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Dr. Ramajayan Pandian
Senior Scientist
Pharmacology Division
CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: pramajayan[dot]iiim[at]csir[dot]res[dot]in / p[dot]ramajayan[at]iiim[dot]res[dot]in
Bio Sketch
Dr. Ramajayan Pandian is a veterinarian cum biologist and a FELASA-certified scientist with immense experience in the field of laboratory animal science. His research group’s work focuses on the identification of small molecules/peptides as enhancers or inhibitors targeting different receptors involved in the pathophysiology of Parkinson’s Disease (PD), emphasizing multitargeted therapeutic approaches for PD. His team explores natural products and their derivatives for their neuroprotective and neuroinflammatory activities in defined in-vitro and in-vivo models of Parkinson’s Disease. Currently, his group focuses on the therapeutic role of cannabinoid and non-cannabinoid molecules/extracts in PD via the modulation of CB1 and CB2 receptors of dopaminergic neurons and glial cells. The other targets aimed at include neurotrophic factor agonists and Monoamine Oxidase B (MAO-B) inhibition, which plays a major role in these neurological conditions. Furthermore, the preclinical evaluation of molecules are performed in α-synuclein A53T transgenic mice model for motor, cognitive behaviors, and clearance of α-synuclein misfolded protein aggregates.
He is expertise in developing syngeneic, xenograft, and humanized mice models in immunocompromised mice for cutting-edge research in cancer. His work experience gained from GLP-certified CRO’s is instrumental in GLP standard facility creation at IIIM and conducting regulatory toxicity studies as per OECD and CDSCO guidelines.
Education
| Degree | Subjects | University | Year |
| M.V.Sc. | Animal Genetics | Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Madras Veterinary College, Chennai. | 2016 |
| B.V.Sc. & A.H. | Veterinary Science | Pondicherry University, Rajiv Gandhi Institute of Veterinary Education & Research, Puducherry. | 2014 |
Position Held
| Position Held | Period | Organization |
| Senior Scientist | 21/08/2024 – Present | CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu |
| Scientist | 08/2020 – 08/2024 | CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu |
| Veterinarian | 2018 – 2020 |
International Institute of Biotechnology and Toxicology (IIBAT), Chennai |
| Veterinarian Scientist | 2017 – 2018 |
Centre for Toxicology and Developmental Research, SRMC, Chennai |
| Veterinarian | 2016 – 2017 |
BCG Vaccine Laboratory, Ministry of Health and Family Welfare, Govt. of India, Chennai |
Area of Expertise
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Neuropharmacology and Neuroinflammation with special focus on Parkinson’s Disease and ALS.
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Target based screening of small molecules in robust in-vitro Parkinson’s Disease models to identify potent molecules as therapeutic agents.
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In-vitro and in-vivo mechanistic studies on primary culture models and transgenic (α-synuclein A53T) mice models of Parkinson’s Disease.
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Development of syngeneic, xenograft, and humanized mice models in immunocompromised mice for cutting-edge research in cancer.
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Development of in-vivo models for any pharmacological conditions for preclinical experiments.
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Expertise in performing regulatory toxicology studies as per OECD GLP guidelines.
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Expertise in molecular genetics and breeding of various strains, including knockout and transgenic mice.
