investigation.
- Development of marine natural product (MNP) based CDK inhibitors for the treatment of cancer: Elucidating the Signal Transduction Pathways of 3-pyrimidyl-azaindole.
Publications
| Authors | Title | Journal |
| Aboti , Mohd Parvez , Mohd Zuhaid , Sweta Sharma , Rafia Basit , Manmeet Kour , Kalicharan Sha rma , ShashankKumar Singh , Gousia Chashoo* , Jamshed Haneef , M. Naveen , M. Samim , Sim one Giovanuzzi , Claudiu T. Supuran , Syed Shafi . | Synthesis of benzenesulfonamide tethered pyrazolyl stilbene derivatives: Their anti-proliferative and carbonic anhydrase inhibitory potentials. |
Bio Organic Chemistry |
| Arif Khan, Fatima Naaz, Rafia Basit, Deepak Das, Piyush Bisht, Majeed Shaikh, Bilal Ahmad Lone, Yuba Raj Pokharel, Qazi Naveed Ahmed, Shazia Parveen, Intzar Ali, Shashank Kumar Singh, Gousia Chashoo*, and Syed Shafi. | Correction to 1, 2, 3-Triazole Tethered Hybrid Capsaicinoids as Antiproliferative Agents Active against Lung Cancer Cells (A549). |
ACS Omega |
| Jabeena Khazir, Bilal Ahmad Mir, Meeshu Pandita, Lynne Pilcher, Darren Riley & Gousia Chashoo* | Design and synthesis of sulphonyl acetamide analogues of quinazoline as anticancer agents |
Medicinal Chemistry Research |
| Umed Singh, Gousia Chashoo, Sameer U. Khan, Priya Mahajan, Amit Nargotra, Girish Mahajan, Amarinder Singh, Anjna Sharma, Mubashir Javeed Mintoo, Santosh Kumar Guru, Hariprasad Aruri, Thanusha Thatikonda, Promod Sahu, Pankaj Chibber, Vikas Kumar, Sameer A Mir, Sonali S. Bharate, Sreedhar Madishetti, Utpal Nandi, Gurdarshan Singh, Dilip Manikrao Mondhe, Shashi Bhushan, Fayaz Malik, Serge Mignani, Ram A. Vishwakarma, and Parvinder Pal Singh. | Design of Novel 3-Pyrimidinylazaindole based CDK2/9 Inhibitors with Potent In-vitro and In-vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model. |
J of Med Chem |
| Gousia Chashoo, Shashank K. Singh, Dilip M. Mondhe, Parduman R. Sharma, Samar S. Andotra, Bhahwal. A. Shah, Subhash C. Taneja, Ajit K. Saxena. | Potentiation of the antitumor effect of 11 keto-β-boswellic acid by its 3-α-hexanoyloxy derivative. | European journal of pharmacology |
| Gousia Chashoo, Shashank K. Singh, Paraduman R. Sharma, Dilip M. Mondhe, Abid H. Dar, Arpita Saxena, Samar S. Andotra, Bhahwal A. Shah, Naveed A. Qazi, Subhash C. Taneja, Ajit K. Saxena. | A Propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 5 cells mediated through topoisomerase I &II inhibition. |
Chemico-Biological Interactions.
