Publications during 2019

Discovery of benzo[cd] indol- 2- one and benzylidene- thiazolidine- 2, 4- dione as new classes of NLRP3 inflammasome inhibitors via ER- β structure based virtual screening. Bioorganic Chemistry, 2019.
Catalytic advances in direct functionalizations using arylated hydrazines as the building blocks. Catalysis Reviews: Science and Engineering, 2019.
Approaches for the genetic improvement of Lavender: a short review.  Journal of Pharmacognosy and Phytochemistry 2019, 8(2), 736-740.
A Modified, Efficient and Sensitive pH Indicator Dye Method for the Screening of Acid-Producing Acetobacter Strains Having Potential Application in Bio-Cellulose Production. Applied Biochemistry and Biotechnology 2019.
Trigonelline, a naturally occurring alkaloidal agent protects ultraviolet-B (UV-B) irradiation induced apoptotic cell death in human skin fibroblasts via attenuation of oxidative stress, restoration of cellular calcium homeostasis and prevention of endoplasmic reticulum (ER) stress. Journal of Photochemistry and Photobiology, B: Biology 2019.
Functionalization of Alkynes and Alkenes Using a Cascade Reaction Approach: Synthesis of β-Keto Sulfones under Metal-free Conditions. Journal of Organic Chemistry 2019.
Chromatography: An important tool for drug discovery. Journal of Separation Science 2019.
Solvent free stereoselective iodoacetoxylation of alkenes and glycals using N-iodosuccinimide and acetic anhydride. Chemical Methodologies 2019, 3(5), 663-669.
LC-MS/MS profile of an active pharmaceutical ingredient and its impurities in commercial preparation.  Journal of Liquid Chromatography & Related Technologies 2019.
A Marine-based Meriolin (3-Pyrimidinylazaindole) Derivative (4ab) Targets PI3K/AKT /mTOR Pathway Inducing Cell Cycle Arrest and Apoptosis in Molt-4 Cells. Clinical Cancer Drugs 2019, 6(1), 33-40.
Hyaluronic Acid-Tacrolimus Bioconjugate: Synthesis, Characterization, and Pharmacokinetic Investigation of an Acid-Responsive Macromolecular Prodrug. ACS Applied Bio Materials2019, 2(11), 4728-4736.
Metal-free, room temperature, acid-K2S2O8 mediated method for the nitration of olefins: an easy approach for the synthesis of nitroolefins. RSC Advances 2019, 9(52), 30428-30431.
Corrigendum to “Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction” [Bioorg. Chem. 89 , 2019 103022]. Bioorganic Chemistry 2019, 92, 103257.
Binary and ternary solid dispersions of an anticancer preclinical lead, IIIM-290: In vitro and in vivo studies. International Journal of Pharmaceutics 2019,
Recent Advances in Solid Dispersion Technology for Efficient Delivery of Poorly Water-Soluble Drugs. Current Pharmaceutical Design2019, 25(13), 1524-1535.
Chorismate synthase from malaria parasites is bifunctional enzyme. Molecular & Biochemical Parasitology 2019,
Method validation and simultaneous quantification of five triterpenoids from Codonopsis ovata by high-performance thin-layer chromatography. Journal of Planar Chromatography–Modern TLC 2019, 32(3), 251-256.
Consistent production of kojic acid from Aspergillus sojae SSC-3 isolated from rice husk. Molecular Biology Reports , 2019, 46(6), 5995-6002.
Synthesis and Investigation of the Role of Benzopyran Dihydropyrimidinone Hybrids in Cell Proliferation, Migration and Tumor Growth. Anti-Cancer Agents in Medicinal Chemistry , 2019, 19(2), 276-288.
Vimentin activation in early apoptotic cancer cells errands survival pathways during DNA damage inducer CPT treatment in colon carcinoma model. Cell Death & Disease , 2019, 10(6), 1-16.
Effect of IS01957, a para-coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy. Drug Development Research , 2019, 80(7), 948-957.
Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb. BMC Plant Biology , 2019, 19(1), 1-15.
Isolation, Synthesis And Structure Determination Of Cannabidiol Derivatives And Their Cytotoxic Activities. Natural Product Research , 2019.
Preclinical development of gastro-protective botanical candidate from Woodfordia fruticosa (Linn.) Kurz: Chemical standardization, efficacy, pharmacokinetics and safety pharmacology. Journal of Ethnopharmacology , 2019, 241, 112023pp.