Projects
| Project Title | Funding Agency | PI/Co-PI |
|
Investigating the neuroprotective potential of cannabis spiro-indans for the treatment of Parkinson’s Disease through NMDAR modulation. |
CSIR |
PI |
|
Translational Neuroscience: Pharmacological Validation of Key biological pathways involved in neurodegenerative diseases |
CSIR |
Co-PI |
|
Preclinical development of IGF1R selective allosteric small molecule inhibitors and characterization of the newly identified allosteric inhibitors binding pocket in IGF1R |
ANRF |
Co-PI |
|
Preclinical Validation of Poly-herbal Formulation for the Management of Bronchial Asthma |
Industrial Project |
Co-PI |
|
Development and validation of a novel biomimetic 3D-printed dental implant based on the Voronoi algorithm for early osteointegration |
ICMR |
Co-PI |
|
Combating Fluoroquinolone resistant in MRSA by novel antistaphylococcal isatin-di indolyl derivatives |
ICMR |
Co-PI |
|
Exploring the impact of a new endogenous protein-derived peptides on restoring tumor suppressors p53 and pRB in cervical cancer |
ICMR |
Co-PI |
|
Lead optimization of identified Coumarin and Indazoline anti-TB Scaffolds targeting Drug Resistant and Latent Tuberculosis |
ICMR |
Co-PI |
|
Pan-CSIR Cancer Research Program – “Making Cancer Care Affordable: Empowering Women’s Health Focusing on Breast and Gynecological Cancers of Indian Relevance |
CSIR |
Co-PI |
|
CSIR Phytopharmaceutical Mission Phase-II |
CSIR |
Team Member |
Publications
| Authors | Title/Journal/Year/DOI | I.F |
|
Sandha, Kamalpreet Kaur, Sukhleen Kaur, Kuhu Sharma, Syed Mudassir Ali, Ramajayan Pandian, Ajay Kumar, and Prem N. Gupta. |
Autophagy inhibition alleviates tumor desmoplasia and improves the efficacy of locally and systemically administered liposomal doxorubicin. Journal of Controlled Release. 2025, 378, 1030-1044. (https://doi.org/10.1016/j.jconrel.2024.12.078) |
11.5 |
|
Aalim Maqsood Bhat, Irshad Ahmad Bhat, Mushtaq Ahmad Malik, Peerzada Kaiser, Ramajayan Pandian, Sheikh R. Rayees, Zabeer Ahmed, and Sheikh Abdullah Tasduq |
Inhibition of IKK complex by (2 methyl butyryl) Shikonin, a naturally occurring naphthoquinone, abrogates melanoma growth and progression via modulation of the IKK/NFκB/EMT signaling axis. International Immunopharmacology. 2025, 148:114026. (https://doi.org/10.1016/j.intimp.2025.114026) |
4.7 |
|
Dilpreet Kour, Parul Khajuria, Kuhu Sharma, Alpa Sharma, Ankita Sharma, Syed Mudassir Ali, Priya Wazir, Ramajayan Pandian, Sanghapal D Sawant, Utpal Nandi, Zabeer Ahmed, and Ajay Kumar |
Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice. Frontiers in Pharmacology. 2025, 16:1525364. (https://doi.org/10.3389/fphar.2025.1525364) |
4.8 |
|
Sapna Saini, G Lakshma Reddy, Anjali Gangwar, Harpreet Kour, Gajanan G Nadre, Ramajayan Pandian, Sunny Pal, Utpal Nandi, Rashmi Sharma, and Sanghapal D Sawant |
Discovery and biological evaluation of nitrofuranyl–pyrazolopyrimidine hybrid conjugates as potent antimicrobial agents targeting Staphylococcus aureus and methicillin-resistant S.aureus. RSC Medicinal Chemistry. 2025, 16, 1304-1328. (https://doi.org/10.1039/D4MD00826J) |
4.1 |
|
Sukhleen Kaur, Kuhu Sharma, Ankita Sharma, Kamalpreet K Sandha, Syed M Ali, Riyaz Ahmed, Ramajayan Pandian, Parvinder P Singh, Zabeer Ahmed, and Ajay Kumar |
Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology. Frontiers Immunology. 2024, 15:1418422. (https://doi.org/10.3389/fimmu.2024.1418422) |
5.9 |
|
Mir Owais Ayaz, Aadil Qadir Bhat, Zaheen Akhter, Neetu Badsera, Md Mehedi Hossain, Farheen Showket, Sabra Parveen, Mohmmad Saleem Dar, Harshita Tiwari, Nedhi Kumari, Mahir Bhardwaj, Razak Hussain, Ashutosh Sharma, Mukesh Kumar, Umed Singh, Amit Nargorta, Aravind Singh Kshatri, Utpal Nandi, Satdarshan Pal Monga, Ramajayan Pandian, Parvinder Pal Singh, and Mohd Jamal Dar |
Identification of a novel GSK3β inhibitor involved in abrogating KRas dependent pancreatic tumors in Wnt/beta-catenin and NF-kB dependent manner. Life Sciences. 2024, 351, 122840. |
5.2 |
