Natural Products Chemistry (Plants)Division

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Overview

Indian Institute of Integrative Medicine is a World class Institute in the area of Natural Products with expertise in all the relevant fields needed for drug development especially Herbal drugs based on traditional systems of healthcare and validated as per modern systems. It can play a vital role in promoting ASU medicines for making them acceptable world over and also in development of new drugs /new chemical entities. Varieties with desired chemoprofiles and for production of novel phytochemicals. .

Mission and goals

	Isolation of new bioactive molecules from natural sources.
	Development of NCEs by structure modification of natural products/ synthesis.
	Development of standardized herbal products as new drug candidates or PHP’s (Positive Health Promoters).
	Creation of enriched repository of chemical marker compounds by isolating a large number of molecules to be used for chemoprofiling of the medicinal plants/formulations containing them.
	Development of SOPs for standardization of single/polyherbal formulations by using existing /newly developed protocols (HPTLC, HPLC, GLC ,LC-NMR-MS).
	Human resource development in the area of natural products to bring out quality research

Competencies

	A strong natural products resource base with repository of isolated molecules.State of the art extraction facilities including accerated solvent extraction unit, Supercritical extraction plant, Solid phase extraction unit, GMP pilot scale extraction unit
	A large herbarium collection, Repository of raw and synthetic drugs derived from plant sources and a database of all medicinal and aromatic properties associated with major Indian medicinal plants. and quality estimation of various plant based drugs sold in open markets.
	State-of-the-art facilities for isolation of molecules including Flash chromatograph systems, Prep HPLC’s , and scientific expertise for chemical (GC-MS, HPLC etc) and molecular (DNA markers for genetic diversity) evaluation and quality assurance conforming to global standards
	Facility and scientific expertise for characterization of isolated/ synthesized molecules by modern day techniques.

People:

Sr. NO	Name	Expertise	E-mail
1.	Debaraj Mukherjee	Medicinal Chemistry, Glyco-Chemistry, Development of novel synthetic methodologies, Biotransformations and Catalysis	dmukherjee[at]iiim[dot]res[dot]in
2.	Prasoon Gupta	Chemistry of Natural Products	guptap[at]iiim[dot]res[dot]in
3.	Bhawal Ali Shah	Drug Development, Natural Product Chemistry, New synthetic methodologies, Biocatalysis and Organocatalysis.	bashah[at]iiim[dot]res[dot]in
4.	Ravi Shankar	Synthetic Organic Chemistry	rshankar[at]iiim[dot]res[dot]in
5.	Pinky Koul	Chemistry of Natural Products	pkoul[at]iiim[dot]res[dot]in
6.	M.K Verma	Chemistry of Natural Products

Area of research

	Chemistry of Natural products involving isolation and structure elucidation of bioactive molecules from plant sources.
	R & D work on development of new drugs/formulations/new chemical entities.
	Development of processes for isolation/synthesis of drugs and drug intermediates.
	Studies on structure activity relationship/molecular modeling of bioactive molecules
	Development of Novel Target Based Anticancer Therapeutics
	Development of Standard Operation Procedures / marker based standardization methods for medicinal plants/ formulations using modern techniques like HPTLC/HPLC/LC-NMR-MS, GLC etc.

Current

	Nurturing a new Pan-CSIR drug pipe line high intensity preclinical, clinical studies on lead candidates (BSC-0205)
	Medicinal chemistry for Stem Cell Biology and Regenerative Medicine (BSC-0108)
	Bioprospection and plant resources of the Himalayan & Western ghats (BSC-0106)
	Domestication introduction and cultivation of economic important plants (BSC-0110)
	Isolation and characterization of safer and potent antiviral components from new potential medicinal plants to effectively treat and control infections of Human Herpes Virus -1,2 & 3 by in vitro and in vivo studies. (GAP-1137)
	Creation of national repository of pure natural products (MLP-4013)
	Natural Product Chemistry and Pharmacology of Medicinal Plants (MLP-4012)