Research Publications

1

Wani, T.A.;  Pandith, S.A.; Gupta, A.P.; Chandra, S.; Sharma, N.; Lattoo, S.K. Molecular and functional characterization of two isoforms of chalcone synthase and their expression analysis in relation to flavonoid constituents in Grewia asiatica L . PLoS One, DOI:10.1371/journal.pone.0179155.

2

Rasool, R.U.; Nayak, D.; Chakraborty, S.; Faheem, M. M.; Rah, B.; Mahajan, P.; Gopinath, V.; Katoch, A.; Iqra, Z.; Yousuf, S. K. AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress. Oncogenesis, DOI:10.1038/oncsis.2017.41.

3

Dhar, N.; Razdan, S.; Rana, S.; Bhat, W.W.; Vishwakarma, R.A.; Lattoo, S.K. A decade of molecular understanding of withanolide biosynthesis and in vitro studies in Withania somnifera (L.) Dunal: Prospects and perspectives for pathway engineering. Frontiers in Plant Science, DOI: 10.3389/fpls.2015.01031.

1

Chakraborty, S.; Kumar, A.; Faheem, M.M.; Katoch, A.; Kumar, A.; Jamwal, V.L.; Nayak, D.; Golani, A.; Rasool, R.U.; Ahmad, S. Vimentin activation in early apoptotic cancer cells errands survival pathways during DNA damage inducer CPT treatment in colon carcinoma model. Cell Death & Disease, 2019, 10(6), 1-16.

2

Rather, G.A.; Sharma, A.; Jeelani, S.M.; Misra, P.; Kaul, V.; Lattoo, S.K. Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb. BMC Plant Biology, 2019, 19(1), 1-15. 

3

Baba, S.A.; Ashraf, N. Functional characterization of flavonoid 3'-hydroxylase, CsF3'H, from Crocus sativus L: Insights into substrate specificity and role in abiotic stress. Archives of Biochemistry and Biophysics, 2019, 667, 70-78.

4

Arora, D.; Saneja, A.; Jaglan, S. Cyclodextrin-based delivery systems for dietary pharmaceuticals. Environmental Chemistry Letters, 2019, 17(3), 1263-1270. 

5

Hussain, N.; Bhardwaj, M.; Ahmed, A.; Mukherjee, D. Synthesis of Sugar-Based Enones and Their Transformation into 3,5-Disubstituted Furans and 2-Acyl-Substituted 1,2,3-Trideoxy Sugars in the Presence of Lewis Acids. Organic Letters, 2019, 21(9), 3034-3037. 

6

Wani, A.; Gupta, M.; Ahmad, M.; Shah, A.M.; Ahsan, A.U.; Qazi, P.H.; Malik, F.; Singh, G.; Sharma, P.R.; Kaddoumi, A. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy, 2019, 15(10), 1810-1828.

7

Bhat, R.; Vyas, D. Myrosinase: insights on structural, catalytic, regulatory, and environmental interactions. Critical Reviews in Biotechnology, 2019, 39(4), 508-523.

8

Abdullaha, M.; Mohammed, S.; Ali, M.; Kumar, A.; Vishwakarma, R.A.; Bharate, S.B. Discovery of Quinazolin-4(3H)-ones as NLRP3 Inflammasome Inhibitors: Computational Design, Metal-Free Synthesis, and in Vitro Biological Evaluation. Journal of Organic Chemistry, 2019, 84(9), 5129-5140.

9

Rather, S.A.; Kumar, A.; Ahmed, Q.N. Iodine-DMSO-promoted divergent reactivities of arylacetylenes. Chemical Communications (Cambridge, United Kingdom), 2019, 55(31), 4511-4514.

10

Nalli, Y.; Dar, M.S.; Bano, N.; Rasool, J.U.; Sarkar, A.R.; Banday, J.; Bhat, A.Q.; Rafia, B.; Vishwakarma, R.A.; Dar, M.J. Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain. Bioorganic & Medicinal Chemistry Letters, 2019, 29(9), 1043-1046.

11

Khullar, M.; Sharma, A.; Wani, A.; Sharma, N.; Sharma, N.; Chandan, B.K.; Kumar, A.; Ahmed, Z. Acteoside ameliorates inflammatory responses through NFkB pathway in alcohol induced hepatic damage. International Immunopharmacology, 2019, 69, 109-117.