|
Md Mehedi Hossain, et al., Mir Owais Ayaz, Utpal Nandi, Nooruddin Khan, Ramajayan Pandian, Govind Yadav, Zabeer Ahmed, Parvinder Pal Singh, and Mohd Jamal Dar |
Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter.Journal of Translational Medicine. 2024, 22: 370. (https://doi.org/10.1186/s12967-024-05144-4) |
8.4 |
|
Chetan Paul Singh, Rohit Singh, Ghulam Mustafa, Ramajayan Pandian, Ravindra S Phatake, and Yogesh P Bharitkar |
Discovery of structurally important cycloartane-type triterpenes from Dysoxylum binectariferum leaves and their anti-inflammatory activity. Journal of Molecular Structure. 2024, 1309: 138183. (https://doi.org/10.1016/j.molstruc.2024.138183) |
4.7 |
|
Boobalan Gopu, Parampreet Kour, Ramajayan Pandian, and Kuljit Singh |
Insights into the drug screening approaches in leishmaniasis. International Immunopharmacology. 2023, 114: 109591.(https://doi.org/10.1016/j.intimp.2022.109591) |
4.7 |
|
Abhishek Gour, Dilpreet Kour, Ramajayan Pandian, Mahir Bhardwaj, Sanghapal Sawant, Ajay Kumar, Utpal Nandi. |
Ellagic acid exerts dual action to curb the pathophysiological manifestations of sickle cell disease and attenuate the hydroxyurea-induced myelosuppression in Berkeley mice. ACS Pharmacology & Translational Science. 2023, 6, 6: 868-877. (https://doi.org/10.1021/acsptsci.3c00026) |
4.0 |
|
Dilpreet Kour, Mehboob Ali, Parul Khajuria, Kuhu Sharma, Palash Ghosh, Sukhleen Kaur, Surbhi Mahajan, Ramajayan Pandian, Sonali S. Bharate, Subhash Bhardwaj, Sanghapal D. Sawant, D. Srinivasa Reddy, and Ajay Kumar |
Flurbiprofen inhibits heme induced NLRP3 inflammasome in Berkeley sickle cell disease mice. Frontiers in Pharmacology. 2023, 14: 1123734. (https://doi.org/10.3389/fphar.2023.1123734) |
4.8 |
|
Ramajayan Pandian, S.N. Sivaselvam, S.M.K. Karthickeyan, R. Venkataramanan, and A. Gopinathan |
Non‑genetic effects and repeatability estimates of semen production |
1.7 |
|
Mangathayaru. K., Preethi Jenifer, and Ramajayan Pandian |
In vivo evaluation of Acalypha indica extract incorporated electrospun guar/PVA Nanofibrous mats for use as active wound dressing material. Pharmacognosy Magazine. 2022, 17(76): 882-885. (10.4103/pm.pm_275_21) |
1.5 |
|
Ramajayan Pandian, S.N. Sivaselvam, S.M.K. Karthickeyan, A. Gopinathan, and S. Poobitha |
Identification of single nucleotide polymorphism in Y-Chromosome specific DDX3Y Gene in Murrah buffalo bulls. Indian Journal of Animal Research. 2022, 55(2): 160-166. (10.18805/IJAR.B-4692) |
0.4 |
|
Ramajayan Pandian, S.N. Sivaselvam, S.M.K. Karthickeyan, R. Venkataramanan, A. Gopinathan, and K. Kulasekar |
Effect of body weight and scrotal circumference on semen production traits in Murrah buffalo bulls. Indian Journal of Animal Sciences. 2022, 92(1): 59-61. (https://doi.org/ 10.56093/ijans.v92i1.120921) |
0.3 |
|
Ramajayan Pandian, S.N. Sivaselvam, S.M.K. Karthickeyan, R. Venkataramanan, and A. Gopinathan |
Role of non-genetic factors on semen production performance in Murrah buffalo bulls. Indian Journal of Dairy Science. 2022, 75(1): 68-73. (https://doi.org/10.33785/IJDS.2022.v75i01.010) |
0.2 |
|
Ramajayan Pandian, S.N. Sivaselvam, S.M.K. Karthickeyan, and A. Gopinathan |
Identification of genetic variants in Y-Chromosome specific genes associated with seminal production in Murrah buffaloes. Asian Journal of Dairy and Food Research. 2022: 1-8. (10.18805/ajdfr.DR-183) |
|
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Mangathayaru, K., Preethi Jenifer, Ramajayan Pandian, and Gnanamani Arumugam |
Fabrication and characterization of herbal drug enriched Guar galactomannan based nanofibrous mats seeded with GMSC’s for wound healing applications. International journal of biological macromolecules. 2020, 148: 737-749. (https://doi.org/10.1016/j.ijbiomac.2020.01.188) |
8.5 |
|
Ramajayan Pandian, S.N. Sivaselvam, S.M.K. Karthickeyan, R. Venkataramanan, and A. Gopinathan |
Non-genetic effects and repeatability estimates of post-thaw evaluation traits in Murrah buffalo bulls. Journal of Entomology and Zoology Studies. 2020, 9(1): 473-478. |
