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Representative Publications of IIIM

In Press | 2018 |2017 | Publications before 2017


In Press

Mignani, S.; Rodrigues, J.;  Tomas, H.;  Jalal , R.; Singh , P.P; Majoral , J.P.; Vishwakarma, R.A. Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified. Drug discovery today, https://doi.org/10.1016/j.drudis.2018.01.010.
Singh, V.P.; Yedukondalu, N.; Sharma, V.; Kushwaha, M.; Sharma, R.; Chaubey, A.; Kumar, A.; Singh, D.;  Vishwakarma, R.A. Lipovelutibols A–D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum. Journal of Natural Products, DOI:10.1021/acs.jnatprod.6b00873.
Joshi, P.;    Sonawane, V.R.; Williams, I.S.;   McCann, G.J. P.; Gatchie, L.; Sharma, R.;  Satti, N.;  Chaudhuri, B.; Bharate, S.B. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm, DOI:10.1039/c7md00388a.
Kushwaha, M.;  Jain, S.K.; Sharma, N.;  Abrol, V.; Jaglan, S.; Vishwakarma, R.A. Establishment of LCMS Based Platform for Discovery of Quorum Sensing Inhibitors: Signal Detection in Pseudomonas aeruginosa PAO1. ACS Chemical Biology, DOI:10.1021/acschembio.7b00875.
Kour, D.; Gupta, A.; Kapoor, K.K.; Gupta, V.K.; Rajnikant; Singh, D.; Das, P. Iodine–NH4OAc mediated regioselective synthesis of 2-aroyl-3-arylimidazo[1,2-a]pyridines from 1,3-diaryl-prop-2-en-1-ones. Organic & Biomolecular chemistry, DOI:10.1039/C7OB02750H.
Wani, T.A.;  Pandith, S.A.; Gupta, A.P.; Chandra, S.; Sharma, N.; Lattoo, S.K. Molecular and functional characterization of two isoforms of chalcone synthase and their expression analysis in relation to flavonoid constituents in Grewia asiatica L . PLoS One, DOI:10.1371/journal.pone.0179155.
Sharma, A.; Magotra, A.; Rath, S.K.; Wazir, P.; Nandi, U.; Koul, S.; Sangwan, P.L.; Gupta, A.P.; Singh, G. In-vitro and in-vivo pharmacokinetics of IS01957, p-coumaric acid derivative using a validated LC-ESI-MS/MS method in mice plasma. Journal of Pharmaceutical Investigation, DOI:10.1007/s40005-017-0350-8.
Rasool, R.U.; Nayak, D.; Chakraborty, S.; Faheem, M. M.; Rah, B.; Mahajan, P.; Gopinath, V.; Katoch, A.; Iqra, Z.; Yousuf, S. K. AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress. Oncogenesis, DOI:10.1038/oncsis.2017.41.
Dar, N.J.; Satti, N.K.; Dutt, P.; Hamid, A.; Ahmad, M. Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway. Molecular Neurobiology, DOI:10.1007/s12035-017-0515-5.
Singh, S.; Kalia, N.P; Khan, I.A.; Singh, S.; Joshi, P.; Sharma, P.R.; Kumar, A.; Bharate, S.B.; Khan, I.A.; Joshi, P. Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of Staphylococcus aureus and Human P-Glycoprotein, Reduces the Biofilm Formation and Intracellular Invasion of Bacteria. Frontiers in microbiology, DOI:10.3389/fmicb.2017.01868.
Rasool, R.U.; Rah, B.; Amin, H.; Nayak, D.; Chakraborty, S.; Rawoof, A.; Mintoo, M.J.; Yousuf, K.; Mukherjee, D.; Kumar, L.D.; Mondhe, D.M.; Goswami. Dual modulation of Ras-Mnk and P13K-AKT-MTOR pathways : A novel C-FLIP inhibitory mechanism of 3-AWA mediated translational alternation through dephosphorylation of eIF4E. Scientific Reports, DOI: 10.1038/srep18800.
Dhar, N.; Razdan, S.; Rana, S.; Bhat, W.W.; Vishwakarma, R.A.; Lattoo, S.K. A decade of molecular understanding of withanolide biosynthesis and in vitro studies in Withania somnifera (L.) Dunal: Prospects and perspectives for pathway engineering. Frontiers in Plant Science, DOI: 10.3389/fpls.2015.01031.