Synthesis and biological evaluation of indoloquinoline alkaloid cryptolepine and its bromo-derivative as dual cholinesterase inhibitors. Bioorganic Chemistry , 2019, 90, 103062.
Visible Light-Mediated [2 + 2] Cycloaddition Reactions of 1,4-Quinones and Terminal Alkynes. Journal of Organic Chemistry , 2019, 84(14), 8948-8958.
Regeneration of Gardenia gummifera Linn.f by using cyanobacteria – a novel approach to tissue culture. Annals of Plant Sciences , 2019, 8(1), 3489-3494.
Indolylkojyl methane analogue IKM5 potentially inhibits invasion of breast cancer cells via attenuation of GRP78. Breast Cancer Research and Treatment , 2019, 177(2), 307-323.
Trichoderma lixii (IIIM-B4), an endophyte of Bacopa monnieri L. producing peptaibols. BMC Microbiology , 2019, 19(1), 1-10.
Bioprospection of marine actinomycetes: recent advances, challenges and future perspectives. Acta Oceanologica Sinica , 2019, 38(6), 1-17.
Photoredox-Mediated Generation of gem-Difunctionalized Ketones: Synthesis of α,α-Aminothioketones. Organic Letters , 2019, 21(12), 4793-4797.
Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction. Bioorganic Chemistry , 2019, 89, 103022.
C-H Arylation of N-Heteroarenes under Metal-Free Conditions and its Application towards the Synthesis of Pentabromo- and Pentachloropseudilins. European Journal of Organic Chemistry , 2019, 2019(22), 3591-3598.
Reaction Medium as the Installing Reservoir for Key Functionalities in the Molecules. Asian Journal of Organic Chemistry , 2019, 8(6), 777-801.
Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity. Journal of Natural Products , 2019, 82(6), 1710-1713.
Jasmonate responsive transcription factor WsMYC2 regulates the biosynthesis of triterpenoid withanolides and phytosterol via key pathway genes in Withania somnifera (L.) Dunal. Plant Molecular Biology , 2019, 100(4-5), 543-560.
Isolation of depsipeptides and optimization for enhanced production of valinomycin from the North-Western Himalayan cold desert strain Streptomyces lavendulae. Journal of Antibiotics , 2019, 72(8), 617-624.
Functional characterization of flavonoid 3′-hydroxylase, CsF3’H, from Crocus sativus L: Insights into substrate specificity and role in abiotic stress. Archives of Biochemistry and Biophysics , 2019, 667, 70-78.
Identification of embelin, a 3-undecyl-1,4-benzoquinone from Embelia ribes as a multitargeted anti-Alzheimer agent. Drug Development Research , 2019, 80(5), 655-665.
Design, synthesis and biological evaluation of alantolactone derivatives as potential anti-inflammatory agents. Medicinal Chemistry Research , 2019, 28(6), 849-856.
Cyclodextrin-based delivery systems for dietary pharmaceuticals. Environmental Chemistry Letters , 2019, 17(3), 1263-1270.
Construction of Fused Oxabicyclic Scaffolds from Glycals and Styrenes via One-Pot Domino Transformations. Organic Letters , 2019, 21(9), 3038-3042.
Synthesis of Sugar-Based Enones and Their Transformation into 3,5-Disubstituted Furans and 2-Acyl-Substituted 1,2,3-Trideoxy Sugars in the Presence of Lewis Acids. Organic Letters , 2019, 21(9), 3034-3037.
Combining ligand- and structure-based in silico methods for the identification of natural product-based inhibitors of Akt1. Molecular Diversity , 2019,
Myrosinase: insights on structural, catalytic, regulatory, and environmental interactions. Critical Reviews in Biotechnology , 2019, 39(4), 508-523.
Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy , 2019, 15(10), 1810-1828.
Isolation, structural modification of macrophin from endophytic fungus Phoma macrostoma and their cytotoxic potential. Medicinal Chemistry Research , 2019, 28(3), 260-266.
A vicarious, one-pot synthesis of benzo- and naphthofurans: Applications to the syntheses of stereumene B and paeoveitols. Tetrahedron Letters , 2019, 60(16), 1122-1125.
