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Dr. Showkat Rashid
Senior Scientist
Natural Products & Medicinal Chemistry Division (NPMC)
CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: showkat[dot]rashid[at]iiim[dot]res[dot]in
Bio Sketch
Dr. Showkat Rashid is a Senior Scientist at CSIR-Indian Institute of Integrative Medicine (IIIM) Jammu. He has been working in the field of Natural product total synthesis, Synthesis of complex non-natural/biologically important molecules and Synthesis of smart drug delivery biomaterials. He persued masters in chemistry (2010) and M.Phil. (2013) in Medicinal chemistry from the University of Kashmir-Srinagar. Subsequently, he joined Dr. Bilal A. Bhat (Principal Scientist, IIIM Srinagar) for his Ph.D. program and worked in a collaborative research project between Dr. Bhat and Prof. Goverdhan Mehta in the area of Natural product synthesis.
After completing his Ph.D. program, Dr. Showkat did his initial postdoctoral training with Prof. Goverdhan Mehta at University of Hyderabad. Later on, he moved to Prof. Shinichi Saito’s Group, Tokyo University of Science-Japan, wherein his research was oriented towards the Synthesis of molecular machines for smart drug delivery applications.
Dr. Showkat’s current research interests include the total synthesis of bioactive Natural product and multistep synthesis of biologicaly previledged scaffolds having implications in various medicinal chemistry domains.
Education
| Degree | Subjects | University | Qualifying Year |
| PhD | Chemical Sciences | CSIR-IIIM Srinagar, India | 2019 |
| M.Phil. | Organic Chemistry | University of Kashmir-Srinagar | 2013 |
| M. Sc. | Chemistry | University of Kashmir-Srinagar | 2010 |
| B. Sc. | Chemistry | University of Kashmir-Srinagar | 2007 |
Position Held
| Position Held | Period | Organization |
| Senior Scientist | 2022- Present | Natural Products & Medicinal Chemistry Division
CSIR-Indian Institute of Integrative Medicine, Jammu, India |
| Postdoctoral Fellow | 2020-2022 | Tokyo University of Science, Tokyo, Japan |
| Postdoctoral Research Associate | 2019-2020 | `School of Chemistry, University of Hyderabad (UoH), Hyderabad, India |
Area of Expertise
- Development of unprecented strategies towards the synthesis of bioactive natural products
- Multistep synthesis to access complex molecular and supramolecular assemblies
- Medicinal chemistry of natural and non-natural compounds for drug discovery program
Projects
- Total synthesis of bioactive Natural products having implications in Medicinal chemistry
Publications
| Authors | Title | Journal |
| Showkat Rashid, Takashi Murakami, Hiroshi Koganezawa, Yusuke Yoshigoe, Shoichi Hosoya and Shinichi Saito | Fluorinated [2]Rotaxanes with Spirofluorene Motif: Non-symmetric Distribution of the Ring Component along the Axle Component | New J. Chem., 2023, 47, 900. |
| Yusuke Kawasaki, Showkat Rashid, Katsuhiko Ikeyatsu, Yuichiro Mutoh, Yusuke Yoshigoe, Shoko Kikkawa, Isao Azumaya, Shoichi Hosoya and Shinichi Saito | Conformational control of [2]rotaxanes by hydrogen bond | J. Org. Chem. 2022, 87, 5744. |
| Showkat Rashid, Bilal A. Bhat and Goverdhan Mehta | Micelle-mediated trimerization of ynals to orthogonally substituted 4H-pyrans in water: Downstream rearrangement to bioactive 2,8-dioxabicyclo[3.3.1]nona-3,6-diene frameworks. | Eur. J. Org. Chem. 2021, 48, 6646. |
| Showkat Rashid, Bilal A. Bhat and Goverdhan Mehta | Conceptualization and synthesis of first inosito-inositol (decahydroxydecalin, DHD): In silico binding to b-amyloid protein. | Chem. Eur. J. 2020, 26, 17005. |
| Showkat Rashid, Bilal A. Bhat and Goverdhan Mehta | A vicarious, one-pot synthesis of benzo- and naphthofurans: Applications to the syntheses of Stereumene B and Paeoveitols | Tetrahedron Lett. 2019, 60, 1122. |
| Showkat Rashid, Bilal A. Bhat and Goverdhan Mehta | Synthesis of Pleurolactone and related mono- and sesquiterpenoids: Bioactive constituents of edible mushrooms. | Tetrahedron Lett. 2017, 58, 3800. |
| Showkat Rashid, Bilal A. Bhat, Saikat Sen and Goverdhan Mehta | 2,2′-peroxybis(tetrahydrofuran), a tenuously stable but persistent hazardous contaminant of THF: a fortuitous entrapment as co-crystal with a polycyclitol. | Tetrahedron Lett. 2016, 57, 5355. |
| Showkat Rashid, Bilal A. Bhat, Saikat Sen and Goverdhan Mehta | The distinctively singular self-assembly of a “molecular stair”: observation of a quadrilateral C–H∙∙∙O hydrogen bonding cycle in the crystal structure of a tetracyclic oligotetrahydrofuran. | RSC Adv., 2015, 5, 70899. |
| Showkat Rashid, Bilal A. Bhat and Goverdhan Mehta | Regenerative g-lactone annulations: A modular, iterative approach to oligo-tetrahydrofuran molecular stairs and related frameworks. | Org. Lett., 2015, 17, 3604. |
| Showkat Rashid, Bilal A. Dar, Rabiya Majeed, Abid Hamid and Bilal A. Bhat | Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anticancer agents. | Eur. J. Med. Chem. 2013, 66, 238.. |
Awards and Honours
- JSPS Research Grant Awardee for the year 2022-2023
- Post doctoral fellowship, Tokyo University of Science-Japan
- Cover picture contribution to Tetrahedron Lett. 2016, 57, 5355.
- Awarded CSIR-Senior Research Fellowship
Students
- Preeti Dogra (Project Associate-I)
- Auqib Rashid (JRF-Project)
- Waseem Iqbal Lone (Ph.D Student in Co-Supervision)
- Srushti (M. Sc Trainee)
- Shreya (M. Sc Trainee)