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Dr. Khursheed Ahmad Bhat
Senior Principal Scientist
Bio organic Chemistry Division
CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: kabhat[at]iiim[dot]res[dot]in
Bio Sketch
Dr Khursheed Ahmad Bhat, Ph. D. (Born 1973) obtained the masters degree
in Organic Chemistry in 2000 from University of Kashmir and qualified the national eligibility
test (CSIR NET) in 2001. He completed the Ph. D. programme under the joint supervision of
Dr S. C. Taneja (CSIR-IIIM) and Prof M. A. Qureshi (University of Kashmir) from University
of Kashmir (2008). He works in the area of Natural product Chemistry as Pr. Sci. at CSIRIIIM Srinagar.
Dr Bhat was inducted as scientist in 2oo6 at CSIR-IIIM Jammu and
thereafter moved to Srinagar branch of IIIM to establish the Bio-organic Chemistry lab. He
has published more than fifty five papers. His areas of interest are bioprospection of high
altitude medicinal plants of Kashmir Himalayas for product development. Isolation,
characterization and bioevaluation of natural products from plants/ microbes; quantification
of marker compounds and standardization of plant extracts; fine tuning of natural isolates for
value addition; design and synthesis of bioactives based on natural product scaffolds. He
has also worked in the field of biotransformation and discovered new sources of
oxidorectases and lipases from microbial biodiversity.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph D | Bio Organic Chemistry | University of Kashmir | 2008 |
| CSIR- NET | Organic Chemistry | —-d0—— | 2001 |
| M. Sc | Organic Chemistry | —-d0—— | 2000 |
| B. Sc | Chemistry, Zoology and Botany | —-d0—— | 1997 |
Position Held
| Position Held | Period | Organization |
| Senior Principal Scientist | 2023-present | CSIR-IIIM |
| Pr. Sci | 2018-2023 | CSIR-IIIM |
| Sr. Sci | 2013-2018 | CSIR-IIIM |
| Scientist | 2009-2013 | CSIR-IIIM |
| Jr. Scientist | 2006-2009 | CSIR-IIIM |
Area of Expertise
Natural Product Chemistry:
Bioorganic chemistry lab is actively engaged in the bio- prospection of natural products from high altitude medicinal plants/ microflora of Kashmir Himalayas. Exploration of new scaffolds/ novel molecules/ bioactive constituents from endemic plant species of Kashmir is the thrust area of research. Phytochemistry, estimation of marker compounds and development of fingerprints of certain medicinal plants have been carried out. Typically the chemobiological studies, development of standardised and validated analytical methods of Epimedium elatum , Artemisia amygdalina and Artemisia moorcroftiana have been carried out.
A number of novel and known secondary metabolites from plants/ microbes have been isolated and characterised using spectral data analysis. The isolates have diverse chemical structures: lactones, alkaloids, flavonoids, terpenoids, coumarins polyacetylenes etc.
Fine tuning of a few isolated natural products, using some well established chemical procedures, have been carried out. The value added natural products include sclareol, ludartin, phytosterols and icariin.
Hemisynthesis of antitumor arglabin from natural product ludartin, Hemisynthesis of aromatase inhibitors: testololactone and testolactone from phytosterols, Design and synthesis of antitumor sclareol analogues, SAR studies of Ludartin etc have been our focus in natural product based medicinal chemistry programme.
Herbal based product development
Our primary aim is product development from natural resources. In this direction huge data has been generated for
the development of natural product based aphrodisiac product.The necessary chemical, CMC and biological data of the desired formulation has been generated. Thus an encapsulated formulation has been developed using Institute’s cGMP facility
Projects
- Development of 4-ethylpiperic acid congeners as Efflux pump inhibitors (EPIs).