Discovery of Quinazolin-4(3H)-ones as NLRP3 Inflammasome Inhibitors: Computational Design, Metal-Free Synthesis, and in Vitro Biological Evaluation. Journal of Organic Chemistry , 2019, 84(9), 5129-5140.
Introducing Oxo-Phenylacetyl (OPAc) as a Protecting Group for Carbohydrates. Journal of Organic Chemistry , 2019, 84(7), 4131-4148.
Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain. Bioorganic & Medicinal Chemistry Letters , 2019, 29(9), 1043-1046.
Iodine-DMSO-promoted divergent reactivities of arylacetylenes. Chemical Communications , 2019, 55(31), 4511-4514.
Assessment of preclinical drug interactions of bedaquiline by a highly sensitive LC-ESI-MS/MS based bioanalytical method. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , 2019, 1112, 48-55.
BCl3-Mediated C-N, C-S, and C-O Bond Formation of Imidazo[1,2-a]pyridine Benzylic Ethers. ACS Omega , 2019, 4(3), 4530-4539.
Synthesis and Biological Evaluation of Novel Osthol Derivatives as Potent Cytotoxic Agents. Medicinal Chemistry , 2019, 15(2), 138-149.
Pharmacokinetic evaluation of medicinally important synthetic N,N’ diindolylmethane glucoside: Improved synthesis and metabolic stability. Bioorganic & Medicinal Chemistry Letters , 2019, 29(8), 1007-1011.
Acteoside ameliorates inflammatory responses through NFkB pathway in alcohol induced hepatic damage. International Immunopharmacology , 2019, 69, 109-117.
Liquid Chromatography Based Methods for Analysis of Disease-Modifying Antirheumatic Drugs (DMARDs) in Biological Matrices. Critical Reviews in Analytical Chemistry , 2019, 49(3), 224-242.
Murrayanine Attenuates Lipopolysaccharide-induced Inflammation and Protects Mice from Sepsis-associated Organ Failure. Basic & Clinical Pharmacology & Toxicology , 2019, 124(4), 351-359.
Programmed synthesis of triarylnitroimidazoles via sequential cross-coupling reactions. Organic & Biomolecular Chemistry , 2019, 17(8), 2134-2147.
Gemcitabine and betulinic acid co-encapsulated PLGA-PEG polymer nanoparticles for improved efficacy of cancer chemotherapy. Materials Science & Engineering, C: Materials for Biological Applications , 2019, 98, 764-771.
Thioacetamide potentiates high cholesterol and high fat diet induced steato-hepatitic changes in livers of C57BL/6J mice: A novel eight weeks model of fibrosing NASH. Toxicology Letters , 2019, 304, 21-29.
Engineering solid dispersions of anticancer preclinical lead, IIIM-985: Physicochemical characterization and in vivo pharmacokinetics. Journal of Drug Delivery Science and Technology , 2019, 49, 594-602.
Transition Metal-Free Oxidative Coupling of Primary Amines in Polyethylene Glycol at Room Temperature: Synthesis of Imines, Azobenzenes, Benzothiazoles, and Disulfides. European Journal of Organic Chemistry , 2019, 2019(6), 1242-1250.
Impurity profiling of anticancer preclinical candidate, IIIM-290. Journal of Pharmaceutical and Biomedical Analysis , 2019, 166, 1-5.
Recent Advances in Formulation Strategies for Efficient Delivery of Vitamin D. AAPS PharmSciTech , 2019, 20(1), 1-12.
In vitro evaluation of dinactin, a potent microbial metabolite against Mycobacterium tuberculosis.  International Journal of Antimicrobial Agents , 2019, 53(1), 49-53.
Synthesis of amides from (E)-3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus. Bioorganic & Medicinal Chemistry , 2019, 27(2), 343-353.
A basic helix loop helix transcription factor, AaMYC2-Like positively regulates artemisinin biosynthesis in Artemisia annua L.. Industrial Crops and Products , 2019, 128, 115-125.
Carbon-carbon and Carbon-heteroatom Bond Formation Reactions using Unsaturated Carbon Compounds. Chemical Record , 2019, 19(2-3), 644-660.
Amide hydrolyzing potential of amidase from halotolerant bacterium Brevibacterium sp. IIIMB2706. Biocatalysis and Biotransformation , 2019, 37(1), 59-65.
