Dr. Debaraj Mukherjee
Natural Products & Medicinal Chemistry Division
CSIR – Indian Institute of Integrative Medicine, Canal Road, Jammu – 180001
Email: dmukherjee@iiim.res.in
Bio Sketch
Dr Debaraj Mukherjee received his MSc (Organic Chemistry) from Calcutta University in 1999 and his PhD degree in oligosaccharide synthesis from CSIR-IICB (registered under Jadavpur university Kolkata) in 2006. Since 2006, Dr Mukherjee has been working as scientist at CSIR-IIIM Jammu, India. Presently, he is Principal Scientist & Head of Natural Product and Bio-Organic Chemistry division. He worked with Professor David Crich (2011-2012) at Wayne State University USA under DST-Boyscast exchange program on mechanistic study on relative kinetic rates on cation clock glycosylation reaction.
The research of Dr Mukherjee group deals with Carbohydrate, Medicinal and Natural Product Chemistry. His major interest in glycoscience include total synthesis, novel methods for O-/C-/N-glycosylation, glycal chemistry, new protection/deprotection strategies, multicomponent tandem reactions and synthesis of carbohydrate-fused bicyclic systems containing medium-ring to macro cyclic ethers, thio-ethers and lactones, synthesis of nucleosides, noninfringing routes for carbohydrate based API synthesis. He has significantly contributed in the generation of several lead molecules of therapeutic importance from natural product origin.
He is recipient of several awards like D.S.T award for ‘Participation in the meeting of Nobel Laureates’ in Lindau, Germany (2002), Young Scientist Award in International Carbohydrate Conference at Delhi university (2006), Professor D.K. Banerjee Memorial Lecture Award at IISC Bangalore (2020) for his outstanding research work in the field of carbohydrate chemistry.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph.D. | Organic Chemistry | Jadavpur university (from IICB, CSIR Kolkata) | 2006 |
| M.Sc. | Organic Chemistry | Calcutta University | 1999 |
| B.Sc.(Hons) | Chemistry | Calcutta University | 1997 |
Position Held
| Position Held | Period | Organization |
| Principal Scientist and
Head of the Department
|
2017-Present | Natural Product Chemistry Plants, Microbes and Bio-Organic Chemistry Division
CSIR-Indian Institute of Integrative Medicine, Jammu, India |
| Scientist Fellow/ Senior Scientist | 2012-2017 | NPC Plant, Microbes, BioOrganic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India |
| Scientist | 2009-2012 | NPC Plant, Microbes, BioOrganic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India |
| Jr. Scientist | 2006-2009 | NPC Plant, Microbes, BioOrganic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India |
| Post-doctoral Scientist | 2012-2013 | Wayne State University, USA. |
Area of Expertise
Projects
- Synthesis of Dapagliflozin and sofosbuvir by novel glycosylation (GAP 2155) (2017-till date).
- Non-Infringing Process for APIs (MLP110009).
- Nucleoside as biofilm inhibitors of bacteria and to understand the underlying mechanism of action (MLP110008).
- Setting up a small molecule compound library screening platform for human serine protease TMPRSS2 and SARS-CoV2 RdRp (MLP-110001)
- Repositioning of antiviral drugs for management of Covid-19 (HCP-29)
- Discovery of molecules from Natural Product Chemistry Microbes (MLP-4011)
- CYP mediated bio transformation of drugs and natural products (MLP-4012)
Publications
| Authors | Title | Journal |
| Nazar Hussain, Monika Bhardwaj, Ajaz Ahmed and Debaraj Mukherjee* | Synthesis of Sugar-Based Enones and Their Transformation into 3,5-Disubstituted Furans and 2‑Acyl-Substituted 1,2,3-Trideoxy Sugars in the Presence of Lewis Acids. | Organic. Letters, 2019, 21, 3034−3037. |
| Monika Bhardwaj, FaheemRasool, MadhuBabuTatina, and Debaraj Mukherjee*
|
Construction of Fused Oxabicyclic Scaffolds from Glycals and Styrenes via One-Pot Domino Transformations. | Organic. Letters,2019, 21, 3038−3042. |
| Faheem Rasool, Ajaz Ahmed, NazarHussain Syed Khalid Yousuf, Debaraj Mukherjee*
|
One-pot Regio and Stereoselective Synthesis of C-Glycosyl Amides From Glycals Using Vinyl Azides as Glycosyl Acceptors, | Organic Letters, 2018, 20, 4036-4039 |
| Nazar Hussain, Kalyanashis Jana, BishwajitGanguly, Debaraj Mukherjee*
|
Transformation of Substituted Glycals to Chiral Fused Aromatic Cores via Annulative π-Extension Reactions with Arynes, | Organic Letters,2018, 20, 1572-1575. |
| Faheem Rasool, Debarajmukherjee* | Pd-CatalyzedRegio- and StereoselectiveCNucleosideSynthesisv from UnactivatedUracils and PyranoidGlycals. | Organic Letters,2017, 19, 4936–4939. |
| M. B. Tatina, A. K. Kusunuru, Debaraj Mukherjee* | Organo-zinc Promoted Diastereoselective C-Arylation of 1,2-Anhydrosugars from Arylboronic Acids” | Organic Letters,2015, 17, 4624–4627. |
| A. K. Kusunuru, C. K. Jaladanki, M. B. Tatina, P.V.Bharatam,Debaraj Mukherjee*
|
TEMPO-Promoted Domino Heck−Suzuki Arylation: DiastereoselectiveCis-Diarylation of Glycals and Pseudoglycals | Organic Letters,2015, 17, 3742–3745 |
