Animal House

Overview

The Animal House (AH) project is the backbone of research activities of Drug Discovery of Indian Institute of Integrative Medicine (IIIM). It breeds, maintain and provides various species and strains of quality animals to researchers of Institute. Annually, around 25,000 rodents are produced and reared in the Animal House, out of which around 20,000 rodents are put to actual research use by scientists. The AH has its own institutional Animal Ethics Committee constituted specifically to address scientific and ethical considerations of animal use for research, and this has been in existence since 1998. The AH is also registered with the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Environment and Forests, Government of India for breeding and conducting experiment on small animals.

The chief mandate of the AH is to breed and maintain different strains of mice, rats, guinea pigs and rabbits, and supply them upon request to institutional researchers. Surplus animals supplied on request to Govt. & Non-Govt. organizations registered with CPCSEA.

The Facility Breeds and Supplies the Following Species and Strains of Animals

Species	Strains	Status
Mouse	Swiss mice	Outbred
	BALB/c mice	Inbred
	C57BL/6J Mice	-do-
	DBA/2 Mice	-do-
	DBA-1 Mice	-do-
	CDF1 Mice	F1 Hybrid
Rat	Wistar	Outbred
Guinea Pig	English, albino	-do-
Rabbit	New Zealand White	-do-

Upcoming New Animal House Facility

GLP Standard In vivo Laboratory (Animal House)

GLP Standard In vivo Laboratory will be functional very soon to conduct regulatory studies for drug Development as per FDA, ICH, OECD, DCGI and AAALAC, CPCSEA for animal experimentation.

GLP Standard In vivo Laboratory

For the purpose of Drug Development under strict GLP guidelines.
As per Regulatory and FDA requirements
In Compliance of for GLP (National GLP Programme & OECD GLP) ,ICH,FDA,DCGI and other Accreditations (i.e., AAALAC)
To follow CPCSEA guidelines
To produce specific pathogen free (SPF) to germ free laboratory animals in this in vivo laboratory (Animal house)

Capacity of Animal Breeding/Holding Rooms

Total number of animal rooms: 24
Number of animal breeding/holding rooms: 12
Number of Quarantine Rooms: 2
Each room having capacity to hold two double sided IVC racks (rat/mice) and each rack can hold 160 cages for mice and 144 cages for rats.
Capacity of each room: 320/ 288 cages for mice and rats respectively.

Facility Available

Animal Breeding /Holding Rooms (12 Nos.)	3100 x 5070 mm/3135 x 7470 mm
In vivo Toxicology Laboratory (4Nos.):	3100 x 5070 mm
Experimental Laboratory (2Nos.) :	3135 x 7470 mm
Clean Cage Store:	3248 x 7470 mm
Clinical Pathology Laboratory:	3100 x 5070 mm
Necropsy Lab	3520 x 4470 mm
Animal Holding Room For Necropsy	2020 x 2400 mm
Central Nervous System with sound proof room	4435 x 7290 mm
Cardiovascular System with Animal Room:	3193 x 5125 mm
G.I. with Animal Room:	3193 x 5125 mm
Respiratory with Animal Room :	3125 x 4805 mm
Histopathology:	6500 x 7520 mm
Clinical Pathology:	3100 x 5070 mm
HERG & APD:	6270 x 4735 mm
Genotoxicology:	4470 x 4735 mm
Tissue Culture (2Nos.):	4470 x 4735 mm
AMES Mutagenecity:	4135 x 5451 mm

Construction

No. of Floors	G+1+Service Floor
Ground Floor Covered area	1378 sq.m
First floor covered area	1372 sq.m
Service floor covered area	554 sq.m
Total covered area	3304 sq.m
Start of Construction	12.12.2012
Completion period	11.07.2014

Service/Utility

Service floor for housing Air Handling Units of the HVAC System.
Exhaust fans/Compressors for HVAC System.
Equipments for Solar Water Heating System, RO Plant, etc.

Provisions in HVAC System

Centralized Air Conditioning for Clean areas in Ground Floor & First Floor with 250 TR capacity.
Split/Window ACs for Management/Office Area.
100% backup with provision of standbys in all animal rooms and equipments (supply as well as exhaust).
Proper distribution of air changes as per requirements of specific rooms.
Exclusive exhaust system for IVCs.

Provisions in Electrical System

Sub-station with 630 KVA transformer
100% power backup with 500 KVA DG Set
UPS supply for LAN network & Pass boxes
Passenger Lift of 8 persons-1 No., Goods cum passenger lift of 1000kg -2Nos ( 1 No. Clean Lift and 1 No. Dirty Lift)
LAN Network, Access Control System, Video Conference System, Telephone Network, CCTV

Provisions in Fire Fighting & Alarm System

Underground Water Tank with Pump room, pumps with 50m head capacity, Fire tank at terrace
Internal & External Fire hydrants, Fire Hydrant Chambers
Fire Extinguishers & Smoke Detectors inside the building

Provisions in PHE

Treated water supply from Water Treatment plant (1500 lit per hr.) & RO Plant (400 lit per hr.)
Solar Water Heating System for 1500 lit per day
ETP of 10 KLD & Softener for HVAC 1 No.
Rain Water Harvesting System


	Proposed designed of Animal Room

IIIM supported INVIVO Studies of various other Institutions in India by providing Rodents (Animals) during last five years.

Sr.No.	Name of institute
1	PGIMER, Chandigarh
2	CSIR-IGIB, New Delhi
3	ICAR-National Dairy Research Institute(NDRI, Karnal)
4	ICAR-National institute of high security animal Disease(NIHSAD),Bhopal
5	CSIR-IHBT, Palampur
6	GNDU, Amritsar
7	Regional Research Institute of Unani Medicine, Srinagar
8	University of Kashmir
9	Institute of Animal health & Biological Product,Zakura,Srinagar
10	Institute of Animal health & Biological Product,R.S Pura,jammu.
11	Dept. Of Pharmacology and Therapeutics,Govt. Medical college, Jammu
12	Dept of Anatomy, Govt. Medical college, Jammu
13	Department of Pharma,biochem,parasitology of Veterinary college, SKUAST, Jammu
14	Department of Pharmacology and toxicology,Veterinary college,Palampur(H.P)
15	ISF College of pharmacy, Moga,Punjab
16	ICAR-IVRI,Palampur
17	Dept. of Biosciences, H.P.U. Shimla