Characterization of the gene encoding 4-coumarate:CoA ligase in Coleus forskohlii. Journal of Plant Biochemistry and Biotechnology , 2019, 28(2), 203-210.
Antiproliferative activity of diarylnaphthylpyrrolidine derivative via dual target inhibition. European journal of medicinal chemistry , 2019, 188111986,
Andrographolide: Chemical modification and its effect on biological activities. Bioorganic chemistry , 2019, 95103511,
Antibacterial potential of Juglomycin A isolated from Streptomyces achromogenes, an endophyte of Crocus sativus Linn. Journal of applied microbiology , 2019.
Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-β structure based virtual screening.  Bioorganic chemistry , 2019, 95103500.
Carbohydrate Modifications of Neoandrographolide for Improved Reactive Oxygen Species-Mediated Apoptosis through Mitochondrial Pathway in Colon Cancer. ACS omega , 2019, 4(24), 20435-20442.
In vitro bactericidal activity of 3-Cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against drug-susceptible, resistant and tolerant isolates of Mycobacterium tuberculosis. Journal of global antimicrobial resistance , 2019.
Data set of in-silico analysis and 3D modelling of boiling stable stress-responsive protein from drought tolerant wheat. Data in brief , 2019, 27104657.
Possible Pathways of Hepatotoxicity Caused by Chemical Agents. Current drug metabolism , 2019, 20(11), 867-879.
Molecular characterization and overexpression analyses of secologanin synthase to understand the regulation of camptothecin biosynthesis in Nothapodytes nimmoniana (Graham.) Mabb. Protoplasma , 2019,
Green chemistry appended synthesis, metabolic stability and pharmacokinetic assessment of medicinally important chromene dihydropyrimidinones. Bioorganic & medicinal chemistry letters , 2019, 29(24), 126750.
Fungal endophytes of Plumbago zeylanica L. enhances plumbagin content. Botanical studies , 2019, 60(1), 21.
Gene Silencing and Over-Expression Studies in Concurrence With Promoter Specific Elicitations Reveal the Central Role of WsCYP85A69 in Biosynthesis of Triterpenoids in Withania somnifera (L.) Dunal. Frontiers in plant science , 2019, 10842.
Carbon-Carbon Bond Formation Facilitated by π-Complexed Organometallic Auxiliaries: An Overview. Letters in organic chemistry , 2019, 16(9), 689-696.
Glycyrrhizic Acid Prevents Oxidative Stress Mediated DNA Damage Response through Modulation of Autophagy in Ultraviolet-B-Irradiated Human Primary Dermal Fibroblasts. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2019, 53(1), 242-257.
Comparison of the reactivation rates of acetylcholinesterase modified by structurally different organophosphates using novel pyridinium oximes. Environmental toxicology and pharmacology , 2019, 71103218.
Pre-clinical and cellular toxicity evaluation of 7-methylxanthine: an investigational drug for the treatment of myopia. Drug and chemical toxicology , 2019, 1-10.
Corrigendum to “Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast” [Bioorg. Med. Chem. Lett. 29 , 2019 454-460. Bioorganic & medicinal chemistry letters , 2019, 29(16), 2437-2438.
Jasmonic acid application triggers detoxification of lead (Pb) toxicity in tomato through the modifications of secondary metabolites and gene expression. Chemosphere , 2019, 235734-748.
Corrigendum to “CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance” [Eur. J. Pharm. Sci. 131 , 2019 177-194]. European journal of pharmaceutical sciences : , 2019, 136104960.
Rottlerin is a pan phosphodiesterase inhibitor and can induce neurodifferentiation in IMR-32 human neuroblastoma cells. European journal of pharmacology , 2019, 857172448.
A comprehensive review of the antibacterial, antifungal and antiviral potential of essential oils and their chemical constituents against drug-resistant microbial pathogens. Microbial pathogenesis , 2019, 134103580.
Identification of dinactin, a macrolide antibiotic, as a natural product-based small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Cancer chemotherapy and pharmacology , 2019, 84(3), 551-559.
Supplementation with plant growth promoting rhizobacteria (PGPR) alleviates cadmium toxicity in Solanum lycopersicum by modulating the expression of secondary metabolites. Chemosphere , 2019, 230628-639.
Global Proteome Profiling Reveals Drug-Resistant Traits in Elizabethkingia meningoseptica: An Opportunistic Nosocomial Pathogen. Omics : a journal of integrative biology , 2019, 23(6), 318-326.