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| Gousia Chashoo*, Umed Singh, Parvinder Pal Singh, Dilip M. Mondhe and Ram A. Vishwakarma. | A Marine-based Meriolin (3-Pyrimidinylazaindole) Derivative (4ab) Targets PI3K/AKT /mTOR Pathway Inducing Cell Cycle Arrest and Apoptosis in Molt-4 Cells. |
Clinical Cancer Drugs. |
| Priya Mahajan, Gousia Chashoo, Monika Gupta, Amit Kumar, Parvinder Pal Singh, and Amit Nargotra. | Fusion of Structure and Ligand based methods for identification of novel CDK2 Inhibitors. |
J. Chem. Inf. Model. |
| Madhu Gupta, Gousia Chashoo, Parduman Raj Sharma, Ajit Kumar Saxena, Prem Narayan Gupta, Govind Prasad Agrawal, and Suresh Prasad Vyas. | Dual Targeted Polymeric Nanoparticles Based on Tumor Endothelium and Tumor Cells for Enhanced Antitumor Drug Delivery. |
Molecular Pharmaceutics. |
| Doma M. Reddy, Jada Srinivas, Gousia Chashoo, Ajit K. Saxena, H. M. Sampath Kumar. | 4β-[(4 Alkyl)-1,2,3-triazol-1-yl] podophyllotoxins as anticancer compounds: Design, synthesis and biological evaluation. |
European Journal of Medicinal Chemistry |
Patents
| Inventors/ Contributors | Title | Description | Year |
| Qazi Naveed Ahmed, Loveleena Kaur Anand. Gousia Chashoo, Ashish Dogra. Kaneez Fatima, Baseerat Hamza, Sameer Ullah Khan, Shahnawaz Khan, Amit Kumar, Atul Kumar, Fayaz Malik, Mir Shahid Maqbool, Sameer Ahmad Mir, Utpal Nandi, Nadiem Nazir, Anil Padala, Masroor Ahmad Paddar, Bhahwal Ali Shah, Gurdarshan Singh, Govind Yadav. | Composition for treating paclitaxel-resistant breast cancer and method for preparation thereof | Australia Patent. Publication No. AU2010213696B2 | 2025 |
| Ahmed, Q.N.;Padder, A.H.;Ahmed S.;Shafeeq Z.;Bhat, M.Y.;Chand J.; Garg, Y.; Dar, M.S.;Garg Y.;Hussain, F.; Goswami, A.; Dar, M.J.; Ahmed, Z Chashoo, G.; Dogra, S.; Pandian, R.; Bhardwaj, M.; Kour, G. | Synthesis of Phosphorylated Rucaparib Analogues as New Generation PARP Inhibitors | PCT/IN2025/051428 | 2024 |
| Rafia Basit, Ajeet Singh, Tenzen Yodun, Ghulam Mustafa, Umed Singh, Ramajayan Pandian, Parvinder Pal Singh, Gousia Chashoo, Shashank Kumar Singh, and Zabeer Ahmed. | Synergistic composition of CDK inhibitor and cytotoxic agent in the Treatment of Lung Cancer. | Indian Patent (202411050124) | 2024 |
| Umed Singh, Gousia Chashoo, Girish Mahajan, Thanusha Thatikonda, Priya Mahajan, Hari Prasad Aruri, Satish Gudup, Amit Nargotra, Dilip Manikrao Mondhe, Ram A. Vishwakarma, Parvinder Pal Singh. | 3-Pyrimidinyl pyrrolo [2,3-b] pyridine as new anticancer agents and the process for the preparation thereof | (WO2017094026A1). | 2017 |
| Kamal, Y.V.V. Srikanth, M.N.A. Khan, M. Ashraf, I.Sehar, G. Chashoo, P.R. Sharma, A.H. Dar, S.Bhushan, S.K.Singh, D.M.Mondhe and A.K. Saxena. | 2-Anilino nicotinyl linked 2-amino benzothiazole conjugates as potential anticancer agents, apoptosis inducers and process for preparation thereof. | US Patent. Publication No. 9029553 | 2015 |
Awards and Honours
- Best Oral Presentation Award, International Conference on Mitochondrial Research held at Shri Mata Vaishno Devi University, Katra for the paper entitled “A Propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase I & II inhibition.
- Annual Best Paper award, Indian Institute of Integrative Medicine, Jammu.
Fellowships:
- DST-Women Scientist
- DHR-Young Scientist
- CSIR- POOL Scientist
- CSIR-Research Associate
- CSIR-Senior Research Fellow
