Dr. Sreedhar Madishetti

Inflammation Pharmacology Division & Head Engineering Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: sreedhar[at]iiim[dot]ac[dot]in

Positions Held  
Position Held Date Organization
Scientist 2016 onwards CSIR-IIIM, Jammu
Associate Professor 2012-2015 VIPS, Kakatiya University, Warangal
Assistant Research Scientist -2 2007-2009

Infection Pharmacology Division,AstraZeneca India, Pvt., Ltd., Bangalore

Assistant Research Scientist -1 2005-2007

Pharmacokinetics & Drug Metabolism Division,AstraZeneca India, Pvt., Ltd., Bangalore

Honours & Awards  
  • Best team award as part of PK – PD team at AstraZeneca India Pvt Ltd., Bangalore, 2008

  • Appreciation award at AstraZeneca India Pvt. Ltd., Bangalore, 2008

  • Jitendar Reddy, Sreedhar Madishetti, Sheshagiri Gaonkar, Prakash Vachaspati., A fast PK method to Screen compounds in Drug Discovery’, at the international conference on Laboratory Animal Science held in Mumbai, 2009. Won best poster award. (as a co-author)

  • Sreedhar Madishetti, Suvarna T, Harikrishna D, Vidya Sagar J, Rama Krishna D., “Anticancer activity of some novel copper complexes” at UGC sponsored National Seminar on Recent Development in Co–ordination & Bioinorganic Chemistry held at Department of Chemistry, Kakatiya University, Warangal 2005 - Won 2nd best   poster award

  • Qualified GATE- 2003 with 94.05 percentile to receive AICTE fellowship during M. Pharm

Membership  
  • Member of Andhra Pradesh State Pharmacy Council

Major research areas:

Emerging trends indicate life style disorders like diabetes mellitus, obesity and rheumatoid arthritis are chronic inflammatory conditions. The research focus of our group is towards addressing these diseases. Herbal extracts/preparations/derivatives of natural compounds form a promising group of agents, from the times of Ayurveda and other ancient Indian medical systems, especially for the treatment of chronic diseases/inflammatory conditions. The main research activities of our group involves discovery and development of natural products as promising therapies for addressing inflammation with an aim to develop anti-diabetic/ anti-obesity/ pain relieving medications.

Publications

  • Madishetti, S.; Schneble, N.;  König, C.;  Hirsch, E.; Schulz, S.;  Müller, J. P. ; Wetzker, R., Phosphoinositide 3-kinase γ integrates cAMP and AKT signaling of the μ-opioid receptor, British Journal of Pharmacology (2014), 171, 3328–3337.

  • Reddy, J.;  Madishetti, S.;  Vachaspati., P. R.; Fast mouse PK (fast PK ): A rapid screening method to increase pharmacokinetics throughput in preclinical drug discovery. European Journal of Pharmaceutical Sciences (2012), 47, 444-450.

  • Singh, U.; Chashoo, G.; Khan, S. U.; Mahajan, P.;  Nargotra, A.;  Mahajan, G.; Singh, A.; Sharma, A.;  Mintoo, M. J.;  Guru, S. K.;  Aruri, H.;  Thatikonda, T.; Sahu, P.; Chibber, P.; Kumar, V.;  Mir, S. A.;  Bharate, Sonali S. ; Madishetti, S.; Nandi, U.;  Singh, G.;  Mondhe, D. M.;  Bhushan, S.;  Malik, F.;  Mignani, S.; Vishwakarma , R. A. and Singh., P. P. Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model. J. Med. Chem. (2017), 60, 9470−9489.

  • Tripathy, B.;  Satyanarayana, S. ; Khan, K. A.;   Ahmed, Z.; Madishetti, S.; Sawhney, G.; Raja, K. Biological evaluation of crude plant extracts for antiadipogenenic activity in 3t3 l1 cells, IJIPSR / 7 (01), 2019, 14-29. Doi: 10.21276/Ijipsr.2019.07.01.76.

Group

Mr. Parveen Kumar