Dr. D. Srinivasa Reddy

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Director
CSIR - Indian Institute of Integrative Medicine,Canal Road, Jammu – 180001
Email: reddy.ds[at]iiim[dot]res[dot]in, director[at]iiim[dot]res[dot]in

Education

Ph.D., Synthetic Organic Chemistry, University of Hyderabad, India, 2000
Adviser: Professor Goverdhan Mehta
M.Sc., Organic Chemistry, Osmania University, India, 1993
B.Sc., Chemistry, Botany and Zoology, Osmania University, India, 1991

 

Experience

07/2020-present Director,CSIR- Indian Institute of Integrative Medicine,Jammu, Canal Road, India.
12/2018-07/2020 SeniorPrincipal Scientist,Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
11/2014-12/2018 Principal Scientist,Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
11/2010-11/2014 Senior Scientist,Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
11/2007-10/2010 Section Head/Group Leader, Discovery Chemistry, Advinus Therapeutics Pvt. Ltd, Pune, India.
12/2003-10/2007 Research Investigator/Principal Scientist,Discovery Chemistry, Dr. Reddy’s Laboratories Ltd., Hyderabad, India.
9/2001-11/2003 Postdoctoral Fellow, Department of Medicinal Chemistry, University of Kansas, KS, USA; Mentor: Prof. Jeffrey Aubé
6/2000-8/2001 Postdoctoral Fellow, Department of Chemistry, University of Chicago, Chicago, IL, USA; Mentor: Prof. Sergey A. Kozmin
8/1994-5/2000  Doctoral Student; Adviser: Prof. Goverdhan Mehta
  • 20 Years of research experience (post-PhD) in total synthesis of natural products/medicinal chemistry/drug discovery

  • Experienced in leading drug discovery programs (7 years of pharmaindustry experience).

  • One of the molecules (Licogliflozin)discovered by his team in industry is currently in human clinical trials (Phase-II), where he was a project leader.

  • Has experience in coordinating multi-disciplinary teams as a project leader, in particular, during the tenure at pharma industry.

  • Acquired skills in designing novel small molecules and lead optimization.

  • Experienced in planning and execution of projects (Govt. and Industry).

  • Has developed skills in executing total synthesis of biologically active compounds.

  • Discovered an anti-diabetic molecule which is ready for out-licensing.

  • Patent out-licensed to Ahammune Biosciences for Vitiligo drug development.

  • IdentifiedSilinezolid with high brain:plasma ratio with a potential to treat brain infections.

  • Identified novel Insect Repellents – Signed MOU with Ross Lifesciences.

  • Developed a method to access enantiopure pheromones towards crop protection.

  • Identified of novelCladologs towards potent anti-malarials.

  • Identification of an antibiotic lead compound for treating food infections.

Research Interests:

  • Total Synthesis of Biologically Active Natural/Unnatural Products.

  • Medicinal Chemistry and Drug Discovery.

Selected list of Publications

J. Med. Chem., 2020, ASAP; Org. Lett., 2020, 22, 3104; J. Org. Chem, 2020, 85, 5, 3297; Chem. Asian J., 2019, 4572; Eur. J. Org. Chem., 2019, 1257; J. Med. Chem., 2018, 61, 5664; Org. Lett., 2018, 20, 7003; J. Med. Chem., 2018, 61, 3779; J. Org. Chem., 2017, 82, 7614; Eur. J. Med. Chem., 2017, 135, 89; J. Nat. Prod. 2017, 80, 1125; Bioconjugate Chem., 2016, 27, 2062; Org. Lett., 2016, 18, 3178; Org. Biomol. Chem., 2016, 14, 8457; ACS Med. Chem. Lett., 2015, 6, 1111; Org. Lett., 2015, 17, 2090; Org. Lett., 2015, 17, 1652; J. Org. Chem., 2015, 80, 7785.

Selected list of Patents

US20180134650; US20170233324; WO 2015/015519; WO 2015/004687; US 20140256976; WO 2014/195970; WO 2014/181357; WO 2014/170915; WO 2014/128723; WO 2014/128724; WO 2014/097322; WO 2014115172; US 20140296133; WO 2014083578

Click here for complete list of Publications and Patents

Awards and Recognitions

  • CDRI Award–Chemical Sciences for the contribution in Drug discovery (2013)

  • Scientist of the year by the NCL Research Foundation (2013)

  • The Shanti SwarupBhatnagar Award (SSB) in Chemical Sciences (2015)

  • NASI-Reliance Industries Platinum Jubilee Award for application oriented innovations in physical sciences (2015)

  • Elected as a Fellow of the Maharashtra Academy of Sciences (2015)

  • CRSI Bronze Medal in recognition of his contribution in chemical science (2016)

  • Elected as a Fellow of the Telangana Academy of Sciences (2016)

  • Nominated member of Scientific Body of Indian Pharmacopoeia Commission, Govt. of India (2017)

  • Editor of Bioorganic & Medicinal Chemistry Letters, an Elsevier publication (from April 2017)

  • Elected as a Fellow of the National Academy of Sciences, India – NASI (2017)

  • OPPI (Organization of Pharmaceutical Producers of India) Scientist Award (2017)

  • Sun Pharma Research Award (Ranbaxy Research Award) in the field of pharmaceutical sciences (2018)

  • DST-SERB PAC member (co-opt) for the Organic Chemistry (from 2016)

  • KKG Menon Memorial Lecture Award of Institute of Chemical Technology, Mumbai (2018)

  • Council Member of the (NOST) National Organic Symposium Trust (2019)

  • Nominated member of the General and Governing Body of National Dope Testing Laboratory (NDTL), Ministry of Youth Affairs and Sports, Govt of India (2020)

  • Council Member of the Chemical Research Society of India (CRSI) (2020)