Overview
The primary focus is to provide support to the ongoing drug discovery program of the institute in the areas of Pharmacokinetics, ADME and Toxicology and generate preclinical data.
Mission and goals
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Development of validated protocols for HPLC/LC-MS-MS in terms of recovery, presicision, accuracy and reproducibility. |
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PK studies of new chemical entities. |
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Absorption (A), distribution (D), Metabolism (M), Elimination (E) and protein binding profile. |
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Safety pharmacology |
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Regulatory Toxicology |
Competencies
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Pre-formulation |
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Pharmacokinetics |
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Bioavailability/ Bioequivalence studies |
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ADME Studies |
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Phase I Studies |
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Preparation of Pre-clinical/ Phase I Dossiers |
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In vivo toxicology (as per OECD/Schedule Y guidelines) |
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Safety pharmacological studies (as per ICH guidelines) |
Area of
research
| S/No |
Name |
Area of Research/Expertise |
E-mail |
1. |
Gurdarshan Singh |
Regulatory Toxicology |
singh_gd[at]iiim[dot]res[dot]in |
2 |
P.N. Gupta |
Formulation & drug Delivery |
pngupta[at]iiim[dot]res[dot]in |
3 |
Sheikh Tasduq Abdullah |
Toxicology, Chronic Skin and Liver Disorders |
stabdullah[at]iiim[dot]res[dot]in |
4 |
Ajay Kumar |
Alzheimer’s disease, autophagy, NLRP-3 inflammasome |
ajaykumar[at]iiim[dot]res[dot]in |
5 |
Utpal Nandi |
Pharmacokinetics & Toxicity, Phytochemical –drug interaction |
unandi[at]iiim[dot]res[dot]in |
6 |
Bhavna Vij |
Operation & maintenance of HPLC |
bhavna[at]iiim[dot]res[dot]in |
7 |
Priya Wazir |
Operation & maintenance of LCMS/MS |
pjaswal[at]iiim[dot]res[dot]in |
Facilities
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Pharmacokinetics and General Instrumentation
Main Instrumentation.
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Shimadzu HPLC system (Class VP series)
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Thermofinningan HPLC System (Spectra Series)
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Thermo Multiscan Spectrum Elisa Reader
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Perkin-Elmer LS 50B Well plate Spectroflurometer
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Perkin-Elmer LS 55 Spectroflurometer
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Shimadzu UV-1601 PC- Spectrophotometer
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Safety Pharmacology lab facility
Main Instrumentation.
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Multichannel Polygraph (Expermentia, Hungry)
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Telemetry System (DSI, USA)
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Radial Arm Maze (Coulbourn, USA)
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Isolated Organ Bath (Bio-Pack System, USA)
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Hot plate Analgesiometer (Ugo basile, Italy)
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Clinical Biochemistry analyzer Chem-7 (Erba, Manheim, Germany)
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Automated hematology analyzer (Sysmex, XT-1800i, Kobe, Japan)
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Current
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PK studies of various in-house lead molecules |
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Screening of in house molecules for CYP 450 activities |
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Microsomal stability studies of in-house lead molecules |
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Safety Pharmacological and regulatory toxicological studies of various in-house/sponsored molecules. |
Projects
| SNO |
Project Title |
Sponsored by |
1. |
Pre-clinical (PK-PD, Safety and toxicity profile) of new bioactive leads, and development of new combination drugs for cancer/tuberculosis |
Council of Scientific and Industrial Research |
2. |
Pre-clinical Development of Botanical Leads and NCEs for IND Phase |
Council of Scientific and Industrial Research |
3. |
Nurturing a new Pan-CSIR drug pipe line: high Intensity preclinical, clinical studies on lead candidates (CSIR-DPL) |
Council of Scientific and Industrial Research |
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