5.83 |
|
Alagudurai. K., Murugan. S., Sugumar. M., Mangayarkarasi. B., Sravani. B., and Ramajayan Pandian |
Chrysin restores MPTP induced neuroinflammation, oxidative stress and neurotrophic factors in an acute Parkinson’s disease mouse model. Neuroscience Letters. 2019, 709: 134382. |
2.0 |
|
Vanitha Jebamalar. R., Senthil Kumar. S., Jaideep Mahendra, Jayamathi Govindaraj, and Ramajayan Pandian |
Anti – Demential Effect of EGB 761 on Dementia Induced Wistar Rats. International Journal of Innovative Science and Research Technology. 2019, 4: 189-194. |
8.22 |
|
Vanitha Jebamalar. R., Senthil Kumar. S., Jaideep Mahendra, Jayamathi Govindaraj, and Ramajayan Pandian |
Effect of Ginkgo Biloba extract against the behavioral changes induced by dementia in Wistar Rat. International Journal of Medical Science and Current Research. 2019,2:293-299. (PMID: 101739732) |
5.56 |
Book Chapters
| Authors & Title of the Chapter | Editors & Book Title | Publisher | Year of Publication |
|
Boobalan Gopu, Ramajayan Pandian, Angayarkanni Sevvel, and Sanket Shukla. Routes of Nano-drug administration and nano-based drug delivery system, and toxicity. |
P.V. Mohanan and Sudha Kappalli. Biomedical Applications and Toxicity of Nanomaterials |
Springer Nature, Singapore. ISBN: 978-981-19-7833-3 (https://doi. org/10.1007/978-981-19-7834-0) |
2023 |
Patents
| Names of other inventors | Title | Country | Filed/Granted on |
|
Rubina Chowdhary, Aminur Rahman Sarkar, Manzoor Ahmed, Gulam Mustafa, Diljeet Kumar, Ramajayan Pandian, Sanket Kumar Shukla, Zabeer Ahmed, and Raj Kishore Rai |
Anticancer properties of /β hybrid peptides containing 2-(1-amino-4-(tert-butyl) cyclochexyl) acetic acid and 1-(aminomethyl) cyclohexane-1-carboxylic acid. |
India |
2024 |
|
Rafia Basit, Ajeet Singh, Tenzen Yodun, Ghulam Mustafa, Umed Singh, Ramajayan Pandian, Parvinder Pal Singh, Gousia Chashoo, Shashank Kumar Singh, and Zabeer Ahmed |
Synergistic composition of CDK inhibitor and cytotoxic agent in the Treatment of Lung Cancer. |
India |
2024 |
|
Md Mehedi Hossain, Amit Nargorta, Utpal Nandi, Nooruddin Khan, Govind Yadav, P Ramajayan, Zabeer Ahmed, Parvinder Pal Singh, Mohd Jamal Dar |
Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter. |
India |
2024 |
Awards and Honours
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Selected as an Associate of the Indian Academy of Sciences (IASc).
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Selected as CCSEA Nominee, Ministry of Fisheries, Animal Husbandry & Dairying, Dept. of Animal Husbandry and Dairying, Govt. of India.
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Editorial member of the Journal of Laboratory Animal Science (JLAS).
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National Eligibility Test of ASRB, ICAR for lecturership / Assistant Professorship.
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Received INTAS “Neomec Project Shiksha Scholarship” for Clinical Subjects.
Students
| Photo | Name | Area of Interest | Position |
 |
Ms. Sundas Chowdhary |
Exploring cannabinoids and non-cannabinoid molecules/enriched extracts targeting CB1 and CB2 receptors of neurons and glial cells for the therapeutics of Parkinson’s disease |
UGC-JRF, Neuroscience Lab, Pharmacology Division, CSIR-IIIM, Jammu |
 |
Ms. Ritu |
Identification of small molecule inhibitors and agonists targeting MAO-B and neurotropic factors with a focus on Parkinson’s Disease |
UGC-JRF, Neuroscience Lab, Pharmacology Division, CSIR-IIIM, Jammu |
 |
Dr. Samriti Dogra |
Dr. Samriti Dogra is currently working in the PAN CSIR Cancer project HCP-40. Her work focuses on the development of in-vivo cancer models, i.e., syngeneic mice models in Balb/c, xenograft mice models in athymic nude mice, NOD SCID mice, and humanized mice models in NSG mice to perform in-vivo efficacy studies for in-house anti-cancerous molecules. |
Project Associate I, Centre for Preclinical Research, Pharmacology Division CSIR-IIIM, Jammu |