Representative Publications During 2018

Kumar, S.; Mehra, R.; Sharma, S.; Bokolia, N.P.; Raina, R.; Nargotra, A.; Singh, P.P.; Khan, I.A. Screening of antitubercular compound library identifies novel ATP synthase inhibitors of Mycobacterium tuberculosis. Tuberculosis, 2018, 108, 56-63.
Gupta, N.; Qayum, A.; Raina, A.; Shankar, R.; Gairola, S.; Singh, S.; Sangwan, P. L. Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents. European Journal of Medicinal Chemistry, 2018, 145, 511-523.  
Rather, G.A.; Sharma, A.; Pandith, S.A.; Kaul, V.; Nandi, U.; Misra, P.; Lattoo, S.K. De novo transcriptome analyses reveals putative pathway genes involved in biosynthesis and regulation of camptothecin in Nothapodytes nimmoniana (Graham) Mabb. Plant Molecular Biology, 2018, 96, 197-215.


Representative Publications During 2017


Malik, A. H.; Ashraf, N. Transcriptome wide identification, phylogenetic analysis, and expression profiling of zinc-finger transcription factors from Crocus sativus L. Molecular Genetics and Genomics. (2017),  292, 3,  619–633.
Singh, U.; Chashoo, G.; Khan, S.U.; Mahajan, P.; Nargotra, A.; Mahajan, G.; Singh, A.; Sharma, A.; Mintoo, M.J.; Guru, S.K. Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model. Journal of Medicinal Chemistry , 2017, 60, 23, 9470-9489.
Rather, M.A.; Rasool, F.; Bhat, Z.S.; Dar, H.U.; Maqbool, M.; Amin, S.; Yousuf, S.K.; Ahmad, Z. Design and synthesis of indolopyridone hybrids as new antituberculosis agents. Microbial Pathogenesis, 2017, 113, 330-334.
Sharma, A.; Magotra, A.; Dogra, A.; Rath, S.K.;  Rayees, S.; Wazir, P.; Sharma, S.; Sangwan, P.L.; Singh, S.; Singh, G. Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception. Regulatory Toxicology and Pharmacology, 2017, 91, 216-225.
Sultan, S.; Gupta, V.; Shah, B.A. Photoredox-Catalyzed Isatin Reactions: Access to Dibenzo-1,7-Naphthyridine Carboxylate and Tryptanthrin. ChemPhotoChem, 2017,1,4, 120-124.
Rather, M.A.; Lone, A.M.; Teli, B.; Bhat, Z.S.; Singh, P.; Maqbool, M.; Shairgojray, B.A.; Dar, M.J.; Amin, S.; Yousuf, S.K. The synthesis, biological evaluation and structure-activity relationship of 2-phenylaminomethylene-cyclohexane-1,3-diones as specific anti-tuberculosis agents. MedChemComm , 2017, 8,11, 2133-2141.
Wani, N.A.; Singh, G.; Shankar, S.; Sharma, A.; Katoch, M.; Rai, R. Short hybrid peptides incorporating β- and γ-amino acids as antimicrobial agents. Peptides, 2017, 97, 46-53.
Jeelani, S.M.; Farooq, U.; Gupta, A.P.; Lattoo, S.K. Phytochemical evaluation of major bioactive compounds in different cytotypes of five species of Rumex L. Industrial Crops and Products, 2017, 109, 897-904.
Bhat, Z.S.; Rather, M.A.; Maqbool, M.; Ul Lah, H.; Yousuf, S.Khalid.; Ahmad, Z. Cell wall: A versatile fountain of drug targets in Mycobacterium tuberculosis.  Biomedicine & Pharmacotherapy, 2017, 95, 1520-1534.
Kumar, V.; Gupta, M.; Gandhi, S.G.; Bharate, S.S.; Kumar, A.; Vishwakarma, R.A.; Bharate, S.B. Anti-inflammatory chromone alkaloids and glycoside from Dysoxylum binectariferum. Tetrahedron Letters, 2017, 58, 42, 3974-3978.
