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CSIR-Indian Institute of Integrative Medicine

CSIR-Indian Institute of Integrative Medicine

(Council of Scientific & Industrial Research)

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Dr. D. Srinivasa Reddy

Dr. D. Srinivasa Reddy

Director, CSIR-IIIM 

CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: director@iiim.res.in, reddy.ds@iiim.res.in

  • Profile
  • Position Held
  • Area of Expertise
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Profile

Bio Sketch

Dr. Srinivasa Reddy has more than 20 years of research experience in the synthesis of natural products/medicinal chemistry/drug discovery. Dr. Reddy is best known for his application oriented organic synthesis towards human wellbeing. He is also known for the application of “Silicon-switch approach” in medicinal chemistry. In addition, the work carried out by his group on crop protection is worth highlighting. He is an author of ~120 publications and an inventor in ~35 patents.

  • Accomplished total synthesis of ~50 natural products of biological importance.
  • One of the molecules (Licogliflozin) discovered by his team in industry is currently in human clinical trials (Phase-II), where he was a project leader.
  • Has experience in coordinating multi-disciplinary teams as a PL.
  • Acquired skills in designing novel small molecules and lead optimization.
  • Experienced in planning and execution of projects (Govt. and Industry).
  • Discovered an anti-diabetic lead molecule (along with Shantani Pvt Ltd, Pune).
  • Out-licensed patent/technology (two nos.) developed by team at CSIR-NCL
  • Identified Silinezolid with high brain:plasma ratio with a potential to treat brain infections.
  • Identified of an antibiotic lead compound for treating food infections.
  • Identified novel Insect Repellents – Further work is in progress.
  • Developed a method to access enantiopure pheromones towards crop protection.
  • Identified of novel Cladologs towards potent anti-malarial drug discovery.

Dr. Reddy received several recognitions including the prestigious Shanti Swarup Bhatnagar Award (SSB) in Chemical Sciences and J. C. Bose National Fellowship by DST-SERB, Govt of India. He is also an editor of Bioorganic & Medicinal Chemistry Letters (BMCL), an Elsevier journal.

Education

Degree Subjects University Qualifying Year
Ph.D. Synthetic Organic Chemistry,

Adviser: Professor Goverdhan Mehta

University of Hyderabad, India 2000
M.Sc Organic Chemistry Osmania University, India 1993
B.Sc. Chemistry, Botany and Zoology Osmania University, India 1991
Click Here to Download CV

Position Held

Position Held

Position Held Period Organization
Director 07/2020-Present CSIR- Indian Institute of Integrative Medicine,Jammu, Canal Road, India.
Senior Principal Scientist 12/2018-07/2020 Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
Principal Scientist 11/2014-12/2018 Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
Senior Scientist 11/2010-11/2014 Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
Section Head/Group Leader 11/2007-10/2010 Discovery Chemistry, Advinus Therapeutics Pvt. Ltd, Pune, India.
Research Investigator/Principal Scientist 12/2003-10/2007 Discovery Chemistry, Dr. Reddy’s Laboratories Ltd., Hyderabad, India.
Postdoctoral Fellow 9/2001-11/2003 Department of Medicinal Chemistry, University of Kansas, KS, USA; Mentor: Prof. Jeffrey Aubé
Postdoctoral Fellow 6/2000-8/2001 Department of Chemistry, University of Chicago, Chicago, IL, USA; Mentor: Prof. Sergey A. Kozmin
Doctoral Student 8/1994-5/2000 Adviser: Prof. Goverdhan Mehta

Area of Expertise

Area of Expertise

  • Total Synthesis of Natural Products
  • Medicinal Chemistry and Drug Discovery.

