Dr. Sanket Kumar Shukla
Senior Technical Officer (3)
Pharmacology
CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: sanket[dot]shukla[at]iiim[dot]res[dot]in
Bio Sketch
My early scientific training and publications came from my PhD. work where I focused on the study of various microbial triggers, with special emphasis on Helicobacter pylori and Epstein-Barr virus (EBV) implicated in the development of gastroduodenal cancer. Besides my thesis work, I was also involved in other projects, in which I evaluated the certain multi drug resistant organisms at molecular level such as VRE, MRSA, NDM-1 and KPC producing gram negatives. During my post-doctoral training (2013-2020), I studied the genetic, proteomic, and biochemical approaches to identify viral pathways to induce cell mediated growth transformation. I explored the immunotherapeutic agents (vaccine, checkpoint inhibitors) combined with conventional treatment modalities (radiation/targeted agents) to enhance anti-tumor effects in virus associated cancer. I also got opportunity to learn inflammation as a means to identify promising new targets to treat patients with diabetes. That filed was little different from my previous experience however, it encouraged me to learn the translational research linked with metabolic diseases. Currently, I am exploring the gut microbiome modification based therapeutic approach for cancer and metabolic diseases. Moreover, I am also exploring different natural product as an immunotherapeutic agent against virus associated cancers. I am also engaged in evaluating in-vitro in-vivo anticancer/antiviral potential of natural and semi-synthetic natural products.
Education
Degree | Subjects | University | Qualifying Year |
Ph.D | Microbiology | Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS),Lucknow,U.P. | 2013 |
M.Sc | Biotechnology | D.D.U. Gorakhpur University, U.P. | 2007 |
B.Sc | Zoology, Botany, Chemistry | D.D.U. Gorakhpur University, U.P. | 2005 |
Position Held
Position Held | Period | Organization |
Senior Technical Officer (3) | 2022 to Present | CSIR-IIIM, Jammu |
Ramanujan Fellow | 2020 to 2022 | CSIR-IIIM, Jammu |
Post-doctral Fellow | 2015 to 2020 | Thomas Jefferson University, Philadelphia, USA |
Post-doctral Fellow | 2013 to 2015 | University of Pennsylvania, Philadelphia, USA |
Area of Expertise
- Screening of anti-viral compounds and development of anti-viral drug discovery assays for human pathogenic viruses
- Dietary and microbiome modification based therapeutic approaches for cancer and other metabolic diseases
- Tumor Virology and Immunotherapy
- Anti cancer potential of natural and semi-synthetic natural products
- Dietary and gut microbiome modification based therapeutic approaches for diabaets and other metabolic diseases
- Tumor Virology and Immunotherapy
- Anti cancer potential of natural and semi-synthetic natural products
- Confocal Microscopy
Projects
- Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Type 2 Diabetes with Inflammatory Bowel Disease (PI, SERB-DST)
Publications
Authors | Title | Journal | |
Luginbuhl AJ, Johnson JM, Harshyne LA, Linnenbach AJ, Shukla SK, et. al. | Tadalafil enhances immune response to neoadjuvant nivolumab in resectable head and neck squamous cell carcinoma. Clin Cancer Res.