12

Dogra, A.; Sharma, A.; Kumar, M.U.; Kotwal, P.; Bhatt, S.; Nandi, Utpal. Liquid Chromatography Based Methods for Analysis of Disease-Modifying Antirheumatic Drugs (DMARDs) in Biological Matrices. Critical Reviews in Analytical Chemistry, 2019, 49(3), 224-242.

13

Hussain, A.; Rather, M.A.; Bhat, Z.S.; Majeed, A.; Maqbool, M.; Shah, A.Manzoor.; Aga, M.A.; Shah, A.; Mushtaq, S.; Sangwan, P.L. In vitro evaluation of dinactin, a potent microbial metabolite against Mycobacterium tuberculosis.  International Journal of Antimicrobial Agents, 2019, 53(1), 49-53.

14

Majid, I.; Kumar, A.; Abbas, N. A basic helix loop helix transcription factor, AaMYC2-Like positively regulates artemisinin biosynthesis in Artemisia annua L. Industrial Crops and Products, 2019, 128, 115-125.

15

Sultan, S.; Shah, B.A. Carbon-carbon and Carbon-heteroatom Bond Formation Reactions using Unsaturated Carbon Compounds. Chemical Record, 2019, 19(2-3), 644-660.

16

Kumar, G.; Singh, D.; Tali, J.A.; Dheer, D.; Shankar, R. Andrographolide: Chemical modification and its effect on biological activities. Bioorganic chemistry, 2019, 95103511.

17

Ahmad, T.; Arora, P.; Riyaz-Ul-Hassan, S.; Ali, A.; Nalli, Y. Antibacterial potential of Juglomycin A isolated from Streptomyces achromogenes, an endophyte of Crocus sativus Linn. Journal of applied microbiology, 2019, https://doi.org/10.1111/jam.14568

18

Sharma, A.; Rather, G.A.; Misra, P.; Lattoo, S.K.; Dhar, M.K. Gene Silencing and Over-Expression Studies in Concurrence With Promoter Specific Elicitations Reveal the Central Role of WsCYP85A69 in Biosynthesis of Triterpenoids in Withania somnifera (L.) Dunal. Frontiers in plant science, 2019, 10842.

19

Sonawane, V.R.; Gatchie, L.; Williams, I.S.; Siddique, Mohd. U.M.; Jayaprakash, V.; Sinha, B.N.; Bharate, S.B.; Chaudhuri, B. Corrigendum to "CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance" [Eur. J. Pharm. Sci. 131 (2019) 177-194]. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, 136104960.

20

Khanna, K.; Jamwal, V.L.; Sharma, A.; Gandhi, S.; Ohri, P.; Bhardwaj, R.; Al-Huqail, A.A.; Siddiqui, M.H.; Ali, H.M.; Ahmad, P. Supplementation with plant growth promoting rhizobacteria (PGPR) alleviates cadmium toxicity in Solanum lycopersicum by modulating the expression of secondary metabolites. Chemosphere, 2019, 230628-639.

21

Arora, P.; Wani, Z.A.; Ahmad, T.; Sultan, P.; Gupta, S.; Riyaz-Ul-Hassan, S. Community structure, spatial distribution, diversity and functional characterization of culturable endophytic fungi associated with Glycyrrhiza glabra L. Fungal biology, 2019, 123,5, 373-383.

22

Arif, T.; Rahman, S.; Choi, I.; Khan, S.; Tasduq, S.A. Biology, Pathophysiological Role, and Clinical Implications of Exosomes: A Critical Appraisal. Cells (2019), 8(2).

23

Dheer, D.; Nicolas, J.; Shankar, R. Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases. Advanced drug delivery reviews, 2019, 151-152130-151.

24

Awasthi, P.; Mahajan, V.; Jamwal, V.L.; Chouhan, R.; Kapoor, N.; Bedi, Y. S.; Gandhi, S.G. Characterization of the gene encoding 4-coumarate:CoA ligase in Coleus forskohlii. Journal of Plant Biochemistry and Biotechnology, 2019, 2, 203–210.

