Dr. Sandip B. Bharate
Principal Scientist / HOD of NPMC Division
Natural Products & Medicinal Chemistry Division
CSIR – Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: sbharate@iiim.res.in
Bio Sketch
Sandip B. Bharate is a Principal Scientist & Associate Professor (Medicinal Chemistry) at Indian Institute of Integrative Medicine, the constituent laboratory of Council of Scientific and Industrial Research, India. He received M.S. and Ph.D. in Natural Products from the National Institute of Pharmaceutical Education and Research Mohali in 2002 and 2007, respectively. Subsequently, he worked as a Research Scientist at Piramal Life Sciences Ltd, Mumbai for 1.5 years. Following an NIH postdoctoral fellowship with Prof. Charles M. Thompson at the University of Montana (U.S.), he began his independent research career at the Indian Institute of Integrative Medicine in 2011.
His laboratory focuses on the discovery and development of natural products based small-molecule kinase inhibitors. He is the lead inventor of a Cdk inhibitor IIIM-290 which has recently entered a clinical trial. His group is also working on the rational drug design of multi-targeted anti-Alzheimer agents. One of the anti-Alzheimer lead IIIM-141 discovered from his group has been licensed to the industry as a nutraceutical product.
Academic honors to his credit include InnoCentive awards, NASI Platinum Jubilee Young Scientist Award, CSIR Young Scientist award, OPPI Young Scientist Award and MEDI Young Investigator Award 2020.He has been listed among the World’s top 2% Scientists(Medicinal Chemistry) in the list released by Stanford University in 2020.
Education
| Degree | Subjects | University | Qualifying Year |
| Ph.D. | Natural Products | NIPER Mohali | 2007 |
| M.S. Pharm. | Natural Products | NIPER Mohali | 2002 |
| B. Pharm. | Pharmacy | University of Pune | 2001 |
Position Held
| Position Held | Period | Organization |
| Principal Scientist & Head | 2021-Present | Natural Products & Medicinal Chemistry Division,
CSIR-Indian Institute of Integrative Medicine, Jammu, India |
| Principal Scientist | 2015-2021 | Medicinal Chemistry Division,
CSIR-Indian Institute of Integrative Medicine, Jammu, India |
| Scientist Fellow/ Senior Scientist | 2011-2015 | Medicinal Chemistry Division,
CSIR-Indian Institute of Integrative Medicine, Jammu, India |
| Post-doctoral Scientist | 2008-2010 | NIH COBRE Centre for Structural & Functional Neuroscience, The University of Montana, USA. |
| Research Scientist | 2007-2008 | Piramal Life Sciences Ltd, Mumbai |
| Research Chemist | 2003-2003 | Dr. Reddy’s Laboratories, Hyderabad, India |
Area of Expertise
- Natural products driven drug discovery via employing computational tools, and medicinal chemistry approaches, followed by preclinical and clinical development.
- Specific interests: Kinase inhibitors (Cancer, Alzheimer’s), Multi-targeted agents (Alzheimer’s)
Projects
- Preclinical development of crocin-1 enriched Crocus sativus as phytopharmaceutical lead [P90807- CSIR (Young scientist award grant); 2017-2022] – PI
- Repurposing of colchicine for management of COVID-19 patients [MLP-110002] [2020-2021] – PI
- Process development for COVID-19 API’s: [2020-21] – PI for one API.