Ecological niche modeling as a cumulative environmental impact assessment tool for biodiversity assessment and conservation planning: A case study of critically endangered plant Lagerstroemia minuticarpa in the Indian Eastern Himalaya.  Journal of environmental management , 2019, 243299-307.
Community structure, spatial distribution, diversity and functional characterization of culturable endophytic fungi associated with Glycyrrhiza glabra L. Fungal biology , 2019, 123(5), 373-383.
Metal resistant PGPR lowered Cd uptake and expression of metal transporter genes with improved growth and photosynthetic pigments in Lycopersicon esculentum under metal toxicity. Scientific reports , 2019, 9(1), 5855.
Potential of fungi isolated from the dumping sites mangrove rhizosphere soil to degrade polythene. Scientific reports , 2019, 9(1), 5390.
Discovery and preclinical development of IIIM-160, a Bergenia ciliata-based anti-inflammatory and anti-arthritic botanical drug candidate. Journal of integrative medicine , 2019, 17(3), 192-204.
Identification and expression profiling of miRNAs in two color variants of carrot (Daucus carota L.) using deep sequencing. PloS one , 2019, 14(3), e0212746.
Role of P-type ATPase metal transporters and plant immunity induced by jasmonic acid against Lead (Pb) toxicity in tomato. Ecotoxicology and environmental safety , 2019, 174283-294.
Breadth of Functional Antibodies Is Associated With Plasmodium falciparum Merozoite Phagocytosis and Protection Against Febrile Malaria. The Journal of infectious diseases , 2019, 220(2), 275-284.
Gas chromatography-Mass Spectra analysis and deleterious potential of fungal based polythene-degradation products. Scientific reports , 2019, 9(1), 1599.
Artemisia amygdalina Upregulates Nrf2 and Protects Neurons Against Oxidative Stress in Alzheimer Disease. Cellular and molecular neurobiology , 2019, 39(3), 387-399.
Biology, Pathophysiological Role, and Clinical Implications of Exosomes: A Critical Appraisal. Cells , 2019, 8(2).
Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases. Advanced drug delivery reviews , 2019, 151-152130-151.
Self-assembled organic nanoparticles of benzimidazole analogue exhibit enhanced uptake in 3D tumor spheroids and oxidative stress induced cytotoxicity in breast cancer. Materials science & engineering. C, Materials for biological applications , 2019, 97467-478.
Rohitukine inhibits NF-κB activation induced by LPS and other inflammatory agents. International immunopharmacology , 2019, 6934-49.
Synthetic pyrethroid resistance in Rhipicephalus (Boophilus) microplus ticks from north-western Himalayas, India. Tropical animal health and production , 2019, 51(5), 1203-1208.
Radicicol rescues yeast cell death triggered by expression of human α-synuclein and its A53T mutant, but not by human βA4 peptide and proapoptotic protein bax. Bioorganic chemistry , 2019, 85152-158.
Current scenario of artemisinin and its analogues for antimalarial activity. European journal of medicinal chemistry , 2019, 163804-829.
Inhibitors of Aβ42-induced endoplasmic reticular unfolded protein response (UPR(ER)), in yeast, also rescue yeast cells from Aβ42-mediated apoptosis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences , 2019, 128118-127.
p110α and p110β isoforms of PI3K are involved in protection against H2O2 induced oxidative stress in cancer cells. Breast cancer , 2019, 26(3), 378-385.
AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer. Molecular cancer therapeutics , 2019, 18(2), 356-363.
Plant growth promoting rhizobacteria induced Cd tolerance in Lycopersicon esculentum through altered antioxidative defense expression. Chemosphere , 2019, 217463-474.
Roles of potential plant hormones and transcription factors in controlling leaf senescence and drought tolerance. Protoplasma , 2019, 256(2), 313-329.
In Silico Evaluation of Variable pH on the Binding of Epidermal Growth Factor Receptor Ectodomain to its Ligand Through Molecular Dynamics Simulation in Tumors. Interdisciplinary sciences, computational life sciences , 2019, 11(3), 437-443.
Development of DNA barcode for rapid identification of Epimedium elatum (Morren & Decne) from Northwestern Himalayas in India. Journal of Applied Research on Medicinal and Aromatic Plants, 2019, 13, May 2019, 100205