Fermentation and Microbial Biotechnology

Our main focus is on exploration and exploitation of India`s rich microbial diversity (both cultivable and uncultivable) for novel bioactive molecules and biocatalysts with application in health, agriculture and industry, and their overproduction using conventional and molecular biology tools. Our aim is R&D leading to the production of industrially important biopharmaceuticals including bioactive, biocatalysts, biotransformation of drug/intermediates, nutraceuticals and agriculture crop yield improvement through microbial fertilizers, biopesticides and minerals salts. Main activities include production, process optimization, scale up, downstream processing, purification & characterization of biomolecules for industrial applications.

  • Vision: To become recognized Centre of Excellence for Industrial microbiology research
  • Mission: Helping Indian industries for scale up of processes and building confidence in Indian industry through transferring technology and training on microbial fermentation processes
  • Isolation, characterization & identification of microbes for repository of psychrotrophic, mesophilic and thermo-tolerant microorganism including bacteria, actinomycetes, fungi and endophytes,
  • Screening for specific microbial enzymes and secondary metabolites, enantio/ regio-specific biotransformations
  • Indigenous novel expression system for heterologous protein production, Hyperexpression and protein engineering
  • Strain development for production of bioactive molecules and novel enzymes using traditional and molecular tools (genomics and proteomics)
  • Multi-functional fermentation scale up facility from lab scale to 500L capacity with compatible downstream processing
  • Technology development for agricultural crop yield increase by biofertilizers, biocontrol agents and micronutrients.
  • Well equipped Microbiology laboratory to carryout cutting edge research on isolation and characterization of microorganisms and their bioactive metabolites
  • State of Art Micro-processor controlled fermentation facility upto 500L scale with supporting down-stream processing facilities for bacterial, fungal and yeast based products.
  • State-of–art equipments required for Microbiology, Enzymology and Bio-process development
  • State-of-the-art facility to undertake nucleic acid amplification, biomarker development, gene cloning, heterologous gene expression
  • Metabolic pathway engineering for production of novel/ desired metabolites

Dr. Asha Chaubey
Principal Scientist / HOD FMB Division

Dr. Sundeep Jaglan
Principal Scientist

Dr. Saurabh Saran

Dr. Saurabh Saran
Principal Scientist

Dr. Meenu Katoch
Senior Scientist

Dr. Vikash Babu
Senior Scientist

Dr. Vinod Kumar
Scientist

Mrs. Urmila Jamwal
Principal Technical Officer

MLP1008: Bioprospecting microbial species from unexplored ecological niches for novel molecules and enzymes (MLP-1008)

Development of Zinc gluconate-Vitamin C formulation for immunity improvement and management of Corona Virus Disease (COVID-19) (MLP-110004)

Deciphering the mechanism(s)of host-entophytes’ coevolution, enhanced secondary metabolite production and crop productivity (MLP-0048)

CSIR-Aroma mission (HCP-0007)

An essential oil based formulation/ product for Post harvest storage of fruits (MLP110005)

Nucleoside as biofilm inhibitors of bacteria and to understand the underlying mechanism of action

Induction of secondary metabolites in microbes via co-cultivation based elicitation (GAP-2175)

Development and validation of fermentation based immunomodulatory AYUSH kwath formulation (GAP-3105)

Fermentation based process development for the production of tacrolimus drug (GAP-2187)

Development of nutraceutical products from algae (CLP-0309)

Authors Title Journal
Devtulya Chander, Jasmine Kour Khosla, Diksha Koul, Md. Mehedi Hossain, Mohd Jamal Dar and Asha Chaubey

Purification and characterization of thermoactive serratiopeptidase from Serratia marcescens AD-W2

AMB Express
Rahul V Singh, Hitesh Sharma, Ananta Ganjoo, Amit Kumar and Vikash Babu Novel amidase catalysed process for the synthesis of vorinostat drug J Applied Microbiology
Diksha Koul, Devtulya Chander,  Ravi  S. Manhas and Asha Chaubey Isolation and characterization of Serratiopeptidase producing bacteria from Mulberry phyllosphere Current Microbiology
Manoj Kumar, Nipunta Tanoj and Saurabh Saran A Modified, Efficient and Sensitive pH Indicator Dye Method for the Screening of Acid-Producing Acetobacter Strains Having Potential Application in Bio-Cellulose Production Applied Biochemistry and Biotechnology
Singh G, Singh J, Singamaneni V, Singh SK, Gupta P, Katoch M Serine-glycine-betaine, a novel dipeptide from an endophyte Macrophomina phaseolina: Isolation, bioactivity and biosynthesis J Appl Microbiol 2020
Singh G, Katoch M Antimicrobial activities and mechanism of actionof Cymbopogon khasianus (Munro ex Hackel)Bor essential oil BMC Comp. Med Therapies
Divya Arora, Prasoon Gupta, Sundeep Jaglan, Catherine Roullier, Olivier Grovel, Samuel Bertrand Expanding the chemical diversity through microorganisms co-culture: Current status and outlook

Biotechnology Advances

 

Shifali Chib, Ashish Dogra, Utpal Nandi&Saurabh Saran Consistent production of kojic acid from Aspergillus sojae SSC-3 isolated from rice husk Molecular Biology Reports
Shifali Chib, Ashish Dogra, Utpal Nandi&Saurabh Saran Consistent production of kojic acid from Aspergillus sojae SSC-3 isolated from rice husk Molecular Biology Reports
Nisha Sharma, Manoj Kushwaha, Divya Arora, Shreyans Jain, Venugopal Singamaneni, Sonia Sharma, Ravi Shankar, Shashi Bhushan, Prasoon Gupta, Sundeep Jaglan New cytochalasin from Rosellinia sanctae‐cruciana, an endophytic fungus of Albizia lebbeck

Journal of Applied Microbiology

 

 

Format for Patents (max 10)

Inventors/ Contributors Title Description Year
Vikash Babu, Rahul Vikram Singh, Hitesh Sharma, Amit Kumar, Shaista Sultan, Varun Pratap Singh, Bhahwal Ali Shah, Parvinder Pal Singh Enzymatic Process for the Preparation of Vorinostat Filed (IN 201911047261) 2019
Deepika Singh, Sharma Jai Parkash, Sundeep Jaglan, Hamid Dar Abid, Anamika Khajuria, Pratap Singh Varun, Asrey Vishwakarma Ram

Brachiatins D and process for their production thereof

 

United States Patent

US 9,624,266 B2

 

  2017
Meenu Katoch, Ruchika  Sharma, Gulam Nabi Qazi Inducible Catalase R Promoter Useful for Expressing Foreign Genes in Fungus Present invention discloses an inducible promoter being derived from a gene encoding catalase inA. niger for expression of a protein in filamentous fungus, preferably Aspergillus. It has not so far described and used for heterologous protein production. 2012
Meenu Katoch, Gulam Nabi Qazi Glucose Oxidase Promoter For Use In Aspergillus Present invention discloses an effective promoter being derived from a gene encoding glucose oxidase inA. niger for expression of a protein in filamentous fungus, preferably Aspergillus. The A. niger glucose oxidase is an oxido-reductase enzyme whose promoter is not so far described and used for heterologous protein production. 2009