Publications

Publications

Authors Title Journal
Vidya B. Gunjal,
RiteshThakare, Sidharth Chopra*, D. Srinivasa Reddy*
Teixobactin: A Paving Stone toward a New Class of Antibiotics? J. Med. Chem., (ASAP).
Paresh R. Athawale, Hanuman P. Kalmode, Zenia Motiwala, Kiran A. Kulkarni, D.Srinivasa Reddy* Overturning the Peribysin Family Natural Products Isolated from Periconiabyssoides
OUPS-N133: Synthesis and Stereochemical Revision of Peribysins A, B, C, F, and G,
Org. Lett., 2020, 22, 3104
Gianluigi Lauro, Pronay Das, Raffaele Riccio, D. Srinivasa Reddy*, Giuseppe Bifulco DFT/NMR Approach for the Configuration Assignment of Groups of Stereoisomers by
the Combination and Comparison of Experimental and Predicted Sets of Data
J. Org.
Chem.,2020, 85, 3297.
Dr. Gorakhnath R. Jachak, Paresh R. Athawale, Rahul Choudhury, Dr. K. Kashinath, D. Srinivasa Reddy* Access to a Stereoisomer Library of Solomonamide Macrocycles Chem. Asian J., 2019,14, 4572.
Ramana Sreenivasa Rao, Femil Joseph Shajana, D. Srinivasa Reddy* A route to access imidazol[1,5-a]indole-1,3-diones and pyrrolo[1,2-c]imidazole-1,3-
diones
Org. Biomol.
Chem., 2019, 17, 8384
Paresh R. Athawale , Neeta Kumari, Monica R. Dandawate, K. Kashinath, D. Srinivasa Reddy* Synthesis of Chiral Tetrahydrofuran Building Blocks from Pantolactones: Application in
the Synthesis of Empagliflozin and Amprenavir Analogs
Eur. J. Org. Chem.
2019, 4805
Vidya B.Gunjal,D. Srinivasa Reddy* Total synthesis of Met10-teixobactin Tetrahedron
Letters, 2019, 60, 1909
Kishor L. Handore, Hanuman P. Kalmode, Shahebaz Sayyad, B.
Seetharamsingh, Ganesh Gathalkar, Sarang Padole, Pushpa V. Pawar, Mary Joseph,Avalokiteswar Sen*, D. Srinivasa Reddy*
Insect-Repellent and Mosquitocidal Effects of Noreremophilane- and NardoaristoloneBased Compounds ACS Omega., 2019, 4, 2188
Hanuman P. Kalmode ,Suhag S. Patil ,Kishor L. Handore , Paresh R. Athawale , Rambabu Dandela, Abhishek Kumar Verma, Anirban Basu, D. Srinivasa Reddy* Neural Anti‐ Inflammatory Natural Product Periconianone A: Total Synthesis and
Biological Evaluation
Eur. J. Org. Chem. 2019, 2376
Pronay Das, Yash Mankad,

D. Srinivasa Reddy*

Scalable synthesis of cladosporin Tetrahedron Letters, 2019, 60, 831
List of Publications

Patents

Patents

Inventors/ Contributors Title Description
D. Srinivasa Reddy, Remya Ramesh Enantiospecific synthesis of pheromones WO2016181413A4;US10221122B2.
D. Srinivasa Reddy, N.
Vasudevan, GorakhJachak
Process for the synthesis of ivacaftor and related compounds WO2016181414A1;US20180127373A1
Tricyclic compounds and process for preparation thereof D. Srinivasa Reddy, Kishor
L. Handore
WO2016013032A1;US9950983B2.
D. Srinivasa Reddy, K.
Kashinath, PrakashJadhav
Synthesis of tricyclic compounds and uses thereof WO2015121876A1
D. Srinivasa
Reddy, Revannath L. Sutar, Vinod Kumar, Rahul D. Shingare
Novel N-heterocyclic carbene compounds, their preparation and use WO2015102020A1
D. Srinivasa Reddy,
GorakhJachak, Remya Ramesh, SantoshTupe, MukundDeshpande
Silicon based fungicides and process for producing the same US10053472B2,
WO2015102025A1; EP3089985B1
D. Srinivasa
Reddy,ChaitanyaSaxena,K.Kashinath
Novel indazole compounds and a process for the preparation thereof ,WO2015015519A1;US9737510B2;

DK3027605T3;EP3027605B1;

JP6474808B2;KR20160053916A;

CN106103427A;CA2919953A1;

DK3027605T3;ES2656475T3

D. Srinivasa Reddy,
VasudevanNatarajan, Sachin B. Wagh, Remya Ramesh
Novel pyrrole compounds with silicon incorporation US9657037B2;WO2014195970A4
List of Patents

Awards / Honours

Awards and Honours

  • J.C. Bose National Fellowship by SERB, DST, Govt. of India
  • Shanti Swarup Bhatnagar Prize in chemical sciences
  • Fellow of the Indian Academy of Sciences, India (FASc)
  • Fellow of the National Academy of Sciences, India (FNASc)
  • NASI-Reliance Industries Platinum Jubilee Award in physical sciences
  • Sun Pharma Research (Ranbaxy) Award in pharmaceutical sciences
  • OPPI (Organization of Pharmaceutical Producers of India) Scientist Award for contributions in pharmaceutical sciences
  • Nominated member of the scientific body of Indian Pharmacopoeia, Govt. of India
  • CRSI Bronze Medal in Chemical Science
  • CDRI Award for Excellence in drug discovery research – Chemical Sciences
  • Editor of Bioorganic & Medicinal Chemistry Letters (BMCL), an Elsevier journal
  • Fellow of the Maharashtra Academy of Sciences
  • Fellow of the Telangana Academy of Sciences
  • Scientist of the year award by NCL Foundation
  • DST-SERB PAC member (co-opt) for the Organic Chemistry
  • KKG Menon Memorial Lecture Award of ICT, Mumbai
  • Council Member of the (NOST) National Organic Symposium Trust
  • Council Member of the Chemical Research Society of India (CRSI)
  • Nominated member of the General and Governing Body of National Dope Testing Laboratory (NDTL), Ministry of Youth Affairs and Sports, Govt of India

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