| M. R. Lambu, S. Kumar, S. K. Yousuf, D. K. Sharma, A. Hussain, A. Kumar, F. Malik, Debaraj Mukherjee*
|
“Medicinal chemistry of dihydropyran based medium ring macrolides related to aspergillides: selective inhibition of PI3K-alpha” | Journal of Medicinal Chemistry, 2013, 56, 6122–6135. |
| S. K. Yousuf, S. C. Taneja, Debaraj Mukherjee*
|
“Highly regio-and stereoselective one pot synthesis of carbohydrate based butyrolactones”; | Organic Letters, 2011, 13, 576-579. |
| Anil Kumar, Syed Khalid Yousuf, Debaraj Mukherjee* | “Copper mediated highly stereoselective synthesis of C-glycosides from unactivated alkynes”; | Chemical Communication, 2013, 49, 10154-10156. |
| T. Madhubabu, A. K. Kusunuru, Syed Khalid Yousuf and Debaraj Mukherjee* | “Tandem regio- and diastereo-selective synthesis of halogenated C-vinyl glycosides from unactivatedarylacetylenes‟ | Chemical Communication, 2013, 49, 11409-11411. |
| S. K. Yousuf, S. C. Taneja, Debaraj Mukherjee*. | “Multi-component cascade transformation of D-glucal to furan appended triazole glycoconjugates”
|
Journal of Organic Chemistry, 2010, 75, 3097-3100. |
| S. K. Yousuf, S.. C Taneja. Debaraj Mukherjee*, | “Domino Transformation of D-Glucal to Racemic-a-Substituted-β-Hydroxymethyl Furfuryl Derivatives”
|
Organic Letters, 2008, 10, 4831-4834 |
| B. A. Shah, P. Gupta, S. C. Taneja, Debaraj Mukherjee | Tandem acetalation-acetylation of sugars and related derivatives with enolacetates under solvent-Free conditions. | Journal of Organic Chemistry, 2007, 72, 8965-8968. |
Patents
| Inventors/ Contributors | Title | Description | Year |
| D. Mukherjee, A. Goswami, D. Sharma, D. Nayak, S. K. JAIN,
|
Indolylkojyl Derivatives as Inhibitor Of Invasion And Metastasis In Human Mammary Gland Carcinomas. | WO2019/003237 | 2019 |
Awards and Honours
- “2020 Professor D.K. Banerjee Memorial Lecture Award” at Pfizer Symposium on Organic Chemistry organized by Department of Organic Chemistry, Indian Institute of Science, Banglore, February 2020.
- “Dr. H C Srivastava Memorial Award-2019 by the ACCTI Executive Committee members in the International Carbohydrate conference (CARBO-XXXIV) on “Emerging Frontiers in Carbohydrate Chemistry and Glycobiology”
- The DST Boyscast fellowship for exchange programme for USA with Professor. David Crich, Wayne State University, USA (Nov2011-Nov2012).
- Had been selected for the prestigious D.S.T award for ‘Participation in the meeting of Nobel Laureates’ in Lindau, Germany in 2002.
- ACCT Young Scientist Award in International Carbohydrate Conference (November 2006) at Delhi university 2006
Students
| Photo | Name | Area of Interest | Position |
 |
Ajaz Ahmad |
C-1,C-2- functionalizaton of sugar enol ethers for the synthesis of medicinally important compounds, Development of Novel N-glycosylation methods particularly Nucleoside synthesis, Carbonylation at various position of sugars, Biotransformations. | CSIR-NET/JRF (Dec. 2016, June 2017). GATE 2016, 2019, 2020.
CSIR-Senior Research Fellow (2019 onwards) M.Sc. Organic Chemistry, B. U. Jhansi. Email:ajaz_ahmed36@yahoo.com |
 |
Monika Bhardwaj |
Non infringing routes for carbohydrates based API synthesis, C-glycosylation and its mechanistic study, Biotransformations, Protection and deprotection in sugars. |
DST- Junior Research Fellow
CSIR-Senior Research Fellow M.Sc. Organic Chemistry Email:monikabharadwaj103@gmail.com |
 |
Irshad Ahmad Zargar |
C-glycosylation, C-arylation, Non –infringing routes for carbohydrates based API synthesis, medicinally important C-Branced sugars | Irshad Ahmad Zargar
UGC-Junior Research Fellow M.Sc.Organic Chemistry Email: irshadcsir@gmail.com |
 |
Junaid Shafi Bandey |
Protection Deprotection strategy in carbohydrates, aza-sugars, Nucleoside synthesis, Multi component reaction. | Project Assistant
M.Sc. Organic Chemistry Email: junaidbanday121@gmail.com |
| Alumni with Current Affiliation | |||
 |
Dr. Syed Khalid Yousuf | Scientist at CSIR-IIIM, Srinagar | |
 |
Dr.AltafHussain | Assistant Professor of Chemistry, Higher Education Department, Govt. of Jammu& Kashmir, India (2017-present) | |
 |
Dr. Deepak K Sharma | Assistant Professor at Indian Institute of Technology (Banaras Hindu University), Varanasi (At present | |
 |
Dr.MalikharjunaRaoLambu | Postdoc. Ntu Singapore (At present) | |
 |
Dr.MadhuBabuTatina | Postdoc. Research Fellow, NTU, Singapore (At present) | |
 |
Dr. Anil Kumar Kunusuru | Research associate in Nicolas Piramal, Gujrat, India (At present) | |
 |
Dr.Ashutosh K. Dash | Associate Professor at Shoolini University, Solan | |
 |
Dr.FaheemRasool | Assistant Professor of Chemistry, Higher Education Department, Govt. of Jammu & Kashmir (At present) | |
 |
Dr.NazarHussain | Postdoctoral Research Fellow Centre Armand-Frappier Santé BiotechnologieInstitut national de la recherchescientifique (INRS) 531, boul. des Prairies Laval (Québec), Canada, H7V 1B7 | |