- Development nutraceutical products from algae [CLP-0309- Industry sponsored project]- co-PI
Publications
| Authors | Title | Journal |
| Raghuvanshi R.; Bharate SB.* | Recent developments in the use of kinase inhibitors in management of viral infections | J. Med. Chem. 2021, ASAP |
| Nuthakki VK; Yadav RR; Bharate SB.* | Identification of Aplysinopsin as a Blood-brain Barrier Permeable Scaffold for Anti-cholinesterase and Anti-BACE-1 activity | Bioorg. Chem. 2021, 107, 104568
|
| Abdullaha M; Nuthakki VK; Bharate SB.* | Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase | Eur. J. Med. Chem., 2020, 207, 112761
|
| Abdullaha M; Mohammed S; Ali M; Kumar A; Vishwakarma RA; Bharate SB* | Discovery of Quinazolin-4(3H)-ones as NLRP3 Inflammasome Inhibitors: Computational Design, Metal-free Synthesis and In-vitro Biological Evaluation | J. Org. Chem., 2019, 84, 5129-5140 |
| Bharate SB;* Kumar V; Jain SK; Mintoo NJ; Guru SK; Nuthakki VK; Sharma M; Bharate SS; Gandhi SG; Mondhe DM; Bhushan S; Vishwakarma RA. | Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-dependent Kinase Inhibitor | J. Med. Chem. 2018, 61, 1664-1687 |
| Joshi P; McCann GJP; Sonawane VR; Vishwakarma RA; Chaudhuri B; Bharate SB* | Identification of Potent and Selective CYP1A1 Inhibitors via Combined Ligand and Structure-Based Virtual Screening and Their in Vitro Validation in Sacchrosomes and Live Human Cells | J. Chem. Inform. Model., 2017, 57, 1309–1320 |
| Bharate SB;* Singh B; Kachler S; Oliveira A; Kumar V; Bharate SS; Vishwakarma RA; Klotz KN; Gutiérrez de Terán H. | Discovery of 7-(prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as novel non-nucleoside partial agonists for the A2A adenosine receptor: Prediction from molecular modeling | J. Med. Chem., 2016, 59, 5922-5928 |
| Sharma R; Patel N; Vishwakarma RA; Bharatam PV; Bharate SB* | Metal-free oxidative cyclization of acetophenones with diamines: A facile access to phenylpyridines | Chem. Commun., 2016, 52, 1009-1012 |
| Mahale S; Bharate SB;* Manda S; Joshi P; Bharate SS; Jenkins PR; Vishwakarma RA; Chaudhuri B. | Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a non-planar analog of fascaplysin inhibits Cdk4 and tubulin polymerization: Evaluation of in vitro and in vivo anticancer activity | J. Med. Chem., 2014, 57, 9658-9672 |
| Jain SK; Singh S; Khajuria A; Guru SK; Joshi P; Meena S; Nadkarni J; Singh A; Bharate SS; Bhushan S; Bharate SB*; Vishwakarma RA. | Pyrano-isochromanones as IL-6 inhibitors: Synthesis, in-vitro and in-vivo anti-arthritic activity | J. Med. Chem., 2014, 57, 7085−7097 |
| Mudududdla R; Sharma R; Abbat S; Bharatam PV; Vishwakarma RA; Bharate SB* | Synthesis of 2-phenylnaphthalenes from styryl-2-methoxybenzenes | Chem. Commun., 2014, 50, 12076-12079 |
| Bharate SB; Sawant SD; Singh PP; Vishwakarma RA. | Kinase inhibitors of marine origin | Chem. Rev., 2013, 113, 6761-6815 |
Patents
| Inventors/ Contributors | Title & patent number | Description | Year |
| Vishwakarma RA, Bharate SB, Bhushan S, Mondhe DM, Jain SK, Meena S, Guru SK, Pathania AS, Kumar S, Behl A, Mintoo MJ, Bharate SS, Joshi P. | Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof. US9932327B2, EP2986605.
|
Granted in US, EP
|
2018 |
| Bharate SB, Bhushan S, Mohammed S, Guru SK, Bharate SS, Kumar V, Mahajan G, Javed MM, Mondhe DM, Vishwakarma RA. | Fused pyrimidines as isoform-selective phosphoinositide-3-kinase-alpha inhibitors and process for preparation thereof, US10696688. | Granted in US | 2020 |
| Bharate SB, Kumar A, Manda S, Joshi P, Bharate SS, Wani A, Sharma S, Vishwakarma RA. | Alkylidene Phosphonate esters as P-glycoprotein inducers. US10377781B2, EP3209671. | Granted in US, EP
|
2019 |
| Bharate SB, Kumar A, Manda S, Joshi P, Bharate SS, Vishwakarma RA. | N-Substituted beta-carbolinium compounds as potent P-glycoprotein inducers. US10072009
|
Granted in US | 2018 |
| Jain SK, Sidiq T, Meena S, Khajuria A, Vishwakarma RA, Bharate SB. | Preparation of tetrahydro-2H-pyrano[3,2-c]isochromene-6-one analogs for the treatment of inflammatory disorders. US9777014B2, EP3004116, CA2913281 | Granted in US, EP, CA
|
2017-18 |
| Vishwakarma RA, Bharate SB, Bhushan S, Yadav RR, Guru SK, Joshi P. | 6-Aryl-4-phenylaminoquinazolines as phosphoinositide 3 kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. EP3110801B1 | Granted in EP | 2019 |
| Bharate SB, Kumar A, Bharate JB, Joshi P, Wani A, Mudududdla R, Sharma R, Vishwakarma RA. | Polyalkylated acyl and benzoyl-phloroglucinols as potent P-glycoprotein inducers. US10202326B2, EP15774722.1 | Granted in US, EP
|
2019 |
| Vishwakarma R, Jain SK, Bharate SB, Dar AH, Khajuria A, Meena S, Bhola SK, Qazi AK, Hussain A, Sidiq T, Uma Shaanker R, Ravikanth G, Vasudeva R, Patel MK, Ganeshaiah KN. | New chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders. US9776989B2, EP2984078
|
Granted in US, EP
|
2017 |
| Bharate SS, Kumar V, Singh R, Rani S, Gupta M, Kumar A, Bharate SB, Vishwakarma RA. | Sustained release formulations of Crocus sativus. IN201711036084, WO2019077621A1, EP18796784.9, US16753969 | Patent licensed to industry | 2018 |
| Thompson CM, Bharate SB. | Benzothiazole-based pyridinium compounds. US9255091B2
|
Patent granted in US | 2016 |
Awards and Honours
-
- Listed among top 2% World’s Scientists (Field: medicinal & biomolecular chemistry) in a analysis done of Stanford University (PLOS Biology, October 2020).
