Dr. Zabeer Ahmed

Inflammation Pharmacology Division & Head Engineering Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: zabeerahmed[at]gmail[dot]com; zahmed[at]iiim[dot]res[dot]in; zahmed[at]iiim[dot]ac[dot]in

Positions Held  
Position Held Date Organization
Sr. Principal Scientist 2016- till date CSIR-IIIM
Principal Scientist 2011 - 2016 CSIR-IIIM
Senior Scientist 2006 – 2011 CSIR-IIIM
Scientist 2002 – 2006 CSIR-IIIM
Jr. Scientist /Scientist B 1998 – 2002 CSIR-IIIM
Honours & Awards  
  • Knowledge Partnership Award Scheme of CSIR, 2007 – Visited National Centre for Natural Product Research (NCNPR), School of Pharmacy, University of Mississippi, USA for three months w.e.f. 30th August, 2007 to 29th Nov., 2007

Membership  
  • Indian Pharmacological Society : Life Member

Major research areas:

efflux pumps

Twenty years research experience in the area of drug design and discovery from herbal and synthetic sources. During this period actively worked on following important research projects:

I Development of traditional herbal drugs as Immunomodulators/Adaptogens.
II Development of anti-diabetic agents.
III Prospecting biodiversity for its chemistry and bioactivity.
IV Newer Scientific Herbal Preparation for Global Positioning.
V Herbal Based Preparations for Degenerative Disorders: Diabetes mellitus type II (NIDDM) with emphasis on insulin sensitization and Herboprint-A tool for standardization of herbal medicine.
VI Golden Triangle Partnership Programme.
VII Design, Synthesis of Novel Sugar-Oxasteroid-Quinones as Non-Steroidal Dissociated Glucocorticoid Receptor (GR) Agonists for Rheumatoid Arthritis.
VIII Studied the Anti-inflammatory molecules from Boswellia serrata for Rheumatoid Arthritis.
IX Development of boswellic acid analogue as Anti-arthritic agent through combinatorial approach.

 

PATENTS: 05

TECHNOLOGY TRANSFER

Under the CSIR-New Millennium Indian Technology Leadership Initiative (CSIR-NMITLI) programme, as a Co-Principal Investigator at CSIR-IIIM, Jammu, a herbal based formulation was developed for treatment of diabetes. The knowhow has been transferred to Viridis Biopharma Pvt Ltd., Mumbai. Licensing agreement for the purpose was signed between CSIR and Viridis on August 8, 2013.

Ongoing research:

The anti-inflammatory activity of natural products or their derivatives like Kaempferol-3-o-β-glucuronate (Khajuria et al., 2018) and Murrayanine (Gupta et al., 2017) were explored

efflux pumps

efflux pumps

  Kaempferol-3-o-β-glucuronate

Figure 1: Anti-inflammatory activity of Kaempferol-3-o-β-glucuronate in mice

 

efflux pumpsMurrayanine

Figure 3 : Inhibition of LPS induced mortality by Murrayanine in mice

Current Research Projects:

  • Development of boswellic acid analogue as Anti-arthritic agent through combinatorial approach, SERB – DST, 2017 onwards.

  • Phytopharmaceutical development of Ficus semicordata Buch.-Ham. ex Sm. as per regulatory guidelines of DCGI, DBT, 2018 onwards.

  • Formulation, Pre-clinical and Clinical Development of a Antidiabetic phytopharmaceutical agent, based on the phytopharmaceutical guidelines, from Enicostemma littorale Blume, a lead from the earlier CSIR NMITLI Programmes, CSIR, 2019 onwards.

Publications

  • Ahmed, Z.;  Bhagat , A.; Gupta, O. P.; Gupta , K. K.; Gandhi ,R.; Qazi, G. N. Insulin-Secretagogue Fraction of Argyrolobium roseum. Diabetologia Croatica, (2008), 37-1.

  • Ahmed, Z.; Chishti, M. Z.;  Johri, R. K.; Bhagat, A.; Gupta, K. K.; Gandhi R. Antihyperglycemic and antihyperlipidemic activity of aqueous extract of Dioscorea bulbifera Tubers. Diabetologia Croatica (2009), 38-3.

  • Kant, T.H.; Ahmed, Z.; Pooja .; Samanta, K.C. Anti hyperglycaemic activity of petroleum ether extract & ethyl acetate extract of Sarcococca saligna.  Int J Curr Pharm Res. (2011,) 3, 1, 26-29.

  • Ahmed, Z.. Modulation of antioxidant enzymes and inflammatory cytokines: possible mechanism of antidiabetic effect of ginger; Olufemi A Morakinyo, Abidemi James James Akindele. African Journal of Biomedical Research ( 2011),14(3), 186-192.

  • Kumar, Kour G.;  Singh, P.P.;  Sharma, S.;  Bhagat, A.; Vishwakarma ,R.A.;  Zabeer, A . Preclinical comprehensive physicochemical and pharmacokinetic profiling of novel nitroimidazole derivative IIIM-019 - A potential oral treatment for tuberculosis .Pulmonary Pharmacology & Therapeutics (2016), 40; 44-51.

  • Chinthakindi , P. K. .; Singh, J .;  Gupta , S .; Nargotra , A.; Mahajan , P.;  Kaul , A.;  Ahmed, Za.;  Koul , S.; Sangwan., P. L. Synthesis of a-santonin derivatives for diminutive effect on T and B-cell proliferation and their structure activity relationships. European Journal of Medicinal Chemistry (2016), 1-12.

