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सीएसआईआर-भारतीय समवेत औषध संस्थान

सीएसआईआर-भारतीय समवेत औषध संस्थान

(Council of Scientific & Industrial Research)

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Dr. Varun Pratap Singh

Dr.Varun

Dr. Varun Pratap Singh

Senior Technical Officer-III

Division:Natural Products and Medicinal Chemistry Division
Email id:varunp[dot]singh[at]iiim[dot]res[dot]in

  • Profile
  • Position Held
  • Area of Expertise
  • Project Involved / Ongoing Projects
  • Publications and Patents
  • Awards / Honours
  • Group

Profile

Bio Sketch

Dr. Varun Pratap Singh is a Senior Technical Officer-III and Assistant Professor at CSIR-Indian Institute of Integrative Medicine, Jammu, the constituent laboratory of CSIR, India. He holds PhD in Chemistry on “Isolation and Synthesis of Small Peptide of Microbial Origin and Lead Optimization of Bioactive Peptide” from SMVDU, Katra while working in Medicinal Chemistry Division at CSIR-IIIM Jammu, India under the supervision of Dr. Ram A Vishwakarma, former Director, CSIR-IIIM Jammu, India.
He holds Bachelor degree in Pharmacy from M. J. P. Rohilkhand University, Bareilly and a M. Tech. in Pharmaceutical Chemistry from VIT University, Vellore. He has more than 10 years of research experience and he has worked in various pharmaceutical R&D/production laboratories including CIPLA Ltd., Gennova Biophramaceuticals Ltd., Unichem Labs, apart from his research endeavour in the Medicinal Chemistry Division at CSIR-IIIM Jammu. Prior to joining CSIR-IIIM as Senoir Technical Officer-III, he worked as Sr. Expert at R&D department of OmniActive Health Technologies Ltd.
His research interest broadly includes peptide natural products with emphasis on isolation, characterization, synthesis and their medicinal chemistry aspects.

Education

Degree Subjects University Qualifying Year
PhD Chemistry University: SMVDU, Katra

Institute: CSIR-IIIM, Jammu

2019
M. Tech. Pharmaceutical Chemistry
VIT University, Vellore
2008
B. Pharmacy
Pharmacy
M. J. P. Rohilkhand University, Bareilly 2005

Position Held

Position Held

Position Held Period Organization
Senior Technical Officer-III 15-Jun-2022 to present
CSIR-IIIM,JAMMU
Senior Expert
18-Nov-2020 to 31-May-2022 OmniActive Health Technologies Limited, Hosur
Work Contract 10-May-2019 to 31-Mar-2020 CSIR-IIIM, Jammu
Senior Research Fellow 01-Oct-2014 to 30-Sep-2018 CSIR-IIIM, Jammu
Senior Project Fellow 16-Apr-2014 to 30-Sep-2014 CSIR-IIIM, Jammu
Project Assistant level-III 05-Feb-2013 to 04-Feb-2014 CSIR-IIIM, Jammu
Project Assistant level-II 09-Nov-2010 to 30-Sep-2012 CSIR-IIIM, Jammu
Research Associate 21-Dec-2009 to 04-Nov-2010 Unichem Laboratories Limited, Mumbai
Officer (R&D) 08-Sep-2008 to 19-Dec-2009 Gennova Biopharmaceuticals Limited, Pune
Officer 09-Dec-2005 to 04-Jul-2006 Cipla Limited

Area of Expertise

Area of Expertise

  • Peptide Natural Products
  • Medicinal Chemistry of Peptides
  • Structural Ilusidation of Peptides
  • NMR and MASS Spectroscopy
  • Separation Chemistry of peptides

Project Involved / Ongoing Projects

Projects

Cyclic Peptides from Plants of Himalayan Region: Their Screening, Isolation and Characterization

Publications and Patents

Publications

Authors Title Journal
Pankaj Singh Cham, Pankul Kotwal, Kuhu Sharma, Sumit Dhiman, Lakhvinder Singh, Varun Pratap Singh, Ajay Kumar, Utpal Nandi and Parvinder Pal Singh Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation ACS Med. Chem. Lett. 2024, 

