
Dr. Varun Pratap Singh
Senior Technical Officer-III
Division:Natural Products and Medicinal Chemistry Division
Email id:varunp[dot]singh[at]iiim[dot]res[dot]in
Bio Sketch
Dr. Varun Pratap Singh is a Senior Technical Officer-III and Assistant Professor at CSIR-Indian Institute of Integrative Medicine, Jammu, the constituent laboratory of CSIR, India. He holds PhD in Chemistry on “Isolation and Synthesis of Small Peptide of Microbial Origin and Lead Optimization of Bioactive Peptide” from SMVDU, Katra while working in Medicinal Chemistry Division at CSIR-IIIM Jammu, India under the supervision of Dr. Ram A Vishwakarma, former Director, CSIR-IIIM Jammu, India.
He holds Bachelor degree in Pharmacy from M. J. P. Rohilkhand University, Bareilly and a M. Tech. in Pharmaceutical Chemistry from VIT University, Vellore. He has more than 10 years of research experience and he has worked in various pharmaceutical R&D/production laboratories including CIPLA Ltd., Gennova Biophramaceuticals Ltd., Unichem Labs, apart from his research endeavour in the Medicinal Chemistry Division at CSIR-IIIM Jammu. Prior to joining CSIR-IIIM as Senoir Technical Officer-III, he worked as Sr. Expert at R&D department of OmniActive Health Technologies Ltd.
His research interest broadly includes peptide natural products with emphasis on isolation, characterization, synthesis and their medicinal chemistry aspects.
Education
| Degree | Subjects | University | Qualifying Year | |
| PhD | Chemistry | University: SMVDU, Katra
Institute: CSIR-IIIM, Jammu |
2019 | |
| M. Tech. | Pharmaceutical Chemistry |
|
2008 | |
| B. Pharmacy |
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M. J. P. Rohilkhand University, Bareilly | 2005 |
Position Held
| Position Held | Period | Organization | |
| Senior Technical Officer-III | 15-Jun-2022 to present |
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18-Nov-2020 to 31-May-2022 | OmniActive Health Technologies Limited, Hosur | |
| Work Contract | 10-May-2019 to 31-Mar-2020 | CSIR-IIIM, Jammu | |
| Senior Research Fellow | 01-Oct-2014 to 30-Sep-2018 | CSIR-IIIM, Jammu | |
| Senior Project Fellow | 16-Apr-2014 to 30-Sep-2014 | CSIR-IIIM, Jammu | |
| Project Assistant level-III | 05-Feb-2013 to 04-Feb-2014 | CSIR-IIIM, Jammu | |
| Project Assistant level-II | 09-Nov-2010 to 30-Sep-2012 | CSIR-IIIM, Jammu | |
| Research Associate | 21-Dec-2009 to 04-Nov-2010 | Unichem Laboratories Limited, Mumbai | |
| Officer (R&D) | 08-Sep-2008 to 19-Dec-2009 | Gennova Biopharmaceuticals Limited, Pune | |
| Officer | 09-Dec-2005 to 04-Jul-2006 | Cipla Limited |
Area of Expertise
- Peptide Natural Products
- Medicinal Chemistry of Peptides
- Structural Ilusidation of Peptides
- NMR and MASS Spectroscopy
- Separation Chemistry of peptides
Projects
Cyclic Peptides from Plants of Himalayan Region: Their Screening, Isolation and Characterization
Publications
| Authors | Title | Journal | |
| Pankaj Singh Cham, Pankul Kotwal, Kuhu Sharma, Sumit Dhiman, Lakhvinder Singh, Varun Pratap Singh, Ajay Kumar, Utpal Nandi and Parvinder Pal Singh | Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation | ACS Med. Chem. Lett. 2024, | |