2022;28(5):915-927 |
Clinical Cancer Research
(IF = 12.53) |
|
Luginbuhl AJ, Hobelmann K, Rodin J, Shukla SK, Rodeck U, Linnenbach A | The synthetic triterpenoid RTA-408 limits radiation damage to normal tissue, enhancing vascular integrity, and improves post-irradiation surgical outcomes. Laryngoscope. 2021.doi: 10.1002/lary.29930 | Laryngoscope
(IF = 2.44) |
|
Pei Y, Singh RK, Shukla SK, Lang F, Zhang S, Robertson ES | Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2. J Virol. 2018;92(18) | Journal of Virology
(IF = 4.50) |
|
Shukla SK, Sikder K, Sarkar A, Addya S, Rafiq K | Molecular network, pathway, and functional analysis of time-dependent gene changes related to cathepsin G exposure in neonatal rat cardiomyocytes. Gene. 2018. pii: S0378-1119(18)30621-8 | Gene
(IF = 3.68) |
|
Pandey S, Jha HC, Shukla SK, Shirley M, Robertson ES | Epigenetic Regulation of Tumor Suppressors by Helicobacter pylori Enhances EBV-Induced Proliferation of Gastric Epithelial Cells. MBio. 2018;9(2) | MBio
(IF = 6.78) |
|
Jha HC, Mehta D, Lu J, El-Naccache D, Shukla SK, Kovacsics C, Kolson D, Robertson ES | Gammaherpesvirus Infection of Human Neuronal Cells. MBio. 2015 Dec 1;6(6). pii: e01844-15. doi: 10.1128/mBio.01844-15 | MBio
(IF = 6.78) |
|
Shukla SK, Liu W, Sikder K, Addya S, Sarkar A, Wei Y, Rafiq K | HMGCS2 is a key ketogenic enzyme potentially involved in Type 1 diabetes with high cardiovascular risk. Sci. Rep. 2017;7(1):4590. | Scientific Reports
(IF = 4.37) |
|
Shukla SK, Jha HC, El-Naccache DW, Robertson ES | An EBV recombinant deleted for residues 130-159 in EBNA3C can deregulate p53/Mdm2 and Cyclin D1/CDK6 which results in apoptosis and reduced cell proliferation. Oncotarget 2016;7(14):18116-34 | Oncotarget
(IF = 3.31) |
|
Shukla SK, Prasad KN, Rai R, Ghosal UC, Krishnani N | Transforming growth factor beta 1 (TGF-β1) modulates Epstein-Barr virus reactivation in absence of Helicobacter pylori infection in patients with gastric cancer. Cytokine 2016; 77:176–179 | Cytokine
(IF = 3.48) |
|
Shukla SK, Prasad KN, Tripathi A, Jaiswal V, Ghoshal UC, Krishnani N, Nuzhat H | Helicobacter pylori cagL amino acid polymorphisms and its association with gastroduodenal diseases. Gastric Cancer. 2013; 16(3):435-9 | Gastric Cancer
(IF = 7.37) |
|
Khurana D, Ahmed M, Shukla SK, Soni S. et. al. | Gold nanoblackbodies-based multifunctional nanocomposite for multimodal cancer therapy. Int J Pharm. 2023 Jul 25;642:123112. |
|
|
Khurana D, Dudi R, Shukla SK, Singh D, Mondhe DM, Soni S. | Gold nanoblackbodies mediated plasmonic photothermal cancer therapy for melanoma. Nanomedicine. 2022 Aug;17(19):1323-38 | Nanomedicine
(IF = 6.1) |
|
Malik S, Mintoo MJ, Bharate SB, Nandi U, Mondhe DM, Shukla SK et.al | In vitro and in vivo anticancer potential and molecular targets of the new colchicine analog IIIM-067. J Integr Med. 2022 | Journal of Integrative Medicine
(IF = 2.44) |
|
Luginbuhl AJ, Johnson JM, Harshyne LA, Linnenbach AJ, Shukla SK, et. al. | Tadalafil enhances immune response to neoadjuvant nivolumab in resectable head and neck squamous cell carcinoma. Clin Cancer Res.
2022;28(5):915-927 |
Clinical Cancer Research
(IF = 12.53) |
|
Pei Y, Singh RK, Shukla SK, Lang F, Zhang S, Robertson ES | Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2. J Virol. 2018;92(18) | Journal of Virology
(IF = 4.50) |
Patents
NIL
Awards and Honours
- Ramanujan Fellowship- Awarded by the SERB-DST, Government of India 2019
- AHA- Postdoctoral fellowship from American Heart Association (AHA), USA (Not Availed) 2018
- Young Scientist Award from European Society of Microbiology and Infectious Diseases 2011
- Gold medal for best oral paper in 6th Annual Conference of Association of Medical Microbiologists, U. P. Microcon, India 2010
- Qualified Graduate Aptitude Test in Engineering exam (GATE), India 2007
Students
S NO. | Name & Position | Area of Interest | Education |
Manzoor Ahmed UGC-SRF
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