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CSIR-Indian Institute of Integrative Medicine

CSIR-Indian Institute of Integrative Medicine

(Council of Scientific & Industrial Research)

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Dr. Deepika Singh

Dr. Deepika Singh

Principal Scientist

Quality Management & Instrumentation Division

CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: dsingh@iiim.res.in

  • Profile
  • Position Held
  • Area of Expertise
  • Project Involved / Ongoing Projects
  • Publications and Patents
  • Awards / Honours
  • Group

Profile

Bio Sketch

Deepika Singh is Principal Scientist and Head of NABL accreditated Quality Control & Quality Assurance Division. She holds expertise in regulatory affairs for Quality Control & Quality Assurance for Indian System of Medicine.  Dr Deepika is the authorized signatory as per the scope of accreditation by NABL, a constituent board of Quality Council of India.  She is the only government analyst in the UT of J & K for ISM medicines. She holds expertise for generation of Chemistry, Manufacturing & Control (CMC) data for phytopharmaceuticals as well as AYUSH formulations. She is an expert in method development and validation for antibiotic drug residues, heavy metals, and pesticides using sophisticated spectrophotometric and chromatographic techniques like LC-MS/MS, GC-MS/MS, HPTLC and ICPMS. She has established procedures and standardized the protocols for phytopharmaceuticals. She has good experience in monitoring and evaluation of trace residues in processed agricultural products. Her research interest lies in dereplication of non-ribosomal peptide synthetases using mass spectrometric techniques and in isolation and characterization of peptaibols and peptaibiotics from natural resources. She has more than 25 international publications in peer reviewed international journals to her credit.

Education

Degree Subjects University Qualifying Year
Ph.D. Chemistry University of Jammu, Jammu 2020
Post-Graduation

(M. Tech.)

 

Chemical Sciences (Modern methods of Chemical Analysis) Indian Institute of Technology

IIT, New Delhi

2002
Post-Graduation

(M. Sc.)

Organic Chemistry Agra College, Agra

(Dr B.R. Ambedkar University, Agra)

2000

Position Held

Position Held

Position Held Period Organization
Principal Scientist 2019-Till Date CSIR-Indian Institute of Integrative Medicine
Senior Scientist 2013-2019 CSIR-Indian Institute of Integrative Medicine
Scientist 2009-2013 CSIR-Indian Institute of Integrative Medicine

 

Area of Expertise

Area of Expertise

  • Dereplication for identification of novel metabolites from natural products using modern chromatographic and spectrometric techniques.
  • Isolation and characterization of peptaibols isolated from endophytes.
  • Method development and validation of characteristic markers isolated from high value medicinal plants. Chemistry Manufacturing and Control (CMC) study of Botanical Raw Material, Botanical Drug Substance and formulations.
  • Trace residue analysis of antibiotics drug residues, pesticides, heavy metals in agricultural and processed foods.

Project Involved / Ongoing Projects

Projects

  • Quality Control and Quality Assurance and Chemistry Manufacturing and Control of Drugs (MLP 7001): Ongoing.
  • Phytopharmaceutical development of Ficus semicordata as per regulatory guidelines of DCGI.(GAP 2180): Ongoing.
  • Advanced phase of Dengue Herbal Project-I (CNP 1313): Completed and formulation of Advanced Phase II is in process.
  • CSIR-Phytopharmaceutical mission (HCP-0010): Completed and formulation of CSIR-Phytopharmaceutical Mission Project-Phase II is in process.
  • Establishment of NIDHI-a Technology Business Incubator IIIM-TBI Incubator (IIIM-TBI) (GAP 2160): Ongoing.
  • Isolation and characterization of novel peptaibols from microbes (MLP 4010) (Completed).
  • Establishment of dereplication methods for natural product research in IIIM (MLP 4014) (Completed).

 

 