  • Kour, G.; Chandan, B. K .; Khullar, M.;  Munagala, G.; Singh, P. P.; Bhagata, A.;  Gupta, A. P.; Vishwakarma, R. A.  Ahmed, Z . Development and validation of a highly sensitive LC–MS/MS-ESI method for quantification of IIIM-019—A novel nitroimidazole derivative with promising action against Tuberculosis: Application to drug development. Journal of Pharmaceutical and Biomedical Analysis; American Journal (2016), 124, 26–33.

  • Sharma , S.;  Gupta , S.;  Khajuria , V.;  Bhagat , A.; Ahmed, Z.; Shah, B.A. Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-a and IL-6. Bio-organic and Medicinal Chemistry Letters (2015), 26,695-698.

  • Sharma, D. K.;   Rah, B.;     Lambu, M.R.;  Hussain, A.;    Yousuf, S. K. ;   Tripathi, A. K.;  Singh, B.;   Jamwal, G.;   Ahmed, Z.;  Chanauria, N.;  Nargotra, A.;   Goswami , A.; and   Mukherjee, D. Design and synthesis of novel N,N′-glycoside derivatives of 3,3′-diindolylmethanes as potential antiproliferative agents. Med. Chem. Commun.( 2012), 3, 1082-1091.

  •  Nargotra, A., Sharma, S., Alam M.I, Ahmed, Z., Bhagat, A., Taneja, S.C. In silico identification  of Viper PhospholipaseA2 inhibitors: validation by in vitro / in vivo studies .et. al., J Mol Model(2011), 12, 3063-73.

  • Ahmed, Z. Modulation of antioxidant enzymes and inflammatory cytokines: possible mechanism of antidiabetic effect of ginger extracts; Olufemi A Morakinyo, Abidemi James James Akindele. African Journal of Biomedical Research (2011), 14(3), 186-192.

  • Kour, G.;  Kumar, A.;  Singh, P. P.; Sharma, S.;  Bhagat, Asha.;  Ahmed., Z. Biopharmaceutic parameters, pharmacokinetics, transport and CYP-mediated drug interactions of IIIM-017: A novel nitroimidazooxazole analogue with anti-tuberculosis activity . European Journal of Pharmaceutical Sciences (2017).

  • Khajuria, V.;  Gupta, S.;  Bhagat, A.;  Ahmed, Z.;  In-vitro assessment of Cytotoxicity, Antioxidant and Anti-inflammatory activities of Ficus palmate. Journal of Herbal Medicine (2017), [10.1016/j.hermed.2017.12.001].

  • Khajuria, V.;  Gupta, S.;  Sharma, N.;  Kumar, A.; Lone, N. A.  Khullar, M.;  Dutt, P.; Sharma, P.R.;  Bhagat, A.;  Ahmed, Z. Anti-inflammatory potential of hentriacontane in LPS stimulated RAW 264.7 cells and mice model. Biomedicine & Pharmacotherapy(2017), 92, 175–186.

  • Gupta, S.;  Ahsan, A. U.;  Wani, A.; Khajuria, V.; Nazir, L. A.; Sharma, S.;  Bhagat, A.; Sharma, S.;  Bhardwaj, P. R.;  Peerzada, K. J.;  Shah, B.A.;  Ahmed, Z. The amino analogue of ß-Boswellic Acid efficiently attenuates the release of pro-inflammatory mediators than its parent molecule through the suppression of NF-κB/IκBa signaling axis. Epub ,Cytokine (2018) ,107:93-104.

  • Khajuria, V.;  Gupta, S.;  Sharma, N.;  Tiwari, H.;  Bhardwaj, S.;  Dutt, P.;  Satti, N.; Nargotra, A.;  Bhagat, A.;  Ahmed, Z. Kaempferol-3-o-ß-D-Glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model. International Immunopharmacology (2018), 57,  62–71.

  • Gupta, S.; Khajuria, V.;  wani , A.; Nalli, Y.;  Bhagat, A.; Alid, A.;  Ahmed, Z.  Murrayanine Attenuates Lipopolysaccharide-induced Inflammation and Protects Mice from Sepsis-Associated Organ Failure. Basic and Clinical Pharmacology and Toxicology, (2018) Accepted.

  • Tripathy, B.; Satyanarayana, K. S. ; Khan, A.;  Ahmed, Z.; Sreedhar, M. ; Sawhney, G.;  Raja, K. Biological evaluation of crude plant extracts for antiadipogenenic activity in 3t3 l1 cells, IJIPSR,(2019),7(01),14-29. Doi: 10.21276/Ijipsr.2019.07.01.76.

 

Group

  • Dr. Sreedhar Madishetti, Scientist

  • Mrs. Asha Bhagat, Senior Technical Officer (III)

  • Mrs. Neelam Sharma, Senior Technical Assistant

Students

Ms. Gurleen Kour Completed in 2018
Ms. Vidushi Khajuria Completed in 2019
Ms. Shilpa Gupta Development of boswelic acid analogues as anti-rheumatoid arthritis agents through combinatorial approach – Submitted

 

Ms. Sadhana Sharma

Ms. Mowkshi Khullar

Mr. Anil Kumar

     

Ms. Gifty Sawhney

Ms. Diksha Saroch

Mr. Amjed Mahmood


Facilities
1

Cell culture facility

2

Fluorescence Microscope