10.1021/acsmedchemlett.3c00461

Varun Pratap Singh, Anup Singh Pathania, Sonia Sharma, Fayaz Ahmed Malik, Anil Kumar, Deepika Singh, and Ram A. Vishwakarma Total synthesis and conformational analysis of naturally occurring lipovelutibols along with lead optimization of lipovelutibol D
ACS Omega 2021, 6, 6070−6080 
Varun Pratap Singh, Anup Singh Pathania, Manoj Kushwaha, Samsher Singh, Vandana Sharma, Fayaz A. 14-Residue Peptaibol Velutibol A from Trichoderma velutinum: RSC Advances, 2020, 10, 31233 – 31242
Malik, Inshad A. Khan, Anil Kumar, Deepika Singh and Ram A. Vishwakarma Its structural and cytotoxic evaluation AJP-Lung
Varun P. Singh,  Richa Sharma, Vandana Sharma, Chand Raina, Kamal K. Kapoor, Anil Kumar, Asha Chaubey, Deepika Singh, Ram A. Vishwakarma Isolation of depsipeptides and optimization for enhanced production of valinomycin from the North-Western Himalayan cold desert strain Streptomyces lavendulae J. Antibiot. 2019, 72, 617–624
Varun Pratap Singh, Nalli Yedukondalu, Vandana Sharma, Manoj Kushwaha, Richa Sharma, Asha Chaubey, Anil Kumar, Deepika Singh, Ram A. Vishwakarma Lipovelutibols A-D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum J. Nat. Prod. 2018, 81, 219−226
Yedukondalu Nalli, Shilpa Gupta,  Vidushi Khajuria, Varun P. Singh, Mehak Sajgotra, Zabeer Ahmed, Narsinh L. Thakur, Asif Ali TNF-α and IL-6 inhibitory effects of cyclic dipeptides isolated from marine bacteria Streptomyces sp Med. Chem. Res., 2017, 26, 93–100
Richa Sharma, Varun P. Singh,  Deepika Singh,  Farnaz Yusuf,  Anil Kumar,  Ram A. Vishwakarma, and  Asha Chaubey Optimization of nonribosomal peptides production by a psychrotrophic fungus: Trichoderma velutinum ACR-P1
Appl. Microbiol. Biotechnol, 2016, 100,  9091–9102
Pankaj Singh Cham, Loveleena Anand, Yassir Arfath, Nadia Rashid, Mir Shahid Maqbool, Ria Gupta, Zaheen Akhter, Varun Pratap Singh, Zabeer Ahmed, Sheikh Rayees Rafiq, Fayaz Ahmad Malik, Parvinder Pal Singh 2′-{Heterocyclyl (aryl/alkyl)methyl}-cannabidiol as anti-depressant and anti-inflammatory agents PATENT:0057NF2023

YEAR:2023

Radhika Anand, Sumit Sharma, Pankaj Singh Cham, Veeranjaneyulu Gannedi, Mukesh Kumar, Varun Pratap Singh, Vishav Prakash Rahul, Ram Asrey Vishwakarma, Parvinder Pal Singh Process for the synthesis of cannabidiol and intermediates thereof PATENT :IN 202011010503

YEAR:2020

Vikash Babu, Rahul Vikram Singh, Hitesh Sharma, Amit Kumar, Shaista Sultan, Varun Pratap Singh, Bhahwal Ali Shah, Parvinder Pal Singh Enzymatic process for the preparation of vorinostat PATENT :IN 201911047261

YEAR:2019

Deepika Singh, Jai Prakash S

harma, Sundeep Jaglan, Abid Hamid Dar, Anamika Khajuria, Varun Pratap Singh, Ram Asrey Vishwakarma

Brachiatin d and process for production thereof PATENT :US 9,624,266 B2, EP 3039031 B1

YEAR:2017

Awards / Honours

Awards and Honours

  • CSIR-SRF
    University 3rd Rank

Group

Students

Photo Name Area of intrest Position Education
Akshima Sharma  Natural Product Chemistry of plant based peptides.  Project Assistant-1 M.Sc Chemistry
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वैज्ञानिक तथा औद्योगिक अनुसंधान परिषद्
Council of Scientific & Industrial Research

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