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Dr. D. Srinivasa Reddy
IIIM Director
Natural Products & Medicinal Chemistry Division
CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: reddy.ds@iiim.res.in, director@iiim.res.in
Bio Sketch
- 20 Years of research experience (post-PhD) in total synthesis of natural products/medicinal chemistry/drug discovery
- Experienced in leading drug discovery programs (7 years of pharmaindustry experience).
- One of the molecules (Licogliflozin)discovered by his team in industry is currently in human clinical trials (Phase-II), where he was a project leader.
- Has experience in coordinating multi-disciplinary teams as a project leader, in particular, during the tenure at pharma industry.
- Acquired skills in designing novel small molecules and lead optimization.
- Experienced in planning and execution of projects (Govt. and Industry).
- Has developed skills in executing total synthesis of biologically active compounds.
- Discovered an anti-diabetic molecule which is ready for out-licensing.
- Patent out-licensed to Ahammune Biosciences for Vitiligo drug development.
- IdentifiedSilinezolid with high brain:plasma ratio with a potential to treat brain infections.
- Identified novel Insect Repellents – Signed MOU with Ross Lifesciences.
- Developed a method to access enantiopure pheromones towards crop protection.
- Identified of novelCladologs towards potent anti-malarials.
- Identification of an antibiotic lead compound for treating food infections.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph.D. | Synthetic Organic Chemistry,
Adviser: Professor Goverdhan Mehta |
University of Hyderabad, India | 2000 |
| M.Sc | Organic Chemistry | Osmania University, India | 1993 |
| B.Sc. | Chemistry, Botany and Zoology | Osmania University, India | 1991 |
Position Held
| Position Held | Period | Organization |
| Director | 07/2020-present
|
CSIR- Indian Institute of Integrative Medicine,Jammu, Canal Road, India. |
| SeniorPrincipal Scientist | 12/2018-07/2020 | Division of Organic Chemistry, National Chemical Laboratory, Pune, India. |
| Principal Scientist | 11/2014-12/2018 | Division of Organic Chemistry, National Chemical Laboratory, Pune, India. |
| Senior Scientist | 11/2010-11/2014 | Division of Organic Chemistry, National Chemical Laboratory, Pune, India. |
| Section Head/Group Leader | 11/2007-10/2010 | Discovery Chemistry, Advinus Therapeutics Pvt. Ltd, Pune, India. |
| Research Investigator/Principal Scientist | 12/2003-10/2007 | Discovery Chemistry, Dr. Reddy’s Laboratories Ltd., Hyderabad, India. |
| Postdoctoral Fellow | 9/2001-11/2003 | Department of Medicinal Chemistry, University of Kansas, KS, USA; Mentor: Prof. Jeffrey Aubé |
| Postdoctoral Fellow | 6/2000-8/2001 | Department of Chemistry, University of Chicago, Chicago, IL, USA; Mentor: Prof. Sergey A. Kozmin |
| Doctoral Student | 8/1994-5/2000 | Adviser: Prof. Goverdhan Mehta |
Area of Expertise
- Total Synthesis of Biologically Active Natural/Unnatural Products.
- Medicinal Chemistry and Drug Discovery.
Publications
| Authors | Title | Journal |
| Vidya B. Gunjal, RiteshThakare, Sidharth Chopra*, D. Srinivasa Reddy* |
Teixobactin: A Paving Stone toward a New Class of Antibiotics? | J. Med. Chem., (ASAP). |
| Paresh R. Athawale, Hanuman P. Kalmode, Zenia Motiwala, Kiran A. Kulkarni, D. Srinivasa Reddy* |
Overturning the Peribysin Family Natural Products Isolated from Periconiabyssoides OUPS-N133: Synthesis and Stereochemical Revision of Peribysins A, B, C, F, and G, |
Org. Lett., 2020, 22, 3104 |
| Gianluigi Lauro, Pronay Das, Raffaele Riccio, D. Srinivasa Reddy*, Giuseppe Bifulco |
DFT/NMR Approach for the Configuration Assignment of Groups of Stereoisomers by the Combination and Comparison of Experimental and Predicted Sets of Data |
J. Org. Chem.,2020, 85, 3297. |
| Dr. Gorakhnath R. Jachak, Paresh R. Athawale, Rahul Choudhury, Dr. K. Kashinath, D. Srinivasa Reddy* |
Access to a Stereoisomer Library of Solomonamide Macrocycles | Chem. Asian J., 2019,14, 4572. |
| Ramana Sreenivasa Rao, Femil Joseph Shajana, D. Srinivasa Reddy* | A route to access imidazol[1,5-a]indole-1,3-diones and pyrrolo[1,2-c]imidazole-1,3- diones |