Nissar, A.U.; Sharma, L.; Mudasir, M.A.; Nazir, L.A.; Umar, S.A.; Sharma, P.R.; Vishwakarma, R.A.; Tasduq, S.A. Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy. Journal of Lipid Research, 2017, 58, 9, 1855-1868.
Singh, R.; Kumar, V.; Bharate, S.S.; Vishwakarma, R.A. Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis. Bioorganic & Medicinal Chemistry, 2017, 25, 20, 5513-5521.
Sharma, R.; Abdullaha, M.; Bharate, S.B. Oxidant-Controlled C-sp2/sp3-H Cross-Dehydrogenative Coupling of N-Heterocycles with Benzylamines. Journal of Organic Chemistry, 2017, 82,18, 9786-9793.
Hussain, A.; Rather, M. A.; Shah, A. M.; Bhat, Z. S.; Shah, A.; Ahmad, Z.; Parvaiz Hassan, Q. Antituberculotic activity of actinobacteria isolated from the rare habitats. Letters in Applied Microbiology, 2017, 65, 3, 256-264.
Mahajan, P.; Chashoo, G.; Gupta, M.; Kumar, A.; Singh, P.P.; Nargotra, A. Fusion of Structure and Ligand Based Methods for Identification of Novel CDK2 Inhibitors. Journal of Chemical Information and Modeling, 2017, 57, 8, 1957-1969.
Joshi, P.; Vishwakarma, R.A.; Bharate, S.B. Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer. European Journal of Medicinal Chemistry, 2017, 138, 273-292.
Gupta, N.; Sharma, S.; Raina, A.; Bhushan, S.; Malik, F.A.; Sangwan, P.L. Synthesis of Novel Mannich Derivatives of Bakuchiol as Apoptotic Inducer through Caspase Activation and PARP-1 Cleavage in A549 Cells. ChemistrySelect, 2017, 2,18, 5196-5201.
Nayak, D.; Kumar, A.; Chakraborty, S.; Rasool, R.Ur.; Amin, H.; Katoch, A.; Gopinath, V.; Mahajan, V.; Zilla, M.K.; Rah, B. Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells. Cell Death & Differentiation, 2017, 24, 7, 1275-1287.
Shah, A.M.; Shakeel-u-Rehman.; Hussain, A.; Mushtaq, S.; Rather, M.A.; Shah, A.; Ahmad, Z.; Ali Khan, I.; Bhat, K.A.; Hassan, Q.P. Antimicrobial investigation of selected soil actinomycetes isolated from unexplored regions of Kashmir Himalayas, India. Microbial Pathogenesis, 2017,110, 93-99.
Magotra, A.; Sharma, A.; Gupta.; Wazir, P.; Sharma, S.; Singh, P.P.; Tikoo, M.K.; Vishwakarma, R.A.; Singh, G.; Nandi, U. Development and validation of a highly sensitive LC-ESI-MS/MS method for estimation of IIIM-MCD-211, a novel nitrofuranyl methyl piperazine derivative with potential activity against tuberculosis: Application to drug development. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017, 1060, 200-206.
Kour, G.; Singh, P.P.; Bhagat, A.; Ahmed, Z. Biopharmaceutic parameters, pharmacokinetics, transport and CYP-mediated drug interactions of IIIM-017: A novel nitroimidazooxazole analogue with anti-tuberculosis activity. European Journal of Pharmaceutical Sciences, 2017, 106, 71-78.
Sharma, R.; Jamwal, V.; Singh, V.P.; Wazir, P.; Awasthi, P.; Singh, D.; Vishwakarma, R.A.; Gandhi, S.G.; Chaubey, A. Revelation and cloning of valinomycin synthetase genes in Streptomyces lavendulae ACR-DA1 and their expression analysis under different fermentation and elicitation conditions. Journal of Biotechnology, 2017, 253, 40-47.