1

Bharate, S.S.; Mignani, S.; Vishwakarma, R.A. Why Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical Analysis. Journal of Medicinal Chemistry, 2018, 13, 10345-10374.

2

Mudududdla, R.; Mohanakrishnan, D.; Bharate, S.S.; Vishwakarma, R.A.; Sahal, D.; Bharate, S.B. Orally Effective Aminoalkyl 10H-Indolo-[3,2-b]quinoline-11-carboxamide Kills the Malaria Parasite by Inhibiting Host Hemoglobin Uptake. ChemMedChem, 2018, 13, 2581-2598.

3

Thottacherry, J,J.;  Kosmalska, A.J.; Kumar, A.; Vishen, A.S.; Elosegui-Artola, A.; Pradhan, S.; Sharma, S.; Singh, P.P.; Guadamillas, M.C.; Chaudhary, N.; Vishwakarma, R.; Trepat, X.; Pozo, M.A.d.; Parton, R.G.; Rao, M.; Pullarkat, P.; Roca-Cusachs, P.; Mayor, S. Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells. Nature Communications, 2018, 9, 4217.

4

Bharate, S.B.; Kumar, V.; Jain, S.K.; Mintoo, N.J.; Guru, S.K.; Nuthakki, V.K.; Sharma, M.; Bharate, S.S, Gandhi, S.G.; Mondhe, D.M.; Bhushan, S.; Vishwakarma, R.A. Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-dependent Kinase Inhibitor. Journal of Medicinal Chemistry, 2018, 61, 1664-1687.

5

Bharate, S.S.; Kumar, V.; Singh, G.D.; Singh, A.; Gupta, M.; Singh, D.; Kumar, A.; Vishwakarma, R.A.; Bharate, S.B. Preclinical development of Crocus sativus based botanical lead IIIM-141 for Alzheimer's disease: Chemical standardization, efficacy, formulation development, pharmacokinetics and safety pharmacology. ACS Omega, 2018, 3, 9572−9585.

6

Gupta, M.; Wani, A.; U.l Ahsan, A.; Chopra, M.; Vishwakarma, R.A.; Singh, G.; Kumar, A. Soluble Aβ1-42 suppresses TNF-α and activates NLRP3 inflammasome in THP-1 macrophages. Cytokine, 2018, 11184-87.

7

Bhat, Z.S.; Rather, M. A.; Maqbool, M.; Ahmad ,Z.; Bhat, Z. S.; Ahmad, Z.; Yousuf, S. K.; Ul Lah, H.; Yousuf ,S. K.; Ara ,T. Synthesis and in vitro evaluation of substituted 3-cinnamoyl-4-hydroxy-pyran-2-one (CHP) in pursuit of new potential antituberculosis agents .MedChemComm, 2018, 9,1, 165-172.

8

Rasool, F.; Ahmed, A.; Hussain, N.; Mukherjee, D.; Rasool, F.; Ahmed, A.; Hussain, N.; Yousuf, S.K.; Mukherjee, D . One-Pot Regioselective and Stereoselective Synthesis of C-Glycosyl Amides from Glycals Using Vinyl Azides as Glycosyl Acceptors .Organic letters, 2018, 20,13, 4036-4039.

9

Saneja, A.; Arora, D.; Dubey, R.D.; Kumar, R.; Panda, A. K.; Gupta, P. N. CD44 targeted PLGA nanomedicines for cancer chemotherapy. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, 12147-58.

10

Sharma, V.; Sharma, N.; Arora, D.; Singamaneni, V.; Kumar, A.; Kushwaha, M.; Bhushan, S.; Jaglan, S.; Gupta, P. Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill. Bioorganic & medicinal chemistry letters, 2018, 28,12, 2217-2221.

11

Wani ,N. A.; Singh, G.; Shankar, S.; Sharma, A.; Katoch, M.; Rai, R. Corrigendum to “Short hybrid peptides incorporating β- and γ-amino acids as antimicrobial agents” [Peptides 97 (2017) 46-53]. Peptides, 2018, 10485.

12

Mignani, S.; Rodrigues, J.;  Tomas, H.;  Jalal , R.; Singh , P.P; Majoral , J.P.; Vishwakarma, R.A. Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified. Drug discovery today, 2018, 23,3, 605-615.

