Dr. Utpal Nandi

PK-PD, Toxicology and Formulation Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: unandi[at]iiim[dot]ac[dot]in, utpalju[at]gmail[dot]com

Positions Held  
Position Held Date Organization
Scientist 2015 - Present CSIR-IIIM
Scientific Assistant 2012 - 2015 Indian Pharmacopoeia Commission, Ghaziabad.
Honours & Awards  
  • Qualified Graduate Aptitude Test in Engineering (GATE) with percentile 96.62 in 2007.

  • Awarded scholarship for pursuing Master of Pharmacy by UGC (2007-2009).

  • Awarded research fellowship by UGC (2009-2012).

  • Awarded with ‘Best Paper Award’ in ‘PHARMACON-2010’, Ranchi, India.

  • Presented ‘Second Best Poster’ by our group in ‘ICPDD-2018’, Solan, India.

Membership and Proffessional activities  
  • Registered Pharmacist under West Bengal Pharmacy Council.

  • Reviewer of Elsevier, Wiley, Bentham Science, Springer journals.

Major research areas:

Bioanalysis: Bioanalytical method development and validation of drug/drug-like molecule in biological matrices by HPLC or LC-MS/MS as per regulatory guidelines.

Pharmacokinetics(in-vitro/ex-vivo/in-situ): Biopharmaceutical profiling of drug/drug-like molecule viz. lipophilicity (logP/logD), permeability (PAMPA/perfusion model), transporter activities (P-gp), plasma protein binding, RBC partitioning, CYP inhibition.

Pharmacokinetics (in-vivo): Pharmacokinetic study of drug/drug-like molecule in animal models through different routes viz. bioavailability, dose proportionality, tissue distribution, toxicokinetics.

Drug interaction: Effect of natural products (druggable/dietary supplement/food additive) on pharmacokinetics of drugs under the purview of enhancement in plasma concentration of drugs for improved efficacy.

Toxicity study: Acute and sub-chronic toxicity study in rodents as per regulatory guidelines.

Publications

Click here for complete list.

  • Sharma, A.; Gour, A.; Bhatt, S.; Rath, S.K.; Malik, T.A.; Dogra, A.; Sangwan, P.L.; Koul, S.; Abdullah, S.T.; Singh, G.; Nandi, U.; Effect of IS01957, a para-coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy. Drug Development Research (2019). [Accepted]

  • Khan, I.A.; Singh, A.; Mindala, D.P.; Meena, S.; Vij, B.; Yadav, A.K.; Roy, S.; Nandi, U.; Katare, A.K.; Jaglan, S.; Singh, D.; Gupta, A.P.; Gupta, P.; Singh, S.; Tikko, M.K.; Singh, G.; Vishwakarma, R.A. Preclinical development of gastro-protective botanical candidate from Woodfordia fruticosa: Chemical standardization, efficacy, pharmacokinetics and safety pharmacology. Journal of Ethnopharmacology (2019). [Accepted]

  • Reddy, G.L.; Dar, M.I.; Hudwekar, A.D.; Mahajan, P.; Nargotra, A.; Baba, A.M.; Nandi, U.; Wazir, P.; Singh, G.; Vishwakarma, R.A.; Syed, S.H.; Sawant, S.D. Design, Synthesis and Biological Evaluation of Pyrazolopyrimidinone Based Potent and Selective PDE5 Inhibitors for Treatment of Erectile Dysfunction. Bioorganic Chemistry (2019). [Accepted]

  • Magotra, A.; Gour, A.; Sharma, D.K.; Dash, A.K.; Singh, G.; Mukherjee, D.; Nandi, U. Pharmacokinetic evaluation of medicinally important synthetic N, N′ diindolylmethane glucoside: Improved synthesis and metabolic stability. Bioorganic & Medicinal Chemistry Letters (2019), 29(8), 1007-1011.

  • Kotwal, P.; Magotra, A.; Dogra, A.; Sharma, S.; Gour, A.; Bhatt, S.; Wazir, P.; Singh, P.P.; Singh, G.; Nandi, U. Assessment of preclinical drug interactions of bedaquiline by a highly sensitive LC-ESI-MS/MS based bioanalytical method. Journal of Chromatography B (2019), 1112, 48-55.