- CSIR AROMA MISSION
- Pilot scale optimization for standardization of processing & agro technologies of selected high value aromatic & medicinal plants including technology demonstration and extension for socio-economic upliftment
Publications
| Authors | Title | Journal |
| Salman Jameel Loveleena Kaur Showkat Ahmad Bhat Fayaz A Malik , Khursheed Ahmad Bhat | Neuroprotective activity of natural products isolated from Senecio graciliflorus DC against corticosterone-induced impairment in SH-SY5Y cells | Naunyn Schmiedebergs Arch Pharmacol, 2021; 394(12): 2389-2399. doi: 10.1007/s00210-021-02136-9 |
| Khursheed A. Bhat, Syed Naseer, Ifshana Gani, Salman Jameel, Henna Amin, Showkat Ahmad Bhat, and Ajai P. Gupta |
Isolation and Identification of Cytotoxic and Antimalarial Constituents from Artemisia moorcroftiana | ChemistrySelect 2021, 6, 962 –967 doi.org/10.1002/slct.202003944 |
| Shabir H. Lone, Salman Jameel, Muzzaffar A. Bhat, Rayees A. Lone
Ray J. Butcher and Khursheed A. Bhat |
Synthesis of an unusual quinazoline alkaloid: theoretical and experimental investigations of its structural, electronic, molecular and biological properties | RSC Adv. 2018, 8, 8259-
8268. |
| Shabir H. Lone, Muzzaffar A. Bhat, Rayees A. Lone, Salman Jameel, Javeed
A. Lone, Khursheed A. Bhat |
Hemisynthesis, Computational and Molecular Docking studies of
novel Nitrogen containing steroidal aromatase inhibitors: Testolactum and Testololactum |
New Journal of Chemistry,
2018, 42, 4579-4589. |
| Masood-ur-Rahman, Younis Mohammad, Khalid Majid Fazili, Khursheed Ahmad Bhat, Tabassum. | Synthesis and biological evaluation of novel 3-O- tethered triazoles of diosgenin as potent antiproliferative agents | Steroids, 2017, 118, 1-8. |
| Syed Naseer, Khursheed A Bhat, Masroor Qadri, syed
Riyaza-ul-hassan, Fayaz A Milk, |
Bioactivity guided isolation and cytotoxic evaluation of secondary metabolites from
Cladosporium tenuissimum |
Chemistry select, 2017, 2,
1311- 1314. |
| Shabir H. Lone, Khursheed A. Bhat | Hemisynthesis of a naturally occurring clinically
significant antitumor arglabin |
Tetrahedron Letters, 2015,
56, 1908– 1910. |
| Shakeel-u-Rehman,
Bilal Rah, Shabir H. Lone, Reyaz Ur Rasool, Saleem Farooq,Debasis Nayak, Naveed Anjum Chikan, Souneek Chakraborty, Akanksha Behl, Dilip Manikaro Mondhe, Anindya Goswami, Khursheed Ahmad Bhat |
Design and Synthesis of Antitumor Heck-Coupled Sclareol Analogues:
Modulation of BH3 Family Members by SS-12 in Autophagy and Apoptotic Cell Death |
Journal of Medicinal Chemistry 2015, 58, 3432-
3444. |
| Syed Naseer , Shabir H.,Lone, Javeed A. Lone ,Mohd A. Khuroo ,Khursheed A. Bhat | LC–MS guided isolation, quantification and antioxidant evaluation of bioactive principles from
Epimedium elatum |
Journal of Chromatography B, 2015, 989, 62–70. |
| Shabir H. Lone , Khursheed
A. Bhat , Mohd A. Khuroo |
Arglabin: From isolation to antitumor evaluation | Chemico- Biological Interactions 2015, 240,
180-198. |
| K. Ahmad, S. C. Taneja, A.P Singh,N Anand,M.A Qurashi,S.Koul,GN Qazi | A chemo-enzymatic
route to diastereoisomers of 2-methyl-1- phenyl-1,3-butanediol: the dual role of microorganisms |
Tetrahedron 2007, 63, 445–450 |
| Ahmad, S. Koul, S.
C. Taneja, A. P. Singh, M. Kapoor, Riyaz-ul- Hassan, V. Verma, G. N. Qazi |
Enzyme directed diastereoselectivity in chemical reductions: studies towards the preparation of all four isomers of 1-phenyl-1,3-
butanediol |
Tetrahedron Asymmetry
2004, 15, 1685–1692 |
Awards and Honours
- NIL
Students
| Photo | Name | Area of Interest |
 |
Mr Salman Jameel | Natural Product
Chemistry |
 |
Mr Showkat Ahmad
Bhat |
Development of
Natural product based Efflux pump inhibitors |
 |
Ms Ifshana Gani | Natural Product
Chemistry |
 |
Ms Henna Amin | Isolation and evaluation
of Natural products against triple negative breast cancer |