Dr Ravi Shankar

Dr Ravi Shankar

Principal Scientist

Natural Products & Medicinal Chemistry Division

CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: rshankar[at]iiim[dot]res[dot]in

Profile

Bio Sketch

Ravi Shankar was born (1980) in Jaipur, India. He received his M.Sc. (2003) at the Mohanlal Sukhadia University Udaipur and his Ph.D. (2004-2009) in Medicinal Chemistry at the CSIR-Central Drug Research Institute (CDRI) under the supervision of Dr. Kanchan Hajela. He then joined Prof. Rohit Kolhatkar (2009-2011) group at University of Maryland, Baltimore as a Postdoctoral fellow and worked on development of peptide based drug delivery thereafter he moved to University of Illinois with same group. He continued his Postdoctoral carrier with distinguished Prof. C.K. Chu’s (2011-2013) at University of Georgia, USA to work for the anti-viral drug development of nucleoside as well as non-nucleoside analogues for HIV, HBV, HCV and influenza. In October 2013, he joined as a Scientist at CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), India where he established a medicinal chemistry research group focused on the design and synthesis of natural product analogues for identification of potent biological hit and development of target specific Drug Delivery Systems.

Education

Degree Subjects University Qualifying Year
Ph.D. Medicinal Chemistry Dr. Bhim Rao Ambedkar University (*C.D.R.I. Lucknow) 2010
M.Sc. Organic Chemistry MohanLal Sukhadia, University, Udaipur, Rajasthan 2003
B.Sc. Chemistry, Zoology and Botany Rajasthan University, Jaipur, Rajasthan 2001

 

 

Overview

Our group deals with development new methods towards construction of natural and pharmaceutically relevant compounds. Generation of focused library of natural product and their derivatives for identification bioactive lead molecules.

Our research group also involve development of polymeric systems to carry small molecular weight therapeutics at specific sites by passive targeting as well as active targeting. The prerequisite for such polymeric therapeutics is to release the drug at targeted sites with maximizes the drug release by pH or enzyme based degradation.

Position Held

Position Held

Position Held Period Organization
Sr. Scientist 2018- till date CSIR-Indian Institute of Integrative Medicine, Jammu
Scientist 2013-2018 CSIR-Indian Institute of Integrative Medicine, Jammu
Post Doctoral Fellow 2011-2013 University of Georgia, Athens, USA
Post Doctoral Fellow 2010-2011 University of Illinois, Chicago, USA
Post Doctoral Fellow 2009-2010 University of Maryland, Baltimore, USA
Executive 2009-2009 IPCA Pharmaceutical LTD. Mumbai

 

Area of Expertise

Area of Expertise

  • Development of Site specific drug delivery
  • Design and synthesis of small organic molecules of biological interest
  • Develop new methods towards construction of natural and pharmaceutically relevant compounds

 

 

 

 

Project Involved / Ongoing Projects

Projects

  • Investigation of novel strategies for efficient the delivery of Tacrolimus, DST, SERB (EMR), PI
  • Design & synthesis of andrographolide analogues for identification of potent anti-cancerous hit, DST, SERB, 2017-2021; PI

Process development for COVID-19 API’s: [2020-21] – PI for one API.

 

 

 

 

Publications and Patents

Publications

Authors Title Journal
Divya Dheer, Chittaranjan Behera, Davinder Singh, Mohd Abdullaha, Gousia Chashoo, Sandip B Bharate, Prem N Gupta, Ravi Shankar Design, synthesis and comparative analysis of triphenyl-1, 2, 3-triazoles as anti-proliferative agents Eur. J. Med. Chem., 2020, 207, 112813

 
Divya Dheer, Julien Nicolas, Ravi Shankar Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases Adv Drug Deliv Rev., 2019;151-152:130-151
Divya Dheer, Rahul Gupta, Davinder Singh, Asmita Magotra, Gurdarshan Singh, Prem N Gupta, Ravi Shankar Hyaluronic Acid-Tacrolimus Bioconjugate: Synthesis, Characterization, and Pharmacokinetic Investigation of an Acid-Responsive Macromolecular Prodrug ACS Applied Bio Materials, 2019,2, 4728-4736
Davinder Singh, Gulshan Kumar, Divya Dheer, Jyoti, Manoj Kushwaha, Qazi Naveed Ahmed,  Ravi Shankar BCl3-Mediated C–N, C–S, and C–O Bond Formation of Imidazo[1,2-a]pyridine Benzylic Ethers

 

 ACS Omega. 2019 Mar 31; 4(3): 4530–4539.
Divya Dheer, Jyoti, Prem N Gupta, Ravi Shankar Tacrolimus: An updated review on delivering strategies for multifarious diseases

 

 Eur J Pharm Sci., 2018, 114:217-227
Divya Dheer, Virender Singh, Ravi Shankar Medicinal attributes of 1,2,3-triazoles: Current developments BioorgChem.,

2017, 71:30-54
Divya Dheer, K. Ranjith Reddy, Santosh K. Rath, P. L. Sangwan, Parthasarathi Das, Ravi Shankar Cu(I)-catalyzed double C–H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines RSC Adv., 2016, 6, 38033–38036
Uma S Singh, Ram C Mishra, Ravi Shankar, Chung K Chu A Stereoselective Synthesis of 2′-Fluoro-6′-Methylene-Carbocyclic Adenosine via Vince Lactam The Journal of organic chemistry, 2014, 3917-3923
Ravi Shankar, Abhilash Samykutty, Corinne Riggin, Sneha Kannan, Ursula Wenzel, Rohit Kolhatkar Cathepsin B Degradable Star Shaped Peptidic Macromolecules for Delivery of 2-methoxyestradiol Mol Pharm

2013, 7;10,3776-88
Ravi Shankar, Bandana Chakravarti, Uma Sharan Singh, Mohd Imran Ansari, Shreekant Deshpande, Shailendra Kumar Dhar Dwivedi, Hemant Kumar Bid, Rituraj Konwar, Geetika Kharkwal, Vishal Chandra, Anila Dwivedi, K Hajela Synthesis and biological evaluation of 3,4,6-triaryl-2-pyranones as a potential new class of anti-breast cancer agents

 

 Bioorg Med Chem, 2009;17(11):3847-56
Click here more Publications

Patents

Inventors/ Contributors Title Description Year
Shankar, R.; Chandra, S.; Meena, SR.; Verma, MK.; Bindu, K.; Vij, B.; Dheer, D.; Jyoti; Vishwakarma, RA. A process for the preparation of natural crystallized thymol from Monarda citriodora (jammu monarda) oil The process utilized in the claimed invention involves the unique strategy for the production of pure crystallized thymol in good quantity from novel Jammu Monarda In process

(W.O. Patent Application No. PCT/IN2019/050003

Awards / Honours

Awards and Honours

  • Certificate of Excellence, Antiviral Drug Discovery, University of Georgia, Athens, USA
  • CSIR-SRF, Council of Scientific and Industrial Research, Government of India
  • CSIR-JRF, Council of Scientific and Industrial Research, Government of India

 

 

 

 

 

Group

Students

Photo Name Area of Interest Designation
Davinder Singh Development of Stimuli Responsive Drug Delivery System ICMR-SRF
Gulshan Kumar Design & synthesis of andrographolide analogues for identification of potent anti- cancerous hit. Project Assistant
Javeed Ahmad Tali Development of  site specific substitution on heterocyclic compounds UGC-JRF