Joshi, P.; McCann, G.J. P.; Sonawane, V.R.; Vishwakarma, R.A.; Chaudhuri, B.; Bharate, S.B. Identification of Potent and Selective CYP1A1 Inhibitors via Combined Ligand and Structure-Based Virtual Screening and Their in Vitro Validation in Sacchrosomes and Live Human Cells. Journal of Chemical Information and Modeling, 2017, 57, 6, 1309-1320.
Bhat, Z.S.; Rather, M.A.; Maqbool, M.; Lah, H.U.L.; Yousuf, S.K.; Ahmad, Z. α-pyrones: Small molecules with versatile structural diversity reflected in multiple pharmacological activities-an update. Biomedicine & Pharmacotherapy, 2017, 91, 265-277.
Ahmad, M.; Aga, M.A.; Bhat, J.A.; Kumar, B.; Rouf, A.; Capalash, N.; Mintoo, M.J.; Kumar, A.; Mahajan, P.; Mondhe, D.M. Exploring Derivatives of Quinazoline Alkaloid L-Vasicine as Cap Groups in the Design and Biological Mechanistic Evaluation of Novel Antitumor Histone Deacetylase Inhibitors. Journal of Medicinal Chemistry, 2017, 60, 8, 3484-3497.
Baba, S.A.; Vishwakarma, R.A.; Ashraf, N. Functional Characterization of CsBGlu12, a β-Glucosidase from Crocus sativus, Provides Insights into Its Role in Abiotic Stress through Accumulation of Antioxidant Flavonols. Journal of Biological Chemistry, 2017, 292,11, 4700-4713.
Vishwakarma, R. Editorial: Medicinal Chemistry Research in India.  ACS Medicinal Chemistry Letters, 2017, 8, 3, 270-272.
Malik, A.H.; Ashraf, N. Transcriptome wide identification, phylogenetic analysis, and expression profiling of zinc-finger transcription factors from Crocus sativus L. Molecular Genetics and Genomics, 2017, 292, 3, 619-633.
Siva Reddy, A.; Ranjith Reddy, K.; Nageswar Rao, D.; Jaladanki, C.K.; Bharatam, P.V.; Lam, P.Y.S.; Das, P. Copper(II)-catalyzed Chan-Lam cross-coupling: chemoselective N-arylation of aminophenols. Organic & Biomolecular Chemistry, 2017, 15, 4, 801-806.
Qadri, M.; Nalli, Y.; Jain, S.K.; Chaubey, A.; Ali, A.; Strobel, G.A.; Vishwakarma, R.A.; Riyaz-Ul-Hassan, S. An Insight into the Secondary Metabolism of Muscodor yucatanensis: Small-Molecule Epigenetic Modifiers Induce Expression of Secondary Metabolism-Related Genes and Production of New Metabolites in the Endophyte. Microbial Ecology, 2017, 73, 4, 954-965.
Koul, M.; Kumar, A.; Singh, J.; Sharma, P.R.; Singh, S.; Koul, M.; Kumar, A.; Deshidi, R.; Sharma, V.; Singh, J. Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells. BMC cell biology, 2017, 18, 1, 26.

               Complete list of publications during 2017


Publications before 2017

               Complete list of publications during 2016

               Complete list of publications during 2015

               Complete list of publications during 2014

               Complete list of publications during 2013

               Complete list of publications during 2012

               Complete list of publications during 2011