Microbial Biotechnology Division

Our main focus is on exploration and exploitation of India`s rich microbial diversity (both cultivable and uncultivable) for novel bioactive molecules and biocatalysts with application in health, agriculture and industry, and their overproduction using conventional and molecular biology tools. The group is also working on development of new fungal expression systems, Diagnostic Microbiology and expression of cryptic biosynthetic pathways of microorganisms.

  • Exploration of microbes for human healthcare
  • Development of microbial repository from extreme environments and endophytes of endemic plants
  • To study the plant- microbe interactions for disease management, adaption and optimum production of key metabolites in selected medicinal plants
  • Bioprospecting and characterization of novel endophytes and other microbes for bioactives and biocatalysts
  • Production of microbial enzyme and high value microbial products from wild type and  genetically modified strains
  • Repository of psychrotrophic, mesophilic and thermo-tolerant microorganism including bacteria, actinomycetes, fungi and endophytes
  • Metagenomic libraries of environmental samples from unique niches
  • High altitude medicinal plant gene bank
  • Indigenous in vitropropagation methods for many high value medicinal plants
  • Indigenous methods for rapid molecular detection of several microbial pathogens
  • Indigenous novel expression system for heterologous protein production in fungi
  • Hyperexpression and protein engineering
  • Strain development for production of bioactive molecules and novel enzymes using traditional and molecular tools (genomics and proteomics)
  • Well equipped Microbiology laboratory to carryout cutting edge research on isolation and characterization of microorganisms and their bioactive metabolites
  • State-of-the-art facility to undertake nucleic acid amplification, biomarker development, gene cloning, heterologous gene expression
  • Metabolic pathway engineering for production of novel/ desired metabolites

Dr. Asha Chaubey
Principal Scientist

Dr. Meenu Katoch
Senior Scientist

Dr. Sundeep Jaglan
Senior Scientist

Mr. Rajinder Kumar
Senior Technical Officer

MLP 1008 Bioprospection and development of technologies for the production of bioactive molecules from the microbial wealth of north western region.

GAP-2175 Induction of Secondary Metabolites in microbes via co-cultivation based elicitation

Authors Title Journal
Singh G, Singh J, Singamaneni V, Singh SK, Gupta P, Katoch M Serine-glycine-betaine, a novel dipeptide from an endophyte Macrophomina phaseolina: Isolation, bioactivity and biosynthesis J Appl Microbiol 2020
Singh G, Katoch M Antimicrobial activities and mechanism of actionof Cymbopogon khasianus (Munro ex Hackel)Bor essential oil BMC Comp. Med Therapies 2020
Divya Arora, Prasoon Gupta, Sundeep Jaglan, Catherine Roullier, Olivier Grovel, Samuel Bertrand Expanding the chemical diversity through microorganisms co-culture: Current status and outlook Biotechnology Advances

2020

 

Katoch M#*, Singh D, Kapoor KK, Vishwakarma RA Trichoderma lixii (IIIM-B4), an endophyte of Bacopa monnieri L. producing peptaibols BMC Microbiol 2019
Arora N, Kumar S, Satti N, Ali A, Gupta P, Katoch M A strain of Streptomyces sp. isolated from rhizospheric soil of Crataegus oxycantha producing Nalidixic acid, a synthetic antibiotic. J Appl Microbiol 2018; 124, 1393-1400.
Vishal Sharma, Venugopal Singamaneni, Nisha Sharma, Amit Kumar, Divya Arora, Manoj Kushwaha, Shashi Bhushan, Sundeep Jaglan, Prasoon Gupta Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill Bioorganic & Medicinal Chemistry Letters  2018

 

Nisha Sharma, Manoj Kushwaha, Divya Arora, Shreyans Jain, Venugopal Singamaneni, Sonia Sharma, Ravi Shankar, Shashi Bhushan, Prasoon Gupta, Sundeep Jaglan New cytochalasin from Rosellinia sanctae‐cruciana, an endophytic fungus of Albizia lebbeck Journal of Applied Microbiology 2018