  • Dogra, A.; Bhatt, S.; Magotra, A.; Sharma, A.; Kotwal, P.;  Gour, A.; Wazir, P.; Singh, G.; Nandi U. Intervention of curcumin on oral pharmacokinetics of daclatasvir in rat: A possible risk for long‐term use. Phytotherapy Research (2018), 32(10), 1967-1974.

  • Singh, A.; Thatikonda, T.; Kumar, A.; Wazir, P.; V, V.; Nandi, U.; Singh, P.P.; Singh, S.;  Gupta, A.P.; Tikoo, M.K.; Singh, G.; Vishwakarma, R. Determination of ZSTK474, a novel Pan PI3K inhibitor in mouse plasma by LC–MS/MS and its application to Pharmacokinetics. Journal of Pharmaceutical and Biomedical Analysis (2018), 149, 387-393.

  • Magotra, A.; Sharma, A.; Singh, S.; Ojha, P.K.; Kumar, S.; Bokolia, N.; Wazir, P.; Sharma, S.; Khan, I.A.; Singh, P.P.; Vishwakarma, R.A.; Singh, G.; Nandi, U. Physicochemical, pharmacokinetic, efficacy and toxicity profiling of a potential nitrofuranyl methyl piperazine derivative IIIM-MCD-211 for oral tuberculosis therapy via in-silicoin-vitroin-vivo approach. Pulmonary Pharmacology & Therapeutics (2018), 48, 151-160.

  • Sharma, A.; Magotra, A.; Rath, S.K.; Wazir, P.; Nandi, U.; Koul, S.; Sangwan, P.L.; Gupta, A,P.; Singh, G. In-vitro and in-vivo pharmacokinetics of IS01957, p-coumaric acid derivative using a validated LC–ESI–MS/MS method in mice plasma. Journal of Pharmaceutical Investigation (2018), 48(5), 565-574.

  • Sharma, A.; Magotra, A.; Dogra, A.; Rath, S.K.; Rayees, S.; Wazir, P.; Sharma, S.; Sangwan, P.L.; Singh, S.; Singh, G.; Nandi, U. Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception. Regulatory Toxicology and Pharmacology (2017), 91, 216-225.

  • Magotra, A.; Sharma, A.; Gupta, A.P.; Wazir, P.; Sharma, S.; Singh, P.P.; Tikoo, M.K.;  Vishwakarma, R.A.; Singh, G.; Nandi, U. Development and validation of a highly sensitive LC-ESI-MS/MS method for estimation of IIIM-MCD-211, a novel nitrofuranyl methyl piperazine derivative with potential activity against tuberculosis: Application to drug development. Journal of Chromatography B (2017), 1060, 200-206

  • Nandi, U.; Dan S.; Pal, T.K. Development and validation of a liquid chromatography–mass spectrometry method for simultaneous determination of metoprolol and telmisartan in rat plasma and its application to pharmacokinetic study. Journal of Pharmaceutical Investigation (2015), 45(3), 329-340.

Book chapters

  • Dogra, A.; Mandal, U.K.; Nandi, U. Chapter on ‘Pharmacognosy, phytochemistry and pharmacology of Dysoxylum binectariferum’ in the book entitled ‘Recent Progress in Medicinal Plants’ (2018) Studium Press (In Press)

  • Gorain, B.; Bhattamishra, S.K.; Choudhury, H; Nandi, U.; Pandey M. Chapter on ‘Overexpressed receptors and proteins in lung cancer’ in the book entitled “Nanotechnology-based targeted drug delivery systems for lung cancer’ (2018)  Elsevier (In Press)

Current Students

1
Mr. Ashish Dogra, SRF
2
Ms. Pankul Kotwal, JRF
3
Ms. Shipra Bhatt, JRF
4
Mr. Abhishek Gour, Inspire Fellow



Facilities in the laboratory
1
Analytical balance
6
Water purification system
2
pH meter
7
Perfusion pump
3
Refrigerated centrifuge
8
Spectrophotometer
4
Vacuum drying system
9
HPLC
5
Freezer
10
LC-MS/MS

Facilities in the Department
1
Multimode plate reader
7
Plethysmometer
2
Automated hematology analyzer
8
Analgesiometer (Hot plate)
3
Automated biochemical analyzer
9
Analgesiometer (Tail Flick)
4
Automated urine analyzer
10
Convulsometer
5
Optical microscope
11
Deep freezer
6
Shaking water bath
12
Ultrasonic homogenizer