Publications and Patents

Publications

Authors Title Journal
Varun P. Singh, Anup S. Pathania, Manoj Kushwaha, Samsher Singh, Vandana Sharma, Fayaz Malik, Inshad Khan, Anil Kumar, Deepika Singh*, Ram A. Vishwakarma* 14-Residue Peptaibol Velutibol A from Trichoderma velutinum: Its structural and cytotoxic evaluation. RSC Advances, 2020, 10, 31233-31242.
Vikas Kumar, Sonali Bharate, M. Gupta, S. G. Gandhi, Deepika Singh, Sundeep Jaglan, A. Kumar, Ram A Vishwakarma, Sandip B Bharate Evaluation of rohitukine-enriched fraction of Dysoxylum binecteriferum Hook. F. (Leaves) as Anti-arthritic Phytopharmaceutical Candidate: Chemical Standardization, In-vivo validation, Formulation development and Oral Pharmacokinetics. Journal of Ethnopharmacology, 2020, 254, 112758.
Varun P Singh, Richa Sharma, Vandana Sharma, Chand Raina, Kamal K Kapoor, Anil Kumar, Asha Chaubey, Deepika Singh*, Ram A Vishwakarma* Isolation of depsipeptides and optimization for enhanced production of valinomycin from the North-Western Himalayan cold desert strain Streptomyces lavendulae Journal of Antibiotics, 2019, 72, 617-624
I A Khan*, A Singh, D. P Mindala, S. Meena, B. Vij, A K. Yadav, Sumit Roy, Utpal Nandi, Anil K Katare, S Jaglan, Deepika Singh, A. P Gupta, Prasoon Gupta, Surjeet Singh, M. K. Tikko, G D Singh, Ram A Vishawakarma* Preclinical development of gastro-protective botanical candidate from Woodfordia fruticosa (Linn.) Kurz: Chemical standardization, efficacy, pharmacokinetics and safety pharmacology. Journal of Ethnopharmacology, 2019, 241, 112023.
Meenu Katoch*, Deepika Singh*, Kamal K Kapoor, Ram A Vishwakarma. Trichoderma lixii (IIIM-B4), an endophyte of Bacopa monnieri L. producing peptaibols BMC Microbiology, 2019, 19:98.
Sandip B. Bharate, Vikas Kumar, Sonali S. Bharate, Bikarma Singh, Gurdarshan Singh, Amarinder Singh, Mehak Gupta, Deepika Singh, Ajay Kumar, Surjeet Singh, Ram A Vishwakarma. Discovery and preclinical development of IIIM-160, a Bergenia ciliata-based anti-inflammatory and anti-arthritic botanical drug candidate Journal of Integrative Medicine, 2019, 17, 192-204.
V. P Singh, Yedukondalu N, M. Kushwaha, R. Sharma, A. Chaubey, A. Kumar, Deepika Singh*, Ram A. Vishwakarma*, Lipopeptaibols A-D: Cytotoxic lipopeptaibols from the Himalyan Cold Habitat fungus Trichoderma velutinum J. Nat. Prod., 2018, 81, 219-226.

 

S. S. Bharate, V. Kumar, G. D. Singh, A. Singh, Mehak Gupta, Deepika Singh, Ajay Kumar, Ram A Vishwakarma, Sandip B. Bharate. Preclinical Development of Crocus sativus-Based Botanical Lead IIIM-141 for Alzheimer’s Disease: Chemical Standardization, Efficacy, Formulation Development, Pharmacokinetics and Safety Pharmacology ACS Omega, 2018, 3, 9572-9585
R Sharma, Varun P Singh, Deepika Singh*, Farnaz Yusuf, Anil Kumar, Ram A Vishwakarma, Asha Chaubey Optimization of nonribosomal peptides production by a psychrotrophic fungus: Trichoderma velutinum ACR-P1. Applied Microbiology & Biotechnology, 2016, 100, 9091-9102
R. Sharma, V. L. Jamwal, V. P. Singh, P.  Awasthi, Deepika Singh, Ram A Vishwakarma, Sumit Gandhi, Asha Chaubey, Revelation and cloning of valinomycin synthetase genes in Streptomyces lavendulae ACR-DA1 and their expression analysis under different fermentation and elicitation conditions. Journal of Biotechnology, 2017, 253, 40-47

Patents

Inventors/ Contributors Title Description Year
Deepika Singh, Jai Prakash Sharma, Sundeep Jaglan, Anamika Khajuria, Abid Hamid Dar, Varun Pratap Singh, Ram Asrey Vishwakarma. Brachiatin D and process for their production thereof 2563/DEL/2013

WO201529069

2013

Awards / Honours

Awards and Honours

  • Authorized Signatory & Quality Manager of NABL accredited Quality Control and Quality Assurance Division, CSIR-Indian Institute of Integrative Medicine, Jammu-India since 2015 as per scope in area of Chemical testing.
  • Notified as Government Analyst for whole state of J &K for the purpose of Chapter IV-A by the State Government for Sub Section (1) and Sub-section (2) of Section 33-F of the Drugs and Cosmetics Act, 1940 (Central Act).

Group

Students

Photo Name Area of Interest  Position
Mr Gourav Sharma Operation and troubleshooting of ICP-MS, HPTLC and Quality Analysis of Water as per regulatory guidelines. Technical Officer
Arvind Kumar Operation and troubleshooting of HPLCs. Quantification of markers, aflatoxins and stability studies as per standardized protocols. Technical Assistant
Sunita Devi Extraction of aflatoxin and carrying out physico-chemical parameters for ISM, processed food and agricultural products. Sr. Technician
Vandana Sharma Dereplication, structural elucidation and biological evaluation of secondary metabolites from natural resources. ICMR-SRF

 

 

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