Dr. Utpal Nandi

PK-PD, Toxicology and Formulation Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: unandi[at]iiim[dot]ac[dot]in, utpalju[at]gmail[dot]com

Positions Held  
Position Held Date Organization
Scientist 2015 - Present CSIR-IIIM
Scientific Assistant 2012 - 2015 Indian Pharmacopoeia Commission, Ghaziabad.
Honours & Awards  
  • Qualified Graduate Aptitude Test in Engineering (GATE) with percentile 96.62 in 2007.

  • Awarded scholarship for pursuing Master of Pharmacy by UGC (2007-2009).

  • Awarded research fellowship by UGC (2009-2012).

  • Awarded with ‘Best Paper Award’ in ‘PHARMACON-2010’, Ranchi, India.

  • Presented ‘Second Best Poster’ by our group in ‘ICPDD-2018’, Solan, India.

Membership and Proffessional activities  
  • Registered Pharmacist under West Bengal Pharmacy Council.

  • Reviewer of Elsevier, Wiley, Bentham Science, Springer journals.

Major research areas:

Bioanalysis: Bioanalytical method development and validation of drug/drug-like molecule in biological matrices by HPLC or LC-MS/MS as per regulatory guidelines.

Pharmacokinetics(in-vitro/ex-vivo/in-situ): Biopharmaceutical profiling of drug/drug-like molecule viz. lipophilicity (logP/logD), permeability (PAMPA/perfusion model), transporter activities (P-gp), plasma protein binding, RBC partitioning, CYP inhibition.

Pharmacokinetics (in-vivo): Pharmacokinetic study of drug/drug-like molecule in animal models through different routes viz. bioavailability, dose proportionality, tissue distribution, toxicokinetics.

Drug interaction: Effect of natural products (druggable/dietary supplement/food additive) on pharmacokinetics of drugs under the purview of enhancement in plasma concentration of drugs for improved efficacy.

Toxicity study: Acute and sub-chronic toxicity study in rodents as per regulatory guidelines.


Click here for complete list.

  • Sharma, A.; Gour, A.; Bhatt, S.; Rath, S.K.; Malik, T.A.; Dogra, A.; Sangwan, P.L.; Koul, S.; Abdullah, S.T.; Singh, G.; Nandi, U.; Effect of IS01957, a para-coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy. Drug Development Research (2019). [Accepted]

  • Khan, I.A.; Singh, A.; Mindala, D.P.; Meena, S.; Vij, B.; Yadav, A.K.; Roy, S.; Nandi, U.; Katare, A.K.; Jaglan, S.; Singh, D.; Gupta, A.P.; Gupta, P.; Singh, S.; Tikko, M.K.; Singh, G.; Vishwakarma, R.A. Preclinical development of gastro-protective botanical candidate from Woodfordia fruticosa: Chemical standardization, efficacy, pharmacokinetics and safety pharmacology. Journal of Ethnopharmacology (2019). [Accepted]

  • Reddy, G.L.; Dar, M.I.; Hudwekar, A.D.; Mahajan, P.; Nargotra, A.; Baba, A.M.; Nandi, U.; Wazir, P.; Singh, G.; Vishwakarma, R.A.; Syed, S.H.; Sawant, S.D. Design, Synthesis and Biological Evaluation of Pyrazolopyrimidinone Based Potent and Selective PDE5 Inhibitors for Treatment of Erectile Dysfunction. Bioorganic Chemistry (2019). [Accepted]

  • Magotra, A.; Gour, A.; Sharma, D.K.; Dash, A.K.; Singh, G.; Mukherjee, D.; Nandi, U. Pharmacokinetic evaluation of medicinally important synthetic N, N′ diindolylmethane glucoside: Improved synthesis and metabolic stability. Bioorganic & Medicinal Chemistry Letters (2019), 29(8), 1007-1011.

  • Kotwal, P.; Magotra, A.; Dogra, A.; Sharma, S.; Gour, A.; Bhatt, S.; Wazir, P.; Singh, P.P.; Singh, G.; Nandi, U. Assessment of preclinical drug interactions of bedaquiline by a highly sensitive LC-ESI-MS/MS based bioanalytical method. Journal of Chromatography B (2019), 1112, 48-55.