 

Manoj Kushwaha, Shreyans K Jain, Nisha Sharma, Vidushi Abrol, Sundeep Jaglan, Ram A Vishwakarma

 

Establishment of LCMS based platform for discovery of quorum sensing inhibitors: signal detection in Pseudomonas aeruginosa PAO1 ACS Chemical Biology

2018

 

Divya Arora, Gousia Chashoo, Venugopal Singamaneni, Nisha Sharma, Prasoon Gupta, Sundeep Jaglan Bacillus amyloliquefaciens induces production of a novel blennolide k in co-culture of Setophoma terrestris Journal of Applied Microbiology 2018

 

Singh G, Katoch A, Razak M, Goswami A, Katoch M Bioactive and biocontrol potential of endophytic fungi associated with Brugmansia aurea Lagerh. FEMS Microbiol Letters 2017
Wani Naiem; Singh G, Shankar S; Sharma S, Katoch M, Rai R Short Hybrid Peptides Incorporating β- and γ-Amino Acids as Antimicrobial Agents. Peptides 2017
Katoch M, Bindu K, Phull S, Verma MK An endophytic Fusarium sp. isolated from Monarda citriodora producing industrially important plant like Volatile Organic Compound-hexanal. Microbiology 2017
 

 

Format for Patents (max 10)

Inventors/ Contributors Title Description Year
Deepika Singh, Sharma Jai Parkash, Sundeep Jaglan, Hamid Dar Abid, Anamika Khajuria, Pratap Singh Varun, Asrey Vishwakarma Ram Brachiatins D and process for their production thereof

 

United States Patent

Patent No.: US 9,624,266 B2

 

  2017
Meenu Katoch, Ruchika  Sharma, Gulam Nabi Qazi Inducible Catalase R Promoter Useful for Expressing Foreign Genes in Fungus Present invention discloses an inducible promoter being derived from a gene encoding catalase in A. niger for expression of a protein in filamentous fungus, preferably Aspergillus. It has not so far described and used for heterologous protein production. 2012
Meenu Katoch, Gulam Nabi Qazi Glucose Oxidase Promoter For Use In Aspergillus Present invention discloses an effective promoter being derived from a gene encoding glucose oxidase in A. niger for expression of a protein in filamentous fungus, preferably Aspergillus. The A. niger glucose oxidase is an oxido-reductase enzyme whose promoter is not so far described and used for heterologous protein production. 2009
Bikram Singh, Meenu Katoch, Raja Ram, Aizaz Azghar Zaidi Aescin: a new antiviral agent from Indian horse chestnut (Aesculus indica)

6 countries

 

The present invention relates to a composition containing aescin obtained from Indian horse chestnut (Aesculus indica) as an antiviral agent. More particularly this invention relates to β-aescin present in horse chestnut (Aesculus indica seeds) which is a natural source to inhibit cucumber mosaic virus. The antiviral activity of β-aescin against CMV is better than Amantadine, 2- Thiouracil, Zidovudine and Acyclovir, commercial antiviral products available in the market. Another usage of the present invention is meaningful utilization of Indian horse chestnut (Aesculus indica seeds) growing wild in temperate region for production of β-aescin, which has been identified as a potent antiviral agent. 2007-09
Meenu Katoch, Raja Ram, Aizaz Azghar Zaidi Development of diagnostic kit for the detection of Bean Yellow Mosaic Virus The present invention relates to develop a diagnostic kit for the detection of Bean Yellow Mosaic Virus. 2002
Meenu Katoch, Raja Ram, Aizaz Azghar Zaidi A process for developing Diagnostic Kit for detection of Bean Yellow Mosaic Virus in commercial crop The present invention relates to a process for developing Diagnostic Kit for detection of Bean Yellow Mosaic Virus in commercial crop. 2002