Dr. Parvinder Pal Singh

Medicinal Chemistry Division
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: ppsingh[at]iiim[dot]ac[dot]in, ppsingh[at]iiim[dot]res[dot]in

Positions Held  
Position Held Date Organization
Scientist 2011- Present CSIR-IIIM

Research Area

Organic Synthesis: To develop new synthetic methodologies.

  • New methods for the synthesis of C-C/C- N/C- S/C-X bond via C-H activation/ functionalization.

  •  Synthesis of natural/synthetic bio-active molecules.

  • Synthesis of fluorescent labeled natural/unnatural GPI and PI based probes.

  Medicinal Chemistry: To develop novel and potent anti-TB and anti-cancer agents.

  • Medicinal Chemistry on nitro-imidazole and Rif scaffolds to develop new generation analogs which also have potency against resistant MTB.

  • Medicinal Chemistry on clinically validated anti-cancer kinase based targets viz., Phosphoinositide 3-kinase (PI3K) and Cyclin Dependent Kinase (CDK) to discover novel anti-cancer agents.

  • Bharate,S.; Sawant,SD.; Singh, PP.; Vishwakarma,RA.Kinase Inhibitors from Marine OriginChemical Review 2013, doi.org/10.1021/cr300410v.

  • Singh,PP.;  Aithagani, SK.;Yadav,M .;   Singh,VP.;  Vishwakarma, RA.Iron-catalyzed Cross-Coupling of Electron-Deficient Heterocycles and Quinone with Organoboron Species via Innate C−H Functionalization: Application in Total Synthesis of Pyrazine Alkaloid Botryllazine AJ. Org. Chem., 201378, 2639–2648. 

  • Singh,PP .;Thatikonda,T .; Kumar,KAA .; Sawant,SD.; Singh, B.; Sharma,AK.; Sharma,PR.; Singh,D .; Vishwakarma, RA. Cu−Mn Spinel Oxide Catalyzed Regioselective Halogenation of Phenols and N- Heteroarenes Journal of Organic Chemistry, 2012, 77, 5823−5828.

  • Singh,PP .;Gudup, S .; Aruri, H .; Singh, U.;Ambala,S .; Yadav, M .; Sawant ,SD.; Vishwakarma,RA . New method for C–H arylation/alkylation at α-position of cyclic aliphatic ethers by iron-oxide mediated reaction Organic & Biomolecular Chemistry, 2012, 10, 1587-1597.

  • Jada,S.;  Doma,MR.;  Singh, PP.; Kumar,S.;Malik, F .; Sharma,A.; Khan,IA .; Qazi,GN.; Kumar,HMS. Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds European Journal of Medicinal Chemistry 2012, 51, 35–41.

  • Singh,PP.; Gudup,S.; Ambala, S.; Singh, U.;Dadhwal,S .; Singh, B.; Sawant,SD.; Vishwakarma,RA . Iron oxide mediated direct C–H arylation/alkylation at a-position of cyclic aliphatic ethers Chem. Comm., 2011, 47, 5852–5854
    (Selected as Hot Article by Editor; http://blogs.rsc.org/cc/2011/05/17/iron-oxide-mediated-c-c-bond-formation/).

  • Saikam,V .; Yadav,M .; Gannedi,V .; Raghupathy, R .;Singh,PP .; Qazi,NA .; Sawant ,SD .;Vishwakarma, RA. Synthesis of new fluorescently labeled glycosylphosphatidylinositol (GPI) anchors Tetrahedran Lett., 2011, 52, 4277-4279.

  • Wani,WY .; Gudup, S .;Sunkaria,A .; Bal,A .; Singh, PP.; Kandimalla,RJL.;Sharma , DR .; Gill ,KD.Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain Neuropharmacology, 2011, 1, 1193-1201.

  • Kumar,HMS .; Singh,PP.; Suri, KA.; Satti,NK.; Qazi, NA.;Shafi,S .; Khajuria, A.;Gupta,A .; Qazi,GN ..Development of novel lipidated analogs of picroside as vaccine adjuvants: Acylated analogs of picroside-II elicit strong Th1 and Th2 response Vaccine, 2010, 28, 8327-8337.

  • Singh,PP.; Reddy,PB.; Sawant,SD .; Koul,S .; Taneja ,SC .; Kumar,HMS . Domino synthesis of indenols and alkyl-indene ethers under modified Vilsmeier conditions. Tetrahedran Lett. 2007, 47, 7241-7243.


  • Vishwakarma,RA.; Sawant, SD.; Singh,PP.; Dar,AH.; Sharma,PR.; Saxena,AK.; Nagrotra,A .; Arvind,KA.; Ramesh,M.; Qazi,AK.; Hussain, A.; Nuyan,C. Synthesis and biological evaluation of isoform selective analogs of liphagane scaffolds as anti-cancer agents: PI3K-α/β inhibitors.( International/Indian Patent Application Filed 0794DEL2012).

  • Vishwakarma, RA.;Sawant,SD .; Singh,PP.; Dar,AH .; Nargotra, A .;Sharma,PR .; Mondhe,DM.; Saxena,AK .; Mahesuni, S.; Qazi, AK.;Hussain, A .; Mahajan,P .Design, Synthesis And Biological Evaluation Of Isoform Selective Analogs Of Tetrazolyl Quinazolinone Scaffold As Anticancer Agents: PI3K-α/δ Inhibitors:(International/Indian Patent Application Filed 150NF2012) .