- MEDI Young Investigator Award from American Chemical Society 2020
- OPPI Young Scientist Award 2019
- CSIR Young Scientist Award 2016
- NASI-Young Scientist Platinum Jubilee Award 2015
- RSC – OSDD Ambassador 2014
- Several Innocentive Awards 2009-2010 (from Innocentive Inc. USA)
Professional memberships:
- Life Member of Chemical Research Society of India (CRSI) – 2020 onwards
- Honorary membership of American Chemical Society (ACS) (2016-2019) (2020-2021)
- Member of American Chemical Society (ACS) 2010-2011
- Member of Royal Society of Chemistry (RSC) – Affiliate member (honorary membership)
- Life Member of Maharashtra State Pharmacy Council (MSPC)
- Life Member of Indian Society for Mass Spectrometry (ISMAS)
Students
| Photo | Name | Area of Interest | Position |
 |
Dr. Venu Sharma | Medicinal chemistry of natural products to discover anticancer lead candidates | DST Women Scientist |
 |
Vijay K. Nuthakki | Natural products driven drug discovery for Alzheimer’s disease | Project Associate; AcSIR PhD Student |
 |
Rinky Raghuvanshi | Natural products driven drug discovery for Alzheimer’s disease | UGC-SRF; AcSIR PhD Student |
 |
Mohit Sharma | Rational drug design, and synthesis of potential anti-Alzheimer agents | Project Fellow; AcSIR PhD Student |
 |
Razia Banoo | Rational drug design, and synthesis of potential anti-Alzheimer agents | UGC-JRF; AcSIR PhD Student |
 |
Deendyal Bhurta | Medicinal chemistry of natural products to discover Cdk inhibitors | AcSIR PhD Student |
 |
Ankita Sharma | Natural products driven drug discovery for Alzheimer’s disease | AcSIR PhD Student |
| Alumni (PhD completion year) | Current affiliation |
| Ramesh Mudududdla (2016) | Postdoc, Monash University, Australia |
| Rammohan R. Yadav (2016) | Scientist at Sci Life Sciences Hyderabad |
| Sudhakar Manda (2016) | Scientist at Aurigene discovery, Bangalore |
| Rohit Sharma (2017) | Assistant Professor, Dr. Y.S. Parmar University, HP, India |
| Prashant Joshi (2018) | Assistant Professor, NMIMS Shirpur, Maharashtra |
| Abubakar Wani (2019) | Postdoc, Washington University, USA |
| Shreyans K. Jain (2015) | Asst Prof, IIT-BHU Varanasi |
| Baljinder Singh (2016) | Postdoc, Northeastern University Boston, USA |
| Mohd Shabber (2016) | Postdoc, Ohio State University, USA |
| Rajni Sharma (2017) | Research Associate, DRDO |
| Mohd. Abdullaha (2021) | – |
Technologies out licensed / IND applications filed
- IIIM-141, nutraceutical product out-licensed to the industry (in July 2018)
- IIIM-160, phytopharmacetuical product: out-licensing to the industry is in progress (Oct 2020) as a nutraceutical.
- IIIM-290 (NCE lead for pancreatic cancer), IND approved by DCGI (May 2020)
- IIIM-160 (phytopharmaceutical lead for rheumatoid arthritis) – IND application filed to DCGI in April 2020
- Developed the process for synthesis of niclosamide (drug being repurposed for COVID-19).