13

Kumar, S.; Bokolia, N.P.; Mehra, R.; Nargotra, A.; Sharma, S.; Singh, P.P.; Raina, D.; Khan, I. A. Screening of antitubercular compound library identifies novel ATP synthase inhibitors of Mycobacterium tuberculosis.Tuberculosis (Edinburgh, Scotland), 2018, 10856-63.

14

Saneja, A.; Kumar, R.; Panda, A. K.; Arora, D.; Jaglan, S.; Kumar, S. Recent advances in near-infrared light-responsive nanocarriers for cancer therapy. Drug discovery today, 2018, 23, 5, 1115-1125.

15

Gupta, N.; Qayum, A.; Singh, S.; Raina, A.; Shankar, R.; Gairola, S.; Sangwan, P. L. Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents. European journal of medicinal chemistry, 2018, 145511-523.

16

Gupta, S.; Khajuria ,V.; Ahsan, A. U.; Wani, A.; Nazir, L. A.; Sharma, S.; Ali, S. The amino analogue of β-boswellic acid efficiently attenuates the release of pro-inflammatory mediators than its parent compound through the suppression of NF-κB/IκBα signalling axis. Cytokine, 2018, 10793-104.

17

Joshi, P.; Sonawane, V.R.; Williams, I.S.;   McCann, G.J. P.; Gatchie, L.; Sharma, R.;  Satti, N.;  Chaudhuri, B.; Bharate, S.B. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm, 2018, 9, 2, 371-382.

18

Dar, N.J.; Satti, N.K.; Dutt, P.; Hamid, A.; Ahmad, M. Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway. Molecular Neurobiology, 2018, 55, 4, 2725-2739.

19

Singh, V.P.; Yedukondalu, N.; Sharma, V.; Kushwaha, M.; Sharma, R.; Chaubey, A.; Kumar, A.; Singh, D.;  Vishwakarma, R.A. Lipovelutibols A–D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum. Journal of Natural Products, 2018, 81, 2, 219–226.

20

Kushwaha, M.;  Jain, S.K.; Sharma, N.;  Abrol, V.; Jaglan, S.; Vishwakarma, R.A. Establishment of LCMS Based Platform for Discovery of Quorum Sensing Inhibitors: Signal Detection in Pseudomonas aeruginosa PAO1. ACS Chemical Biology, 2018, 13, 3, 657–665.

21

Kour, D.; Gupta, A.; Kapoor, K.K.; Gupta, V.K.; Rajnikant; Singh, D.; Das, P. Iodine–NH4OAc mediated regioselective synthesis of 2-aroyl-3-arylimidazo[1,2-a]pyridines from 1,3-diaryl-prop-2-en-1-ones. Organic & Biomolecular chemistry,2018, 16, 1330-1336.

22

Sharma, A.; Magotra, A.; Rath, S.K.; Wazir, P.; Nandi, U.; Koul, S.; Sangwan, P.L.; Gupta, A.P.; Singh, G. In-vitro and in-vivo pharmacokinetics of IS01957, p-coumaric acid derivative using a validated LC-ESI-MS/MS method in mice plasma. Journal of Pharmaceutical Investigation, 2018, 48, 5, 565–574.

23

Kumar, S.; Mehra, R.; Sharma, S.; Bokolia, N.P.; Raina, R.; Nargotra, A.; Singh, P.P.; Khan, I.A. Screening of antitubercular compound library identifies novel ATP synthase inhibitors of Mycobacterium tuberculosis. Tuberculosis, 2018, 108, 56-63.

24

Gupta, N.; Qayum, A.; Raina, A.; Shankar, R.; Gairola, S.; Singh, S.; Sangwan, P. L. Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents. European Journal of Medicinal Chemistry, 2018, 145, 511-523.  

25

Rather, G.A.; Sharma, A.; Pandith, S.A.; Kaul, V.; Nandi, U.; Misra, P.; Lattoo, S.K. De novo transcriptome analyses reveals putative pathway genes involved in biosynthesis and regulation of camptothecin in Nothapodytes nimmoniana (Graham) Mabb. Plant Molecular Biology, 2018, 96, 197-215.