Org. Biomol. Chem., 2019, 17, 8384 |
| Paresh R. Athawale , Neeta Kumari, Monica R. Dandawate, K. Kashinath, D. Srinivasa Reddy* |
Synthesis of Chiral Tetrahydrofuran Building Blocks from Pantolactones: Application in the Synthesis of Empagliflozin and Amprenavir Analogs |
Eur. J. Org. Chem. 2019, 4805 |
| Vidya B.Gunjal,D. Srinivasa Reddy* | Total synthesis of Met10-teixobactin | Tetrahedron Letters, 2019, 60, 1909 |
| Kishor L. Handore, Hanuman P. Kalmode, Shahebaz Sayyad, B. Seetharamsingh, Ganesh Gathalkar, Sarang Padole, Pushpa V. Pawar, Mary Joseph, Avalokiteswar Sen*, D. Srinivasa Reddy* |
Insect-Repellent and Mosquitocidal Effects of Noreremophilane- and NardoaristoloneBased Compounds | ACS Omega., 2019, 4, 2188 |
| Hanuman P. Kalmode ,Suhag S. Patil ,Kishor L. Handore , Paresh R. Athawale , Rambabu Dandela, Abhishek Kumar Verma, Anirban Basu, D. Srinivasa Reddy* |
Neural Anti‐ Inflammatory Natural Product Periconianone A: Total Synthesis and Biological Evaluation |
Eur. J. Org. Chem. 2019, 2376 |
| Pronay Das, Yash Mankad, D. Srinivasa Reddy* |
Scalable synthesis of cladosporin | Tetrahedron Letters, 2019, 60, 831 |
Patents
| Inventors/ Contributors | Title | Description |
| D. Srinivasa Reddy, Remya Ramesh | Enantiospecific synthesis of pheromones | WO2016181413A4;US10221122B2. |
| D. Srinivasa Reddy, N. Vasudevan, GorakhJachak |
Process for the synthesis of ivacaftor and related compounds | WO2016181414A1;US20180127373A1 |
| Tricyclic compounds and process for preparation thereof | D. Srinivasa Reddy, Kishor L. Handore |
WO2016013032A1;US9950983B2. |
| D. Srinivasa Reddy, K. Kashinath, PrakashJadhav |
Synthesis of tricyclic compounds and uses thereof | WO2015121876A1 |
| D. Srinivasa Reddy, Revannath L. Sutar, Vinod Kumar, Rahul D. Shingare |
Novel N-heterocyclic carbene compounds, their preparation and use | WO2015102020A1 |
| D. Srinivasa Reddy, GorakhJachak, Remya Ramesh, SantoshTupe, MukundDeshpande |
Silicon based fungicides and process for producing the same | US10053472B2, WO2015102025A1; EP3089985B1 |
| D. Srinivasa Reddy,ChaitanyaSaxena,K.Kashinath |
Novel indazole compounds and a process for the preparation thereof | ,WO2015015519A1;US9737510B2;
DK3027605T3;EP3027605B1; JP6474808B2;KR20160053916A; CN106103427A;CA2919953A1; DK3027605T3;ES2656475T3 |
| D. Srinivasa Reddy, VasudevanNatarajan, Sachin B. Wagh, Remya Ramesh |
Novel pyrrole compounds with silicon incorporation | US9657037B2;WO2014195970A4 |
Awards and Honours
- Selected for the highly prestigious J C Bose Fellowship (2021)
- Elected as a Fellow of Indian Academy of Sciences, Bengaluru (2021)
- CDRI Award–Chemical Sciences for the contribution in Drug discovery (2013).
- Scientist of the year by the NCL Research Foundation (2013)
- The Shanti SwarupBhatnagar Award (SSB) in Chemical Sciences (2015)
- NASI-Reliance Industries Platinum Jubilee Award for application oriented innovations in physical sciences (2015)
- Elected as a Fellow of the Maharashtra Academy of Sciences (2015)
- CRSI Bronze Medal in recognition of his contribution in chemical science (2016)
- Elected as a Fellow of the Telangana Academy of Sciences (2016)
- Nominated member of Scientific Body of Indian Pharmacopoeia Commission, Govt. of India (2017)
- Editor of Bioorganic & Medicinal Chemistry Letters, an Elsevier publication (from April 2017)
- Elected as a Fellow of the National Academy of Sciences, India – NASI (2017)
- OPPI (Organization of Pharmaceutical Producers of India) Scientist Award (2017)
- Sun Pharma Research Award (Ranbaxy Research Award) in the field of pharmaceutical sciences (2018)
- DST-SERB PAC member (co-opt) for the Organic Chemistry (from 2016)
- KKG Menon Memorial Lecture Award of Institute of Chemical Technology, Mumbai (2018)
- Council Member of the (NOST) National Organic Symposium Trust (2019)
- Nominated member of the General and Governing Body of National Dope Testing Laboratory (NDTL), Ministry of Youth Affairs and Sports, Govt of India (2020)
- Council Member of the Chemical Research Society of India (CRSI) (2020)