Inflammation-Pharmacology Division

Emerging trends indicate life style disorders like diabetes mellitus, obesity and rheumatoid arthritis are chronic inflammatory conditions. Herbal extracts/preparations/derivatives of natural compounds form a promising group of agents, from the times of Ayurveda and other ancient Indian medical systems, especially for the treatment of chronic diseases/inflammatory conditions. The research focus of our group is towards addressing these diseases. The main research activities of our group involves discovery and development of natural products as promising therapies for addressing inflammation with an aim to develop anti-diabetic/ anti-obesity/ pain relieving medications

Discovery and development of products/solutions to positively benefit the quality of life of individuals with chronic inflammatory diseases like diabetes, rheumatoid arthritis, obesity and pain associated with these conditions.

 

  • In vitro, in vivo anti-inflammatory activities in cell culture models and rodent models respectively.
  • In vivo anti-rheumatoid arthritis models (CIA induced arthritis in mice)
  • In vivo rodent models of diabetes and obesity
  • Histopathology investigations

Dr. Zabeer Ahmed
Sr. Principal Scientist

Dr. Sreedhar Madishetti
Scientist

Asha Bhagat
Sr. Tech. Off. (III)

  • Cell culture facility
  • Flourescence Microscope
  • State-of-the-Art Animal House Facility
Authors Title Journal
Gupta, S.;  Ahsan, A. U.;  Wani, A.; Khajuria, V.; Nazir, L. A.; Sharma, S.;  Bhagat, A.; Sharma, S.;  Bhardwaj, P. R.;  Peerzada, K. J.;  Shah, B.A.;  Ahmed, Z. The amino analogue of ß-Boswellic Acid efficiently attenuates the release of pro-inflammatory mediators than its parent molecule through the suppression of NF-κB/IκBa signaling axis Epub ,Cytokine (2018), 107:93-104
Gupta S, Khajuria V, Wani A, Nalli Y, Bhagat A, Ali A, Ahmed Z. Murrayanine Attenuates Lipo polysaccharide-induced Inflammation and Protects Mice from Sepsis-Associated Organ Failure Basic and clinical pharmacology & toxicology 124(4):351-359; 2019
Mowkshi Khullar, Ankita Sharma, Abubakar Wani, Neha Sharma,Neelam Sharma,B.K. Chandan,Ajay Kumar, Zabeer Ahmed; Acteoside ameliorates inflammatory responses through NFkB pathway in alcohol induced hepatic damage International Immuno-pharmacology; 69, 109-117, 2019
Singh, U.; Chashoo, G.; Khan, S. U.; Mahajan, P.;  Nargotra, A.;  Mahajan, G.; Singh, A.; Sharma, A.;  Mintoo, M. J.;  Guru, S. K.;  Aruri, H.;  Thatikonda, T.; Sahu, P.; Chibber, P.; Kumar, V.;  Mir, S. A.;  Bharate, Sonali S. ; Madishetti, S.; Nandi, U.;  Singh, G.;  Mondhe, D. M.;  Bhushan, S.;  Malik, F.;  Mignani, S.; Vishwakarma , R. A. and Singh., P. P Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model J. Med. Chem. (2017), 60, 9470−9489
Tripathy, B.; Satyanarayana, K. S. ; Khan, A.;  Ahmed, Z.; Sreedhar, M. ; Sawhney, G.;  Raja, K Biological evaluation of crude plant extracts for antiadipogenenic activity in 3t3 l1 cells IJIPSR, (2019), 7(01),14-29. Doi: 10.21276/Ijipsr.2019.07.01.76
Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi, Mubashir Hussain Masoodi Oreganum Vulgare: In-vitro assessment of cytotoxicity, Molecular docking studies, Antioxidant, and evaluation of anti-inflammatory activity in LPS stimulated RAW 264.7 cells

 

Medicinal Chemistry, 2020, 16, 1-11

DOI : 10.2174/1573406416666200904110828

Reyaz Hassan Mir & Gifty Sawhney & Faheem Hyder Pottoo & Roohi Mohi-ud-din & Sreedhar Madishetti &

Sanjay M. Jachak & Zabeer Ahmed & Mubashir Hussain Masoodi

Role of environmental pollutants in Alzheimer’s disease: a review Environmental Science and Pollution Research doi:10.1007/s11356-020-09964-x Published online: 27 July 2020
Vidushi Khajuria, Shilpa Gupta, Neha Sharma, Harshita Tiwari, Subhash Bhardwaj, Prabhu Dutt, Naresh Satti, Amit Nargotra, Asha Bhagat, Zabeer Ahmed., Kaempferol-3-o-ß-D-Glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model International Immunopharmacology 57,  62–71, 2018
Gurleen Kour, Anil Kumar, Parvinder Pal Singh, Sumit Sharma, Asha Bhagat,,  Zabeer Ahmed., Biopharmaceutic parameters, pharmacokinetics, transport and CYP-mediated drug interactions of IIIM-017 A novel nitroimidazooxazole analogue with anti-tuberculosis activity European Journal of Pharmaceutical Sciences, 2017
Nargotra, A., Sharma, S., Alam M.I, Ahmed, Z., Bhagat, A., Taneja, S.C. et. al In silico identification  of Viper PhospholipaseA2 inhibitors: validation by in vitro / in vivo studies J Mol Model; 12, 3063-73; 2011
  • GAP 2180 – PhyPhytopharmaceutical Development of Ficus semicordata-Ham. ex Sm. as per regulatory guidelines of DCGI – ongoing 2018-2021; DBT
  • Investigation on the anti-obesity activity of Argyreia nervosa, Garcinia species
  • Discovery of cannabinoids and their derivatives from Cannabis sativa for the management of chronic disease conditions like rheumatoid arthritis/neuropathic pain