| Varun Pratap Singh, Anup Singh Pathania, Sonia Sharma, Fayaz Ahmed Malik, Anil Kumar, Deepika Singh, and Ram A. Vishwakarma | Total synthesis and conformational analysis of naturally occurring lipovelutibols along with lead optimization of lipovelutibol D |
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| Varun Pratap Singh, Anup Singh Pathania, Manoj Kushwaha, Samsher Singh, Vandana Sharma, Fayaz A. | 14-Residue Peptaibol Velutibol A from Trichoderma velutinum: | RSC Advances, 2020, 10, 31233 – 31242 | |
| Malik, Inshad A. Khan, Anil Kumar, Deepika Singh and Ram A. Vishwakarma | Its structural and cytotoxic evaluation | AJP-Lung | |
| Varun P. Singh, Richa Sharma, Vandana Sharma, Chand Raina, Kamal K. Kapoor, Anil Kumar, Asha Chaubey, Deepika Singh, Ram A. Vishwakarma | Isolation of depsipeptides and optimization for enhanced production of valinomycin from the North-Western Himalayan cold desert strain Streptomyces lavendulae | J. Antibiot. 2019, 72, 617–624 | |
| Varun Pratap Singh, Nalli Yedukondalu, Vandana Sharma, Manoj Kushwaha, Richa Sharma, Asha Chaubey, Anil Kumar, Deepika Singh, Ram A. Vishwakarma | Lipovelutibols A-D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum | J. Nat. Prod. 2018, 81, 219−226 | |
| Yedukondalu Nalli, Shilpa Gupta, Vidushi Khajuria, Varun P. Singh, Mehak Sajgotra, Zabeer Ahmed, Narsinh L. Thakur, Asif Ali | TNF-α and IL-6 inhibitory effects of cyclic dipeptides isolated from marine bacteria Streptomyces sp | Med. Chem. Res., 2017, 26, 93–100 | |
| Richa Sharma, Varun P. Singh, Deepika Singh, Farnaz Yusuf, Anil Kumar, Ram A. Vishwakarma, and Asha Chaubey | Optimization of nonribosomal peptides production by a psychrotrophic fungus: Trichoderma velutinum ACR-P1 |
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| Pankaj Singh Cham, Loveleena Anand, Yassir Arfath, Nadia Rashid, Mir Shahid Maqbool, Ria Gupta, Zaheen Akhter, Varun Pratap Singh, Zabeer Ahmed, Sheikh Rayees Rafiq, Fayaz Ahmad Malik, Parvinder Pal Singh | 2′-{Heterocyclyl (aryl/alkyl)methyl}-cannabidiol as anti-depressant and anti-inflammatory agents | PATENT:0057NF2023
YEAR:2023 |
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| Radhika Anand, Sumit Sharma, Pankaj Singh Cham, Veeranjaneyulu Gannedi, Mukesh Kumar, Varun Pratap Singh, Vishav Prakash Rahul, Ram Asrey Vishwakarma, Parvinder Pal Singh | Process for the synthesis of cannabidiol and intermediates thereof | PATENT :IN 202011010503
YEAR:2020 |
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| Vikash Babu, Rahul Vikram Singh, Hitesh Sharma, Amit Kumar, Shaista Sultan, Varun Pratap Singh, Bhahwal Ali Shah, Parvinder Pal Singh | Enzymatic process for the preparation of vorinostat | PATENT :IN 201911047261
YEAR:2019 |
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| Deepika Singh, Jai Prakash S
harma, Sundeep Jaglan, Abid Hamid Dar, Anamika Khajuria, Varun Pratap Singh, Ram Asrey Vishwakarma |
Brachiatin d and process for production thereof | PATENT :US 9,624,266 B2, EP 3039031 B1
YEAR:2017 |
Awards and Honours
- CSIR-SRF
University 3rd Rank
Students
| Photo | Name | Area of intrest | Position | Education |
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Akshima Sharma | Natural Product Chemistry of plant based peptides. | Project Assistant-1 | M.Sc Chemistry |
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