  • Dogra, A.; Bhatt, S.; Magotra, A.; Sharma, A.; Kotwal, P.;  Gour, A.; Wazir, P.; Singh, G.; Nandi U. Intervention of curcumin on oral pharmacokinetics of daclatasvir in rat: A possible risk for long‐term use. Phytotherapy Research (2018), 32(10), 1967-1974.

  • Singh, A.; Thatikonda, T.; Kumar, A.; Wazir, P.; V, V.; Nandi, U.; Singh, P.P.; Singh, S.;  Gupta, A.P.; Tikoo, M.K.; Singh, G.; Vishwakarma, R. Determination of ZSTK474, a novel Pan PI3K inhibitor in mouse plasma by LC–MS/MS and its application to Pharmacokinetics. Journal of Pharmaceutical and Biomedical Analysis (2018), 149, 387-393.

  • Magotra, A.; Sharma, A.; Singh, S.; Ojha, P.K.; Kumar, S.; Bokolia, N.; Wazir, P.; Sharma, S.; Khan, I.A.; Singh, P.P.; Vishwakarma, R.A.; Singh, G.; Nandi, U. Physicochemical, pharmacokinetic, efficacy and toxicity profiling of a potential nitrofuranyl methyl piperazine derivative IIIM-MCD-211 for oral tuberculosis therapy via in-silicoin-vitroin-vivo approach. Pulmonary Pharmacology & Therapeutics (2018), 48, 151-160.

  • Sharma, A.; Magotra, A.; Rath, S.K.; Wazir, P.; Nandi, U.; Koul, S.; Sangwan, P.L.; Gupta, A,P.; Singh, G. In-vitro and in-vivo pharmacokinetics of IS01957, p-coumaric acid derivative using a validated LC–ESI–MS/MS method in mice plasma. Journal of Pharmaceutical Investigation (2018), 48(5), 565-574.

  • Sharma, A.; Magotra, A.; Dogra, A.; Rath, S.K.; Rayees, S.; Wazir, P.; Sharma, S.; Sangwan, P.L.; Singh, S.; Singh, G.; Nandi, U. Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception. Regulatory Toxicology and Pharmacology (2017), 91, 216-225.

  • Magotra, A.; Sharma, A.; Gupta, A.P.; Wazir, P.; Sharma, S.; Singh, P.P.; Tikoo, M.K.;  Vishwakarma, R.A.; Singh, G.; Nandi, U. Development and validation of a highly sensitive LC-ESI-MS/MS method for estimation of IIIM-MCD-211, a novel nitrofuranyl methyl piperazine derivative with potential activity against tuberculosis: Application to drug development. Journal of Chromatography B (2017), 1060, 200-206

  • Nandi, U.; Dan S.; Pal, T.K. Development and validation of a liquid chromatography–mass spectrometry method for simultaneous determination of metoprolol and telmisartan in rat plasma and its application to pharmacokinetic study. Journal of Pharmaceutical Investigation (2015), 45(3), 329-340.

Book chapters

  • Dogra, A.; Mandal, U.K.; Nandi, U. Chapter on ‘Pharmacognosy, phytochemistry and pharmacology of Dysoxylum binectariferum’ in the book entitled ‘Recent Progress in Medicinal Plants’ (2018) Studium Press (In Press)

  • Gorain, B.; Bhattamishra, S.K.; Choudhury, H; Nandi, U.; Pandey M. Chapter on ‘Overexpressed receptors and proteins in lung cancer’ in the book entitled “Nanotechnology-based targeted drug delivery systems for lung cancer’ (2018)  Elsevier (In Press)

Current Students

Mr. Ashish Dogra, SRF
Ms. Pankul Kotwal, JRF
Ms. Shipra Bhatt, JRF
Mr. Abhishek Gour, Inspire Fellow

Facilities in the laboratory
Analytical balance
Water purification system
pH meter
Perfusion pump
Refrigerated centrifuge
Vacuum drying system

Facilities in the Department
Multimode plate reader
Automated hematology analyzer
Analgesiometer (Hot plate)
Automated biochemical analyzer
Analgesiometer (Tail Flick)
Automated urine analyzer
Optical microscope
Deep freezer
Shaking water bath
Ultrasonic homogenizer